Buoyant Scotland will go in search of back-to-back wins over Wales for the first time in 18 years and France travel to Ireland for a mouthwatering Six Nations showdown this weekend.
Scotland ended a 38-year wait for a win at Twickenham on the opening weekend with a dominant 11-6 defeat of the defending champions.
Gregor Townsend's side need to follow that up on Saturday with a victory over a Wales side that got the better of 14-man Ireland at the Principality Stadium following Peter O'Mahony's first-half red card.
France started the tournament by hammering Italy 50-10, but will face a bigger test in Dublin, while England should respond to their Calcutta Cup defeat by beating Italy at home on Saturday.
Ahead of the second round, we preview the upcoming matches with help from Opta.
ENGLAND v ITALY
FORM
The Red Rose have won each of their 21 fixtures against Italy in the Six Nations, and they are the only team yet to suffer defeat against the Azzurri in the championship.
England have hosted Italy on 10 occasions in the Six Nations, winning each of those 10 fixtures by an average margin of 31 points and scoring 5.6 tries per game.
Italy have won just twice away from home in the Six Nations (losing 50 and drawing one), with both victories coming against Scotland at Murrayfield (2007 and 2015).
ONES TO WATCH
George Ford comes into the England side, with captain Owen Farrell moving to outside centre, in one of five changes to the side, and the fly-half will be ready to make a statement after being named on the bench for the loss to Scotland.
Italy endured a torrid start to the competition, but Luca Sperandio scored a fine try. The wing had seven carries and made 52 metres. The Azzurri will need to get Sperandio flying down the flank again in London.
SCOTLAND v WALES
FORM
Scotland were superb against England and will be aiming for consecutive wins over Wales in the Six Nations for the first time since 2002-2003.
Wales had an extra man, but Ireland could consider themselves unfortunate to go down 21-16 in Cardiff. The Welsh have lost their last six Tests away from home and will be in for another huge battle at Murrayfield.
They have conceded 30 points per game in that miserable sequence of matches on their travels.
ONES TO WATCH
Captain Stuart Hogg was man of the match in a rousing performance from Scotland against Eddie Jones' men. The full-back made 112 metres and had 13 carries. He was also brilliant with the boot, kicking for 367 metres.
Louis Rees-Zammit showed why he is so highly rated in Wales' win over Ireland. He dived to finish magnificently in the corner as Wayne Pivac's side made a winning start at home last Sunday.
IRELAND v FRANCE
FORM
Flanker O'Mahony's reckless dismissal proved to be costly for Andy Farrell's Ireland side in Cardiff. They will be looking to avoid suffer back-to-back losses to Les Bleus in the Six Nations, having not endured such a fate since 2010-11.
Ireland have won five of their last seven clashes with France in the Six Nations (L2) after winning only four of their 30 previous meetings with them in the Five/Six Nations (D3 L23).
ONES TO WATCH
Antoine Dupont was the player of the opening round of the tournament. The mercurial scrum-half assisted four tries, the joint-most by any player in a Six Nations match, equalling the record set by Frederic Michalak against Italy in 2006. He also scored a try of his own in a sublime performance.
Ireland lock Tadhg Beirne made the most carries (21) of any player in the opening round. He also hit the most rucks of any player (48) and was Ireland’s joint-highest tackler (10, level with CJ Stander).
Gatland 'still the best coach in the world', says Wales assistant Howley
Wales assistant Rob Howley described Warren Gatland as the "world's best coach" and insists the under-fire boss is going nowhere.
Wales have lost each of their last 11 Test matches, their longest ever run in men’s rugby, overtaking a 10-game stretch between November 2002 and August 2003.
Their most recent defeat came by 32 points (20-52 v Australia), their heaviest loss since a 36-point thrashing at home to South Africa in August last year (16-52).
And it is not going to get any easier with world champions South Africa the visitors to the Principality Stadium on Saturday for Wales' Autumn Nations Series finale.
South Africa have emerged victorious in six of their last seven Tests against Wales (L1) and have also won each of their last three games against Wales by margins of 16+ points.
Another triumph would see Wales going the calendar year without winning a Test, which has not happened since 1937, though Howley has no doubt that Wales are in safe hands.
"We've got the best coach in the world who has had a legacy of more than 13 years," said Howley.
"He's won Grand Slams and there is no better coach to have in your camp than Warren. He gives players the confidence and self-belief they need to go out and play."
During Gatland's first stint in charge from 2008 to 2019, Wales were World Cup semi-finalists, Six Nations champions and Grand Slam winners.
This time around, amid far more challenging circumstances and attempting to mould a new squad, Wales have won just six out of his 23 Tests at the helm.
Wales have also won just one of their last 11 Test matches at the Principality Stadium, last winning in Cardiff against Argentina in November 2023.
Howley was asked if he would take an interim head coach job if Gatland departed, but responded defiantly by saying, "Warren Gatland won't leave".
Howley insists Gatland's experiences can help turn Wales around, saying: "Warren is a hugely respected coach and has coached over a number of years.
"His legacy with different teams is a winning legacy. At the moment, we are in this spell where we are losing.
"We at some point know we will win, and I hope it will be the next game on Saturday. I think at the moment we've got the best coach who has got years of experience.
"We've been in changing rooms where we've won and lost, Lions changing rooms going into the series at 1-1 with everything on the line.
"He understands rugby, and I believe Wales have got the best coach in the world to get us out of this."
Farrell backs 'composed' Prendergast to shine on first Ireland start
Andy Farrell believes Sam Prendergast is ready to step up ahead of his first Ireland start against Fiji at the Aviva Stadium on Saturday.
