As in the NFL, not every team maintains an active interest in fantasy football at this stage in the year.
But for those who still have title hopes, there is no room for error.
Finding an edge can be tricky as franchises outside the playoff picture wind down for the year and the league's leading lights think about resting up for the postseason.
But Stats Perform has picked out four players and a defense that could make the difference in Week 16.
Quarterback: Brock Purdy, San Francisco 49ers vs. Washington Commanders
Nobody – at least nobody still in contention now – had any real interest in Purdy at the start of the year as he was the 49ers' third-choice QB, but that means he remains available in a number of leagues. It may well be time to fix that, with Purdy one of the outstanding performers across Weeks 14 and 15.
Josh Allen alone threw more touchdown passes (five to Purdy's four) without throwing an interception, while the rookie's 8.55 yards per pass attempt ranked third. Purdy was the sole QB in the NFL with a passer rating of at least 115.0 in two starts over this period. In fact, Aaron Rodgers is the only other player in league history to have had such a passer rating in his first two career starts.
Purdy is an obvious option for any fantasy player suffering QB woe, with the 49ers having clinched the NFC West but unlikely to slow too much as they hunt down the Minnesota Vikings and the second seed in the NFC.
Running Back: Zack Moss, Indianapolis Colts vs. Los Angeles Chargers
Gardner Minshew would be another popular pick at QB, with Jalen Hurts injured, but the Philadelphia Eagles still have not ruled out their MVP candidate. On the other hand, the Colts have shut down Jonathan Taylor for the year.
However, Indy would be wise to press on with the run game against the Chargers; only the Packers (42.9 per cent) have allowed opponents greater success on run plays this year than the Chargers (42.5 per cent).
That should mean plenty of touches again for Moss, who had 24 carries last week – as many as he had across the rest of the year combined.
Wide Receiver: Christian Watson, Green Bay Packers @ Miami Dolphins
The Packers' season never really got going, with Aaron Rodgers unable to make his receiving corps work without the departed Davante Adams.
But Watson, who had just 14 targets through nine weeks, has really come to the fore of late. Since Week 10, Watson has seven receiving TDs – leading the league ahead of Adams (five) – and has converted 17 of his 19 receptions into first downs.
Over the past two weeks, only two defenses have given up more receiving yards (671) and more receiving TDs (five) than Miami. They have also tied the Detroit Lions in allowing a league-worst 32 receiving first downs in this time.
Tight End: Evan Engram, Jacksonville Jaguars @ New York Jets
Engram has been a steady performer in his first year with the Jaguars, but there is reason to believe he may be able to move to another level now as Trevor Lawrence ignites this Jacksonville offense.
Over the past two weeks, the Jags rank second in net passing yards (679) and lead the way for TD passes (seven) and points (76).
Engram caught two of those TDs and has led the team in targets (25), catches (19) and receiving yards (224) over this period. He and those who can call on him for fantasy purposes are among the chief beneficiaries of Lawrence's late surge.
Defense/Special Teams: Tampa Bay Buccaneers @ Arizona Cardinals
Opposition teams have been successful on only 36.5 per cent of plays against the Buccaneers this year, making this the league's sixth-best defense.
And now they will be faced with a Cardinals offense manned by third-string QB Trace McSorley, who is in line for his first career start despite struggling badly from his limited snaps so far this year.
McSorley has not thrown a single TD pass in 2022 but has tossed three picks, completing only 15 of his 29 pass attempts for an atrocious passer rating of 29.5.
McKenna fired up for 'biggest game in world football' against Man United
Kieran McKenna believes Ipswich Town's Premier League clash with Manchester United will be the "biggest game in world football" this weekend.
United are in action under new manager Ruben Amorim for the first time since the Portuguese officially replaced Arne Slot as head coach.
While plenty of focus is on the visitors at Portman Road, Ipswich are fired up after beating Tottenham 2-1 before the international break.
That was Ipswich's first league win of the season – and their first in the Premier League in 22 years – and now attention turns to facing United.
McKenna, who previously coached United, said at a fan event this week: "Sunday, what a game. It's one we're really, really looking forward to.
"Not for the personal connection, but as manager of Ipswich Town, to be on that stage, it's what we've worked so hard for.
"It's the biggest game in world football anywhere this weekend, the biggest game in the world in the biggest sport in the world and it's at Portman Road."
Ipswich's surprise win at Tottenham last time out moved them up to 17th, while United are 13th after beating Leicester City 3-0 in Ruud van Nistelrooy's final game in caretaker charge.
Amorim took his first training session on Monday, albeit with many first-team stars away on international duty, and the former Sporting CP boss believes his style of play will be clear to see from the off.
"I think you will see an idea," he told the club's website. "You could like it or not, I don't know, but you will see an idea.
"You will see a positioning. You will see something that we want to reach that kind of level. You will feel that.
"We have to know it's [only] two trainings before the first match. This is the best league in the world. But if I have to say something to you, [it's that] you will see an idea. This I can guarantee."
PLAYERS TO WATCH
Ipswich Town - Liam Delap
Delap scored what proved to be Ipswich's winner against Tottenham and has now netted six of his side's 12 Premier League goals this term.
