Ben Chilwell is expected to miss England's World Cup campaign after sustaining a "significant" hamstring injury, Chelsea have confirmed.
Chilwell limped out of the Blues' 2-1 Champions League win over Dinamo Zagreb on Wednesday, leaving head coach Graham Potter concerned.
Potter said the injury represented a "blow" for Chelsea, adding: "Fingers crossed, when we get it scanned it isn't as bad, it can be not as severe, but clearly we are disappointed."
Chilwell's England team-mate Mason Mount said it was "tough to watch" the left-back suffer the injury less than three weeks before the World Cup gets under way, and Gareth Southgate's fears have been realised with the news that his hamstring problem is "significant".
A statement released by Chelsea on Saturday read: "Following the injury sustained in our recent game against Dinamo Zagreb, Ben has undergone a scan on his hamstring.
"Results show that Ben has suffered a significant injury and the defender is unfortunately expected to miss the World Cup.
"Ben will now begin a rehabilitation programme with the club's medical department."
Chilwell's absence for the trip to Qatar deepens a defensive crisis for England, with fellow full-backs Reece James and Kyle Walker doubtful for the tournament.
Southgate only named two recognised left-backs in his squad for the Three Lions' most recent Nations League fixtures in September, and the likes of Bukayo Saka and Kieran Trippier may now be expected to deputise for Manchester United's Luke Shaw.
England begin their Group B campaign against Iran at the Khalifa International Stadium on November 21.
Brentford 3-1 Southampton: Bees begin life after Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
Brentford 3-1 Southampton: Bees begin life without Toney with comfortable win
Brentford began life without Ivan Toney with a comfortable 3-1 victory over Southampton.
Bryan Mbeumo’s brace and a Yoane Wissa goal proved to be the difference between the two sides and condemned the Saints to their third straight loss since promotion back to the Premier League.
With departed striker Toney watching in the stands after his move to Al-Ahli in Saudi Arabia, the hosts proved too strong for Russell Martin’s men. They created the superior chances and capitalised on an error-strewn performance from Southampton’s backline.
Mbeumo opened the scoring on the stroke of half-time before doubling the lead halfway through the second period and Wissa then got on the scoresheet moments later to continue Brentford’s strong start to the campaign. Yukinari Sugawara bagged a consolation in injury time for the Saints.
Brentford sit in fifth place ahead of the first international break, while Southampton are second-bottom of the league table with zero points.
Data debrief: Wissa continues to prove effective at home
Wissa now has five goals and two assists in his last seven matches at the Gtech Community Stadium.
Brentford have recorded consecutive home league wins for the first time since last November, and the first time in their opening home games since August 2018.
Pirlo sacked as Sampdoria head coach after dismal Serie B start
Andrea Pirlo has been sacked as Sampdoria's head coach after just over a season at the helm.
Pirlo, who managed Juventus for the 2020-21 campaign, has been relieved of his duties after an underwhelming start to their Serie B season.
After finishing seventh in Italy's second tier last term, the 45-year-old was given the green light to try and return to Serie A at the second time of asking.
However, an opening day draw with Frosinone was followed up with back-to-back defeats to Reggiana and Salernitana, leaving them second-bottom in the division.
During his time in charge, Pirlo won 18 of his 45 matches in charge (D10 L17), averaging 1.42 points per game, a total only bettered by his time with Juventus (2.15).
Sampdoria return to the Stadio Luigi Ferraris this weekend in search of their first three points of the season, welcoming Bari to Genoa on Saturday.
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