Pep Guardiola left Ruben Dias and Aymeric Laporte on the bench for Manchester City's clash with Manchester United, while Rodri missed out altogether for the Premier League champions with injury.
City manager Guardiola made three changes for the first Manchester derby of the season, with Manuel Akanji and Nathan Ake operating at centre-back.
John Stones was another absentee due to a hamstring injury sustained on international duty, while Guardiola decided to name Dias among the substitutes as Kyle Walker came in at right-back.
Fitness issues for Rodri ruled the Spain international out of the clash at Etihad Stadium, with Ilkay Gundogan starting in midfield behind Jack Grealish, Phil Foden and the in-form Erling Haaland up top.
"It is an injury. Yesterday in the training session he felt something. It was a little more than a niggle in his leg so we did not want to take the risk," Guardiola told Sky Sports of Rodri's injury.
"It is an important role but a strength the biggest clubs have is that excuses don't exist. Nobody is second in the locker room."
Erik ten Hag made just one alteration to his side that defeated Sheriff last time out in the Europa League as Diogo Dalot replaced Cristiano Ronaldo, who dropped to the bench.
Casemiro was again forced to settle for a place among the substitutes, with United head coach Ten Hag opting for Scott McTominay and Christian Eriksen in midfield.
Marcus Rashford kept his place in the starting XI despite injury concerns over the international break, while Antony Martial was deemed fit enough to make the bench.
Arsenal ready to write a different story – Mikel Arteta
Mikel Arteta believes Champions League quarter-final success against Bayern Munich will take Arsenal to the next level as he told his players to “write a different story” at the Allianz Arena.
The Gunners head into Wednesday’s second leg locked at 2-2 with Thomas Tuchel’s Bayern after a thrilling draw at the Emirates Stadium last week.
Defeat to Aston Villa on Sunday has since dented Arsenal’s Premier League title bid as attention now turns to Europe once again.
Arsenal had lost seven last-16 ties in succession before returning to the Champions League this season – three times to Bayern.
Arteta, though, feels reaching a semi-final against either holders Manchester City or record 14-time winners Real Madrid would elevate Arsenal.
Asked how transformative victory would be and whether it would take Arsenal to the next level, the Spaniard replied: “Absolutely.
“It would be unbelievable. If we make it happen tomorrow and we’re in the semi-final, we’ll be in a really high emotional state with something that we haven’t achieved in 15 years and that’s the opportunity.
“All the preparation has been to achieve that. We have earned it. We have earned it for 10 months and everything we did last season, to start our journey in the Champions League after so many years.
“Tomorrow we have an unbelievable opportunity to make it happen.”
Arteta has overseen a sea change in approach to big away games this season, ripping up the recent form books and guiding Arsenal to draws at title rivals City and Liverpool.
They have lost 5-1 on their last two visits to the Allianz – but Arteta wants another memorable away performance to redress more recent history.
“We have to change it and the opportunity comes there,” he added.
“There are lots of things we can do to write our story very differently tomorrow, we know that and it is going to be about putting in a very, very strong performance collectively and individually to earn the right to be in the semi-final.
“Most of our players haven’t experienced a night like this, this is going to be the first one, they are super-motivated, they are prepared, they feel confident and it is something that tomorrow we are going to have to show against an opponent that has this experience – but we want to make it happen.”
Manchester City welcome back Kyle Walker for Real Madrid clash
Kyle Walker is set to return as holders Manchester City bid to reach the Champions League semi-finals for a fourth successive year against Real Madrid on Wednesday.
The England right-back has missed the treble-winners’ last five matches after suffering a hamstring injury on international duty last month.
Walker played a full part in City’s final training session before they host Spanish giants Real in the second leg of their quarter-final tie at the Etihad Stadium, which will begin with the aggregate score 3-3.
Manager Pep Guardiola said: “He’s been training good. I don’t know if from the beginning or from the bench, but I think he will be with us tomorrow.
“It is incredibly good news for many reasons. You know the physicality is massively important and in football it is how you challenge your opponent. Everyone knows the quality Kyle has.”
Walker did not travel to Spain for last week’s pulsating first-leg draw at the Bernabeu Stadium but was an unused substitute for the 5-1 thrashing of Luton on Saturday.
Team-mate Bernardo Silva has welcomed the potential return of the City skipper.
The midfielder said: “He is very important because we know Kyle has controlled some of the best players in the world and always does a phenomenal job when he plays.
“He’s our captain and he’s a player who, in the last few years, has played against players like Vinicius, (Kylian) Mbappe and Neymar and has defended against them like nobody else.”
Jude Bellingham: Joining Real Madrid last summer was ‘no-brainer’
Jude Bellingham admitted joining Real Madrid last summer was a “no-brainer”.
The England midfielder opted for the Spanish giants amid interest from a host of Europe’s top clubs after three highly-impressive seasons with Borussia Dortmund.
The 20-year-old Birmingham academy product has hardly looked back since, netting 20 times in an outstanding debut campaign at the Bernabeu Stadium that has catapulted him into the game’s elite.
Bellingham, speaking at a press conference ahead of Real’s Champions League clash with Manchester City on Wednesday, said: “I had good chats with loads of clubs – including Dortmund – and my family were great in helping me chew up that information.
“It’s difficult while you are still in the season to take in the information and process it and still have to play at the weekend or in the Champions League.
“I had conversations with other teams but when Madrid came in it was a no-brainer really. The size of the club, the project, the plan going forward, the chance to play with such amazing players.
“I just jumped at it. That’s why I made my decision.”
Bellingham has no doubt his game has developed considerably since joining Real and he puts a lot of that down to the influence of veteran manager Carlo Ancelotti.
He said: “I think the sign of a good manager is when he can make you believe that you’re a bit better than maybe you thought you were before.
“I think he fills me with that confidence every day, in training and in the game. Not only that, but he’s a top person. He makes you feel comfortable.”
Real are locked in a ferocious battle with holders City to advance to the semi-finals after an enthralling 3-3 draw at the Bernabeu last week.
City are now regarded as the favourites due to their home advantage – and the fact they thrashed Real 4-0 at the same venue last season – but Bellingham is taking no notice of predictions.
He said: “That’s just the impression from the outside, the feeling from everyone else.
“I’m not a gambler and I’ve never been to the bookies, so I don’t know about betting favourites and things like that.
“But I do know that we’re a pretty good team ourselves. They’re the treble winners, they’re an amazing team but we’ve got some brilliant players.
“There’s external noise, but internally, we’re confident.”
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