Sergio Santos netted three times as Philadelphia crushed Toronto 5-0 at Subaru Park on Saturday.
The result equalled the Union's biggest ever win and Toronto's largest defeat, as per Opta.
Philadelphia needed until the 27th minute to get going, Sergio Santos heading in a wonderful cross from Kai Wagner.
Just six minutes later and the hosts doubled their lead, Mark McKenzie heading in from close range after a corner.
Jamiro scored a spectacular third for Eastern Conference leaders Philadelphia in the 56th minute, his 20-yard effort going in off the underside of the crossbar.
Sergio Santos put away two more to complete his hat-trick – the fourth in the Union's history and first since C.J. Sapong in May 2017.
Western Conference leaders Sporting also enjoyed a fine win, thrashing the Colorado Rapids 4-0.
Alan Pulido, Andreu Fontas, Gadi Kinda and Gerso Fernandes netted in the victory.
Leandro Gonzalez Pirez's 89th-minute winner saw Inter Miami – without the suspended Gonzalo Higuain – edge Orlando City 2-1, while DC United overcame Atlanta United 2-1.
New York City recorded a 3-1 victory over the Montreal Impact and the Vancouver Whitecaps were too good for the San Jose Earthquakes 2-1.
The Chicago Fire and New York Red Bulls drew 2-2, Minnesota United edged Cincinnati 1-0, Houston Dynamo and Columbus Crew drew 1-1 and Real Salt Lake and Dallas played out a goalless draw.
Super sub Ruidiaz came off the bench and scored a delightful game-winning goal just past the hour-mark as the Sounders downed Dallas 1-0 in MLS on Wednesday.
The Sounders were winless in 10 consecutive visits to Dallas (D3 L7, including play-offs) dating back to 2014 – their second-longest winless away run against a single opponent in MLS (11 straight at LA Galaxy from 2010 to 2015).
But Seattle snapped that skid thanks to Ruidiaz as Sporting KC's 1-1 draw with Portland Timbers allowed the Sounders to move top of the west by one point.
Atlanta extended their winning streak to three matches after Ezequiel Barco's first-half goal secured a 1-0 win at home to Toronto.
Since the sacking of head coach Gabriel Heinze following a falling out with star Josef Martinez, Atlanta – who had won successive matches for the first time since the opening two games of the 2020 season entering the fixture – have steadily climbed the table.
Atlanta are three points outside of the play-off positions in the Eastern Conference, which is topped by New England Revolution – 3-2 victors against DC United despite ending the contest with 10 men.
Elsewhere, Rodolfo Pizarro's stoppage-time winner guided Inter Miami to a dramatic 3-2 win against Chicago Fire midweek.
Pizarro struck in the 93rd minute to clinch a third straight home triumph for David Beckham's Inter Miami, who have now lost just once in their last six games.
Philadelphia Union and New York Red Bulls were 1-0 winners over New York City and Columbus Crew respectively, Vancouver Whitecaps topped Austin 2-1, Real Salt Lake defeated Houston Dynamo by the same scoreline, 10-man Montreal drew 0-0 with Cincinnati, while Nashville and Orlando City played out a 1-1 draw.
After Raul Ruidiaz's 40th minute opener, the visitors had taken the lead after goals from Cristian Dajome and Lucas Cavallini.
Medranda intervened with his 71st minute strike, coming after a corner was cleared into his path, lashing home from the edge of the box.
The result means Seattle remain top in the Western Conference, having conceded only seven goals in 11 games.
It also ends Vancouver's five-game losing streak, although they remain second last in the west.
Former Manchester United striker Javier 'Chicharito' Hernandez scored a double to lift LA Galaxy to a 3-1 win away to San Jose Earthquakes.
The Mexico international opened the scoring in the 11th minute when he swept home Samuel Grandsir's dangerous cross from the right.
Hernandez produced a similar finish to double their advantage in the 50th minute, tapping home from Kevin Cabral's ball.
Galaxy are third in the Western Conference, four points behind Seattle with a game in hand.
Philadelphia Union extended their unbeaten run to eight games with a 3-3 draw away to Chicago Fire.
