As in the NFL, not every team maintains an active interest in fantasy football at this stage in the year.
But for those who still have title hopes, there is no room for error.
Finding an edge can be tricky as franchises outside the playoff picture wind down for the year and the league's leading lights think about resting up for the postseason.
But Stats Perform has picked out four players and a defense that could make the difference in Week 16.
Quarterback: Brock Purdy, San Francisco 49ers vs. Washington Commanders
Nobody – at least nobody still in contention now – had any real interest in Purdy at the start of the year as he was the 49ers' third-choice QB, but that means he remains available in a number of leagues. It may well be time to fix that, with Purdy one of the outstanding performers across Weeks 14 and 15.
Josh Allen alone threw more touchdown passes (five to Purdy's four) without throwing an interception, while the rookie's 8.55 yards per pass attempt ranked third. Purdy was the sole QB in the NFL with a passer rating of at least 115.0 in two starts over this period. In fact, Aaron Rodgers is the only other player in league history to have had such a passer rating in his first two career starts.
Purdy is an obvious option for any fantasy player suffering QB woe, with the 49ers having clinched the NFC West but unlikely to slow too much as they hunt down the Minnesota Vikings and the second seed in the NFC.
Running Back: Zack Moss, Indianapolis Colts vs. Los Angeles Chargers
Gardner Minshew would be another popular pick at QB, with Jalen Hurts injured, but the Philadelphia Eagles still have not ruled out their MVP candidate. On the other hand, the Colts have shut down Jonathan Taylor for the year.
However, Indy would be wise to press on with the run game against the Chargers; only the Packers (42.9 per cent) have allowed opponents greater success on run plays this year than the Chargers (42.5 per cent).
That should mean plenty of touches again for Moss, who had 24 carries last week – as many as he had across the rest of the year combined.
Wide Receiver: Christian Watson, Green Bay Packers @ Miami Dolphins
The Packers' season never really got going, with Aaron Rodgers unable to make his receiving corps work without the departed Davante Adams.
But Watson, who had just 14 targets through nine weeks, has really come to the fore of late. Since Week 10, Watson has seven receiving TDs – leading the league ahead of Adams (five) – and has converted 17 of his 19 receptions into first downs.
Over the past two weeks, only two defenses have given up more receiving yards (671) and more receiving TDs (five) than Miami. They have also tied the Detroit Lions in allowing a league-worst 32 receiving first downs in this time.
Tight End: Evan Engram, Jacksonville Jaguars @ New York Jets
Engram has been a steady performer in his first year with the Jaguars, but there is reason to believe he may be able to move to another level now as Trevor Lawrence ignites this Jacksonville offense.
Over the past two weeks, the Jags rank second in net passing yards (679) and lead the way for TD passes (seven) and points (76).
Engram caught two of those TDs and has led the team in targets (25), catches (19) and receiving yards (224) over this period. He and those who can call on him for fantasy purposes are among the chief beneficiaries of Lawrence's late surge.
Defense/Special Teams: Tampa Bay Buccaneers @ Arizona Cardinals
Opposition teams have been successful on only 36.5 per cent of plays against the Buccaneers this year, making this the league's sixth-best defense.
And now they will be faced with a Cardinals offense manned by third-string QB Trace McSorley, who is in line for his first career start despite struggling badly from his limited snaps so far this year.
McSorley has not thrown a single TD pass in 2022 but has tossed three picks, completing only 15 of his 29 pass attempts for an atrocious passer rating of 29.5.
Paris Saint-Germain 2-3 Clermont: Messi and Ramos denied winning send-off as visitors fight back
Paris Saint-Germain failed to muster a winning send-off for Lionel Messi and Sergio Ramos as they ended the Ligue 1 season by squandering a two-goal lead in a 3-2 loss against Clermont.
Early goals for the Spaniard and Kylian Mbappe put the champions on top at Parc des Princes, before Johan Gastien, Mehdi Zeffane and Grejohn Kyei completed a stirring comeback from the visitors.
It was a damp last note for ex-LaLiga heroes Messi and Ramos, who leave Paris as two-time league champions but without having won supporters' hearts – with Messi booed ahead of kick-off.
