Djokovic was hoping history did not repeat itself on Wednesday, having lost to a wildcard - Denis Istomin - in the second round at Melbourne Park three years ago.
But Djokovic was never threatened as the 16-time grand slam champion swept aside Ito in straight sets on Rod Laver Arena midweek.
In warm but breezy conditions, Djokovic barely raised a sweat as the second seed asserted his authority from the outset against the Japanese underdog.
Djokovic, eyeing his record-extending eighth Australian Open crown, picked his shots with comfort from the baseline, hitting seven winners in a lopsided 22-minute first set.
After racing through the opener, Djokovic - who dropped a set and won in the Australian Open first round for the first time in his career by getting past Jan-Lennard Struff on Monday - faced a sterner test in the second.
Having only won 50 per cent of his first serves in the opening set, Ito improved by winning 20 of 28, though he was broken in the ninth game and it proved decisive for Djokovic.
The third set was similar to the first as Djokovic dismantled Ito with a relentless display to earn another Japanese date - this time against Yoshihito Nishioka.
STATISTICAL BREAKDOWN
Novak Djokovic [2] bt Tatsuma Ito 6-1 6-4 6-2
WINNERS/UNFORCED ERRORS
Djokovic – 31/17
Ito – 18/29
ACES/DOUBLE FAULTS
Djokovic – 16/5
Ito – 9/1
BREAK POINTS WON
Djokovic – 5/9
Ito – 0/0
FIRST SERVE PERCENTAGE
Djokovic – 72
Ito – 65
PERCENTAGE OF POINTS WON ON FIRST/SECOND SERVE
Djokovic – 93/56
Ito – 66/33
TOTAL POINTS
Djokovic – 88
Ito – 53
Federer and Krajinovic will do battle on Rod Laver Arena on Wednesday, while Djokovic eased into the third round earlier in the day.
Djokovic said he had spoken to Krajinovic, 27, ahead of the second-round clash with the Swiss great.
"We spoke last night. I thought he fought well to win his opening-round match. He was very close to losing that match. He won in five sets. That was great for his confidence," he told a news conference after beating Tatsuma Ito 6-1 6-4 6-2.
"Obviously today is a completely different match-up against Roger. We did speak a little bit about things that he can do to be, I guess, his best self on the court. Again, it doesn't depend only on him.
"It depends how well Roger starts and how well Roger plays. It can be a very interesting match-up. I think Krajinovic is a very talented player and has been around the Tour for a while, knows Roger's game.
"It just depends on how it starts. It can be a long one. It can be a short one. It's going to be interesting to see."
Djokovic continued his fine start to 2020, winning an eighth straight singles match and setting up a clash with Yoshihito Nishioka.
The 16-time grand slam champion was particularly pleased with his serve after sending down 16 aces and not facing a break point against Ito.
"My serve was working extremely well in first round and second round. That's something I worked on in the off-season," Djokovic said.
"That's one of the priorities I guess of the training sessions, trying to get that I think advantage of winning a lot of easy points on the first serve.
"It has been paying off so far I think in the ATP Cup and here with the two matches."
The Serbian star, a record seven-time champion of the event, needed four sets to get through his opener.
Still, Djokovic remains on track ahead of facing wildcard Tatsuma Ito in the second round on Wednesday.
We take a closer look at the 16-time grand slam champion's form heading into the clash.
Form and results
Even Djokovic managed a first in his opening-round win. The 32-year-old dropped a set and won in the Australian Open first round for the first time in his career by getting past Jan-Lennard Struff in four. The last time he had dropped a set in his opener in Melbourne was in 2006, when he was beaten by Paul Goldstein. Djokovic may be better off for the test, having gone 6-0 in singles at the ATP Cup to begin his 2020.
R1: bt Struff 7-6 (7-5) 6-2 2-6 6-1
Next up
Due to rain, Ito's opener was pushed back to Tuesday, but the 31-year-old from Japan needed little time to brush past lucky loser Prajnesh Gunneswaran 6-4 6-2 7-5. Ito is the world number 146, but did manage a best ranking of 60 in 2012. However, he has played mostly on the Challenger Tour since 2013 and has never met Djokovic, who will be favoured to ease through.
Draw
If Djokovic gets past Ito as expected, he will face 30th seed Dan Evans or Japan's Yoshihito Nishioka in the third round. Diego Schwartzman (14th seed) and Dusan Lajovic (24th) are potential fourth-round opponents.
What he said
"It’s great to be back in this arena that has a very special place in my heart. This has been by far the most successful court in my career, I love coming back to Australia, the land of tennis. I want to thank everyone for staying until midnight and supporting both players."