Toronto's struggles continued with a 2-0 home defeat to Cincinnati, condemning them to five consecutive defeats.
Sporting Kansas City defeated Los Angeles FC 2-1, Real Salt Lake and Houston Dynamo drew 1-1, Minnesota United won 1-0 at Portland Timbers and Abu Danladi netted a late leveller to help Nashville claim a 1-1 home draw with Montreal.
Cristian Roldan, Jimmy Medranda and Joao Paolo scored in a three-goal first half to inspire the Sounders against the Rapids in Seattle.
The Rapids were enjoying their second-best unbeaten run in club history, only behind the 15-game undefeated streak from April 2016 to July 2016.
But Colorado came unstuck away to the Sounders at Lumen Field, where Roldan broke the deadlock in the second minute before Medranda and Paolo's moment of individual brilliance made it 3-0 prior to half-time.
The Sounders are top of the west, two points clear of Sporting Kansas City, who beat Houston Dynamo 4-2 behind Daniel Salloi's magical performance (one goal and an assist) and Johnny Russell's brace.
Entering the contest, Salloi and Russell had been directly involved, either together or individually, in Sporting KC's previous seven goals (Salloi three goals, Russell three goals and two assists). At least one of those two players had scored or assisted on 19 of the 23 goals Kansas City scored since late July.
David Beckham's Inter Miami and their hopes of featuring in the play-offs were dealt a blow following a 1-0 defeat to Portland Timbers.
Jaroslaw Niezgoda struck to extend Portland's unbeaten run to eight matches, including seven wins, and condemn Inter Miami to a fourth consecutive loss.
Inter Miami are eight points adrift of the post-season places in the Eastern Conference with seven fixtures remaining, while the fourth-placed Timbers are seven points clear of Real Salt Lake in the battle for home-field advantage.
Elsewhere, 10-man Philadelphia Union were 3-0 winners over defending champions Columbus Crew, Toronto defeated Chicago Fire 3-1 and New York City drew 0-0 with Nashville, while the El Trafico derby between LA Galaxy and Los Angeles FC ended 1-1.
Roldan struck in the 18th minute for the unbeaten Sounders, who left PayPal Park in San Jose with maximum points on Wednesday.
After the Earthquakes failed to clear their lines, Roldan riffled a thunderous half-volley into the back of the net from outside the penalty area.
The Sounders are now four points clear of the Earthquakes and LA Galaxy, who have played a match less in the west.
David Beckham's Inter Miami – coached by former Manchester United defender and midfielder Phil Neville – suffered a 2-0 defeat at home to Montreal following a 140-minute weather delay.
Bjorn Johnson scored twice in the space of 11 first-half minutes to give visitors Montreal a 2-0 lead inside the opening half an hour in Miami.
The match was then suspended in the 47th minute due to lightning strikes at DRV PNK Stadium, where Montreal held on for victory after more than two hours of waiting.
Montreal top the Eastern Conference, level on eight points with New England Revolution, who played out a 1-1 draw against Philadelphia Union, while Inter Miami have five points from five games.
Elsewhere, Toronto celebrated their first win of the season after topping defending champions Columbus Crew 2-0, Houston Dynamo were 1-0 victors over Sporting Kansas City, while Minnesota United defeated Vancouver Whitecaps by the same scoreline.
Ruidiaz scored twice in the second half after Joao Paulo's memorable opener to give last season's runners-up Seattle the perfect start on opening day.
The Sounders – beaten by Columbus Crew in the 2020 MLS Cup final – hit the front four minutes into the second half, Joao Paulo cushioning a cleared cross with one touch before rifling a thunderous volley into the top corner on Friday.
Ruidiaz entered the new season on the back of 12 MLS goals last term. According to Stats Perform, his 0.76 goals per 90 minutes led the league in 2020. When the Peruvian star was on the field, the Sounders scored two goals per 90 – besting their average of 1.5 goals per 90 when he was not last year.
A dominant force in the Western Conference since Brian Schmetzer succeeded legendary former boss Sigi Schmid in 2016, the Sounders doubled the lead with 20 minutes remaining when Will Bruin teed up Ruidiaz.
