Lionel Messi will miss the annual MLS All-Star game in Columbus on Wednesday due to his ongoing ankle injury, MLS has confirmed.

The Argentina captain sustained the injury during his nation's Copa America final victory over Colombia on July 14.

Messi subsequently left the pitch in tears, and watched from the dugout as substitute Lautaro Martinez struck an extra-time winner in Miami.

The eight-time Ballon d'Or winner was expected to be part of the annual clash between an MLS XI and Liga MX XI.

However, he was listed as unavailable on the MLS website along with fellow Inter Miami forward Luis Suarez, though their team-mates Jordi Alba and Sergio Busquets are both included.

The likes of Hugo Lloris, Christian Benteke and Federico Bernadeschi also feature in the MLS roster, while Andre-Pierre Gignac and Salomon Rondon will feature for the Liga MX All-Stars.

Jordi Alba scored the winner for Inter Miami in a 2-1 victory over the Chicago Fire as they moved five points clear at the top of the Eastern Conference.

Matias Rojas had given the Herons an early lead before being pegged back by Rafael Czichos, but Alba's winner ensured Miami made it back-to-back wins.

FC Cincinnati's third defeat in a row, a 3-1 loss to the New York Red Bulls, means Miami now have some breathing space at the summit of the table.

The hosts were still without Lionel Messi, who watched on from the sidelines with an ankle injury, but made a quick start without their talisman.

Robert Taylor's bursting run opened up the space in behind Chicago for him to pull it back into the middle, and Rojas fired his shot across goal to pick out the bottom-right corner.

Moments later, Hugo Cuypers almost pegged them back when he benefitted from Drake Callendar's spill, but the goalkeeper recovered well to deny him.

Julian Gressel then fired a brilliant chance wide, not realising he had more time, but almost made up for it on the stroke of half-time, only to fire a powerful shot against the crossbar.

The Fire improved after the break and got their reward in the 73rd minute, with Czichos pushing out from defence before nestling a shot into the bottom-left corner.

Their joy was short-lived though, as just two minutes later, Alba made the most of a mix-up at the back and slotted into an empty net to seal the three points.

Data Debrief: Miami on target once more

Miami have scored in each of their last 11 games in MLS, their longest streak this season. In fact, they have only failed to score in two of their 25 matches in the league so far.

Alba's last strike here ensured they ended a four-match winless streak against the Fire (drawing one, losing three), having failed to beat them since August 2021. 

Inter Miami will again be without injured superstar Lionel Messi as they look to continue on their course for the Supporters' Shield on Saturday.

Miami will host Chicago Fire with Messi absent, just as he was for the midweek home win over Toronto FC.

"Leo will continue to be evaluated by our medical staff week to week," coach Tata Martino said.

"We will see how he recuperates without taking any type of risk."

Messi suffered an ankle injury while on Copa America duty with Argentina, winning that competition but appearing to hamper Inter's title hopes in the process.

But Martino's men are still well placed to achieve their goals, starting with the regular-season championship.

With victory over Toronto, in which Federico Redondo took centre stage with two goals, Miami became the first team to reach 50 points this season.

They have achieved that feat within 24 games, joining esteemed company. The only six teams to previously tally 50 points inside 24 games have gone on to win the Supporters' Shield.

Next opponents Chicago at least head into this encounter off the back of a win of their own, beating FC Cincinnati on the road on Wednesday.

"When you come on the road and get a result like this, it's a great team effort," said Fire coach Frank Klopas.

"Certain guys are playing really well at the moment, but I still feel that everyone can give more. There's a lot more potential in there with the group.

"That's why this game on Saturday is so massive for us."

PLAYERS TO WATCH

Inter Miami – Federico Redondo

Miami may be missing Messi, but the supporting cast has consistently stepped up this season. They have had four different players score two or more goals in a match, tied for the most in MLS.

The latest of those was Redondo, scoring his first goals in MLS against Toronto. With an assist in that game, too, he will hope that is the start of a strong run of game.

Chicago Fire – Brian Gutierrez

The Fire have had just three goals from substitutes in 2024, yet two of those have been among their past three goals. The latest, their winner against Cincy, saw Gutierrez emerge from the bench to score.

