Reece Topley is set to be ruled out of the T20 World Cup, which would leave England without one of their leading bowlers in the shortest format.
The 28-year-old was originally listed as an injury doubt for England's first game of the competition against Afghanistan on Saturday.
But according to widespread reports, an assessment of his ankle injury has revealed a more serious problem than initially hoped, with Topley found to have sustained ligament damage.
Left-arm paceman Topley rolled his ankle during a fielding drill ahead of Monday's warm-up win over Pakistan at the Gabba.
The blow for Topley comes after he made an impressive return to the international stage following fears his career could be over due to back injuries.
He played in all three of England's matches in the recent T20I series win over Australia, having featured in four of the seven games in the 4-3 victory in Pakistan.
With 17 wickets, he is the team's leading wicket taker in T20Is in 2022, and his bowling at the end of the innings has been particularly impressive.
England cannot confirm the news until the ICC has ratified Topley's replacement, with fellow left-armer Tymal Mills and right-arm seamer Richard Gleeson among the reserves who have travelled with England.
Jos Buttler's side will go into their Group 1 opener as strong favourites to defeat Afghanistan at Perth Stadium.
England will face a qualifier in their second World Cup match next Wednesday, then take on hosts Australia two days later.
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