Ruidiaz made it 3-0 three minutes later after Cristian Roldan turned provider before Fredy Montero completed the rout four minutes from time at CenturyLink Field in Seattle, where the Sounders had an expected goals (xG) difference of 20.9 last season, well clear of next-best team Los Angeles FC (12.0)
In the only other match on Friday, Houston Dynamo edged San Jose Earthquakes 2-1.
Houston built a two-goal buffer by the 55th minute thanks to Memo Rodriguez and Maximiliano Urruti.
A stunning 74th-minute strike from San Jose substitute Paul Marie set up a tense finish, but the Dynamo held on for maximum points.
Sporting claimed a 2-1 win over Minnesota United at Allianz Field to pull clear atop the Western Conference.
Michael Boxall's 55th-minute own goal proved decisive as Sporting claimed a fifth win in six MLS games, going four points clear of second-placed Minnesota.
Gadi Kinda got on the end of a Jaylin Lindsey cross to give Peter Vermes' Sporting a 12th-minute lead.
Minnesota were level just after the half-hour mark, an unfortunate deflection off Lindsey leading to an own goal.
But Boxall turned a cross into his own net 10 minutes into the second half for what proved to be the winner.
Toronto recorded a second win in four days over the Vancouver Whitecaps with a 1-0 victory.
Richie Laryea's low finish in the 15th minute was all Toronto needed, getting back to within a point of Eastern Conference leaders Columbus Crew.
In the day's other games, Cincinnati and DC United drew 0-0, while the Houston Dynamo's clash with Dallas also finished goalless.
Johnny Russell scored a goal and assisted two others as Sporting KC routed Minnesota at Children's Mercy Park on Wednesday.
Russell converted a penalty as part of a three-goal first half, with Khiry Shelton and Daniel Salloi also on target against the visitors.
Cameron Duke added a fourth goal seven minutes into the second half as Sporting KC found the back of the net in their 28th consecutive regular-season home game dating back to August 2019 – the longest active streak in MLS.
Sporting KC are a point clear in the west, though second-placed Seattle Sounders have played two games less, while Minnesota are two points outside the play-off positions.
San Jose Earthquakes star Javier Lopez scored a hat-trick, but Real Salt Lake still prevailed 4-3 in a wild clash.
Lopez opened the scoring in the 26th minute and completed his treble in the second half, however, RSL emerged victorious thanks to Rubio Rubin's brace.
The result snapped a five-match away losing streak for RSL, who ended San Jose's run of three consecutive wins over their rivals in MLS – a run that had equalled the longest streak by either team in history.
Elsewhere, former Manchester United and Real Madrid striker Javier 'Chicharito' Hernandez salvaged a 1-1 draw for LA Galaxy against Houston Dynamo.
Another ex-United star, Nani, was sent off in the first half as Orlando City were beaten 4-2 by Montreal, Ola Kamara's opening-half hat-trick lifted DC United past Chicago Fire 3-0, Atlanta United were 4-0 winners against FC Cincinnati courtesy of a Josef Martinez double, Los Angeles FC edged Austin 2-1 and 10-man Portland Timbers drew 2-2 with Colorado Rapids.
Supporters' Shield winners the Revolution trailed 2-0 with nine minutes of regulation remaining before Poland international Buksa rescued an unlikely point for the high-flying outfit on Sunday.
Buksa pulled a goal back in the 81st minute and then struck in the third minute of stoppage time to salvage a dramatic draw and extend the Revs' undefeated run to nine matches.
Orlando had been in control thanks to quick-fire goals from former Manchester United star Nani and Daryl Pike, who made it 2-0 five minutes into the second half.
With the point, New England (70 through 32 games) – having equalled the record for most road wins in a single regular season in the post-shoot-out era in MLS thanks to Wednesday's 10th away victory – closed within two points of the league record of 72, set by Los Angeles FC in 2019.
Elsewhere, lowly Austin upstaged Houston Dynamo 2-1 courtesy of a two-goal first half.
