Indianapolis Colts quarterback Carson Wentz could miss the Week 17 showdown with the Las Vegas Raiders after he was placed on the reserve/COVID-19 list.
Wentz is unvaccinated, so he will be out for at least five days if he is deemed to be a high-risk close contact with a positive coronavirus case.
The 28-year-old will not be available for 10 days if he returns a positive test, as per the NFL's protocols.
Rookie Sam Ehlinger looks set to make his first NFL start if Wentz is unable to face the Raiders on Sunday.
Offensive coordinator Marcus Brady says Ehlinger will be ready to step up if needed.
Brady said: "We go through the plan, [Ehlinger] goes through it and, like, okay, what are your top calls that you feel comfortable with? [It] Doesn't have to be all of them.
"And so, we have that separate call sheet for him ready to go. He goes through all the reads just like Carson does. He may not get the live rep, but he'll get it on the side. So, he's ready to go."
The Colts beat the Arizona Cardinals 22-16 on Christmas Day despite having several players on the COVID list.
Indianapolis had also added Jahleel Addae, T.J. Carrie, Malik Jefferson, Marlon Mack, Braden Smith and Chris Wilcox to the reserve-COVID list on Monday.
A win over Las Vegas at Lucas Oil Stadium would put the 9-6 Colts in the playoffs for the third time in four years under head coach Frank Reich.
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