That makes the Manchester City academy product one of only three players to have scored at least half of his side's goals in the competition this season, along with Erling Haaland at City (55%) and Chris Wood at Nottingham Forest (53%).
Manchester United - Alejandro Garnacho
Garnacho was among the scorers against Leicester two weeks ago and has now been directly involved in 20 Premier League goals for United (13 goals and seven assists).
The Argentina international is one of only two non-British players to reach that figure for United before turning 21, along with Cristiano Ronaldo (25 goals).
MATCH PREDICTION: MANCHESTER UNITED WIN
Ipswich are seeking back-to-back Premier League wins for the first time since February 2022, with that run also beginning with a 2-1 victory against Tottenham.
The Tractor Boys are the only side in the competition without a home win this season. Only five newly promoted clubs have failed to win any of their first six home matches, all of whom went back down.
United have won 17 of their past 19 Premier League games against newly promoted opponents, meanwhile, including nine wins in a row in away fixtures.
The Red Devils were 1-0 winners on their most recent league trip to Portman Road in April 2022, but only once have they won successive league games away to Ipswich.
However, the Tractor Boys have lost four of their past five league matches against Man United, failing to score in each of those losses.
OPTA WIN PROBABILITY
Ipswich Town - 22.2%
Draw - 23%
Manchester United - 54.8%
Slot deserves praise for modest approach to Liverpool job – Mills
Arne Slot deserves praise for not being "arrogant" with his approach to succeeding Jurgen Klopp as Liverpool boss, according to Danny Mills.
The Dutchman has made a hugely positive start to life at Anfield since replacing long-serving Klopp ahead of the 2024-25 season.
The 28 points Slot has collected is the joint-most of any manager in their opening 11 Premier League games along with Guus Hiddink at Chelsea.
Liverpool's only blemish on an otherwise perfect start to the top-flight campaign was a 1-0 loss to Nottingham Forest in September.
Indeed, only in 2019-20 (31 points) have Liverpool collected more points after 11 games of a Premier League season than their 28 this campaign.
Former Leeds United and Manchester City defender Mills has been particularly impressed by Slot's approach to a new era at Anfield.
"Arne Slot has surprised me," Mills told Stats Perform. "They did have a difficult defeat against Nottingham Forest at home. That was a defeat not many people saw that coming, but the start he's had is unbelievable. It's incredible.
"Training might be slightly different, but the style of play is very similar. The players are comfortable with it. They've been high-energy, closing people down, and playing at 100 miles an hour when they win the ball back.
"It shows managerial intelligence to understand the players' qualities and build on what they had when they were successful. He hasn't overthought it or tinkered too much.
"He hasn’t been arrogant and said, 'I'm going to rip it up and start fresh'. It wasn't broken; it was already successful. He's just added to it."
Liverpool won a first ever Premier League title during Klopp's eight-and-a-half years in charge, as well the Champions League in 2018-19.
Klopp also lifted the FA Cup, two EFL Cups, the UEFA Super Cup and FIFA Club World Cup, setting a high benchmark to follow.
"Liverpool identified the man they wanted, brought him in, and he's been very clever," Mills added. "He looked at the squad and thought, 'these are good players. I don't need to change too much'.
"That's smart because Liverpool were very successful under Klopp. If you come in and rip up the playbook and it doesn't work, players will question why they're not doing what worked under Klopp."
Liverpool have conceded just six goals in the Premier League this season – four fewer than next-best Nottingham Forest.
They are conceding at a rate of around 0.5 goals per game, compared to around 1.1 in Klopp's final season in charge (41 goals in 38 matches).
"Slot has tweaked things slightly, maybe made them more defensively solid, which they needed to really challenge," Mills said. "Championship-winning or Champions League-winning teams are built on solid defences.
"You don't win without that. He's shored up the defence and allowed the players to continue doing what they were doing before."
Barca weren't going to sign Williams if they could not register him, says Laporta's advisor
Barcelona were not going to sign Nico Williams if his registration with LaLiga could not be guaranteed, according to Blaugrana president Joan Laporta's advisor, Enric Masip.
The Spain international was a top target for Hansi Flick's side after playing a starring role during La Roja's Euro 2024 triumph.
Williams netted a fine solo goal in the 4-1 win over Georgia in the round of 16, becoming the first player on record at the Euros (since 1980) to score, assist and complete 100% of his passes (46 from 46) in a game he started.
The Athletic Bilbao forward was then named Player of the Match after finding the net in Spain's 2-1 victory over England in the final.
Williams was expected to reunite with international team-mate Lamine Yamal at Camp Nou.
It was reported he chose to remain with Bilbao after Barca were unable to guarantee his registration with LaLiga due to complying with the salary cap, but Masip - advisor to Laporta - has refuted those claims.
"If a player who is of your interest doesn't want to move, you don't have much leeway," he told El Chiringuito. "There was not much you could do.
"It's hard for me to think that if you were going to sign Nico Williams, you wouldn't be able to register him.
"Barca weren't going to pay €50 million or €60 million for a player if they weren't going to be able to register him. So, well, it surely would have been done."
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