After Marco Maric's seventh-minute own goal, Sebastian Driussi put Austin 2-0 ahead in the fourth minute of added time in the opening half.
Another own goal, this time in favour of the Dynamo after Julio Cascante's moment of misfortune, made things interesting in stoppage time.
Last season was the first time in Houston's 15 MLS campaigns they finished averaging less than one point per match (0.91 – 21 points in 23 games). With 30 points in 32 rounds this term, the Dynamo are on pace to do so for a second consecutive year.
Sibling pair Diego and Yimmi Chara were among the goals as the Timbers – unbeaten in six matches – eased past RSL at Providence Park on Saturday.
Felipe Mora, Dairon Asprilla, Jaroslaw Niezgoda and Cristhian Paredes also scored for the Timbers, who have netted in 16 consecutive matches against RSL (including play-offs) – the second longest streak against any opponent in their history, behind the 17 straight versus Dallas from August 2012 to March 2018.
The Timbers led 2-1 at half-time before putting RSL to the sword in the second period to match their six-game unbeaten streak from September-October last season.
Portland are fourth in the Western Conference, six points behind leaders Sporting Kansas City, while RSL occupy the seventh and final play-off position in the west.
Los Angeles FC are three points outside the top seven following their 2-0 defeat to San Jose Earthquakes, while Vancouver Whitecaps are also on 33 points after topping Dallas 1-0.
The Union defeated Atlanta 1-0 thanks to Kacper Przybylko's goal with less than 20 minutes remaining.
Back-to-back wins sent Philadelphia up to fourth in the Eastern Conference as Atlanta's three-game winning streak came to an end to leave them eighth in the east and outside the post-season positions.
In other results, Supporters' Shield leaders New England Revolution were 2-1 winners over Orlando City.
The Revolution extended their MLS single-season record for wins by one-goal margins to 16. Nine of New England's last 10 MLS victories have come by a one-goal margin.
It continued Orlando's misery against New England – the team have never won at the Revolution (D1 L5), the only side they have visited more than three times without recording a victory in MLS play.
DC United prevailed 4-2 against FC Cincinnati, New York Red Bulls overcame rivals New York City 1-0, defending champions Columbus Crew won 2-1 against Montreal, Houston Dynamo lost 2-0 to Minnesota United, while Colorado Rapids and Toronto played out a 0-0 draw.
Alejandro Pozuelo's fine run of form continued as Toronto came from behind to beat the Philadelphia Union 2-1 in Connecticut.
Sergio Santos' delicate chip had put Philadelphia ahead in the fifth minute, but Toronto fought back in the second half.
Ayo Akinola headed in a Tony Gallacher cross from the left approaching the hour-mark to bring Greg Vanney's side level.
Pozuelo scored what proved to be the winner in the 76th minute, heading in at the back post following a corner.
As Toronto won for the 10th time in their past 13 meetings with the Union, Pozuelo has been directly involved in 10 goals since the MLS regular season resumed in August, as per Opta.
Toronto joined Columbus on 31 points atop the Eastern Conference after the Crew were held to a 2-2 draw by Dallas.
LA Galaxy are bottom of the Western Conference after slumping to a 2-1 loss to the San Jose Earthquakes in the California Clasico.
The Galaxy seemed on track when Sebastian Lletget put away the opener after Javier Hernandez hit the post, and goalkeeper David Bingham saved Chris Wondolowski's 12th-minute penalty.
But Marcos Lopez drilled in a wonderful equaliser before half-time, and Andres Rios made no mistake with San Jose's second spot-kick of the game in the 82nd minute.
Orlando City continued their fine season with a 3-1 victory over the New York Red Bulls.
The club's tally of 29 points from their first 15 matches is five more than they have ever had through the same number of games in any previous campaign, according to Opta.
Gonzalo Higuain's Inter Miami fell to a 3-2 loss to New York City, while Atlanta United crushed DC United 4-0.
Montreal Impact and Chicago Fire drew 2-2, Alan Pulido scored a brace as Sporting Kansas City edged Houston Dynamo 2-1 and Minnesota United enjoyed a 2-0 victory over Cincinnati.
