Ireland will be without Johnny Sexton for Sunday's visit of France in the Six Nations after their captain suffered a blow to the head against Wales.
Sexton underwent return-to-play protocols after the incident in the loss but has not been cleared to play.
The news comes after Sexton hit out at a French doctor who claimed the fly-half had suffered approximately 30 concussions in his career, with neurologist Dr Jean-Francois Chermann subsequently apologising.
Billy Burns will start instead for Andy Farrell's side, who lost 21-16 in Cardiff, with Jamison Gibson-Park also in the XV as scrum-half Conor Murray sits it out with a hamstring injury.
The captain's armband goes to Iain Henderson for the first time, with the suspended Peter O'Mahony replaced by Rhys Ruddock following his red card in the Welsh capital.
James Ryan also sustained a blow to the head in that game and, like Sexton, will be absent this weekend.
Ireland: Hugo Keenan; Keith Earls, Garry Ringrose, Robbie Henshaw, James Lowe; Billy Burns, Jamison Gibson-Park; Cian Healy, Rob Herring, Andrew Porter; Tadhg Beirne, Iain Henderson; Rhys Ruddock, Josh Van der Flier, CJ Stander.
Replacements: Ronan Kelleher, Ed Byrne, Tadhg Furlong, Ultan Dillane, Will Connors, Craig Casey, Ross Byrne, Jordan Larmour.
Rees-Zammit relishing Mahomes advice as former rugby star eyes spot on Chiefs roster
Louis Rees-Zammit has likened Patrick Mahomes to an extra coach as he looks to make an impact in the NFL with the Kansas City Chiefs.
Rees-Zammit shocked rugby union fans in January when he announced he was turning his back on the sport to enter the NFL's International Player Pathway programme.
He was signed by two-time defending Super Bowl champions Kansas City in March and is now looking to earn a place on their roster for 2024, learning the role of running back at the Chiefs' rookie minicamp after attending another training camp alongside Mahomes.
Rees-Zammit has made sure to pick the brains of Mahomes, who has led the Chiefs to six straight AFC Championship games and won three Super Bowl rings since being drafted in 2017.
"It was amazing, all the quarterbacks and receivers were there, we were running routes, we were working in the gym", Rees-Zammit said of his experience at that camp in Texas.
"It was a great two weeks, I definitely learned a lot with Pat and the other boys."
Asked if Mahomes was acting like an extra coach, he said: "100 per cent.
"I'm new to the game so I'm trying to pick everyone's brains and try and pick up the sport as quick as possible because I want to be out there playing.
"The way I can do that is picking the brains of everyone that's currently here and trying to learn the game as quickly as possible."
Chiefs head coach Andy Reid has been impressed by Rees-Zammit's attitude, saying: "He's so diligent with everything and wants to be so good at everything. I appreciate that.
"I like the fact he's got shorter steps initially, that's a good thing as a running back. If you're a long strider in there you've got to really work on making it through those tight adjustments you have to make. He seems to have a nice feel."
Lucas Hernandez to miss Euro 2024 after PSG defender sustains knee injury
France have been dealt a blow ahead of Euro 2024 following confirmation that Paris Saint-Germain's Lucas Hernandez will miss the tournament.
Hernandez sustained a knee injury and had to be taken off in the 42nd minute of PSG's Champions League defeat to Borussia Dortmund on Wednesday.
And on Thursday, PSG announced Hernandez had sustained an anterior cruciate ligament (ACL) injury and will now need surgery.
"Lucas Hernandez suffered a torn anterior cruciate ligament in his left knee after coming off injured during the Champions League match," a statement read.
"An MRI scan carried out today confirmed the diagnosis made by the club's doctors on Wednesday evening.
"The player will undergo surgery in the next few days."
Hernandez suffered a similar injury during the last major international tournament, the 2022 World Cup, in which France finished as runners-up to Argentina.
The 28-year-old subsequently posted on his official Instagram account.
"When I signed with PSG, I made a promise that I would give my heart and soul to this team and this is what I have done ever since. Unfortunately, during last night's match I ended up with an injury," Hernandez said.
"I pushed myself back onto the field and tried to keep on fighting for our team, but it was not possible. My comeback will be stronger than ever before."
France defender Hernandez to miss Euro 2024 after suffering ACL injury
Lucas Hernandez will miss France's Euro 2024 campaign after tearing his anterior cruciate ligament during Paris Saint-Germain's 1-0 Champions League defeat to Borussia Dortmund.
Dortmund will take a slender lead to the Parc des Princes for next week's semi-final second leg after Niclas Fullkrug's strike powered them past PSG in Wednesday's first leg in Germany.
Hernandez sustained a knee injury while chasing after Fullkrug in the build-up to the goal and was substituted after a brief attempt to play on.
On Thursday, PSG announced an MRI scan had revealed an ACL tear in his left knee, which will require surgery in the coming days.
Hernandez, who has 37 senior international caps, will now miss Euro 2024, with France set to open their Group D campaign against Austria in Dusseldorf on June 17.
Didier Deschamps' side then face the Netherlands in Leipzig four days later, before taking on Poland in Dortmund on June 25.
Hernandez was part of France's squad for the 2022 World Cup but sustained another ligament injury during Les Bleus' opening match against Australia, missing the rest of the tournament and not returning to club football until the start of 2023-24.
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