Francesco Bagnaia secured back-to-back MotoGP victories to hand a significant boost to his championship hopes.
The Ducati rider came off the five-week break 66 points behind the championship leader but capitalised on Fabio Quartararo's struggles, closing the gap to 49.
Johann Zarco, who started on pole and third in the championship standings, saw his hopes of a first MotoGP victory end after he crashed out in the lead, which will also have a significant impact on his title chances.
With Quartararo affected by a long-lap penalty and Aleix Espargaro – second in the standings – carrying an injury, Bagnaia's win saw Ducati secure another podium.
Quartararo had an excellent start and immediately propelled himself to second on the grid behind Zarco before serving his long-lap penalty on the fourth lap, subsequently returning to the field to take fifth as he crucially came out ahead of Maverick Vinales.
Zarco's hopes of securing a maiden MotoGP victory ended the following lap, crashing out in the lead, leaving Jack Miller and Alex Rins to challenge for first – the latter having surged from 11th at the start.
Espargaro, having been a doubt for the race after a high-side in practice on Saturday, was unable to compete and fell down the field, though the dent to his Championship hopes was not as severe with teammate Vinales overtaking Quartararo on lap nine.
Three laps later, Bagnaia made his move and became the fifth different leader of the race, while Miller rose to second soon after with Rins looking vulnerable heading into the closing stages.
Vinales jumped further up the standings in the final laps, taking Rins, Miller and then Bagnaia to cap off a stellar drive, but he could not retain the lead, with Bagnaia's title hopes boosted by two consecutive victories.
Quartararo finished eighth, narrowly ahead of championship rival Espargaro but both will now be worried about the title charge of Bagnaia.
TOP 10
1. Francesco Bagnaia (Ducati)
2. Maverick Vinales (Aprilia) +0.426
3. Jack Miller (Ducati) +0.614
4. Enea Bastianini (Gresini) +1.651
5. Jorge Martin (Pramac Racing) +1.750
6. Miguel Oliveira (Red Bull KTM) +2.727
7. Alex Rins (Suzuki Ecstar) +3.021
8. Fabio Quartararo (Monster Energy Yamaha) +3.819
9. Alex Espargaro (Aprilia) +3.958
10. Marco Bezzecchi (Mooney VR46) +6.646
CHAMPIONSHIP STANDINGS
Riders
1. Fabio Quartararo (Monster Energy Yamaha) - 180
2. Aleix Espargaro (Aprilia) - 158
3. Francesco Bagnaia (Ducati) - 131
4. Enea Bastianini (Gresini) - 118
5. Johann Zarco (Pramac Racing) - 114
Teams
1. Aprilia Racing - 240
2. Ducati - 238
3. Monster Energy Yamaha - 206
4. Pramac Racing - 195
5. Red Bull KTM - 179
Hamilton could 'take a holiday' after Sao Paulo disappointment
Lewis Hamilton says he "could happily go and take a holiday" instead of finishing the season after a dismal showing at the Sao Paulo Grand Prix.
He made early exits in both qualifying sessions and started the race at Interlagos from 15th on the grid.
However, unlike Max Verstappen, who impressively won the race having started in 17th, the Brit struggled to mount much of a fight, coming away from the weekend with just one point after finishing in 10th.
His performance was made to look worse as team-mate George Russell had been battling for the lead but narrowly missed out on a podium place as he finished fourth.
Hamilton only has three races left with Mercedes before his move to Ferrari next season, bringing an end to their 12-year partnership.
But he was left frustrated in Brazil, expressing his disappointment with the car.
"We were just slow," Hamilton told Sky Sports F1. "The car was really, really tough. I do really want to say still a big thank you to the guys in the garage. They turned up super early this morning and still did a great job throughout the weekend.
"The team could have won also, so at least one car was behaving a lot better.
"The car is like a plank of wood. It's like no suspension.
"It's bouncing on the tyres everywhere, and you can't get on the power anywhere. It's just the worst ride, I think the worst ride that we've definitely ever had, particularly through corners. It's just so stiff.
