Faf de Klerk and Warrick Gelant are back in the South Africa team to face Australia in the Rugby Championship at Adelaide Oval on Saturday.
De Klerk has completed his return to play protocol after missing the second Test against New Zealand due to concussion and replaces Jaden Hendrikse at scrum-half.
Gelant gets the nod over Jesse Kriel, who was unable to return after taking a blow to the head early in the 35-23 loss to the All Blacks at Ellis Park.
Springboks head coach Jacques Nienaber has also made three changes to the replacements, with Hendrikse, Elton Jantjies and Frans Steyn on the bench.
Herschel Jantjies, Willie le Roux and Jasper Wiese miss out as the world champions look to respond to their loss in Johannesburg.
"This is a very important clash for us to set the tone for our Rugby Championship tour and we feel that continuity in selection is important to build momentum in our campaign," Nienaber said.
"Warrick was in good form for the Stormers earlier this season and he has been working hard at training, so we thought it would be good to give him a run on the wing. He also combined well with Damian Willemse in the Rugby Championship, so we are excited to see what they offer us in the match.
"Faf, meanwhile, is back from concussion and his experience will be important in this game.
"We also feel it is important to give the likes of Ox (Nche), Joseph (Dweba) and Duane (Vermeulen) another opportunity to further build combinations and give them valuable game time as we build toward the Rugby World Cup next year."
South Africa team to play Australia:
Damian Willemse, Warrick Gelant, Lukhanyo Am, Damian de Allende, Makazole Mapimpi, Handre Pollard, Faf de Klerk; Ox Nche, Joseph Dweba, Frans Malherbe, Eben Etzebeth, Lood de Jager, Siya Kolisi (captain), Pieter-Steph du Toit, Duane Vermeulen.
Replacements: Malcolm Marx, Steven Kitshoff, Vincent Koch, Franco Mostert, Kwagga Smith, Jaden Hendrikse, Elton Jantjies, Frans Steyn.