Western Conference leaders the Seattle Sounders beat the Vancouver Whitecaps 3-1, while the clash between the New England Revolution and Nashville finished goalless.
Houston routed Sporting KC 5-2 in August and Dynamo claimed another win over their rivals in the west on Saturday.
After a short weather delay at BBVA Stadium, Dynamo came from behind following Erik Hurtado's 30th-minute opener in Houston.
Within a minute of his introduction, Alberth Elis equalised for Houston in the 59th minute – on the end of Darwin Ceren's cross.
Fellow substitute Mauro Manotas completed the fightback with four minutes remaining to extend Houston's unbeaten streak to five matches.
Sporting KC are only two points clear of Seattle Sounders, who are due to play on Sunday, while Houston are third and four points adrift.
Eastern Conference high-flyers Toronto suffered a surprise 3-2 defeat against Canadian rivals the Whitecaps.
Toronto, who had their bid to set an MLS record for consecutive regular-season wins, slumped to back-to-back losses.
Jake Nerwinski's 76th-minute goal saw the Whitecaps trump Toronto at BC Place, where Vancouver snapped a three-game losing streak.
Toronto are second and two points behind Eastern Conference leaders Columbus Crew after 10 games, while Vancouver are 10th in the west.
Elsewhere, Atlanta United salvaged a last-gasp 1-1 draw at Orlando City and San Jose Earthquakes were held to the same scoreline by Colorado Rapids.
Vancouver, who snapped an eight-game winless run with a 2-1 win over LA Galaxy last time out, drew a blank with eight shots but none on target.
Cristian Dajome came close in the 20th minute for the Whitecaps from Deiber Caicedo's ball.
Dynamo forward Maximiliano Urruti had a free-kick hit the post, before Vancouver's Cristian Gutierrez curled wide in the second half.
The result extends Houston's winless run to seven games, having drawn five of their past six.
Vancouver moves up to 11th in the Western Conference with 13 points from 14 games, while Houston are ninth with 16 points.
Inter required a 97th-minute equaliser from Christopher McVey to rescue a point, despite having led 3-2 entering the final 10 minutes thanks to a first-half Gonzalo Higuain hat-trick.
Brandon Vazquez scored twice to turn the game on its head, leaving Neville furious despite McVey's last-gasp intervention.
"We defended like little boys, we defended naively, we didn't compete, we lacked discipline and concentration," the former Manchester United and Everton defender said. "And that's unacceptable, unacceptable.
"Simple balls into the box we didn't deal with. Simple concentration bits we didn't deal with.
"We are in the stage of the season where concentration is the main thing, concentration will get you to win games of football, and it's not going to be easy; you've just got to defend and do the right things all the time, and defensively we were as poor as we have been all season."
Remarkably, it was not Saturday's first eight-goal draw, as Minnesota United and the Portland Timbers had earlier played out a thriller.
Sebastian Blanco got the scoring started in the first minute, but there was no late drama in this one, with all eight goals netted before the 70-minute mark.
This was the first time in MLS history two matches on the same day have seen both teams score at least four goals, but there was a chasm between the Philadelphia Union and the Houston Dynamo in Saturday's third high-scoring game.
The Union ran out 6-0 winners as Mikael Uhre continued his stunning run of form at Subaru Park, netting either side of half-time for his fifth and sixth goals in his past four home games.
Uhre had also scored twice in a 7-0 defeat of DC United earlier in July, making Philly the first team to win multiple games by a six-goal margin in a single MLS season.
Elsewhere, New York City FC lost ground on the Union in the East as they drew with CF Montreal, while Sebastian Druissi continued his MVP bid by inspiring Austin FC to a 2-0 win at Sporting Kansas City.
"He continues to demonstrate why he deserves that [award]," said Austin coach Josh Wolff.
Gerhard Stuber's side looked to absorb pressure for the majority of the match and captain Aaron Long put them ahead in the 53rd minute, heading in at the back post after a finely worked corner routine.
