Lionel Messi is confident that Inter Miami can clinch the title, with a trip to Atlanta United next up for the Eastern Conference leaders.
The Argentine made his long-awaited return from injury in their 3-1 win over Philadelphia Union, having a hand in all three goals as they opened up a 10-point lead over FC Cincinnati in the table.
It was their fifth consecutive win following their heavy 6-1 loss to Cincinnati, and Messi acknowledged how well the team had performed amid some injury troubles this season.
"As we said at the beginning, we know the squad we have, and the title is our goal," he told Apple TV. "We're realistic and take responsibility for it.
"Unfortunately, we've had a lot of bad luck with injuries this year and were never at full strength for one reason or another. We were always missing players, but the team always managed to push through."
On his own return from an ankle problem he sustained playing in the Copa America final, he said: "It was a lot of time off the field. Little by little, I found myself with the group. I felt good, and that's why we decided that I would start. I am very happy."
Meanwhile, Atlanta are down in 10th on 31 points, half of Miami's own points tally, though they did shock the Herons in their last meeting, beating them 3-1 on the road.
They have won just once since the return of MLS action following the Leagues Cup break though – a narrow 1-0 victory over Charlotte FC – and lost last time out at home to Nashville SC.
The Five Stripes were outplayed on Saturday, and midfielder Ajani Fortune has urged his team-mates to show more of a fight when they meet Miami on Wednesday.
"We will change the little things, like the work rate and stuff like that, but we look to keep fighting," he said.
"I think that's the biggest thing we were missing [against Nashville], so once we have that, we'll be in a better spot to perform."
PLAYERS TO WATCH
Atlanta United – Saba Lobjanidze
Saba Lobjanidze had recorded at least one assist in three consecutive home appearances, but that run came to an end against Nashville.
Indeed, nine of his 12 goal contributions this season have come at home, including all six assists.
Inter Miami – Lionel Messi
Messi was straight back into the action for Miami after an eight-game absence, scoring twice and assisting one against Philadelphia last time out.
He has now netted 27 goals for the Herons, and another brace against Atlanta would draw him level with their all-time leading goalscorers, Gonzalo Higuain and Leonardo Campana.
MATCH PREDICTION: INTER MIAMI WIN
Miami are currently on a five-match winning streak in MLS, scoring 14 goals in that run. They have actually netted in each of their last 14 matches; however, they have struggled for clean sheets, only keeping one in their last 13 games in the competition.
Atlanta have proven a thorn in Miami's side over the years and have won their last two matches against the Herons, including that 3-1 victory at Chase Stadium in May. Indeed, they have only failed to beat Miami in four of their previous meetings (W5 D3).
Atlanta have won only two of their last 11 regular season home matches (D3 L5) dating back to the beginning of April, while they have won just two of their last eight outings in MLS (D1 L5).
OPTA WIN PROBABILITY
Atlanta United – 28.6%
Draw – 24.4%
Inter Miami – 47%