Farrell has made seven changes to his team, handing first caps to Leinster's Gus McCarthy and Ulster's Cormac Izuchukwu for the penultimate game of the Autumn Nations Series.
The Ireland head coach has handed Prendergast the number 10 jersey for the first time after he was used off the bench in the closing stages of last week's win over Argentina.
Prendergast has only started eight games for Leinster, but Farrell had no hesitation in handing him a first start after he impressed on the Emerging Ireland tour of South Africa.
"I'm confident from what we've seen. We took him on the Emerging [Ireland] and he played in all of those games," said Farrell.
"The aim of that was to grab hold of that team and make sure that he treated it like it was his own, as though he was in charge, and he did that in spades.
"This week we've seen the benefit of that, but we need to see it transfer, obviously.
"Yes, his character is composed, confident but yet not over-confident. He's assertive in what he wants, and he has a nice way about how he goes about his business.”
Farrell also had a glowing review for Izuchukwu, saying: "Izzy has been in and around the squad for a while. The first Emerging Ireland tour was when we first came across his ability, his athleticism, his point of difference.
"That was a couple of years ago but the improvement in his maturity of his game, because he was young in the 15-a-side game when the first tour was on, but the difference between the first and second tour was like chalk and cheese.
"His ability and potential with that maturity, he deserves a shot to show us all what he's got."
On McCarthy, who captained the Ireland Under-20s to a Six Nations Grand Slam in 2023, Farrell said: "He's been a captain and you can see why because his maturity in how he goes about the game."
He added: "We took him on the training week [to Portugal] as a development player and he showed up unbelievably well. He forced our hand to keep him in the squad first and foremost and he deserves a shot to see what he can do as well."
Ciaran Frawley also returns to the bench after missing out last weekend on the back of a poor outing against New Zealand.
And Cian Healy must wait another week for a record-breaking 134th cap - having drawn level with Brian O'Driscoll against Argentina - after the prop was left out of the 23.
Ireland team to play Fiji
Jamie Osborne; Mack Hansen, Robbie Henshaw, Bundee Aki, Jacob Stockdale; Sam Prendergast, Craig Casey; Andrew Porter, Gus McCarthy, Finlay Bealham; Joe McCarthy, Tadhg Beirne; Cormac Izuchukwu, Josh van der Flier, Caelan Doris (capt).
Replacements: Rob Herring, Tom O'Toole, Thomas Clarkson, Iain Henderson, Cian Prendergast, Conor Murray, Ciaran Frawley, Stuart McCloskey.
McKenna fired up for 'biggest game in world football' against Man United
Kieran McKenna believes Ipswich Town's Premier League clash with Manchester United will be the "biggest game in world football" this weekend.
United are in action under new manager Ruben Amorim for the first time since the Portuguese officially replaced Arne Slot as head coach.
While plenty of focus is on the visitors at Portman Road, Ipswich are fired up after beating Tottenham 2-1 before the international break.
That was Ipswich's first league win of the season – and their first in the Premier League in 22 years – and now attention turns to facing United.
McKenna, who previously coached United, said at a fan event this week: "Sunday, what a game. It's one we're really, really looking forward to.
"Not for the personal connection, but as manager of Ipswich Town, to be on that stage, it's what we've worked so hard for.
"It's the biggest game in world football anywhere this weekend, the biggest game in the world in the biggest sport in the world and it's at Portman Road."
Ipswich's surprise win at Tottenham last time out moved them up to 17th, while United are 13th after beating Leicester City 3-0 in Ruud van Nistelrooy's final game in caretaker charge.
Amorim took his first training session on Monday, albeit with many first-team stars away on international duty, and the former Sporting CP boss believes his style of play will be clear to see from the off.
"I think you will see an idea," he told the club's website. "You could like it or not, I don't know, but you will see an idea.
"You will see a positioning. You will see something that we want to reach that kind of level. You will feel that.
"We have to know it's [only] two trainings before the first match. This is the best league in the world. But if I have to say something to you, [it's that] you will see an idea. This I can guarantee."
PLAYERS TO WATCH
Ipswich Town - Liam Delap
Delap scored what proved to be Ipswich's winner against Tottenham and has now netted six of his side's 12 Premier League goals this term.
That makes the Manchester City academy product one of only three players to have scored at least half of his side's goals in the competition this season, along with Erling Haaland at City (55%) and Chris Wood at Nottingham Forest (53%).
Manchester United - Alejandro Garnacho
Garnacho was among the scorers against Leicester two weeks ago and has now been directly involved in 20 Premier League goals for United (13 goals and seven assists).
The Argentina international is one of only two non-British players to reach that figure for United before turning 21, along with Cristiano Ronaldo (25 goals).
MATCH PREDICTION: MANCHESTER UNITED WIN
Ipswich are seeking back-to-back Premier League wins for the first time since February 2022, with that run also beginning with a 2-1 victory against Tottenham.
The Tractor Boys are the only side in the competition without a home win this season. Only five newly promoted clubs have failed to win any of their first six home matches, all of whom went back down.
United have won 17 of their past 19 Premier League games against newly promoted opponents, meanwhile, including nine wins in a row in away fixtures.
The Red Devils were 1-0 winners on their most recent league trip to Portman Road in April 2022, but only once have they won successive league games away to Ipswich.
However, the Tractor Boys have lost four of their past five league matches against Man United, failing to score in each of those losses.
OPTA WIN PROBABILITY
Ipswich Town - 22.2%
Draw - 23%
Manchester United - 54.8%
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