Nine-time champion Novak Djokovic will make his return to the Australian Open against Spain's world number 75 Roberto Carballes Baena.
After being deported from Australia last year amid a row over his refusal of a COVID-19 vaccination, Djokovic is firmly back in favour and chasing history in Melbourne, with a record-equalling 22nd men's singles grand slam in his sights.
He begins against an opponent who in four previous main draw appearances has only ever won one singles match at Melbourne Park.
Defending champion Rafael Nadal, whose 22 slam titles Djokovic is seeking to match, has a tricky opener against rising British star Jack Draper, the world number 40.
Second seed Casper Ruud will tackle Czech Tomas Machac first up, with the 115th-ranked player unlikely to prove too daunting an obstacle for last season's French Open and US Open runner-up.
Fifth seed Andrey Rublev could face an awkward assignment against wildcard and former US Open winner Dominic Thiem, while Australia's Nick Kyrgios begins against Russian Roman Safiullin.
Neither 13th seed Matteo Berrettini nor five-time runner-up Andy Murray would have been delighted to be paired together, but that is what happened in Thursday's draw.
In the women's singles, top seed Iga Swiatek starts her bid for a first Australian Open title against Germany's Jule Niemeier, who caught the eye last year on a run to the Wimbledon quarter-finals.
American seventh seed Coco Gauff starts against Czech Katerina Siniakova, while Jessica Pegula, Gauff's third-seeded compatriot who recently beat Swiatek in the United Cup, will face Belgian Jaqueline Cristian.
Gauff could face former US Open winner Emma Raducanu in the second round. Unseeded Briton Raducanu starts against Germany's Tamara Korpatsch.
Former champions Sofia Kenin and Victoria Azarenka go head to head in the first round, with American Kenin unseeded this year and Belarusian Azarenka the 24th seed.
Azarenka's compatriot Aryna Sabalenka is fancied to do well, having banished last year's serving yips, and the fifth seed starts against Czech Tereza Martincova.
Tunisian second seed Ons Jabeur, runner-up at Wimbledon and the US Open, begins her latest quest for an elusive grand slam title against Slovenian world number 88 Tamara Zidansek.
Former US Open winner Bianca Andreescu is unseeded in Australia and Czech 25th seed Marie Bouzkova drew a possible short straw by getting the Canadian in round one.
World number one Swiatek sees off Xiyu in Madrid opener
World number one Iga Swiatek overcame Wang Xiyu with the minimum of fuss on Thursday to progress to the third round of the Madrid Open.
Swiatek has yet to win the title in Madrid, which is the only clay-court European event at which the Pole has not triumphed, but she got off to a flying start with a 6-1 6-4 victory over Xiyu.
"I love this place. I got to know the city a little better last year," Swiatek said. "So this time I feel more comfortable around."
Next up for the 22-year-old is a third-round tie against 27th seed Sorana Cirstea on Saturday.
Data Debrief
Swiatek has registered 150 match wins on the WTA Tour since the start of 2022. Elena Rybakina and Coco Gauff are the next best with 108 wins each.
She also became the first player born this century to claim 50 combined match wins in Madrid, Rome and Roland-Garros, since the inaugural women's singles event at the Madrid Open in 2009.
Dominant Gauff double bagels Rus at Madrid Open
Coco Gauff made a flying start to her Madrid Open campaign on Thursday, recording the first double bagel main-draw win of her career as she cruised past Arantxa Rus to reach the round of 32.
Gauff needed just 51 minutes to see off 33-year-old Rus as she booked a meeting with Ukraine's Dayana Yamstremska for Saturday.
The US Open champion lost just 18 points throughout the match – eight in the opener and 10 in the second set – as she put any doubts over her recent form to bed in emphatic fashion.
Gauff's power proved too much for Rus in the opener, the third seed winning 88 per cent of points behind her first serve and converting three of four break points to go a set up in just 23 minutes.
Rus brought up four break points midway through the second set, but when she failed to convert them, Gauff punished her in ruthless fashion by reeling off another three games then finishing things with a terrific forehand winner.
Speaking after her win, the American said: "I played really well today. It was just one of those days for me… 6-0 6-0, I've never done that before, I'll probably never do it again."
Data Debrief: Gauff matches Azarenka, Halep feat
Gauff is just the third player to register a 6-0 6-0 win in the women's singles draw at the Madrid Open, following in the footsteps of two former world number ones in Victoria Azarenka and Simona Halep.
The American, who only turned 20 last month, is also the youngest player to double bagel an opponent in any main-draw match on the WTA Tour since Iga Swiatek did so against Karolina Pliskova in the 2021 Italian Open final in Rome.
Nadal cruises past teen Blanch to tee up De Minaur rematch in Madrid
Darwin Blanch presented little challenge for Rafael Nadal, who dropped just one game in a convincing 6-1 6-0 triumph at the Madrid Open.
Nadal is feeling his way back to fitness, but 16-year-old qualifier Blanch offered little resistance to the 22-time major champion on Thursday.
Making his farewell appearance at the Madrid Open, where he has won five titles, Nadal needed just 64 minutes to progress to round two.
"I think today I played against an opponent with a great future in front [of him], but today, still making mistakes," said Nadal.
"I just tried to be there, be solid all the time without taking a lot of risks. It worked well. I'm happy to be through and I wish him all the very best for the future."
Nadal's reward is a rematch with Alex de Minaur, who he lost to last week in Barcelona.
Data Debrief
This game saw the largest age gap (21 years, 117 days) between two opponents in the history of ATP Masters 1000 events.
Nadal has now registered 57 wins at the Madrid Open, which is 20 clear of any other player.
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