Andrey Rublev will face Andy Murray at the Rotterdam Open after the Russian battled past Marcos Giron 7-6 (7-1) 6-3.
The appetising showdown between Rublev and former world number one Murray was handed a primetime evening slot on Wednesday's schedule by tournament organisers, given the appeal of a clash between one of the ATP Tour's brightest younger stars and the three-time grand slam winner.
World number eight Rublev is, at the age of 23, among the band of players who have emerged as potential torchbearers for the men's tour once the likes of Murray and the big three of Roger Federer, Rafael Nadal and Novak Djokovic make way.
After wildcard Murray's win over Robin Haase on Monday, Rublev secured victory on Tuesday against 80th-ranked Giron, who earned his place in the ATP 500 tournament through qualifying.
Murray and Rublev have played only once before, in entirely different circumstances to those surrounding Wednesday's match. That previous encounter came at the Australian Open in 2017, with Murray, then ranked number one in the world, scorching to a 6-3 6-0 6-2 win in round two.
The Scot has since undergone major surgery on a hip problem that has threatened to end his career, and heads into his clash with Rublev ranked 123rd in the world but eager to show he can compete at a high level.
"Andy is a true legend and I have a really good connection with him. I really like him as a person and as a player. He destroyed me once in the past. I'm sure we'll have great, long rallies and it will be a fight," Rublev said, quoted via the ATP website.
Australian Open semi-finalist Stefanos Tsitsipas passed his first-round test by scoring a narrow win over a player that beat Murray in Montpellier last week – the second seed and world number six overcoming Belarusian Egor Gerasimov 7-6 (7-4) 7-5.
The tournament lost a three-time grand slam champion when Stan Wawrinka was edged out 6-4 7-5 by Russian Karen Khachanov in a tough first-round matchup for the Swiss, who sits just one place above the Russian at number 20 in the world rankings.
Alex de Minaur beat fellow Australian John Millman 6-1 6-4, while top seed Australian Open runner-up Daniil Medvedev begins his challenge on Wednesday when he tackles Serbian Dusan Lajovic.