The midfielder will not want that to develop into a consistent theme, however, surely preferring to play from the start. He had done so in each prior game going back to April.

MATCH PREDICTION: INTER MIAMI WIN

Chicago have actually won four of their six games against Miami, including the past three in a row.

But New York City FC are the only team to further extend such a streak against Miami, and their run of five straight victories ended back in 2022. Miami are a very different prospect in 2024.

Their stretch of scoring in 10 consecutive MLS matches is a club record, with their tally of 19 goals across those games showing the task that lies before Chicago – with or without Messi.

OPTA WIN PROBABILITY

Inter Miami – 64.2%
Chicago Fire – 16.7%
Draw – 19.1%

Inter Miami returned to the summit of the Eastern Conference following their 3-1 win over Toronto FC at the Chase Stadium. 

Federico Redondo scored twice in the second half to add to Diego Gomez's opener, with Derrick Etienne netting a late consolation for the visitors. 

FC Cincinnati's 1-0 loss to Chicago Fire ensured the Herons returned to top spot, bouncing back from their 6-1 defeat to their Queen City rivals last time out. 

Lionel Messi, who is recovering from an ankle injury following Argentina's Copa America success, watched on as his side almost fell behind only for Deandre Kerr to fluff his lines inside the area. 

That opportunity would be capitalised on three minutes before the break, with Gomez firing the ball beyond Sean Johnson for the first real moment of magic in the contest.

Toronto continued to create chances, with Federico Bernardeschi almost providing an instant response only to see his curling effort saved brilliantly by Drake Callender. 

But Inter Miami would increase their advantage shortly after the interval, with Redondo heading in at the back post following Julian Gressel's teasing delivery. 

The Argentine would double his tally for the evening, and the season six minutes later, rounding off a superb team goal with a neat finish inside the area. 

John Herdman's side would get themselves on the scoresheet heading into the final 10 minutes with Etienne placing the ball into the far left corner. 

But Inter Miami would hold on to secure a 15th triumph of the season, ahead of their final fixture before the Leagues Cup against Chicago Fire this weekend. 

John Herdman hopes Toronto FC's bad run is behind them and a playoff push on the horizon as they prepare to meet Inter Miami, who are still bristling at suffering their joint-record defeat last time out in MLS.

Toronto staged a second-half comeback to beat the Philadelphia Union 2-1 on Saturday, snapping a seven-match losing streak across all competitions.

The Reds had been winless in nine ahead of their victory over the Union, which dragged them up to eighth in the Eastern Conference, three points adrift of the top seven. 

With a number of players returning from injury and confidence restored, Herdman hopes that result can be something of a turning point.

"We can go into that match now against Miami with one of my best starting XIs for the first time since the beginning of the season," Herdman said. 

"We're never too high and never too low, and we just keep our feet on the ground, stay focused. 

"It's one win – and I thank the fans, they have been brilliant with us, they kept us going – but it's just the start, the start of a playoff push."

Miami, meanwhile, have been knocked off the top of the Eastern Conference, losing 6-1 to FC Cincinnati on their last outing on July 7.

Cincinnati then won their subsequent match to leapfrog Miami, who have been without Lionel Messi and Luis Suarez due to the Copa America, at the summit.

Boss Gerardo Martino highlighted the Herons' defensive issues after their last match, saying: "We had a period early in the season where we were vulnerable at the back.

"We started to fix that, the previous five or six games we did a solid job defending, but then we reverted defensively to how we played early in the season. 

"We are still not there despite our good results and performances. We have to keep working and hoping in the final part of the season we can improve with our full roster."

However, Miami may have to wait to reintroduce Messi after he exited Argentina's Copa America final victory over Colombia with an ankle injury.

PLAYERS TO WATCH

Inter Miami – Julian Gressel 

Gressel has eight assists in MLS this season, a tally only bettered by Messi (nine) among Miami players.

His tally of 4.19 expected assists (xA), meanwhile, is better than Messi's 3.59. With the Herons still missing some of their key men, they may need Gressel to supply the chances.

Toronto FC – Federico Bernardeschi

Only nine players have bettered Bernardeschi's tally of 53 chances created in MLS this year, while he also has 12 goal involvements (eight goals, four assists).

