Joe Schmidt said he cannot recall ever being involved in a more "bizarre" Test as his Australia side were downed 30-12 by South Africa in the Rugby Championship.
Malcolm Marx touched down twice for the Springboks in rainy Perth to make it two from two in the tournament but the Wallabies were hit by a swathe of injuries.
Front-row pair Allan Alaalatoa and Angus Bell were unable to return for the second half and scrums went uncontested after replacement prop James Slipper failed a head injury assessment.
The Wallabies even went down to 14 briefly when hooker Josh Nasser went off injured, though they did return to a full 15.
Reflecting on the unfortunate series of events, head coach Schmidt told Stan Sport: "It's probably one of the most bizarre games I've ever been involved in.
"In over 100 Test matches that I've been involved in I've never had a situation like that before. It happened so early in the game as well. When Slips got a head knock right after half-time.
"And then we were straight down. And then we played with 14 for a period of time before the officials worked out that we were still entitled to have a full pack because of the HIA.
"But I still am proud of the way that the guys fought their way through that second half. And the way that they stayed in the fight in the first half. It could have been, and I know it could have been as easy to say, but it could have been 12-11 at half-time and that would have been a massive lift for the boys."
Australia are winless through their first two matches, both against the Springboks, and will next face Argentina in La Plata on August 31.
Ireland salvage pride to avoid clean sweep against South Africa
Ireland avoided being on the wrong end of a series sweep with a stunning 69-run victory over South Africa in their final ODI.
South Africa won the series 2-1 but finished with a whimper as they struggled to get on the front foot against the attack-minded Irish on Monday.
Captain Paul Stirling spurred Ireland on their way to victory with his knock of 88, including 11 boundaries, before Harry Tector's enterprising 60 gave them a bigger edge.
Andrew Balbirnie (45), Curtis Campher (34) and Lorcan Tucker (26) also strengthened their grip on the encounter before Lizaad Williams found his footing for South Africa.
He finished with 4-56 after an impressive show in the death overs, which was their only positive in the field, as he helped stop Ireland at 284-9. However, the Proteas had given themselves a mountain to climb that only grew as they lost three early wickets.
Graham Hume (3-29) was the standout for Ireland, but Mark Adair (2-54) and Craig Young (3-40) also played their part, even as Jason Smith's 91 gave South Africa some hope.
Kyle Verreynne (38) and Tristan Stubbs (20) had helped steady the ship before that, but after Smith's stand was cut short, a late collapse ensured South Africa would fall short in the chase on 215 with 29 balls remaining.
Data Debrief: Ireland finish on a high
Ireland pulled off a shock win in the second and final match in their T20I series against the Proteas last month, and once again ensured they would leave Abu Dhabi in high spirits.
Stirling and Balbirnie combined for their first 100-run partnership in an ODI, helping Ireland to their first-ever win over South Africa in the format.
Smith can leave with his head held high though - having been taken for a duck in his first ODI, he made a vast improvement with his 91 on Monday, getting nine fours and four sixes.
South Africa seal ODI series win against Ireland
South Africa claimed an emphatic 174-run victory to seal an ODI series triumph over Ireland ahead of the final game on Sunday in Abu Dhabi.
Having cruised to a 139-run victory in the opening encounter, the Proteas continued to avenge their shock T20I defeat against the same opponents last week with another commanding display.
South Africa made a strong start with the bat before Ryan Rickelton (40) fell in the 13th over, with Temba Bavuma (35) retiring hurt from the contest soon after.
Rassie van der Dussen (35) and Kyle Verreynne (67) also performed well, only for Tristan Stubbs to steal the show with 112 runs from 81 deliveries, handing the Proteas a strong grip on the encounter, with South Africa ending 343-4 from their 50 overs.
Ireland then made a dismal start to their run chase, losing five wickets in the opening 10 overs as Lizaad Williams and Lungi Ngidi ripped through their opening attack and had Ireland 50-5 early on.
Mark Adair (21) and Andy McBrine (10) momentarily halted the onslaught, but were soon sent on their way, with Gavin Hoey hitting 23 runs before he was bowled and caught by Ngidi (2-38).
Graham Hume and Craig Young's 52-run stand frustrated South Africa, only for the former to be bowled out by Bjorn Fortuin (2-36) with just under 20 overs remaining as Ireland ended all out for 169.
Data Debrief: Proteas on song
It was yet another strong display by South Africa, cruising to a comfortable victory in Abu Dhabi, with Stubbs and Williams starring with the bat and ball.
Stubbs' knock of 112 saw him record a maiden century in international cricket, ending with an impressive strike rate of 138.27.
Williams, meanwhile, continued where he left off from the first match, and now has seven wickets during the series so far.
South Africa beat Ireland in ODI opener to avenge T20I loss
South Africa cruised to a 139-run win over Ireland in the teams' first ODI in Abu Dhabi, with Lizaad Williams tearing through their opponents' batting order.
The Proteas approached Wednesday's contest reeling from a shock T20I defeat to Ireland on Sunday, with Ross Adair's maiden international century ensuring the two-match series ended 1-1.
There was not to be a repeat in the 50-over format, however, with Ireland's batting order collapsing after Ryan Rickelton (91) and Tristan Stubbs (79) guided an otherwise shaky South Africa to 271-9.
The Proteas started miserably by losing three wickets for 39 runs, Mark Adair taking two of them on his way to figures of 4-50.
But opener Rickelton stayed cool while the wickets tumbled around him, lasting 102 deliveries and allowing Stubbs to join in on the act with comfortably his best ODI score, dragging South Africa to a respectable total.
Ireland might have harboured hopes of a successful chase, but Paul Stirling's fourth-ball dismissal for just two runs set the tone, and a spate of four more wickets in the space of six overs dropped Ireland to 61-5.
Williams finished with figures of 4-32 from his 10 overs for the Proteas, who needed just 32 overs to finish off the tail and bring some much-needed positivity to their tour of the United Arab Emirates, which started with an ODI series loss to Afghanistan.
Data Debrief: Williams wins it
Rickelton and Stubbs carried South Africa to a score they were capable of defending despite no other batter scoring more than Bjorn Fortuin's 28 – seven scored 13 runs or fewer.
But it was Williams who made sure of the victory, taking three of the first four wickets to leave Ireland in a tailspin, then going on to record the best figures of his young ODI career.
In none of his previous five ODIs had Williams managed more than two wickets, while his 32 runs conceded were also his fewest in the format.
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