Arsenal's assault on the Premier League title suffered a hit at Goodison Park as Sean Dyche provided the new manager bounce for Everton.
The Toffees secured a first league win since October to condemn the Gunners to defeat, opening the door for Manchester City to cut the gap to the leaders to just two points if they beat Tottenham on Sunday.
Sean Dyche's side were not the only relegation-threatened team to pick up a major scalp, as Wolves stunned Liverpool at Molineux to extend a miserable run of form for Jurgen Klopp's Reds.
There was no similar result for Southampton, who were picked apart by in-form Brentford, while Manchester United maintained their fine home run with a hard-fought win against Crystal Palace.
Here, Stats Perform looks at the most interesting facts to emerge from Saturday's Premier League action.
Everton 1-0 Arsenal: Goodison gloom for Gunners
Goodison Park is a ground that used to hold many happy memories for Mikel Arteta, who started his Premier League career at the club, but three consecutive league defeats for Arsenal at the venue may have changed that.
Arteta has lost all of his three Premier League away matches to Everton, the first Gunners manager to endure such a run, while the Toffees boast three consecutive home league victories against Arsenal for the first time since March 1977 to August 1978.
It handed Arsenal just their second defeat in their last 21 Premier League matches (won 17, drawn 2), with the loss ending a streak of 14 unbeaten top-flight games for the league leaders.
Dyche, meanwhile, became just the second manager to beat a side starting the day top of the table in his first Premier League game in charge of a club, after Alan Curbishley defeated Manchester United in his first match with West Ham in December 2006.
Wolves 3-0 Liverpool: Dawson delight amid Klopp rot
Craig Dawson is not a name that would usually strike fear for opposition defenders in the Premier League but the Wolves defender has established a habit of haunting Liverpool, his latest goal representing his third against the Reds.
Each of those goals have come for a different side (West Brom, West Ham, Wolves) and he has scored more goals against Liverpool than he has versus any other side.
Klopp's side have now lost three consecutive away games in the Premier League for the first time since a run of four in April 2012 and have lost back-to-back Saturday 3pm kick-offs in the competition for the first time since March 2012.
A horror start was their downfall against Wolves, with Liverpool conceding more Premier League goals in the opening five minutes of matches than any side this season (five), while Joel Matip's own goal was his first in 135 Premier League appearances.
Brentford 3-0 Southampton: Bees buzzing at home
Unbeaten in their last nine Premier League games (won five, drawn four), only Newcastle United are currently on a longer run without defeat – extending their streak to 16 with a draw against West Ham in the late kick-off.
The Bees' trio of goals against Southampton took their tally to 23 goals in 11 Premier League home games this season, already surpassing the tally of 22 last term. In fact, only Manchester City (38) and Arsenal (25) have scored more at home this term.
On target with a header yet again, 10 of Ben Mee's 12 Premier League goals have come in that fashion and no side has conceded more headed goals in the top-flight this season than Southampton (10), two of them being on Saturday.
Pressure upon Saints boss Nathan Jones continues to rise, with Southampton losing eight of their last nine in the Premier League, winning just once, while they have just a single clean sheet in their last 27 matches in the competition.
Manchester United 2-1 Crystal Palace: Penalties on point for United
With 13 consecutive home wins in all competitions, Manchester United are in their stride and are enjoying their longest such run at Old Trafford since a 20-match streak between December 2010 and September 2011.
While Marcus Rashford scored in five consecutive Premier League home games for the first time, it was Bruno Fernandes' opener from the penalty spot that sent Erik Ten Hag's side on their way – and took the Portugal midfielder's tally of penalty goals in the Premier League to 14.
Only Wayne Rooney (20) and Ruud van Nistelrooy (18) have scored more from the spot for United than Fernandes, with his latest effort being the club's 173rd all-time spot-kick in the Premier League – the joint-highest total alongside Liverpool.
The red mist descended on Casemiro, however, with the Brazilian shown a straight red card for the first time in Europe's top-five leagues; the dismissal coming in his 366th such appearance.
That provided a late charge for Palace, who saw eight of their 10 shots come in the final 20 minutes after Casemiro's dismissal, but Patrick Vieira's side remain winless in the Premier League in 2023 (drawn 2, lost 3), scoring just once in the process.