Ranking fourth for shots attempted (79) but just 34th for expected goals (6.5 xG), the Italian is not afraid to try his luck from any position.

MATCH PREDICTION: INTER MIAMI WIN

Toronto halted a nine-game winless streak by beating Philadelphia last time out, but their last pair of back-to-back victories in MLS came in late April and early May.

They are winless in their last seven away games, losing their last four in a row and conceding multiple goals in six of their last seven.

Miami, meanwhile, have only lost one of their last eight home matches in MLS, winning four of their last six. Despite their absences, they approach the game as favourites.

OPTA WIN PROBABILITY

Inter Miami – 72.4%

Toronto FC – 11.7%

Draw – 15.9%

FC Cincinnati made a statement of intent as they hammered Inter Miami 6-1 to take the lead in MLS' Eastern Conference.

Cincinnati, the reigning Supporters' Shield champions, ended Miami's fine run of form in sensational style on Saturday.

Five different scorers netted for the home side, who are now a point clear of Miami in the standings, with Yuya Kubo helping himself to a double.

Serhii Kryvtsov got the Herons' only goal of the match, cancelling out Kubo's opener.

However, quickfire efforts from Luciano Acosta, Pavel Bucha and Yamil Asad put Cincinnati in complete control by the interval.

And an emphatic victory was wrapped up when Kubo added his second before youngster Gerardo Valenzuela got in on the act with his first senior goal.

A dismal night for Miami was capped off when Sergio Busquets saw red after picking up two quick yellows for dissent, and Gerardo Martino's team – who are still without star players Lionel Messi and Luis Suarez – will have to swiftly bounce back.

Data Debrief: Double-double

Kubo took centre stage with his brace, but Acosta, last season's MVP, was again integral for Cincinnati.

Acosta has now provided 15 assists in MLS this season (more than any other player) after he teed up Bucha's goal from a corner, while he has also scored 10 times himself.

He had 101 touches and played six key passes in this game, as Cincinnati proved they are still the team to beat in the East.

FC Cincinnati coach Pat Noonan is relishing going up against Inter Miami in an enthralling clash at the top of MLS.

Eastern Conference leaders Miami, who will be without Lionel Messi and Luis Suarez due to their continued Copa America duties, visit Cincinnati on Saturday.

The defending Supporters' Shield champions are second in the East, just two points behind Miami.

Both teams have won four of their last five league games, and Noonan is anticipating a stern test of his team's quality.

"They're a very deep team. You can see with key pieces missing the team that they're fielding is very strong," Noonan said.

"There's a reason they're still winning games and doing it home and away.

"They have a lot of quality and a lot of guys that have played meaningful minutes and now are getting more consistent starts.

"But they still look very strong and will be a great test for us."

Cincinnati have a game in hand on Miami, and come into the clash on the back of a record-setting 3-2 win over D.C. United. 

Noonan's team have now won seven straight away matches.

"I give the guys credit because we've gone on the road two games here and gotten results, and it's not easy to do," Noonan said after the win.

"I told them before the game... 'You guys are a good team on the road,' and it might not always be the way we want it to look.

"That's credit to the opponent, that's credit to going on the road in tough atmospheres, but you have to be able to adjust at times and adapt to the conditions, and I think they do a good job of that."

The task for Cincinnati now is to repeat that form at home.

PLAYERS TO WATCH

FC Cincinnati - Luciano Acosta

Acosta has been involved in seven goals (three goals, four assists) in his last four home matches. Since the start of the 2022 season, Acosta has been involved in 52 goals in regular-season home matches (23 goals, 29 assists), seven more than any other player in that time.

Inter Miami - Jordi Alba

With Messi and Suarez absent, fellow superstar Alba has been helping to plug the gap.

He scored a stunner against Nashville SC last week, and adds another potent threat even from left-back.

MATCH PREDICTION: CINCINNATI WIN

Miami have won 11 of their last 14 matches (D2 L1) including the last four in a row. All four wins in Miami’s current run have been by 2-1 scorelines.

But Cincinnati are made the slight favourites for this one.

The win over D.C. was their 11th win in their last 13 matches (L2). The only team in the post-shootout era (since 2000) to record 12 wins in a span of 14 matches in a single regular season was the Seattle Sounders in July-October 2018.

