Serie A champions Napoli were dumped out of the Coppa Italia following a shock 4-0 defeat to Frosinone at the Stadio Diego Armando Maradona.
Napoli had been the favourites to reach the quarter-final stage, but second-half strikes from Enzo Barrenechea, Giuseppe Caso, a Walid Cheddira penalty and Abdou Harroui saw Frosinone record a famous victory.
Walter Mazzarri’s side have endured a turbulent defence of the Serie A championship they secured after a 33-year wait, falling 14 points adrift of leaders Inter Milan with just 16 matches played.
But after ending a three-game losing run to secure their place in the knockout stages of the Champions League place with a 2-0 win against Braga, and then recording a 2-1 victory against Cagliari in the league, Napoli will have expected to take a third win on the bounce against a Frosinone side who were making their debut in the round of 16.
Mazzari made nine changes to the side which beat Cagliari last weekend, while Frosinone boss Eusebio Di Francesco retained only three players from the side that lost at Lecce.
Giovanni Simeone appeared to have given Napoli the lead nine minutes before the interval only to see his goal disallowed by VAR after Jesper Lindstrom was adjudged to have handled the ball in the build-up.
After the interval, Napoli continued to probe for the opener – with Mario Rui’s free-kick striking the woodwork – but the Italian champions were suddenly on the back foot when Barrenechea headed home a corner shortly after the hour mark.
Frosinone then doubled their lead when Giovanni Di Lorenzo’s misplaced pass was intercepted by Caso, who made no mistake in slotting past Napoli goalkeeper Pierluigi Gollini with 70 minutes gone.
The home supporters were left stunned as the six-time winners were suddenly facing up to another early exit from the Coppa Italia after their defeat at this stage of the competition by Cremonese last season.
And it would only get worse for Mazzarri’s men when Matias Soule was fouled by Di Lorenzo in the area with Cheddira, on loan from Napoli, scoring Frosinone’s third of the night from the penalty spot before Harroui netted a fourth deep into stoppage time.
It sealed Frosinone’s first ever win against Napoli, and a quarter-final against either Juventus or Salernitana.
Nuno demands Premier League resolves PSR 'mess' as Forest await appeal verdict
Nuno Espirito Santo has called for the Premier League to provide clarity as Nottingham Forest wait on their appeal against a four-point deduction for breaching profit and sustainability rules, describing the situation as a "mess".
Forest were deducted four points in March after being found to have breached the competition's financial rules in the assessment period culminating in the end of the 2022-23 season.
Everton have also had a total of eight points deducted for two separate breaches, but with the Toffees pulling clear of the relegation zone, it is Forest who are looking over their shoulders.
Nuno's team sit just one point clear of 18th-placed Luton Town as they await the outcome of an appeal against their penalty, and he says the lack of clarity is affecting several clubs.
Asked whether he had received an update on Forest's appeal on Thursday, Nuno said: "Unfortunately we haven't heard yet.
"We are expecting to, but not yet. It is very difficult. We have been dealing with this situation for a while.
"We all expected the decision to come sooner, so we would know exactly how many points we have. Do we have 30, 29, 28, 27? We need it as fast as possible.
"To have 30 points would be fantastic, because this is the number of points that the boys achieved on the pitch.
"It is a mess. It should have been decided before. They have had enough time. It is very difficult for us but also for the rest of the league. It is very hard to be in this situation."
Forest visit already-relegated Sheffield United on Saturday, having taken just one point from four Premier League games since beating Fulham 3-1 in early April.
They could be in the relegation zone by the time that match kicks off, with Luton hosting Everton in a huge clash at Kenilworth Road on Friday.
France defender Hernandez to miss Euro 2024 after suffering ACL injury
Lucas Hernandez will miss France's Euro 2024 campaign after tearing his anterior cruciate ligament during Paris Saint-Germain's 1-0 Champions League defeat to Borussia Dortmund.
Dortmund will take a slender lead to the Parc des Princes for next week's semi-final second leg after Niclas Fullkrug's strike powered them past PSG in Wednesday's first leg in Germany.
Hernandez sustained a knee injury while chasing after Fullkrug in the build-up to the goal and was substituted after a brief attempt to play on.
On Thursday, PSG announced an MRI scan had revealed an ACL tear in his left knee, which will require surgery in the coming days.
Hernandez, who has 37 senior international caps, will now miss Euro 2024, with France set to open their Group D campaign against Austria in Dusseldorf on June 17.
Didier Deschamps' side then face the Netherlands in Leipzig four days later, before taking on Poland in Dortmund on June 25.
Hernandez was part of France's squad for the 2022 World Cup but sustained another ligament injury during Les Bleus' opening match against Australia, missing the rest of the tournament and not returning to club football until the start of 2023-24.
Tonali set for August return after receiving suspended two-month ban from FA
Sandro Tonali has been given a suspended two-month ban by the Football Association (FA) after admitting to breaching gambling rules.
The sanction means the Newcastle United midfielder will be eligible to return to action on August 27, 2024, when his 10-month suspension issued by the Italian Football Federation (FIGC) expires.
FIFA ratified that ban, causing it to become applicable worldwide, after Tonali admitted to placing bets on matches as part of an investigation into unregulated betting platforms in Italy.
In March, the FA charged Tonali with breaching English football's gambling rules 50 times between August and October last year, leading to fears his spell out of the game could be extended.
However, on Thursday it was confirmed that the FA had suspended Tonali's punishment for the duration of the 2024-25 season, meaning he can return in August if he does not reoffend.
In a statement, Newcastle said: "Sandro Tonali has been given a suspended two-month ban from competitive football by an independent regulatory commission after self-declaring breaches of FA betting rules.
"He has also been fined £20,000 and warned by the FA as to his future conduct.
"Provided that he does not commit any further breach of the FA betting rules during the suspension period, Sandro will not serve any part of the two-month sanction.
"As acknowledged by the FA in the independent regulatory commission's written reasons, the level of assistance Sandro has provided by self-referring and fully cooperating with a subsequent investigation is extraordinary and unprecedented.
"Sandro is continuing to follow a therapeutic plan and educational programme with the club's full support and will continue to train with his team-mates."
Tonali's initial ban has limited him to just eight Premier League appearances since he joined Newcastle from Milan in a £55million deal, while he will also miss Italy's Euro 2024 campaign.
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