Likewise, it may prove a dour final chapter for coach Christophe Galtier, who is widely tipped to depart despite leading PSG to a record 11th league title.
PSG, who wore shirts adorned with the name of injured team-mate Sergio Rico in the first half, needed VAR to rescue them after Kyei prodded home an early finish.
The hosts promptly seized control, with Ramos netting a farewell header from Vitinha's delivery before Mbappe doubled their lead with an excellent penalty following Alidu Seidu's foul on Achraf Hakimi.
Clermont refused to fold though, with Gastien capitalising on Marco Verratti's mistake to halve the arrears and Zeffane bundling in a leveller either side of Kyei putting a spot-kick wide in a thrilling first half.
Messi, who misfired on his farewell, spurned a chance to finish Mbappe's square ball after the restart before Kyei nosed the visitors in front with a close-range finish.
PSG continued to toil for an equaliser in the closing stages and Messi almost stole a point in the final minute of injury time, only for goalkeeper Mory Diaw to stop his direct free-kick with an acrobatic save.
RB Leipzig 2-0 Eintracht Frankfurt: Nkunku and Szoboszlai strikes ensure DFB-Pokal defence
Christopher Nkunku and Dominik Szoboszlai scored as RB Leipzig retained the DFB-Pokal with a hard-fought 2-0 win over Eintracht Frankfurt in Saturday's final at the Olympiastadion.
Nkunku – playing what will likely be his final game for Leipzig amid suggestions he is set to join Chelsea – beat Kevin Trapp with a deflected effort 71 minutes into a tight encounter in Berlin.
Leipzig were rarely threatened by an uninspired Eintracht team, and Marco Rose's men wrapped up the victory when Nkunku turned provider, teeing up Szoboszlai to score five minutes from time.
That meant Leipzig capped a third-placed Bundesliga finish with a second major trophy in as many seasons, while Oliver Glasner's final game in charge of Eintracht was one to forget.
Timo Werner spurned a glorious chance to put Leipzig ahead after four minutes, side-footing straight at Trapp following a lightning counter-attack.
Randal Kolo Muani hit the side netting from a tight angle and Nkunku forced Tuta into a last-ditch block at the other end, but both sides struggled to break their opponents down in a cagey first half.
Eintracht's threat grew after the interval, but Mario Gotze volleyed straight at Janis Blaswich when presented with their best sight of goal, and Glasner's side were swiftly punished.
There was a huge stroke of fortune as Nkunku struck first, the Frenchman cutting in from the left before seeing his shot take two deflections to beat the unfortunate Trapp.
Eintracht never looked like fighting back from there, though, and Leipzig put the result beyond all doubt when Szoboszlai fired into the bottom-left corner after composed play by Nkunku.
Torino 0-1 Inter: Brozovic strike sees Nerazzurri warm up for Champions League final in style
Inter warmed up for the Champions League final with a 1-0 win over Torino to cap off their Serie A campaign.
The Nerazzurri head to Istanbul to face Manchester City on June 10, but the Coppa Italia winners had league business to attend to on Saturday.
Marcelo Brozovic's excellent strike proved the difference, with substitute goalkeeper Alex Cordaz making a superb save to preserve Inter's lead in the second half.
Inter will face an altogether tougher test in a week's time, but for now, Simone Inzaghi can reflect on a job well done in Serie A.
Romelu Lukaku sparked what had been an insipid first half into life when he crafted space on the edge of Torino's area and saw a low strike deflected just wide.
Stefan de Vrij headed straight at Vanja Milinkovic-Savic from the resulting corner, but Torino's goalkeeper was beaten in the 37th minute.
Given space and time on the edge around 20 yards out, Brozovic punished Torino with a fine left-footed strike that nestled in the bottom-right corner.
Brozovic turned provider shortly after the restart, only for Roberto Gagliardini to head wide from close range.
Ex-Inter forward Yann Karomah almost made an instant impact from the bench when he forced a fine save out of Samir Handanovic, who subsequently received an ovation when he made way for Cordaz in the 65th minute.
Cordaz made a stunning save soon after, reacting brilliantly to parry Antonio Sanabria's effort wide and ensure Inter ended their domestic campaign with a victory.
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