Miami won each of their first four matches against Cincinnati in 2020 and 2021. Since the start of the 2022 season, however, Cincinnati are unbeaten in four regular-season meetings with Miami (W3 D1).

OPTA WIN PROBABILITY

FC Cincinnati - 43.7%

Inter Miami - 29.5%

Draw - 26.8%

Inter Miami won their fourth straight MLS game as Julian Gressel provided another assist in the Herons' 2-1 victory at Charlotte FC.

With Lionel Messi and Luis Suarez away on Copa America duty, Gressel has stepped up to help fill the void for Gerardo Martino's side.

And he delivered again as his brilliant cross teed up Benjamín Cremaschi for an 86th-minute winner.

Dean Smith's Charlotte team were subsequently reduced to 10 men when Patrick Agyemang, who had earlier cancelled out Robert Taylor's opener for Miami, saw red deep in stoppage time.

Miami stay top of MLS, two points ahead of FC Cincinnati, who they face next, in the Eastern Conference.

Charlotte, meanwhile, sit sixth in the same conference after suffering back-to-back defeats.

Data Debrief: Gressel takes centre stage again

Fresh from recording his 100th MLS goal contribution in Miami's win over Nashville SC, Gressel made it 101 with his sublime assist late on.

Gressel has contributed to goals in his last five games in the league (one goal, four assists), while Miami have scored in 20 of their 22 games, more often than any other team in MLS this season.

Inter Miami are fortunate to have Jordi Alba, so says head coach Gerardo Martino.

Alba scored a stunning volley that ultimately proved the winner just before half-time in Saturday's 2-1 win over Nashville SC. The strike came with an expected goals (xG) value of 0.01.

That victory kept Miami top of the Eastern Conference, with a two-point lead over FC Cincinnati.

Miami face Charlotte in midweek, and with Lionel Messi and Luis Suarez still away at the Copa America, Martino is glad to have such an experienced, quality player as Alba at his disposal.

"I celebrated] as should be celebrated because it was a great goal," Martino said.

"I'm not surprised because he is a player with so much quality.

"He [Alba] puts me at ease for what he gives the team and the options he gives us in attack and how well he played defensively.

"Jordi is an internationally recognised player and we're lucky to have him on our team."

Nashville dragged themselves back into the contest in the second half, and Miami ultimately relied on goalkeeper Drake Callendar to make a late save to earn all three points.

Reflecting on his side's display, Martino added: "I believe we had a very good first half, we controlled the whole thing.

"In the second half, we did not control the ball the same way as the first half, especially when Nashville had a line of three, [but] we didn't suffer.

"I think in the end we won the game rather well."

Charlotte lost 1-0 to the Houston Dynamo last time out, snapping a four-game unbeaten streak for Dean Smith's team.

They sit sixth in the Eastern Conference.

PLAYERS TO WATCH

Charlotte FC - Patrick Agyemang

Agyemang leads Charlotte's scoring charts with five MLS goals. They have come from 14 shots on target, and 26 attempts overall. He will be one Miami's defence has to look out for.

Inter Miami - Julian Gressel

Gressel provided an assist for Miami's opener against Nashville. It was his 100th goal contribution in MLS.

Since he joined MLS in 2017, Gressel has provided 62 assists, with only Cincinnati's Luciano Acosta (65) setting up more goals.

MATCH PREDICTION: DRAW

While Miami are top of the standings, Charlotte are expected to challenge for a positive result in this one, with Opta's supercomputer ranking the draw threat highly.

Miami have won their last three away games in MLS, though, so the Herons still come into this as slight favourites.

That being said, Miami have lost their last two trips to Charlotte. In fact, last season, these teams split the record evenly over their three meetings in all competitions, with Miami winning one, Charlotte winning another and the other game drawn.

OPTA WIN PROBABILITY

Inter Miami - 41.6%

Charlotte - 32.9%

Draw - 25.6%

Jordi Alba filled in for his absent Inter Miami stars Lionel Messi and Luis Suarez as the Herons made it three MLS wins on the spin with a 2-1 victory over Nashville SC.

With his former Barcelona team-mates Messi and Suarez away at the Copa America, Alba provided the stardust as he volleyed home in the 44th minute on Saturday to put the away team 2-0 up.

