Malcolm Marx scored two tries in the second half to lead South Africa to a 30-12 victory over Australia in rainy Perth.
After a tight first half, the Springboks asserted their dominance to make it two wins from two in the Rugby Championship ahead of their meeting with New Zealand next week.
Noah Lolesio's penalty gave Australia the early lead, but they could not hold onto it for long as Sacha Feinberg-Mngomezulu equalised moments before Aphelele Fassi latched onto a long kick to touch down the first try.
Lolesio slotted in two more kicks only to miss another on the stroke of half-time that would have given the Wallabies the lead.
They were punished for it after the break as Marco van Staden and Malcolm Marx twice touched down to maintain South Africa's perfect start.
Though it was a marked improvement for the Wallabies from their opening-day performance in Brisbane, Joe Schmidt still has work to do to get them ready for Argentina next weekend.
Data Debrief: Springboks extend Australian run
South Africa have now won each of their last three Test matches against the Wallabies in Australia. The last time they recorded a longer such winning run was a four-match span from July 1971 to July 1993.
Though Australia have suffered back-to-back defeats, they showed more of a fight. Last week, it took them 75 minutes to score, compared to just three this time around.
Ireland salvage pride to avoid clean sweep against South Africa
Ireland avoided being on the wrong end of a series sweep with a stunning 69-run victory over South Africa in their final ODI.
South Africa won the series 2-1 but finished with a whimper as they struggled to get on the front foot against the attack-minded Irish on Monday.
Captain Paul Stirling spurred Ireland on their way to victory with his knock of 88, including 11 boundaries, before Harry Tector's enterprising 60 gave them a bigger edge.
Andrew Balbirnie (45), Curtis Campher (34) and Lorcan Tucker (26) also strengthened their grip on the encounter before Lizaad Williams found his footing for South Africa.
He finished with 4-56 after an impressive show in the death overs, which was their only positive in the field, as he helped stop Ireland at 284-9. However, the Proteas had given themselves a mountain to climb that only grew as they lost three early wickets.
Graham Hume (3-29) was the standout for Ireland, but Mark Adair (2-54) and Craig Young (3-40) also played their part, even as Jason Smith's 91 gave South Africa some hope.
Kyle Verreynne (38) and Tristan Stubbs (20) had helped steady the ship before that, but after Smith's stand was cut short, a late collapse ensured South Africa would fall short in the chase on 215 with 29 balls remaining.
Data Debrief: Ireland finish on a high
Ireland pulled off a shock win in the second and final match in their T20I series against the Proteas last month, and once again ensured they would leave Abu Dhabi in high spirits.
Stirling and Balbirnie combined for their first 100-run partnership in an ODI, helping Ireland to their first-ever win over South Africa in the format.
Smith can leave with his head held high though - having been taken for a duck in his first ODI, he made a vast improvement with his 91 on Monday, getting nine fours and four sixes.
South Africa seal ODI series win against Ireland
South Africa claimed an emphatic 174-run victory to seal an ODI series triumph over Ireland ahead of the final game on Sunday in Abu Dhabi.
Having cruised to a 139-run victory in the opening encounter, the Proteas continued to avenge their shock T20I defeat against the same opponents last week with another commanding display.
South Africa made a strong start with the bat before Ryan Rickelton (40) fell in the 13th over, with Temba Bavuma (35) retiring hurt from the contest soon after.
Rassie van der Dussen (35) and Kyle Verreynne (67) also performed well, only for Tristan Stubbs to steal the show with 112 runs from 81 deliveries, handing the Proteas a strong grip on the encounter, with South Africa ending 343-4 from their 50 overs.
Ireland then made a dismal start to their run chase, losing five wickets in the opening 10 overs as Lizaad Williams and Lungi Ngidi ripped through their opening attack and had Ireland 50-5 early on.
Mark Adair (21) and Andy McBrine (10) momentarily halted the onslaught, but were soon sent on their way, with Gavin Hoey hitting 23 runs before he was bowled and caught by Ngidi (2-38).
Graham Hume and Craig Young's 52-run stand frustrated South Africa, only for the former to be bowled out by Bjorn Fortuin (2-36) with just under 20 overs remaining as Ireland ended all out for 169.
Data Debrief: Proteas on song
It was yet another strong display by South Africa, cruising to a comfortable victory in Abu Dhabi, with Stubbs and Williams starring with the bat and ball.
Stubbs' knock of 112 saw him record a maiden century in international cricket, ending with an impressive strike rate of 138.27.
Williams, meanwhile, continued where he left off from the first match, and now has seven wickets during the series so far.
South Africa beat Ireland in ODI opener to avenge T20I loss
South Africa cruised to a 139-run win over Ireland in the teams' first ODI in Abu Dhabi, with Lizaad Williams tearing through their opponents' batting order.
The Proteas approached Wednesday's contest reeling from a shock T20I defeat to Ireland on Sunday, with Ross Adair's maiden international century ensuring the two-match series ended 1-1.
There was not to be a repeat in the 50-over format, however, with Ireland's batting order collapsing after Ryan Rickelton (91) and Tristan Stubbs (79) guided an otherwise shaky South Africa to 271-9.
The Proteas started miserably by losing three wickets for 39 runs, Mark Adair taking two of them on his way to figures of 4-50.
But opener Rickelton stayed cool while the wickets tumbled around him, lasting 102 deliveries and allowing Stubbs to join in on the act with comfortably his best ODI score, dragging South Africa to a respectable total.
Ireland might have harboured hopes of a successful chase, but Paul Stirling's fourth-ball dismissal for just two runs set the tone, and a spate of four more wickets in the space of six overs dropped Ireland to 61-5.
Williams finished with figures of 4-32 from his 10 overs for the Proteas, who needed just 32 overs to finish off the tail and bring some much-needed positivity to their tour of the United Arab Emirates, which started with an ODI series loss to Afghanistan.
Data Debrief: Williams wins it
Rickelton and Stubbs carried South Africa to a score they were capable of defending despite no other batter scoring more than Bjorn Fortuin's 28 – seven scored 13 runs or fewer.
But it was Williams who made sure of the victory, taking three of the first four wickets to leave Ireland in a tailspin, then going on to record the best figures of his young ODI career.
In none of his previous five ODIs had Williams managed more than two wickets, while his 32 runs conceded were also his fewest in the format.
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