Luka Jovic made the difference for AC Milan one minute after coming on as an 80th-minute substitute with the winning strike in their 3-2 Serie A victory at Frosinone.

Olivier Giroud nodded in the opener which was cancelled out before the break by Matias Soule’s penalty, but Luca Mazzitelli fired the hosts in front after half-time.

The sides were back on level terms when Matteo Gabbia, assisted by Giroud, found the back of the net with a diving header before Serbia striker Jovic wrapped up the win.

The result sees AC Milan – in third – move to within four points of second-placed Juventus, having played one more game, while Serie A leaders Inter Milan have two games on hand over Stefano Pioli’s men.

There was a chance inside the first minute for Soule, who fired the ball over the crossbar, as the hosts piled on more pressure in the opening exchanges.

Yet it was the visitors who soon settled in and took the lead in the 17th minute, when Giroud connected with Rafael Leao’s pinpoint cross and cushioned the opener into the bottom right.

Milan goalkeeper Mike Maignan had only just made his first save, tipping Demba Seck’s effort over the crossbar, when Leao was punished for a handball at the right edge of his side’s 18-yard box.

Milan protested, but the penalty was ultimately upheld after a VAR check and Soule stepped up to the spot and fired past Maignan, who moved in the right direction but could not make the stop.

The period with electric pace slowed only briefly when Giroud appeared to tweak his ankle but was deemed fit to continue and soon came painstakingly close to picking up an assist, his delivery across the face of goal from a tight angle narrowly evading both the head of Yacine Adli and a diving Leao.

The hosts wanted Christian Pulisic charged with another handball, but the penalty shout was waived off, and Tijjani Reijnders was unable to break the deadlock when he nodded straight at Stefano Turati.

The Frosinone goalkeeper was forced into a nervy save deep in first-half stoppage time, reacting quickly after Leao’s effort took a dangerous deflection off Caleb Okoli and flew dangerously toward the far corner – Turati just able to stretch his hand out for the stop.

The hosts took the lead in the 65th minute, Soule slipping the ball to Mazzitelli, who came up the middle before handing his side the advantage with a low finish.

The home support had barely finished celebrating when Adli, from a corner, sent a cross to Giroud, who nodded towards the ball in the direction of Gabbia, who drew the sides level with a diving header.

Pioli brought in Jovic for Christian Pulisic in the 80th minute, a decision that paid off instantly when the Serbia striker pounced on a loose ball that had bounced off grounded Frosinone defender Simone Romagnoli and fired home.

Teenager Kenan Yildiz scored his first goal for Juventus on his full debut to help his team to a 2-1 victory over Frosinone.

With Federico Chiesa nursing a knee problem, 18-year-old Turkey international Yildiz was given his first start, and, in only the 12th minute, he beat three Frosinone players on the edge of the area before drilling his shot inside the near post.

The hosts levelled six minutes after the break through Jaime Baez but Dusan Vlahovic headed in an 81st-minute winner.

The victory sees Juve close to within one point of Inter Milan at the top of the Serie A table ahead of their clash with Lecce later on Saturday.

Frosinone have been strong at home this season, losing only once previously to Napoli in August, while they went into the clash buoyed by a 4-0 hammering of the same side in the Coppa Italia in midweek.

The visitors would have taken the lead in the seventh minute but for a brilliant block from Simone Romagnoli to cut out Weston McKennie’s cross with Arkadiusz Milik waiting for a tap-in.

They did not have to wait long for the breakthrough, though, Yildiz showing his talent with some brilliant skill after Stefano Turati had been hurried into a clearance.

Both teams were forced into early changes, with Federico Gatti replacing Alex Sandro and Baez coming on for Pol Lirola.

Frosinone were growing into the game and they forced Wojciech Szczesny into his first save in the 36th minute after on-loan Juventus starlet Matias Soule broke into the penalty area on the right and shot from a very tight angle.

Juve then created a good opportunity at the other end but Filip Kostic shot wildly wide of the near post after being played in by Milik.

Six minutes into the second half, the home side drew level. Right-back Ilario Monterisi was the creator with a brilliant pass that allowed Baez to get around the back of the Juve defence and slot first time past Szczesny.

Soule then almost put the hosts ahead with a curling effort from the edge of the box that evaded his team-mates and went just past the far post.