The Spaniard's sensational strike, which came with an expected goals (xG) value of just 0.01, arrived four minutes after Ian Fray had headed home from Julian Gressel's corner to nose Miami ahead.

Yannick Bright's clumsy challenge on Tyler Boyd provided Hany Mukhtar the chance to drag Nashville back into the contest in the second half - an opportunity the German duly took from the penalty spot.

Forster Ajago almost completed the comeback, but Miami goalkeeper Drake Callender made a fine save to deny the hosts a late equaliser.

Miami remain top of the Eastern Conference, two points clear of FC Cincinnati.

Data Debrief: Gressel the creator

Gressel provided an assist to Fray for Miami's opener against Columbus Crew on June 19, and that duo teamed up again this time out.

Since he joined MLS in 2017, Gressel has provided 62 assists, with only Cincinnati's Luciano Acosta (65) setting up more goals.

Gerardo Martino is "the perfect fit" for Inter Miami, so says Julian Gressel.

Miami are top of MLS ahead of playing Nashville SC this weekend, having taken 41 points from 20 matches.

It has been an epic turnaround in fortunes for the Herons, who have been MLS' form team since the arrivals of Lionel Messi, Sergio Busquets and Jordi Alba last year.

This season, that trio have been formed by their former Barcelona team-mate Luis Suarez, who like Messi, has netted 12 goals in the league so far in 2024.

Yet with both Messi and Suarez absent due to the ongoing Copa America, Miami's form has not dropped off.

And Gressel, who supplied an assist in Miami's 2-1 win over the Columbus Crew last time out, says Martino deserves all the credit.

"Tata is the perfect fit for this team," he told the Miami Herald. "He has the intensity to push younger guys but also the experience and knowledge of how to manage a really successful team with stars.

"He knows MLS. He knows Leo Messi and Busquets and Jordi and Suarez. He can combine all that knowledge he gained over those years and really bring out the best in us.

"When Miami made that hire, I wasn't with the club yet, but I remember thinking: 'This is absolutely a no-brainer.'

"You don't really coach Leo Messi anymore, or Luis Suarez; Those guys are so beyond that, so it's about managing them and managing the team around them.

"He has a really good feel for that."

Former Barca boss Martino credited his work in charge of national teams as the ideal preparation for this job.

"Of course, it is rare for four stars to show up together, especially in MLS, but dealing with young players and stars is not new to me," Martino said.

"As a national team coach, you often have world-class players with a lot of experience, and you collaborate with the young players who are developing.

"As a coach, your job is not restricted to training during the week and playing games on weekends. You are also expected to develop and integrate young players while coexisting with the big-name players."

PLAYERS TO WATCH

Nashville SC - Sam Surridge

Hany Mukhtar has not quite scaled the same heights as in seasons gone by in 2024, but striker Surridge has provided the goals. He leads the way for Nashville, with seven strikes in MLS.

Inter Miami - Julian Gressel

Gressel’s assist for Ian Fray to score Miami’s opening goal against Columbus was his 61st MLS assist.

Since he joined MLS in 2017, only Luciano Acosta (65) has recorded more assists than Gressel.

MATCH PREDICTION: DRAW

Nashville limited New York City FC to no shots on target in their 1-0 win on Saturday. It marked the sixth time since the start of the 2021 season that Nashville have not allowed a shot on target in a match, the most such games in the league in that time.

Miami are now on 41 points. Of the 11 previous teams that averaged more than 2.0 points per match through 20 games of the season, 10 went on to win the Supporters' Shield, with the exception being Toronto FC in the shortened 2020 season.

The Herons are unbeaten in six straight meetings with Nashville SC in all competitions (W3 D3) including winning the last two.

Prior to the last two games, Miami had won only two of their first 11 matches against Nashville in all competitions (D5 L4).

OPTA WIN PROBABILITY

Nashville SC - 37.8%

Inter Miami - 35.7%

Draw - 26.4%

Ian Fray made a scoring return from his long injury lay-off, helping Inter Miami to a 2-1 victory over Columbus Crew in the MLS on Wednesday.

Miami, who are without Lionel Messi and Luis Suarez due to their Copa America participation, ensured they stayed top of the Eastern Conference with their second win on the bounce.