Choice became necessity after a VAR review that forced Sean Nealis off in the 73rd minute, but they were able to hold out against a Sporting KC that failed to penetrate in possession.
The win makes for the first time NYRB have managed consecutive wins in the MLS since April, also putting them on 32 points, now two points clear of Philadelphia Union.
The Union were in a similarly dour contest, generating only two shots in the penalty area from open play in a goal-less draw away to Columbus Crew.
The Crew had an opportunity to take the lead in the 19th minute, only for Andre Blake to save Pedro Santos' penalty.
New Yoirk City are a further point back on 29 points, after they played out a 2-2 draw at home to Atlanta United, while the New England Revolution and Cincinnati also managed a 2-2 draw.
In the Western Conference meanwhile, Real Salt Lake critically slipped up in a chance to make up ground following LAFC's loss on Saturday, going down 3-2 to Minnesota United.
RSL were down 3-0 at one stage until Jefferson Savarino inspired a dramatic late fightback, scoring and assisting for substitute Anderson Julio within a five-minute span.
It was not enough however, with LAFC maintaining a five-point gap to second-placed Austin FC.
Elsewhere in the West, Nashville and Portland Timbers played out a 2-2 draw, while Houston Dynamo lost 2-1 at home to Charlotte FC.
In Sunday's final game, the San Jose Earthquakes defeated the Chicago Fire 2-1 via Benjamin Kikanovic's brace, with his first coming after the Quakes extraordinarily hit the frame of the goal twice in the same passage.
City had ended a three-game losing run with a 2-0 win at Chicago Fire 10 days before losing to Orlando City on the weekend but their poor form continued at Red Bull Arena.
Ola Kamara tapped in from point blank range to give the visitors at 24th-minute lead, but Heber side-footed in an equalizer three minutes later.
Steven Birnbaum restored United's lead with a header from a Martin Rodriguez free-kick in the 57th minute and City could not find a response with David Ochoa palming away Gedion Zelalem's 95th-minute effort.
The win is Wayne Rooney's second since taking over at United who are still last in the Eastern Conference, while it sees City slide down to fourth in the east.
Riqui Puig scored a spectacular late equalizer with a long-range curler after a give-and-go to earn LA Galaxy a 2-2 draw away to Toronto.
Douglas Costa had put the Galaxy into a 24th-minute lead before Toronto hit back with second-half goals to Jesus Jimenez and Filippo Bernardeschi before the Spaniard's 89th-minute strike.
Riqui Puig was making only his third appearance for the Galaxy following his August move from Barcelona.
The result dents star-studded Toronto's playoffs aspirations, leaving them 10th in the east, while the Galaxy are eighth in the west.
Philadelphia Union became the second team behind LAFC to book their postseason berth with a 4-1 home win over Atlanta United.
Julian Carranza, Mikael Uhre, Daniel Gazdag and Nathan Harriel were all among the goals for Union who are eight points clear in the east.
New York Red Bulls moved up to third in the east with a 1-0 win at second-placed Montreal with Lewis Morgan hitting the winner in the 43rd minute.
LAFC suffered a shock 2-1 loss to lowly Houston Dynamo, who condemning the Western Conference leaders to their third straight defeat.
Inter Miami slumped to back-to-back losses with a 1-0 defeat at Columbus Crew, while New England's winless run extended to four games after a goalless draw with struggling Chicago Fire who snapped a three-game losing run.
Hany Mukhtar netted a hat-trick as Nashville beat Colorado Rapids 4-1, while Orlando City came from two goals down to defeat Seattle Sounders 3-2.
Real Salt Lake proved too good for Minnesota United 3-0 and Portland Timbers moved into the west's top seven with a narrow win against second-placed Austin 2-1.
City had ended a three-game losing run with a 2-0 win at Chicago Fire 10 days before losing to Orlando City on the weekend but their poor form continued at Red Bull Arena.
Ola Kamara tapped in from point blank range to give the visitors at 24th-minute lead, but Heber side-footed in an equalizer three minutes later.
Steven Birnbaum restored United's lead with a header from a Martin Rodriguez free-kick in the 57th minute and City could not find a response with David Ochoa palming away Gedion Zelalem's 95th-minute effort.
