The Indianapolis Colts moved top of the AFC South after a 34-17 win over the Tennessee Titans in the NFL on Thursday.

The Colts scored 24 unanswered points at LP Field to improve to 6-3 and condemn their divisional rivals to the same record.

Colts quarterback Philip Rivers went 29 of 39 for 308 yards and a touchdown and made some history in the process.

Nyheim Hines had rushing and receiving touchdowns as the Colts capitalised on the Titans' mistakes.

Titans star Derrick Henry had 103 rushing yards, while QB Ryan Tannehill was 15 of 27 for 147 yards and a TD.

The Titans got on the board when Tannehill found D'Onta Foreman to run in the opening TD.

Rivers then made history, passing Hall of Famer Dan Marino (61,361) to go into fifth for all-time passing yards in the NFL.

The QB helped the Colts draw level at 10-10, finding Hines – celebrating his 24th birthday – with a 13-yard TD pass.

But Jonnu Smith took a handoff and jumped into the endzone with three minutes remaining in the half to restore the Titans' lead.

While the Titans held out the Colts early in the third quarter, punter Trevor Daniel endured a couple of tough moments.

His 17-yard punt gave Indianapolis an opportunity they would not relinquish, Hines rushing in to give the Colts a 20-17 lead.

The Colts added to that when Daniel's punt was blocked by E.J. Speed, allowing T.J. Carrie to run in another touchdown.

Stephen Gostkowski missed his eighth field goal of the season – the most in the NFL – in the fourth quarter to further hurt the Titans' chances.

Indianapolis punished the Titans, Jacoby Brissett – coming into the game for Rivers – rushing over to make it 34-17 as the Colts eased to victory.