Making his first appearance since July 2023, defender Fray marked his comeback with an early goal, flicking Julian Gressel's corner into the back of the net after just 10 minutes.

The Herons cemented their control just 11 minutes later when Leonardo Campana latched onto the rebound of his own saved shot to put them 2-0 up.

However, Cucho Hernandez halved the deficit just before half-time, poking a low effort past Drake Callendar into the bottom-left corner.

Despite Miami's dominance in the second half, Columbus almost got the deciding goal, but Callendar prevented Cucho from getting a second with a sharp save to ensure the hosts did not drop points.

Data Debrief: Herons on scoring run

Miami have now scored in each of their last six matches in the MLS, their longest run since a seven-game streak between March and May earlier this year.

Gressel has played a key part in that run, contributing to goals in each of his last three appearances for the Herons (one goal, two assists).

Inter Miami are sitting comfortably at the top of the Eastern Conference table but face a challenge on Thursday when Columbus Crew visit for an MLS clash at Chase Stadium.

The Herons are two points clear at the summit of the East standings after snatching a 2-1 triumph over Philadelphia Union last time out.

Yet Wilfried Nancy's Crew have triumphed in their last four road games in the league, battling to a 3-2 victory over New York City FC at Yankee Stadium on Friday.

"It's a massive run and just shows how good we are mentally" Mohamed Farsi said of the streak.

"I think we have more away wins right now than last year all season. I think so or the same, so I'm happy for that."

Farsi has become a central figure for Columbus and scored the go-ahead goal in the 53rd minute against the Pigeons, much to the delight of head coach Nancy.

"The idea for Mo is to be more consistent because he brings a lot of energy to the team," Nancy said.

"He wants also to show himself that he's a better player than last year when we had the same deal here. Good for him.

"Now, he knows that he has to work on certain things, but I'm happy for him. He's doing a good job."

Despite missing Lionel Messi, Luis Suarez and Matis Rojas – all of whom are on Copa America duty – the nine-man Herons overcame the Union thanks to Leo Afonso's last-gasp strike.

"It is clear that in 10 times, nine of these games we would end up losing," Miami head coach Gerardo Martino said.

"Absolutely all the credit belongs to them. That has to do with the effort, with the character, with the guts that the boys had."

Afonso echoed his coach's sentiment ahead of another crunch match-up.

"It's difficult when you're missing the best players in history in their positions," he said. "But we got to keep working, and we got to try our best."

PLAYERS TO WATCH

Inter Miami – Jordi Alba

With stars Messi and Suarez on international duty, Jordi Alba will be expected to step up once more for the Herons.

The former Barcelona full-back has two goals this year in MLS, as well as five assists – that creative tally is only bettered by Messi (13) and Julian Gressel (six) among Miami team-mates.

Columbus Crew – Diego Rossi

Diego Rossi remains an integral figure in attack for the Crew, whose Javier Hernandez (five goals) has only scored more than the forward's four in 10 MLS games this year.

With other Uruguayan colleagues at the Copa, Rossi will hope to extend his fine scoring form here.

MATCH PREDICTION – DRAW

Miami may be leading the way in the East but a draw appears the most likely outcome at Chase Stadium.

The Herons have never lost a home match against the Crew (W2 D1), though Columbus did earn their first away point against David Beckham's Miami-based side on the last visit to Fort Lauderdale, a 2-2 draw in July 2023.

Martino will hope to continue a strong run of form with another victory, however.

Miami have won eight of their last 11 regular-season matches (D2 L1) following a 2-1 victory at Philadelphia on Saturday. Since that run began in mid-April, Martino's side have managed 26 points and scored 28 goals – both league-leading figures.

Yet Columbus should not be ruled out for a win either.

The Crew have won four straight regular-season away matches for the second time in club history after a four-match run in August-September 2015.

Columbus have lost only one of their last 11 regular-season road matches, dating back to last September (W5 D5), and that streak could continue here.

OPTA WIN PROBABILITY

Inter Miami win – 37.4%

Columbus Crew win – 36.3%

Draw – 26.4%

Leo Afonso scored an incredible 94th-minute winner as Inter Miami fought back to beat the Philadelphia Union 2-1 in MLS on Saturday despite being reduced to nine men.

