The Orlando Magic snapped the Los Angeles Lakers' winning streak in the NBA, while the Houston Rockets were also stunned on Wednesday.
The Lakers' nine-game winning run was ended with a shock 119-118 loss to Orlando.
LeBron James had a double-double of 19 points and 19 assists, but the Lakers (33-8) were stunned at the Staples Center.
Markelle Fultz was the star for Orlando (20-21) with a triple-double of 21 points, 11 rebounds and 10 assists.
Houston were also surprised in a 117-107 defeat to the Portland Trail Blazers.
Russell Westbrook contributed a triple-double of 31 points, 12 assists and 11 rebounds, but James Harden (13 points) went three-of-12 from the field.
Damian Lillard (25 points) and CJ McCollum (24) combined for 49 points for Portland, while Hassan Whiteside (18 points and 18 rebounds) and Carmelo Anthony (18 points and 12 rebounds) managed double-doubles.
Doncic delights as Sabonis shines
Luka Doncic starred with 25 points, 17 assists and 15 rebounds in the Dallas Mavericks' 127-123 win over the Sacramento Kings. The 20-year-old became the youngest player in NBA history to post a triple-double with at least 15 rebounds and 15 assists.
Domantas Sabonis' double-double of 29 points and 13 rebounds helped the Indiana Pacers past the Minnesota Timberwolves 104-99.
The Philadelphia 76ers overcame the Brooklyn Nets 117-106 as Ben Simmons contributed 20 points and 11 assists.
Kuzma struggles
Kyle Kuzma struggled in the Lakers' defeat, going two-of-10 from the field for just four points in 27 minutes.
Mykhailiuk from deep
Sviatoslav Mykhailiuk converted from beyond half-court to beat the buzzer in the third quarter of the Detroit Pistons' 116-103 victory against the Boston Celtics.
Wednesday's results
Detroit Pistons 116-103 Boston Celtics
Philadelphia 76ers 117-106 Brooklyn Nets
Miami Heat 106-100 San Antonio Spurs
Chicago Bulls 115-106 Washington Wizards
Indiana Pacers 104-99 Minnesota Timberwolves
Toronto Raptors 130-121 Oklahoma City Thunder
Denver Nuggets 100-86 Charlotte Hornets
Portland Trail Blazers 117-107 Houston Rockets
Dallas Mavericks 127-123 Sacramento Kings
Orlando Magic 119-118 Los Angeles Lakers
Celtics at Bucks
The Celtics (27-12) get a chance to bounce back when they face Eastern Conference leaders the Milwaukee Bucks (36-6) on Thursday.