Vlahovic came off the bench as the visitors sought a response and he nearly provided it after being set up by Milik but Turati produced a smart block.

Szczesny then pulled off a fine fingertip stop to deny Abdou Harroui while McKennie left the bar shaking with a thunderous leaping volley as both sides chased a winner.

It eventually came from Vlahovic, who met McKennie’s cross from the right with a perfect header into the top corner.

The Serbian thought he had scored again late on but it was ruled out for offside.

Serie A champions Napoli were dumped out of the Coppa Italia following a shock 4-0 defeat to Frosinone at the Stadio Diego Armando Maradona.

Napoli had been the favourites to reach the quarter-final stage, but second-half strikes from Enzo Barrenechea, Giuseppe Caso, a Walid Cheddira penalty and Abdou Harroui saw Frosinone record a famous victory.

Walter Mazzarri’s side have endured a turbulent defence of the Serie A championship they secured after a 33-year wait, falling 14 points adrift of leaders Inter Milan with just 16 matches played.

But after ending a three-game losing run to secure their place in the knockout stages of the Champions League place with a 2-0 win against Braga, and then recording a 2-1 victory against Cagliari in the league, Napoli will have expected to take a third win on the bounce against a Frosinone side who were making their debut in the round of 16.

Mazzari made nine changes to the side which beat Cagliari last weekend, while Frosinone boss Eusebio Di Francesco retained only three players from the side that lost at Lecce.

Giovanni Simeone appeared to have given Napoli the lead nine minutes before the interval only to see his goal disallowed by VAR after Jesper Lindstrom was adjudged to have handled the ball in the build-up.

After the interval, Napoli continued to probe for the opener – with Mario Rui’s free-kick striking the woodwork – but the Italian champions were suddenly on the back foot when Barrenechea headed home a corner shortly after the hour mark.

Frosinone then doubled their lead when Giovanni Di Lorenzo’s misplaced pass was intercepted by Caso, who made no mistake in slotting past Napoli goalkeeper Pierluigi Gollini with 70 minutes gone.

The home supporters were left stunned as the six-time winners were suddenly facing up to another early exit from the Coppa Italia after their defeat at this stage of the competition by Cremonese last season.

And it would only get worse for Mazzarri’s men when Matias Soule was fouled by Di Lorenzo in the area with Cheddira, on loan from Napoli, scoring Frosinone’s third of the night from the penalty spot before Harroui netted a fourth deep into stoppage time.

It sealed Frosinone’s first ever win against Napoli, and a quarter-final against either Juventus or Salernitana.

Luka Jovic opened his AC Milan account as the Rossoneri eased past Frosinone 3-1 at the San Siro.

Christian Pulisic also scored a superb individual effort and Fikayo Tomori put the seal on a comfortable victory before Marco Brescianini’s late consolation for the visitors.

Just one win in five Serie A matches had seen Milan drop off the title pace and Stefano Pioli’s side knew there was no room for error following Juventus’ last-gasp win at Monza on Friday.

Milan were without the likes of Malick Thiaw, Rafael Leao and Olivier Giroud, and full-back Theo Hernandez lined up in the middle of a badly depleted home defence.

A largely uninspiring first half was lit up by Jovic lashing home a superb left-footed volley two minutes before the break.

It was the Serbia striker’s first goal in 10 appearances since joining Milan from Fiorentina in September.

Frosinone, beaten 2-0 at the San Siro by Inter last month, started brightly but Milan had the first opportunity when Yunus Musah’s centre took a wicked deflection and Stefano Turati had to react sharply at his near post.

Milan slowly built up a head of steam and Alessandro Florenzi fired wide, while Samuel Chukwueze’s powerful drive was deflected to safety.

Frosinone full-back Anthony Oyono broke forward but his 25-yard effort went wide as his wait for a first senior goal continued.

The visitors should have taken the lead three minutes before the break after Marvin Cuni dispossessed Tomori.

Cuni had a clear run on goal but the Albania striker lacked conviction and Milan goalkeeper Mike Maignan stood tall to save.

Frosinone were punished for their profligacy within 60 seconds as Simone Romagnoli’s poor pass was picked off by Pulisic, who spotted the unmarked Ruben Loftus-Cheek to his right.

Loftus-Cheek found Chukwueze quickly and, although Romagnoli got his head on the cross, Jovic was waiting to volley in from eight yards.

