The Scorpions, who began day two 173-6, were eventually bowled out for 221 off 68.2 overs.
Carlos Brown added 12 runs to his overnight 68 before becoming one of Rakheem Cornwall’s three wickets.
Brown’s knock came off 178 balls and included 12 fours.
Jeremiah Louis took 3-34 from his 11 overs while Cornwall took 3-69 from his 22 overs.
Collin Archibald and Daniel Doram also took a pair of wickets, each.
The Hurricanes then replied with 213 all out off 58.3 overs thanks to 62 from Justin Greaves and 53 from Keacy Carty.
Greaves faced 113 deliveries and hit two fours and two sixes while Carty hit eight boundaries in his 80-ball knock.
Peat Salmon starred with the ball for the hosts with 5-50 from 23 overs while Ramaal Lewis took 4-80 from 17.3 overs.
Batting a second time, the Scorpions struggled to 59-4 at stumps, a lead of just 49 runs.
Kirk McKenzie (24*) and Peat Salmon (2*) are the batsmen at the crease.
Jeremiah Louis has taken 2-11 from six overs so far.
Full Scores: Jamaica Scorpions 221 all out off 68.2 overs (Carlos Brown 80, Romaine Morris 42, Jeremiah Louis 3-34, Rakheem Cornwall 3-69, Collin Archibald 2-23, Daniel Doram 2-27) & 59-4 off 18 overs (Kirk McKenzie 24*, Brandon King 19, Jeremiah Louis 2-11)
Leeward Islands Hurricanes 231 all out off 58.3 overs (Justin Greaves 62, Keacy Carty 53, Kieran Powell 41, Jewel Andrew 32, Peat Salmon 5-50, Ramaal Lewis 4-80)
At Coolidge, leaders Windward Islands Volcanoes trail the Guyana Harpy Eagles by 363 runs at stumps on day two.
Full Scores: Guyana Harpy Eagles 308 off 80.5 overs (Kevin Sinclair 74, Kevlon Anderson 48, Gudakesh Motie 46, Veerasammy Permaul 30, Darel Cyrus 5-67) & 168-1 off 57 overs (Tevin Imlach 88*, Tagenarine Chanderpaul 78*)
Windward Islands Volcanoes 113 all out off 31.5 overs(Tevyn Walcott 41, Isai Thorne 4-38, Ronaldo Alimohamed 3-30, Gudakesh Motie 2-12)
At the Queen’s Park Oval, Trinidad & Tobago Red Force trail the Barbados Pride by seven runs at stumps on day two.
Full Scores: Trinidad & Tobago Red Force 172 off 53.5 overs (Amir Jangoo 93*, Jason Holder 4-47, Chemar Holder 3-28, Shaquille Cumberbatch 3-50) & 100-3 off 36 overs (Kjorn Ottley 39, Amir Jangoo 30*, Jomel Warrican 2-19)
Barbados Pride 279 all out off 87.3 overs (Jonathan Drakes 72, Zachary McCaskie 46, Shane Dowrich 40, Jason Holder 34, Kevin Wickham 34, Kraigg Brathwaite 30, Khary Pierre 3-54, Jayden Seales 2-33, Bryan Charles 2-57)
At the Sir Frank Worrell Memorial Ground, Combined Campuses and Colleges trail West Indies Academy by 113 runs at stumps on day two.
Full Scores: West Indies Academy 300 all out off 78.3 overs (Carlon Bowen-Tuckett 76*, Johan Layne 63, Joshua Dorne 36, Joshua Bishop 32, Yannic Ottley 5-47, Jediah Blades 3-59) & 44-1 off 11.5 overs (Kadeem Alleyne 32)
Combined Campuses and Colleges 231 all out off 80.2 overs(Demario Richards 59, Zishan Motara 56, Ashmead Nedd 4-51, Joshua Bishop 2-44, Johan Layne 2-60).