Montreal trailed 2-0 after 14 minutes and 4-2 after 46 minutes, but Ahmed Hamdi scored twice in the final 16 minutes to give the home side a wild victory.
In Nashville, Hany Mukhtar scored in the 10th, 13th and 16th minutes on the way to a 5-1 rout of Chicago Fire.
The six-minute span was the second-shortest for a hat-trick in MLS history after LA Galaxy's Harut Karapetyan needed just five minutes to score three in a 1998 match.
Gustavo Bou's team-leading seventh goal gave New England Revolution a 1-0 win at Atlanta United, snapping a three-game win drought for the Eastern Conference leaders.
Second-half goals from Deiber Caicedo and Cristian Dajome gave Vancouver just their third win from 13 games this season, a 2-1 triumph over LA Galaxy.
Darlington Nagbe's impressive individual effort opened the scoring in a 2-1 Columbus Crew win over New York City FC.
Nani's 77th-minute penalty gave Orlando City a 1-1 draw with Toronto after Jozy Altidore had opened the scoring five minutes earlier, while Cole Bassett's second-half goal for Colorado Rapids earned a 1-1 draw against San Jose.
Kacper Przybylko's 83rd-minute decider gave Philadelphia Union a 2-1 victory over DC United, while Jeremy Ebobisse scored in the 84th minute to lift Portland past Dallas 1-0.
Carlos Vela's left-footed rocket in the 79th minute was the difference in LAFC's 2-1 home win over Real Salt Lake.
The New York Red Bulls-Inter Miami match was postponed due to weather.
Former Manchester United attacker Nani scored and provided an assist in Orlando's 4-1 thrashing of the Chicago Fire on Saturday.
After Chris Mueller opened the scoring, he crossed for Nani to head in a second in the 24th minute.
Given a chance to get back into the game, Chicago squandered it when Alvaro Medran had a penalty well saved by Pedro Gallese.
Chicago took their next chance from the spot through Robert Beric early in the second half, but Orlando sealed their win late.
Junior Urso scrambled in from inside the area after Nani's set-piece went uncleared, and the Portuguese attacker's pass later found Benji Michel to finish off in additional time.
Orlando are second in the Eastern Conference, five points behind the high-flying Columbus Crew.
Second-half goals from Pedro Santos and Gyasi Zardes saw Columbus record a 2-0 win over Nashville.
Diego Valeri netted a brace as the Portland Timbers crushed the San Jose Earthquakes 6-1 at Avaya Stadium.
Fresh off confirming the signing of Gonzalo Higuain, Inter Miami recorded a second win in three matches by beating Atlanta United 2-1.
Elsewhere, a 10-man LA Galaxy fell to the Colorado Rapids 2-0 and Dallas also finished with 10 but recorded a 3-2 win over Sporting Kansas City.
Haris Medunjanin scored directly from a corner in the 85th minute as Cincinnati beat the New York Red Bulls 1-0 and the Vancouver Whitecaps beat a 10-man Real Salt Lake 2-1.
New York City drew 0-0 with the New England Revolution, DC United and Toronto played out a 2-2 draw, while the Houston Dynamo and Minnesota United did likewise.
Former Manchester United winger Nani scored his ninth goal of the MLS season as Orlando City missed the chance to close the gap at the top after a 1-1 draw at Cincinnati on Saturday.
Cincinnati, who were winless in their past seven games coming in, opened the scoring in the 42nd minute from Brazilian attacker Brenner.
Nani levelled moments after being brought into the game as a 55th-minute substitute, driving forward and firing in a low left-foot pinpoint shot.
The result means back-to-back draws for Orlando who are second in the Eastern Conference, seven points behind leaders New England.
Third-placed New York City blew an early two-goal lead to draw 2-2 away to Toronto.
Santiago Rodriguez and Ismael Tajouri had put City up 2-0 inside 21 minutes but Toronto netted twice after the break.
Richie Laryea pulled one back in the 49th minute before reigning MVP Alejandro Pozuela equalised in the 55th minute with a tap in.
Portland Timbers beat Real Salt Lake 3-2 in a see-sawing contest with Felipe Mora netting the eventual winner.
Columbus Crew suffered their third straight defeat as Ezequiel Barco netted a double for Atlanta City in a 3-2 win.
Dallas continued their good run of recent form, claiming their third win in four games, with a 2-0 triumph over Austin.
Minnesota United won 2-0 over Houston Dynamo, while Colorado Rapids drew 0-0 with Western Conference leaders Sporting KC.
Tesho Akindele scored the fastest goal in club history as Orlando got off to a quick start at home to Jaap Stam's Cincinnati on Saturday.
Akindele found the back of the net after just 33 seconds, surpassing the Orlando record set by Chris Mueller (62 seconds) in April 2018.
Nani doubled the lead in stunning fashion in the 19th minute – the former Manchester United star leaving Yuya Kubo on the floor after cutting to his right foot and then his left as he curled the ball past Przemyslaw Tyton.
After Nani hit the post minutes later and saw his shot saved by Cincinnati goalkeeper Tyton just past the hour mark, Junior Urso sealed the victory with 10 minutes remaining.
Orlando – who remain unbeaten through three games – are third in the Eastern Conference, behind leaders New England Revolution and second-placed New York City.
The Revolution edged Atlanta United 2-1 and New York City defeated reigning Supporters' Shield winners Philadelphia Union 2-0.
The Earthquakes and Dallas, meanwhile, both won 4-1 against DC United and Portland Timbers respectively.
Jackson Yueill's brace and a pair of assists from Cade Cowell fuelled the Earthquakes, who are top of the Western Conference on goal difference but level on points with Real Salt Lake, LA Galaxy and Austin FC.