Milan doubled their lead five minutes after the interval in route-one style.

Maignan’s long punt was brilliantly brought down by Pulisic, who cut across three defenders to present himself with a shooting opportunity.

Turati rushed out to narrow the angle but the American showed great composure to lift the ball over him for his fifth goal of the season.

Tomori added a third after 74 minutes from a well-worked corner routine, the England defender latching on to Jovic’s far-post header to force home his second goal of the season from close range.

Frosinone gained some reward for their determination to keep going eight minutes from time.

Brescianini’s wide free-kick escaped everyone in a crowded penalty area and surprised Maignan, who had no chance of preserving his clean sheet.

Frosinone coach Eusebio Di Francesco feels his side will have to play beyond their limits when they face the “most complete” team Inter Milan at the San Siro on Sunday.

The Nerazzurri secured a place in the Champions League knockout stages with a 1-0 win away at RB Salzburg on Wednesday night, which was a fifth-straight victory through all competitions.

Simone Inzaghi’s side, though, were knocked off the top of Serie A after Juventus beat Cagliari on Saturday.

Frosinone, who were promoted to the top flight this season, got themselves back on track last weekend with victory over Empoli, having lost back-to-back league games.

Canaries coach Di Francesco, though, is all too aware of just what challenge awaits his side at the San Siro.

“I believe that in order to compete with Inter we will have to outdo ourselves,” Di Francesco said.

“Inter are the most complete team, they are difficult to face and a club who have given continuity to the work of their coach.

“He has many weapons at his disposal, they are so difficult to deal with from all points of view.

“But what is most scary about Inter is the awareness, the knowledge they have among themselves which makes them a tough team to beat.

“If so far we have put in 10 out of 10, now to be able to compete with this Inter we will have to put in, I won’t say double, but come close.

“We must go and play this match with the same enthusiasm we have had so far.”

Despite the challenges ahead, Di Francesco wants his side to stay true to the values which have helped push them towards the top half of the table.

“In terms of the characteristics of the players who will be involved, the right solutions must be chosen, but we must not lose our identity and our principles of play,” said Di Francesco, who took over the newly-promoted side in the summer following the departure of Fabio Grosso.

“We must rely on the fact of enthusiasm, of the great desire to go and play the match.”

The Frosinone coach told a press conference: “I don’t share the concept that it’s not possible to face Inter with a smile and try to have fun – factors that will have to accompany us until the end of the championship this season.”

Di Francesco feels his players must focus on their collective goal, rather than get swept up in the occasion.

“I tried to tell my boys that when you enter the pitch in any stadium the strength lies in putting two plugs in your ears and to just focus on your team’s goal,” he said.

“That is what I did this week too, I didn’t give much weight to the match itself.

“I made it clear that we will have a strong team to fight against, however that doesn’t mean just standing behind them, but we must also be trying to fight back.”

Inter coach Inzaghi did not hold a media conference ahead of Sunday’s Serie A fixture.

Inzaghi is expected to recall Nicolo Barella after the midfielder did not feature in the Champions League.

Nerazzurri captain Lautaro Martinez started on the bench in Salzburg before coming on during the second half and scoring the late penalty which secured a 1-0 win.

Claudio Ranieri’s Cagliari scored four goals in the last 20 minutes to complete a remarkable turnaround by beating Frosinone 4-3 in Serie A.

The visitors were seemingly cruising to victory following Matias Soule’s brace and a Marco Brescianini strike, but the comeback started in the 72nd minute.

Gaetano Oristanio scored Cagliari’s first and Antoine Makoumbou made it 3-2 shortly afterwards.

Just as it looked like the home side would be thwarted, Leonardo Pavoletti scored in the fourth and sixth minutes of stoppage time to secure the unlikeliest of victories.

Inter Milan returned to the top of the table as Marcus Thuram’s strike 10 minutes from time earned them a 1-0 win over Jose Mourinho’s Roma.

Napoli came from two goals down to snatch a point with a 2-2 draw against AC Milan.

Olivier Giroud scored two headers inside the first 30 minutes to put the visitors in control, but Napoli earned a route back into the match through Matteo Politano before Giacomo Raspadori levelled things up for Napoli, who had defender Natan sent off late on.

Udinese’s wait for a first league win goes on but Lorenzo Lucca’s second-half equaliser secured them a seventh draw of the season – 1-1 with Monza.

