Lionel Messi will miss the annual MLS All-Star game in Columbus on Wednesday due to his ongoing ankle injury, MLS has confirmed.

The Argentina captain sustained the injury during his nation's Copa America final victory over Colombia on July 14.

Messi subsequently left the pitch in tears, and watched from the dugout as substitute Lautaro Martinez struck an extra-time winner in Miami.

The eight-time Ballon d'Or winner was expected to be part of the annual clash between an MLS XI and Liga MX XI.

However, he was listed as unavailable on the MLS website along with fellow Inter Miami forward Luis Suarez, though their team-mates Jordi Alba and Sergio Busquets are both included.

The likes of Hugo Lloris, Christian Benteke and Federico Bernadeschi also feature in the MLS roster, while Andre-Pierre Gignac and Salomon Rondon will feature for the Liga MX All-Stars.