"But hopefully we won't have any more bumpy tracks. I think the last three aren't so bumpy. But yeah, I could happily go and take a holiday."
Norris claims Verstappen 'got lucky' in Brazil as title hopes fade
Lando Norris said Max Verstappen benefitted from a rule "no one agrees with" as he won a dramatic Sao Paulo Grand Prix to leave the McLaren's title hopes hanging by a thread.
Verstappen surged to a terrific victory from 17th on the grid in Brazil, with Norris faltering after starting on pole.
Norris and Mercedes' George Russell – who were vying for the lead – both pitted on lap 29, but that strategy backfired as the red flag was shown following a crash involving Franco Colapinto.
With the race suspended, Verstappen was also able to change tires for the restart, negating Norris' advantage from pitting as the world champion raced to a commanding victory.
Norris had cut Verstappen's drivers' championship lead to 44 points by winning Saturday's sprint race but now sits 62 points adrift with just three races of the season remaining.
The Brit refused to hit out at McLaren's strategy after the race, though, putting his struggles down to bad luck.
"I have faith in the team in what they are saying and they have trust in me," he told Sky Sports F1.
"It was just unlucky. I don't care about the hindsight side of things, that's luck for them, nothing more.
"They got lucky on a rule that no one agrees with. Probably they agreed with it today but every driver has disagreed with it in the past.
"Today it benefitted them, it could have benefitted us if we just stayed out, but that's a stupid thing to think of.
"Just a bit unlucky today, nothing more. Of course, disappointing. Max drove well. He got a bit lucky but that's life."
Verstappen 'wanted to destroy' Red Bull garage before Sao Paulo triumph
Max Verstappen revealed he wanted to destroy the Red Bull garage in the hours before he delivered a wet-weather performance for the ages to win the Brazilian Grand Prix.
Verstappen had been left frustrated after Sunday's delayed qualifying session, when a crash by Lance Stroll and subsequent red flag saw him drop out of Q2.
The Dutchman's early exit saw him finish 12th, but a five-place grid penalty for an engine change dropped him to 17th, presenting an opportunity for Lando Norris to take a seismic chunk out of his drivers' championship lead.
But a determined Verstappen then overcame the rain-affected conditions at Interlagos, climbing to P11 on the very first lap before making his charge into the top 10.
His remarkable comeback, which included five consecutive fastest laps, culminated in him passing Alpine’s Esteban Ocon for the lead on lap 43 before romping to victory.
“My emotions were all over the place, from wanting to destroy the garage (after qualifying) to winning the race,” said Verstappen. “It has been a roller coaster.
“It is unbelievable to win here from so far back on the grid. I was expecting to lose points in the championship.
"Now, I just want clean races. But I am not thinking about clinching the title in Vegas.”
A rain-affected race saw several incidents, with Lance Stroll, Alex Albon, Nico Hulkenberg, Franco Colapinto and Carlos Sainz all failing to finish the race.
But Verstappen remained calm in those conditions, snapping his 10-race winless streak, while also becoming the first driver since Kimi Raikkonen at the Japanese Grand Prix in 2005 to emerge victorious after gaining 16 positions.
And the three-time world champion believed his latest win, which was his 62nd in the competition, was his best one to date.
“The rain came, we stayed out, which was very sketchy, and I had to just keep the car on track,” continued Verstappen.
“It was undriveable in the conditions. I felt like I was driving a boat, or a jet-ski.
“There was a lot at stake because I had to be aware of the championship, so for me this is the best one (victory).
"And it is a massive boost for the team because it has been a tough period.”
Verstappen is now 62 points clear of Norris in the drivers' championship with just 86 points remaining, and can win a fourth consecutive drivers' title at the Las Vegas Grand Prix.
However, he insisted that the season was far from over, acknowledging he must remain perfect in the final three races to get over the line after an up and down season.
“Now it’s of course a great result, which if you look a few hours ago, was definitely the other way around, looking like we were going to lose a lot of points," he said.
“So I’m very happy, but still three tough races [to go], so we just need to stay calm and make no mistakes.
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