Atletico Madrid moved up to third in LaLiga with a 2-1 win over Alaves at the Civitas Metropolitan Stadium.

The hosts opened the scoring in the 26th minute through Rodrigo Riquelme’s near-post finish before Alvaro Morata doubled their advantage with a powerful left-footed strike into the top corner.

Ander Guevara’s consolation was not enough to stop the hosts from moving above Barcelona.

Isco scored a stoppage-time winner to hand Real Betis their first league victory in three matches – a 2-1 success against Osasuna.

Willian Jose gave the home side the lead on the stroke of half-time, but Osasuna thought they had stolen a point when Ruben Garcia rifled home from close range.

However, the all-important decider came in time added on when Isco smashed the ball in off the crossbar from inside the area.

Substitute Bebe also left it late to hand Rayo Vallecano a share of the spoils in a 2-2 draw with Real Sociedad.

Mikel Oyarzabal scored twice to give Sociedad the lead after Abdul Mumin had put the hosts in front, but Bebe smashed the ball into the bottom corner from outside the box to level the scores.

Elsewhere, Alex Berenguer also proved to be a last-minute hero when he scored in the seventh minute of stoppage time to earn a 2-2 draw for Athletic Bilbao at home to Valencia.

In France, Kylian Mbappe scored at the death to snatch all three points for Paris St Germain over Brest and move them back to within a point of leaders Nice.

Goals from Warren Zaire-Emery and Mbappe gave PSG a 2-0 lead, but they were pegged back by goals either side of half-time from Jeremy Le Douaron and Steve Mounie.

The decisive moment came when Mbappe missed his initial penalty, but slotted home the rebound.

Marseille’s match against Lyon was postponed after the visiting team’s bus was attacked before the match.

Footage appeared on social media showing items being thrown at Lyon’s team bus, with head coach Fabio Grosso pictured on a stretcher and with a bloodied face.

The match was due to kick off at 1945GMT but French football’s governing body, the Ligue de Football Professionnel, soon confirmed the postponement following an emergency meeting.

Elsewhere, Ivan Cavaleiro and Bafode Diakite scored to secure Lille a 2-0 win over Monaco, while Akor Adams bagged a brace in Montpellier’s 3-0 win against Toulouse.

Rennes and Strasbourg drew 1-1, while it was goalless between Metz and Le Havre.

Borussia Dortmund continued their unbeaten start to the Bundesliga season as they twice came from behind to draw 3-3 with Eintracht Frankfurt.

Omar Marmoush struck a first-half brace to hand the hosts a 2-0 lead before Marcel Sabitzer and Youssoufa Moukoko brought Dortmund level.

Frankfurt went back in front through Fares Chaibi, only for Julian Brandt to level again seven minutes from time and earn a share of the spoils.

Bayer Leverkusen returned to the top of the table with their eighth win of the season thanks to Florian Wirtz’s first-half strike and Noah Atubolu’s own goal in a 2-1 victory over Freiburg.

Lecce and Cremonese have earned promotion to Serie A following an eventful final day of action in Italy's second tier.

Cremonese are back in the top tier of Italian football for the first time since 1995-96, while Lecce return after a two-season absence.

Four teams were battling it out for the two automatic promotion spots on Friday, with Monza and Pisa also in contention.

Lecce led the way at the summit entering the final round of games and beat bottom side Pordenone 1-0 at home through a Zan Majer goal to see the job through.

Monza knew that they would join Lecce in the top flight had they defeated Perugia, but Gabriele Ferrarini's goal in the final five minutes condemned them to a shock 1-0 defeat.

Cremonese took full advantage by seeing off Como 2-1 at Stadio Giuseppe Sinigaglia thanks to a couple of goals from Samuel Di Carmine.

That rendered Pisa's 2-1 victory at Frosinone meaningless in terms of the race for automatic promotion, with the Nerazzurri having to settle for a play-off semi-final spot.

Perugia's win against Lecce saw them book a play-off quarter-final place, where Brescia await, while Ascoli will meet Benevento.

It was just as lively at the opposite end of the division, meanwhile, as there was a three-way fight to avoid the one remaining relegation place.

Alessandria's 1-0 loss to fellow strugglers Vincenza saw them join Pordenone and Crotone in dropping out of the division.