Pep Guardiola left Ruben Dias and Aymeric Laporte on the bench for Manchester City's clash with Manchester United, while Rodri missed out altogether for the Premier League champions with injury.
City manager Guardiola made three changes for the first Manchester derby of the season, with Manuel Akanji and Nathan Ake operating at centre-back.
John Stones was another absentee due to a hamstring injury sustained on international duty, while Guardiola decided to name Dias among the substitutes as Kyle Walker came in at right-back.
Fitness issues for Rodri ruled the Spain international out of the clash at Etihad Stadium, with Ilkay Gundogan starting in midfield behind Jack Grealish, Phil Foden and the in-form Erling Haaland up top.
"It is an injury. Yesterday in the training session he felt something. It was a little more than a niggle in his leg so we did not want to take the risk," Guardiola told Sky Sports of Rodri's injury.
"It is an important role but a strength the biggest clubs have is that excuses don't exist. Nobody is second in the locker room."
Erik ten Hag made just one alteration to his side that defeated Sheriff last time out in the Europa League as Diogo Dalot replaced Cristiano Ronaldo, who dropped to the bench.
Casemiro was again forced to settle for a place among the substitutes, with United head coach Ten Hag opting for Scott McTominay and Christian Eriksen in midfield.
Marcus Rashford kept his place in the starting XI despite injury concerns over the international break, while Antony Martial was deemed fit enough to make the bench.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Ederson slams reports of rift with Man City backup Ortega
Ederson has hit out at reports of a rift between himself and fellow Manchester City goalkeeper Stefan Ortega.
The Brazilian was substituted after suffering a fractured eye socket in City's penultimate game of the Premier League season, a vital 1-0 win over Tottenham.
Ortega replaced him and made a brilliant save to deny Son Heung-min as City maintained their slender lead over Arsenal at the top of the table, sealing an unprecedented fourth straight title by beating West Ham five days later.
Ortega was widely lauded for his role in that triumph, and an article published by The Athletic this week suggested Ederson took issue with that praise.
However, the goalkeeper – who missed the Copa America as a result of his injury – has now moved to shut down those suggestions with a post to his Instagram story.
"I would like to clarify that the note published by The Athletic yesterday, referring to my alleged dissatisfaction with a co-worker, is completely false," he wrote.
"The alleged day reported was, without a doubt, one of the most difficult days of my career, when I suffered a fracture that prevented me from playing in the final stretch of the season and, consequently, from representing my country in the Copa America.
"At the time of the injury, my only thought was to continue in the match, defending City in the fight for the title.
"But the emotion of the match would be greater than the reality and, inevitably, I would not be able to continue as I would have liked due to the damage it caused, completely blocking my field of vision. I remain focused on preparing for the season."
Ederson has been linked with a transfer in recent days, reportedly attracting interest from Saudi Pro League clubs.
Eriksen in 'no rush' to decide Man Utd future
Christian Eriksen says he is in "no rush" to decide his future despite going into the final year of his contract at Manchester United.
Eriksen joined the Red Devils in 2022, making 28 appearances in the Premier League in his first season, though an injury in January 2023 put a halt to his impressive start to life at Old Trafford.
Following Kobbie Mainoo's breakout season last year, Eriksen dropped down the pecking order at United as he made just 12 starts in his 22 league appearances, scoring just once and assisting two goals.
Some reports suggest Eriksen could be heading out on loan to former club Ajax for the final year of his contract, but he insisted he is satisfied in Manchester.
"I am really happy at United," he said. "I have had two very good years and am going into my third.
"It is a special club and a special place. Also, my family is settled in Manchester, so I am in no rush.
"Obviously, I want to play as much as possible and do everything I can. But that is nothing to do with the club - it is up to you and the manager.
"But in terms of how I feel, I feel very good at United."
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