The Philadelphia Eagles may have already won the NFC East and will enter Week 16 without quarterback Jalen Hurts, but a clash with the Dallas Cowboys remains the standout game on the slate.
While the Cowboys' attempts to stick with the Eagles this year were hampered by their road form, Dallas are strong at home and will hope to send a warning to their division rivals ahead of a playoff campaign in which both teams will hope to feature prominently.
Elsewhere, the Kansas City Chiefs have work to do still as they aim, like the Eagles, to secure a bye with the number one seed in the AFC.
But it is not all about the NFL's leading lights, with the battle for position ahead of the postseason ongoing – with a big game in store in Charlotte.
Stats Perform picks out the key facts ahead of a busy Christmas weekend...
Philadelphia Eagles (13-1) @ Dallas Cowboys (10-4)
In beating the Chicago Bears last week, the Eagles secured a 13th win in a single season for only the third time in franchise history. On the two previous occasions, Philly finished with a 13-3 record and reached the Super Bowl, losing to the New England Patriots in the 2004 season and beating the same team in 2017.
The Eagles have never won 14 games in a regular season and will be without injured QB Hurts as they aim to end a four-game losing streak in Dallas.
But the Cowboys are coming into this big home game on a downer, having blown a 17-point lead against the Jacksonville Jaguars last week for their first loss in five.
That game also again showed big QB performances can sometimes prove immaterial, with Dak Prescott throwing for 256 yards and three touchdowns. The Cowboys are 1-2 this season when Prescott has thrown three or more TD passes and only 7-6 since 2020. Prior to that, they were 13-3 in such games.
Seattle Seahawks (7-7) @ Kansas City Chiefs (11-3)
Patrick Mahomes and Geno Smith each earned Pro Bowl selections this week – a fifth for Mahomes but only a first for Smith. Both were well deserved, with the pair third and second respectively for passer rating among qualifying players this year (Smith, 105.3, and Mahomes, 105.0).
However, Mahomes will look to do something he has never done before on Saturday: beat the Seahawks. Having lost 38-31 to Seattle in his only previous such clash in 2018, they are one of just two teams Mahomes has played but never beaten (also 0-2 against the Indianapolis Colts).
Smith, who has never faced the Chiefs, leads the NFC with 26 touchdown passes as he aims to follow Russell Wilson (2017 and 2018) and Matt Hasselbeck (2005) as the only Seahawks to lead the conference across a season. However, with eight interceptions and four fumbles lost by Smith, Seattle are the sole team in the league to have committed a turnover in every game this year.
Detroit Lions (7-7) @ Carolina Panthers (5-9)
The Lions' stunning 6-1 run, including an active three-game winning streak, has them firmly in playoff contention in the NFC. The last time they won six out of seven games in a single season, back in 2016, was also the last time they made the postseason.
However, the Lions have a miserable history against the Panthers. Their 3-7 record in this matchup is their worst against any current NFC franchise, while Detroit are 0-5 on the road against the Panthers since winning on their first trip in 1999.
With Jared Goff in the best form of his career, the Lions will hope to snap that streak. He has gone six games without an interception, which ties the longest such streak by a Lions QB since the statistic was first tracked in 1960. Goff had never previously gone more than three games without throwing a pick.
Elsewhere...
The Bears this week face the Buffalo Bills, the only team in the Super Bowl era to have lost more consecutive games with 125 or more rushing yards in each loss. Chicago have lost seven in a row, but the 1976 Bills were defeated in 10. With 2,616 rushing yards but a 3-11 record, the Bears are on course to become the first team to lead the league in rushing yards yet have one of the worst two records since the 1932 Staten Island Stapletons.
Recent history suggests the Minnesota Vikings will follow up last week's record-breaking comeback against the Colts with another win over the New York Giants. The Vikings' 7-2 record against the Giants since 2005 is their best against NFC opposition and New York's worst.
The Patriots will have to upset the Cincinnati Bengals to get their playoff bid back on track, yet they have won their past seven home games in this matchup, including the last four while scoring at least 35 points. The last team to win five in a row at home to any one team while scoring 35 points or more were the San Francisco 49ers against the Atlanta Falcons between 1992 and 1996.
Tua Tagovailoa will be relieved this week's game against the Green Bay Packers is in Miami and not Wisconsin. Following last week's defeat to Buffalo, the Dolphins QB is 0-4 in starts when the weather is below 50 degrees Fahrenheit; he is 17-7 when the temperature is at least 50 degrees.
Juventus 0-1 Milan: Giroud decides top-four battle in Rossoneri's favour
Milan secured a top-four Serie A finish with a 1-0 win at Juventus as Olivier Giroud's header dealt a knockout blow to the Bianconeri's own hopes of Champions League qualification.
Still reeling from their 10-point deduction and Monday's miserable 4-1 defeat at Empoli, Juve required a win at Allianz Stadium to take the top-four battle to the season's final matchday.
However, the Bianconeri's lack of attacking thrust was on full display once again, with Giroud scoring the only goal of the game with an outstanding header as half-time approached on Sunday.
The Rossoneri were comfortable from there as they ensured Juve's chaotic season will end on another sour note, piling more pressure on embattled head coach Massimiliano Allegri.