The win is Wayne Rooney's second since taking over at United who are still last in the Eastern Conference, while it sees City slide down to fourth in the east.
Riqui Puig scored a spectacular late equalizer with a long-range curler after a give-and-go to earn LA Galaxy a 2-2 draw away to Toronto.
Douglas Costa had put the Galaxy into a 24th-minute lead before Toronto hit back with second-half goals to Jesus Jimenez and Filippo Bernardeschi before the Spaniard's 89th-minute strike.
Riqui Puig was making only his third appearance for the Galaxy following his August move from Barcelona.
The result dents star-studded Toronto's playoffs aspirations, leaving them 10th in the east, while the Galaxy are eighth in the west.
Philadelphia Union became the second team behind LAFC to book their postseason berth with a 4-1 home win over Atlanta United.
Julian Carranza, Mikael Uhre, Daniel Gazdag and Nathan Harriel were all among the goals for Union who are eight points clear in the east.
New York Red Bulls moved up to third in the east with a 1-0 win at second-placed Montreal with Lewis Morgan hitting the winner in the 43rd minute.
LAFC suffered a shock 2-1 loss to lowly Houston Dynamo, who condemning the Western Conference leaders to their third straight defeat.
Inter Miami slumped to back-to-back losses with a 1-0 defeat at Columbus Crew, while New England's winless run extended to four games after a goalless draw with struggling Chicago Fire who snapped a three-game losing run.
Hany Mukhtar netted a hat-trick as Nashville beat Colorado Rapids 4-1, while Orlando City came from two goals down to defeat Seattle Sounders 3-2.
Real Salt Lake proved too good for Minnesota United 3-0 and Portland Timbers moved into the west's top seven with a narrow win against second-placed Austin 2-1.
A day after the MLS is Back Tournament was announced, the league held a draw for the group stage on Thursday, placing the 26 teams into six groups.
Sixteen teams will then progress to the knockout stage, which will begin on July 25 ahead of an August 11 final.
Aside from the opening match, the rest of the tournament schedule has yet to be announced.
The groups for the MLS is Back Tournament:
Group A (Eastern Conference): Orlando City, Inter Miami, New York City, Philadelphia Union, Chicago Fire, Nashville SC.
Group B (Western Conference): Seattle Sounders, Dallas, Vancouver Whitecaps, San Jose Earthquakes.
Group C (Eastern Conference): Toronto, New England Revolution, Montreal Impact, DC United.
Group D (Western Conference): Real Salt Lake, Sporting Kansas City, Colorado Rapids, Minnesota United.
Group E (Eastern Conference): Atlanta United, FC Cincinnati, New York Red Bulls, Columbus Crew.
Group F (Western Conference): Los Angeles FC, LA Galaxy, Houston Dynamo, Portland Timbers.
RSL moved above Portland Timbers into the last playoffs spot in the Western Conference with their 3-1 victory, while Orlando achieved the same feat in the east after beating Columbus Crew 2-1 after a late penalty.
Pablo Mastroeni's RSL will take on two seed Austin in the first round of the MLS playoffs, navigating their way past Portland who started the day in sixth spot, but dropped to eighth, with Minnesota United also qualifying with their 2-0 win over Vancouver Whitecaps.
Jefferson Savarino settled any nerves for RSL, who had claimed only three wins from their past 17 games, by curling in a 19th-minute opener before Rubio Rubin's deflected shot doubled their lead in the 48th minute.
Bode Hidalgo sealed RSL's playoffs spot with a classy finish in the 82nd minute, with Dairon Asprilla scoring a late consolation for the Timbers.
Minnesota, who will take on Dallas in the first round of the playoffs, got their win after Franco Fragapane's low 17th-minute drive. Jonathon Gonzalez added a second with a left-foot volley in the 77th minute to seal the Loons' spot.
Hany Mukhtar was confirmed as the MLS Golden Boot winner with 23 goals, although he did not score as Nashville locked in the five seed with a 1-0 win over Supporters Shield winners LAFC.
