Three-time Vuelta a Espana winner Primoz Roglic has withdrawn from this year's race following a crash at the end of stage 16 on Tuesday.

The Slovenian went down just 150 metres from the finish after seemingly clashing handlebars with Britain's Fred Wright (Bahrain Victorious).

Roglic had been second in the general classification, behind Remco Evenepoel, and his withdrawal leaves the Belgian with a two minute and one second lead over Enric Mas, who moves up a spot from third.

In a tweet, Roglic's team, Jumbo-Visma, stated: "Unfortunately, Primoz Roglic will not be at the start of Stage 17 as a consequence of yesterday's crash.

"Get well soon, champion! Thank you for all the beautiful moments in this Vuelta. You had ambitious plans for the final days, but sadly it isn't meant to be."

The withdrawal continues a difficult year for Roglic, who was forced to leave the Tour de France ahead of the final rest day after suffering injuries sustained in a crash with a stray hay bale on stage five.

The 2022 Vuelta a Espana concludes in Madrid on Sunday.

 #LaVuelta22

Unfortunately, @rogla will not be at the start of stage 17 as a consequence of yesterday’s crash.

Get well soon, champion! Thank you for all the beautiful moments in this Vuelta. You had ambitious plans for the final days, but sadly it isn’t meant to be. pic.twitter.com/C3Vnc8P9EO

— Team Jumbo-Visma cycling (@JumboVismaRoad) September 7, 2022