Sandro Tonali headed Junior Messias' delivery over as Milan started brightly, but Juve soon improved, with Angel Di Maria failing to hook Moise Kean's cut-back home on the stretch.
More Bianconeri chances came and went as Federico Chiesa hammered over and Kean worked Mike Maignan from distance, but Juve found themselves behind five minutes before half-time.
Davide Calabria's hanging cross from the right was met with a textbook header from Giroud, who planted the ball beyond Wojciech Szczesny's despairing dive.
Adrien Rabiot forced a comfortable save from Maignan as Juve toiled after the restart, failing to make any attacking headway without injured striker Dusan Vlahovic.
Szczesny stuck out a leg to deny Alexis Saelemaekers and Rafael Leao fired over on the break, while Danilo had a close-range effort blocked in a goalmouth scramble as Juve's bid for Champions League football ended with a whimper.
What does it mean? Milan profit from Juve woes
When Juventus' 10-point deduction was confirmed earlier this week, Milan were the chief beneficiary after being propelled into the top four.
Stefano Pioli's men were determined not to let that advantage slip here, the Rossoneri weathering the Juve storm midway through the first half and deserving the three points after Giroud's goal.
Milan thus completed just their third Serie A double over Juventus in the last 50 years, also doing so in the 1990-91 and 2009-10 campaigns.
Giroud the man of the moment
Giroud has so often been the man for the big occasion for both club and country, and he gave Szczesny no chance with a firm header just as Juventus looked to be in the ascendency.
The 36-year-old striker has now scored 12 times in Serie A this season, his best return in one of Europe's top five leagues since he hit as many Premier League goals for Arsenal in the 2016-17 campaign.
Fatal blow for Allegri?
Allegri has faced stern criticism for most of the campaign, and the pressure may just become intolerable now they will finish outside of Italy's top four for the first time since 2010-11 (when they finished seventh).
Having also fallen short in the Europa League semi-finals, the Bianconeri have suffered three successive defeats for the first time since doing so in 2011 under Luigi Delneri.
What's next?
Milan wrap up their Serie A season against Verona next Sunday, while Juventus will be playing for a Europa League place when they visit Udinese on the same day.
Barcelona 3-0 Mallorca: Fabulous Fati fires up Camp Nou farewell
Ansu Fati's fabulous first-half double fired LaLiga champions Barcelona to victory in their Camp Nou farewell with a 3-0 win over Real Mallorca.
The Blaugrana signed off from their famous stadium in style, with Gavi also netting in a comfortable win over their 10-men visitors on Sunday.
In what was their final home game at their iconic ground before a temporary move to facilitate a lengthy renovation, Xavi's side ensured they bade it a fitting goodbye.
After losses against Real Sociedad and Real Valladolid, it also marked an impressive return to form.
Barca needed less than a minute to carve open their visitors, with Fati tucking away a Gavi cutback following a neat Robert Lewandowski ball into the box.
Matters soon worsened for Mallorca, when Amath Ndiaye saw his yellow card upgraded to a red by VAR for a shocking foul on Alejandro Balde.
Fati doubled his tally after that with a close-range rocket off Lewandowski's deft one-touch set-up, and Barca never looked like losing control from there on out.
Mallorca dug their heels in, but even then remained under siege, with Jules Kounde hitting the bar with a header shortly after the restart.
Lewandowski crashed a free-kick against the woodwork too, but Barca finally found their third when Gavi lashed a low finish beyond Dominik Greif.
There were standing ovations for Jordi Alba and Sergio Busquets on their final home appearances, with the Camp Nou crowd rising to salute the club legends.
Bologna 2-2 Napoli: Partenopei throw away two-goal lead amid Spalletti exit talk
Napoli squandered a two-goal lead as Lorenzo De Silvestri snatched a 2-2 draw for Bologna against the Serie A champions, who appear set to lose Scudetto-winning coach Luciano Spalletti.
Spalletti said a decision has been made on his Napoli future before kick-off, with many expecting the Partenopei boss to depart, yet his side initially appeared far from distracted at Stadio Renato Dall'Ara.
Victor Osimhen seized on an early Lukasz Skorupski mistake to open the scoring before doubling his – and Napoli's – tally after 54 minutes with a powerful finish across goal.
However, Lewis Ferguson halved the arrears just past the hour before De Silvestri headed home with six minutes remaining, and only the offside flag denied Nicola Sansone a late winner as Napoli were forced to cling on.
A terrible pass from Bologna goalkeeper Skorupski gifted Napoli their 14th-minute opener as Osimhen intercepted on the edge of the area and finished into an empty net.
Skorupski somewhat made amends by thwarting both Osimhen and Alessio Zerbin as Napoli threatened to extend their lead before the break.
Marko Arnautovic skimmed a rare Bologna chance across the face of an empty goal after the interval before Osimhen furthered Napoli's advantage.
The Napoli striker rolled onto Bartosz Bereszynski's delicate throughball before firing through the legs of Skorupski.
An unmarked Ferguson pulled one back shortly thereafter, tapping in a rebound after Pierluigi Gollini saved from Sansone, who subsequently assisted De Silvestri's headed equaliser with a delightful corner.
Sansone then thought he had snatched a late victory with a one-on-one finish, only to be denied by a belated offside flag.
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