Teal Bunbury scored the only goal in the 53rd minute, with Nashville to face LA Galaxy in the playoffs. Galaxy beat Houston Dynamo 3-1 with Riqui Puig and Javier Hernandez among the scorers.
Facundo Torres converted an 84th-minute spot kick to send Orlando into the playoffs with a 2-1 victory over the Crew. The Lions will take on Eastern Conference two seed Montreal.
Columbus came into the game one point ahead of Orlando and had gone ahead through Derick Etienne in the 38th minute.
Junior Urso leveled for Orlando in the 56th minute before Milos Degenek's handball led to Torres' decisive penalty, condemning the Crew to missing the playoffs.
Cincinnati clinched their spot in the playoffs for the first time in franchise history, leapfrogging up into the five seed slot, with their 5-2 win at struggling DC United.
Brenner hit a hat-trick for Cincy, who will take on New York Red Bulls in the playoffs. The Red Bulls won 2-0 over Charlotte after Elias Manoel's double to secure the four seed.
Inter Miami lost 3-1 at home to Montreal, meaning Phil Neville's side slipped to the six seed and will take on reigning MLS Cup champions New York City. City beat Atlanta United 2-1 to clinch the three seed.
In other games, Seattle Sounders and San Jose Earthquakes drew 2-2, Chicago Fire drew 1-1 with New England and Austin and Colorado Rapids ended 1-1 after Diego Rubio's late equalizer for the visitors.
Eastern Conference winners Philadelphia Union thrashed Toronto 4-0 with Daniel Gazdag netting a hat-trick, while Western Conference three seed Dallas got past Sporting KC 2-1.
The Timbers have won three of their last four games, including both at home in that run, and sit ninth in the Western Conference.
Against Austin FC on Wednesday, they kept their first clean sheet of the season with a 2-0 victory.
Neville is hopeful Portland can continue to build on their recent momentum as they look to close the gap to the teams above them.
"There's a good cohesion to the team and a good structure. The players are now doing their jobs and doing it to the ability that you expect," Neville said.
"The last two or three games we've seen a continuation of the work we've been doing. We knew we had a lot of work to do to change things here and that it would take time, and I'm super proud of them all.
"If we really believe in what we're doing and have confidence to be the team that we can be, then we have to go again on Saturday. There's no looking back and resting on your laurels. You've got to be ruthless and got to be relentless."
Houston sit eighth in the league, two points better off than Saturday's opponents, and won 3-1 against Colorado Rapids in midweek.
"This is a team that is always thinking to go forward," assistant coach Juan Guerra said.
"We're very focused on playing attractive possession style soccer to go forward and be able to create opportunities. On [Wednesday], it went in, and I hope it keeps going in, starting with Saturday."
PLAYERS TO WATCH
Portland Timbers – Evander
Evander scored his seventh goal of the season on Wednesday to go along with five assists in his 12 appearances this season. The only other Timbers player to record 12 goal contributions in his first 12 games of a season was Diego Valeri in his 2017 MVP season.
Houston Dynamo – Latif Blessing
Blessing has found the net in consecutive games for the first time in almost five years, since doing so for Los Angeles FC in August 2019.
Blessing's two goals in the last week came after he had scored just two goals in his previous 89 MLS appearances dating back to the start of the 2021 season.
MATCH PREDICTION: PORTLAND TIMBERS WIN
With their win at Austin on Wednesday, the Timbers have won three of their last four matches (L1) after winning just two of their first 12 matches this season (D4 L6). Portland's 2-0 win over Austin on Wednesday also ended a run of 20 straight matches allowing a goal.
However, the Dynamo have won three straight matches against Portland after going winless in the previous eight meetings (D3 L5). Neither team have managed four straight wins over the other in all competitions.
Houston won for just the second time in nine matches in all competitions with a 3-1 victory over Colorado on Wednesday. It was the Dynamo's first three-goal performance since their last visit to Portland, a 3-1 win on Decision Day last season.
OPTA WIN PROBABILITY
Portland Timbers – 42.1%
Draw – 26.7%
Houston Dynamo – 31.2%