Miami's grasp on top spot in the Eastern Conference looked like being weakened when Gerardo Martino's team – who were without both Lionel Messi and Luis Suarez as Argentina and Uruguay continue their Copa America preparations – fell behind after three minutes.

Mikael Uhre's one-on-one finish put the Union ahead, but Miami levelled just after half-time as Julian Gressel fired into the top-right corner from the centre of the box.

The Herons, though, found themselves up against it when both David Ruiz and Tomas Aviles were sent off, the former for a horror challenge on Leon Flach and the latter earning a soft second booking for kicking the ball away.

With the Union throwing men forward in search of a winner, they were struck with a sucker punch.

Afonso raced away on the counterattack, ignoring Benjamin Cremaschi to his right before slotting his finish past Oliver Semmle to hand Miami an eighth win in their last 11 games (two draws, one defeat).

Data Debrief: No Messi, no problem

Ahead of Saturday's game, Miami had only won three of their 14 matches without Messi since the Barcelona great arrived in MLS (five draws, six defeats).

However, even without Messi, Suarez or a full complement, Miami showed they are the team to beat in MLS this year.

Martino's team ended the game having enjoyed more possession (57.4 per cent), shots on target (four to three) and touches in the box (17 to 16) than Philadelphia, despite playing almost 40 minutes at least one player down. 

Saturday's MLS clash between the Philadelphia Union and Inter Miami will require both teams to cope without key players, but Jim Curtin is viewing it as an opportunity.

Miami will be without Lionel Messi and Luis Suarez for the match, with the duo preparing to represent Argentina and Uruguay, respectively, at the Copa America.

Philadelphia, meanwhile, will have to make do without 10-goal leading scorer Daniel Gazdag, who is part of Hungary's squad for Euro 2024.

Asked about the difficulties of coping without Gazdag, Curtin pointed out that Miami will also need to adjust and highlighted 20-year-old midfielder Jack McGlynn as an example of a player who could stand to benefit. 

"He's not a 10 but he has the passing range to unlock a defence," Curtin said of McGlynn. "Maybe he does it from a deeper position, but we might need him to be a little more aggressive.

"Unfortunately, he won't be passing the ball to Daniel Gazdag so all these things weigh in, just like Jordi Alba won't be combining with Messi. 

"Both teams aren't at full strength, so we have to make the most of what it is. I see this as an opportunity to bring out players' skills, like with Jack."

Miami lead the way in the Eastern Conference with 35 points, 15 clear of the eighth-placed Union having played two additional matches.

Since Messi joined the Herons last year, they have only won three of 14 matches without him, drawing five and losing six. 

The Argentine's minutes were managed ahead of him linking up with Argentina, which coach Gerardo Martino says was necessary. 

"With the passage of time, one sees the body does not recover in the same way," he told TyC Sports this week. 

"He understands it, he sees that there are trips that are high-risk and long. That's why we started to agree on when it is necessary for him to stop."

PLAYERS TO WATCH 

Philadelphia Union – Jack McGlynn

McGlynn, who is expected to play a major role for the United States at the 2024 Paris Olympic Games, has two goals and four assists this season.

That first figure is a joint career best, while the latter is a new personal benchmark. The cultured left-footer could be set to play a central role at Subaru Park.

Inter Miami – Sergio Busquets

With Messi and Suarez absent, it could be down to Busquets to lead the way for Miami. 

The Barcelona great trails only Riqui Puig (1,330) for successful passes in MLS this year (1,115), and four of his 17 chances created have become assists. 

MATCH PREDICTION – DRAW

Miami have won two of their last four away games against Philadelphia (one draw, one defeat). 

They are one of just three teams (alongside New York City and Orlando City) with multiple road wins over the Union since the start of the 2021 season.

Philadelphia have struggled at home in general lately, going six regular-season matches without a win (two draws, four defeats) at Subaru Park. 

Since last September, they have only won two of their 13 league games on home soil (seven draws, four defeats), with only two MLS sides collecting fewer home points than their 13 since that run began.

However, with both teams missing key players, it is difficult to have much confidence in either. A draw could be on the cards, with Miami lacking their usual firepower. 

OPTA WIN PROBABILITY 

Philadelphia Union – 38.4%

Inter Miami – 35.2%

Draw – 26.5%