Gareth Southgate is set to be without Jordan Pickford for England's final fixtures before the World Cup.
Stats Perform understands that Everton are optimistic the goalkeeper, who has been struggling with a thigh injury, will miss no longer than four weeks.
A club statement published on Wednesday, following reports of Pickford's injury, confirmed he would not return until after the international break, which starts on September 19.
It is a blow for Frank Lampard's team, who are winless in the Premier League this season, despite having shown promise in recent outings, including the 0-0 derby draw with Merseyside rivals Liverpool on Saturday.
Pickford was outstanding in that match, making eight saves, including an excellent fingertip stop to deny Mohamed Salah a stoppage-time winner at Goodison Park.
It is also bad news for Southgate, whose side face Italy on September 23 and Germany three days later in the Nations League.
England are without a win in the Nations League this year and lost 4-0 to Hungary in their last outing back in June. They do not have another match before kicking off their World Cup campaign against Iran on November 21.
Pickford's injury will, however, present a chance for Nick Pope, Aaron Ramsdale and Dean Henderson to prove their worth to Southgate ahead of the tournament in Qatar.
Everton, meanwhile, will be without their goalkeeper for Sunday's trip to Arsenal and a home match against West Ham on September 18. Pickford might recover to face Southampton on October 1, though a meeting with Manchester United a week later is perhaps more likely to mark a return to action.
After his efforts against Liverpool, Pickford – who was crucial to Everton staying up last season – is the best-performing goalkeeper in the Premier League this term for goals prevented, which uses Opta's expected goals on target conceded (xGOT) model to calculate how well a shot-stopper has performed.
Pickford's 2.6 goals prevented tops the league, though before the Merseyside derby that figure stood at 1.11 (the fifth-best in the competition), showing just how well the 28-year-old performed against Liverpool.
Asmir Begovic, who was reportedly of interest to Manchester United late in the transfer window, will likely fill in for Everton in Pickford's absence.
Slot: Guardiola contract is 'good news' for Premier League
Arne Slot believes it is "good news" for the Premier League that Pep Guardiola has signed a contract extension with Manchester City.
The Spaniard signed a two-year extension with the reigning champions and will remain in the dugout at the Etihad until 2027.
He has won 18 major trophies in his time at City, including six Premier League titles, and twice beat Jurgen Klopp's Liverpool to the top-flight crown by a single point.
Guardiola averages 2.35 points per game in the Premier League, the highest rate of any manager (20+ matches). Indeed, he is so far ahead of the next highest (Alex Ferguson's 2.16), he could lose his next 26 league games in a row and would still be top.
Slot is yet to face City since taking over from Klopp at the start of the season, with the rivals' first meeting of the season set for December 1.
"It's good news for City and for the league because everyone wants the best managers and the best players over here," Slot said when asked about Guardiola's new contract.
"He is definitely one of the best managers, maybe the best manager of the league.
"He's won four titles in a row, so it's fair to say he's maybe the best manager in the league.
"On the other hand, they have so many quality players that, if he would have made the choice to leave, I wouldn't have expected them to end up bottom of the league next season."
Other Premier League managers echoed Slot's sentiment, with Brighton boss Fabian Hurzeler, who inflicted a fourth consecutive defeat on City before the international break, saying it is the "best thing that can happen to the Premier League".
"He is one of the best coaches in the world," Hurzeler said. "With his ideas, he always brings something new to the football stage, and it is always a challenge to compete against him.
"He always adapts quickly, always has new ideas and he can always win the game. I'm very happy because we can learn from him and to compete with him is a big, big experience."
Newcastle United boss Eddie Howe added: "He's contributed so much to English football. He's revolutionised how a lot of teams play.
"I think he's incredibly talented, and it's good for the English game that he's still here.
"He will continue to develop and evolve his style, and people will potentially continue to follow that. From the competition side, I think it keeps the Premier League as the best in the world."
Vlahovic out of Juventus clash with Milan
Dusan Vlahovic will miss Juventus' trip to Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
Vlahovic out of Juventus clash with AC Milan
Dusan Vlahovic will miss Juventus' trip to AC Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A, but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
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