MLS commissioner Don Garber is keen for Lionel Messi to join the competition, though a deal would have to be "outside the box".
Messi has been heavily linked with a move to Inter Miami, as his contract at Paris Saint-Germain enters its final months.
In November, Messi's representative Marcelo Mendez denied reports that the seven-time Ballon D'Or winner would join the MLS club at the end of the Ligue 1 season.
Negotiations between Messi and PSG regarding a new deal are reported to be ongoing but, with less than four months remaining on his agreement, he could become a free agent later this year.
If a move to the MLS was to materialise, Garber explained that they would need to be creative in order to complete the deal due to the league's financial and salary cap rules.
"You're dealing with perhaps the most special player in the history of the game. So, when there are rumours of him connected to Miami, that's great," he told The Athletic.
"And if it could happen, it would be terrific for MLS, it would be terrific for Messi and his family, and like everything with us, we try to run every opportunity down. I can't give any more details than that because we don't have them.
"Teams have the flexibility to do unique things. MLS is a single entity. If you're selling something that the collective owns, the collective has to approve that.
"So, whatever [Inter Miami owner] Jorge [Mas] decides, with [MLS executive vice president] Todd [Durbin's] help to structure something, if we have the opportunity to do that, it's going to be outside the box.
"Because as you all know what's going on in international football today, with Ronaldo at $100million, the transfer market is just exploding in ways that are unimaginable.
"We're going to have to structure a deal that’s going to compensate him in ways that he and his family expect.
"What that is? Honestly, we don't know today, but he's probably not going to be a targeted allocation money player."
Lopetegui rues missed opportunity as West Ham lose to Man City
West Ham manager Julen Lopetegui was not encouraged by the performance of his team despite losing 3-1 at home to Manchester City in their third league game.
“It is true that City is one of the best teams around the world for sure… but it is also true too that in the second half we have been very close to a draw,” he said speaking to BBC Match of the Day.
“I think we have played one very good second half. The start has been very good for us too.”
West Ham threatened for extended periods of the match and had chances to level the match at 2-1 down, with the best coming from Mohammed Kudus as he smashed a shot against the bar in the second half.
They also started the game brightly before going a goal down inside 10 minutes.
“In my mind we started very well, being aggressive,” said Lopetegui.
“We know in this plan normally they have initiative, it’s very difficult to not concede initiative then. That’s why you have to do a lot of very good things to overcome them.
“In the second half we had chances, I think we kept the ball much more, much more, and didn't concede a lot of chances."
But the hosts were ultimately undone by the brilliant finishing of Erling Haaland, who scored his second hat-trick in as many matches.
“He is one of the best players in the world, that's why he plays for Manchester City,” he said.
“You have to compete with these kind of players. City has the power and the quality to create chances.”
But ultimately, he was left frustrated at the sense of a missed opportunity and that his team were unable to earn themselves a draw that hadn’t seemed implausible during the match.
“Today I think the first goal was a pity for us but I’ve said it. I was happy with the performance think we were able to draw but again they damage us,” he said.
“Against this kind of team, if you make a mistake they don’t forgive. This is the difference they have… A little mistake they punish you, they punish us.
“We have to improve, to know to compete against this kind of team to be close to perfection.
“Don't make mistakes, be calm, defend well… we have quality players too.”
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
Sancho given fresh start with Chelsea loan move
Jadon Sancho has secured a move away from Manchester United, having joined Chelsea on Deadline Day on a season-long loan.
The deal includes an obligation to buy for between £20-£25 million at the end of the loan, according to widespread reports, meaning that the 24-year-old will not be returning to Old Trafford next summer.
Work to complete the transfer came late on Deadline Day, with a deal sheet being submitted to ensure the signing could go through after the 11pm deadline.
Chelsea were able to get the deal over the line, confirming the move was complete on Saturday evening.
"I’m really excited to be here," Sancho said. "London is where I grew up and I’m happy to be back.
"The manager spoke to me about the project and, for a young player, it's exciting. Hopefully I can bring goals and assists to the Bridge."
It brings an end to a three-year spell at Old Trafford for Sancho. The winger originally joined United on a five-year contract in 2021 but, following a public falling out with manager Erik ten Hag, found his first-team opportunities limited.
Sancho made 83 appearances in all competitions for United, but his last start for the club came against Manchester City in the 2023 FA Cup final. He made three substitute appearances in August 2023 before moving back to Dortmund on loan in January, where he scored three goals in 21 appearances.
His final outing in a United shirt came off the bench in their Community Shield defeat to Manchester City, but he was not included in the squad for the first two league games.
Sancho joins a club with plenty of competition for attacking places, with Cole Palmer, Christopher Nkunku, Nicolas Jackson, Pedro Neto, Joao Felix and Noni Madueke among their roster.
Chelsea did also manage to move some players on during Deadline Day. Raheem Sterling secured a loan move to Arsenal on Deadline Day, while Trevoh Chalobah joined Crystal Palace, Armando Broja moved to Everton and Djordje Petrovic was loaned by Strasbourg.
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