Aleksei Miranchuk's stunning late goal salvaged a 2-2 draw for Atlanta United, ending Inter Miami's winning streak.
The visitors brought Lionel Messi and Luis Suarez off the bench in the second half but were unable to make it six wins on the bounce.
Miami had the better of the first half, with Julian Gressel forcing Brad Guzan into an acrobatic save before David Ruiz snuck in behind the hosts' defence to slot a lovely low shot into the bottom-right corner.
In the 56th minute, Saba Lobjanidze met Pedro Amador's whipped cross with a thumping header, nodding it through Drake Callender's legs, and the keeper arguably should have done better.
But just three minutes later, Miami were back in front – Leonardo Campana's free-kick from just outside the box took a huge deflection off the wall, giving the keeper no chance.
Messi led the search for a late third, with his low shot palmed away by Guzan straight into Suarez's path, but Amador was perfectly placed on the line to block it.
Atlanta then went straight up the other end, with Miranchuk floating a wonderful shot into the top-left corner after cutting inside from the right before Lobjanidze's late effort deflected off Ian Fray onto the post.
Miami are now eight points clear at the top of the Eastern Conference, while Atlanta sit in 11th.
Data Debrief: Campana makes Miami history
Campana may have got a bit of luck with his goal due to a wicked deflection, but he will not care one bit, as that strike was his 30th goal for Miami.
He now becomes the outright all-time leading scorer for the club, overtaking Gonzalo Higuain, though Messi is just three behind him.
Napoli 5-0 Palermo: Five-star hosts cruise into Coppa Italia last 16
Cyril Ngonge scored twice in an electrifying performance, as Napoli breezed into the Coppa Italia last 16 with a crushing 5-0 win over Serie B Palermo on Thursday.
Ngonge struck first in the seventh minute with a left-footed drive that bounced in front of Salvatore Sirigu before squirming under his body into the net, leaving the goalkeeper shaking his head in disbelief.
Sirigu was at fault again five minutes later when Ngonge lashed another left-footer from a difficult angle, the ball flying across the face of the goal before nestling in the side netting to make it 2-0.
Palermo gave the hosts a scare as Matteo Brunori struck the post 29 minutes in, but Napoli were too big, too strong and too quick for their second-tier visitors, with Juan Jesus nodding home from a corner to make it 3-0 just before the break.
The visitors' hopes of a comeback were shattered when they were reduced to 10 men just before the hour mark. Aljosa Vasic was given a straight red card for dangerous play after catching Billy Gilmour in the face.
David Neres slotted home the fourth in the 70th minute, pressing to help win the ball back before coolly knocking into the net.
Scott McTominay then came off the bench to score with his first touch, rifling home a pass from fellow substitute Romelu Lukaku seven minutes later to complete the rout.
Data Debrief: A perfect performance
Conte's first game in charge was in the first round of this competition, and the Partenopei edged their way through with a penalty shootout win over Modena.
It was a totally different performance this time around though. They had 16 shots, seven of which were on target, accumulating just 1.55 expected goals.
Ngonge's part was perhaps the most impressive - he scored with both of his shots, with those chances equalling just 0.09 xG, though he just could not snatch a hat-trick in the second half to round off a brilliant game.
KC, JC, Excelsior all score heavily in Manning Cup wins
Kingston College, Jamaica College and Excelsior High all scored massive wins in ISSA/Digicel Manning Cup action on Wednesday.
KC hit seven past Meadowbrook High at Meadowbrook to remain atop Zone C with 13 points from five games.
Elsewhere in Zone C, Campion College dispatched Penwood 2-0 to draw level on 10 points with their opponents who are in second place on goal difference.
Jose Marti Technical edged Cumberland High 2-1 in the St. Catherine derby in the day’s other Zone C clash.
Zone F action saw leaders Jamaica College defeat Bridgeport High 9-0 with Giovanni Taylor bagging four goals as the standout performer. Excelsior High hammered Pembroke Hall 11-0 in the other game from the zone.
In Zone D, Vauxhall High grabbed a late equalizer to secure a 1-1 draw against Camperdown High to remain unbeaten this season.
STATHS displayed a vintage performance as they held firm to secure their third win of the season with a 1-0 victory versus Haile Selassie and remain top of the zone with 10 points from their four outings.
Celta Vigo 0-1 Atletico Madrid: Super-sub Alvarez snatches last-gasp win
A late Julian Alvarez goal earned Atletico Madrid a dramatic 1-0 win at Celta Vigo on Thursday to lift them to third in LaLiga.
Atletico looked to be heading to a second straight draw, but the substitute was alert in the final minute of the 90 to ensure they returned to Madrid with all three points.
Goalkeeper Jan Oblak was key as Celta suffered their first home defeat of the season, producing an excellent save to deny Iago Aspas at his near post just before the break.
He kept his side in it throughout a poor showing, also keeping out Borja Iglesias twice after the break as Celta struggled to find their clinical edge.
But big-money signing Alvarez struck in the dying minutes, stretching out a leg to meet Antonie Griezmann's pinpoint cross to poke his second goal of the season past Vicente Guaita.
Data Debrief: Atleti ride their luck
It was not a vintage performance for Atletico by any stretch of the imagination, which was only confirmed as Oblak was awarded player of the match at the end of the contest.
The visitors only had two shots on target (from eight attempts), with both of those coming in the final 11 minutes as they accumulated just 0.63 expected goals.
Celta's profligacy came back to haunt them though as they had 10 shots, four of which hit the target, with three of those classed as big chances. They created an xG of 1.37, but just could not find a way past Oblak.
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