The Oakland Athletics scored three runs in the bottom of the 12th inning to beat the Red Sox 7-6, snapping Boston's eight-game winning streak.
Tony Kemp's sacrifice fly provided the winning margin after a Seth Brown single and Jed Lowrie double negated the two runs the Red Sox had scored to take the lead in the third extra frame.
Brown finished a home run shy of the cycle, driving in a run with all three of his hits.
Kike Hernandez hit his 10th home run of the season and drove home two runs for Boston.
Walker, Mets roll past Yankees
Taijuan Walker did not allow a hit until Aaron Judge's home run with one out in the sixth inning as the New York Mets opened their rain-delayed Subway Series against the Yankees with an 8-3 win.
Austin Slater's two-run homer in the eighth inning gave the San Francisco Giants a 6-5 victory over the Arizona Diamondbacks to maintain a half-game edge in the National League (NL) West.
The Los Angeles Dodgers' bullpen turned in five scoreless innings as the defending World Series champions weathered a rain delay to defeat the Washington Nationals 5-3 for their eighth win in a row.
Joey Votto and Tyler Naquin homered as the Cincinnati Reds sent the Chicago Cubs to an eighth straight defeat with a 3-2 triumph that moved the Reds up into second place in the division for the first time since April 22.
The division-leading Milwaukee Brewers won their 11th in a row with an 11-2 rout of the Pittsburgh Pirates as Omar Narvaez had five hits and Avisail Garcia drove in five runs.
Rays, Indians drop fifth in a row
The Tampa Bay Rays lost a chance to recover some ground on the Red Sox when they surrendered five runs in the sixth inning of a 6-3 loss to the Toronto Blue Jays for their fifth consecutive defeat.
The Cleveland Indians also have lost five in a row and are on the verge of a four-game sweep by the Houston Astros after a 3-2 defeat Saturday.
No-look Story
Colorado Rockies shortstop Trevor Story did not need to see Harrison Bader to get him out, completing a pick-off of the St Louis Cardinals outfielder with a no-look tag.
Saturday's results
Philadelphia Phillies 4-2 San Diego Padres
New York Mets 8-3 New York Yankees
Los Angeles Dodgers 5-3 Washington Nationals
Milwaukee Brewers 11-2 Pittsburgh Pirates
Toronto Blue Jays 6-3 Tampa Bay Rays
Detroit Tigers 11-5 Chicago White Sox
Cincinnati Reds 3-2 Chicago Cubs
Houston Astros 3-2 Cleveland Indians
Miami Marlins 3-2 Atlanta Braves
Kansas City Royals 6-3 Minnesota Twins
Colorado Rockies 3-2 St Louis Cardinals
Oakland Athletics 7-6 Boston Red Sox
Los Angeles Angels 4-1 Baltimore Orioles
San Francisco Giants 6-5 Arizona Diamondbacks
Texas Rangers 7-3 Seattle Mariners
Mets at Yankees
New York will have plenty of baseball to watch on Independence Day as the Yankees host the Mets in a doubleheader highlighted by a Gerrit Cole-Marcus Stroman pitching matchup in the first game.