Dallas showed no mercy at home to the Timbers after Andres Ricaurte and Jader Obrian scored in the opening 13 minutes.
Real Salt Lake came from behind to top Sporting Kansas City 3-1 courtesy of Rubio Rubin's second-half double, while MLS newcomers Austin prevailed 1-0 against Minnesota United.
Elsewhere, New York Red Bulls were 2-0 winners over Chicago Fire, defending champions Columbus Crew were held to a goalless draw by Montreal Impact and Houston Dynamo and Los Angeles FC played out a 1-1 draw.
A last-gasp 1-1 draw against New York Red Bulls was enough for Orlando to secure a place in the MLS Cup play-offs on Sunday.
Orlando were stunned in stoppage time – Brian White's 95th-minute equaliser cancelling out Nani's 56th-minute penalty at Red Bull Arena.
But after Toronto edged Atlanta United 1-0, Orlando were assured of their first trip to the play-offs, having entered the league in 2015.
"We've put ourselves in a good position," Orlando forward Daryl Dike said. "Obviously we just made the play-offs today, but I think we're going to carry on. The goal wasn't just playoffs. We're not done now. We just keep going and keep going.
"We want three points every single game and we want to finish the highest in the table. That's the main goal."
Orlando – fourth in the Eastern Conference – are in the midst of a club-record 12-game unbeaten streak, per Stats Perform.
The Crew's 3-1 win over New York City, coupled with Toronto's triumph, sent the team back to the play-offs after missing out last season.
Columbus also snapped a four-match winless streak to move third in the east, two points ahead of Orlando and a point behind second-placed Philadelphia Union.
Elsewhere, LA Galaxy ended a six-game losing skid by topping Vancouver Whitecaps 1-0 thanks to substitute Kai Koreniuk's late winner.
Koreniuk became the first substitute to score for the Galaxy this season – the Los Angeles club were the only team without a goal from a substitute in 2020.
Los Angeles FC's Christian Torres (16 years, six months and three days) became the youngest player to score in MLS since Sporting Kansas City's Gianluca Busio (16 years, four months and 20 days) in 2018, according to Stats Perform.
Torres' last-gasp equaliser earned LAFC a 1-1 draw at Western Conference high-flyers Portland Timbers.
Seattle Sounders drew 0-0 with San Jose Earthquakes, Houston Dynamo played out a 2-2 draw against Minnesota United and DC United beat FC Cincinnati 2-1.
New England sensationally trailed 3-0 within half an hour against lowly Toronto after early strikes from Yeferson Soteldo, Kemar Lawrence and Tsubasa Endoh.
Japanese midfielder Endoh's strike was spectacular, cutting inside before lashing a fine curling shot home in the 24th minute.
Revolution came into the game after stumbling in their past two games, with a draw and a loss following six straight victories and the defeat extended that winless run.
New England fought in the second half, with Spanish midfielder Carles Gil pulling one back in the 56th minute.
In the 78th minute it was 3-2 when Ghanaian Emmanuel Boateng laid off for Adam Buksa to net his fourth of the season, but there was no late equalizer.
New England's lead in the east remains three points as second-placed Orlando City lost 3-1 to Chicago Fire who claimed back-to-back wins.
Seattle Sounders returned to winning ways and extended their unbeaten season with a 2-0 home victory over Houston Dynamo.
Raul Ruidiaz netted his 10th goal of the campaign in second-half stoppage time after Kelyn Rowe put Seattle ahead just past the hour.
The undefeated Sounders have 29 points from 13 games and are three points clear of the west's second-placed Sporting Kansas City.
LA Galaxy are third in the Western Conference, aided by a 3-1 home triumph over Dallas despite the absence of top scorer Javier 'Chicharito' Hernandez.
Rayan Raveleson, Kevin Cabral and Ethan Zubak netted for the Galaxy, who were without Hernandez to a calf injury.
Real Salt Lake inflicted more pain on struggling Vancouver Whitecaps with a 4-0 road win with Damir Kreilach netting a brace, while Colorado Rapids got past Minnesota United 2-0.
Montreal extended their unbeaten run to five games after Romell Quioto's 73rd-minute winner in a 2-1 victory over New York City, while LAFC moved up to fifth in the Western Conference with a 2-0 win at Austin.
After failing to score in their opening two games – a 1-0 loss to LA Galaxy and a goalless draw with Vancouver Whitecaps – City hit the lead after only seven minutes, with Alexander Callens rifling home after Montreal failed to clear their lines from a corner.
Santiago Rodriguez spectacularly chipped Sebastian Breza to double the margin on 20, but only after Montreal gifted City possession in an attempt to play out from their own half.
Zachary Brault-Guillard pulled one back for CFM, but following further City goals from Telles Magno and Thiago Andrade, the scoreline arguably belied the performance.
Douglas Costa opened his account in the MLS later on Saturday, scoring the equaliser in LA Galaxy's 3-2 loss away to Seattle Sounders.
Javier Hernandez gave the Galaxy a shock lead in the sixth minute, after fine link-up play between Raheem Edwards and Kevin Cabral, but the Sounders fought back to lead before the interval – with goals from Jordan Morris and Fredy Montero.
Costa drew the visitors level from the dead ball after 48 minutes, wrong-footing Stefan Frei, but Xavier Arreaga headed home in the 72nd to give the Sounders their first win of the season.
Los Angeles FC continued their unbeaten start to the season, meanwhile, grinding out a 2-0 win against a 10-man Inter Miami at DRV PNK Stadium.
A deflected Carlos Vela pass put Kwadwo Opoku through on the stroke of the interval, and the 20-year-old Ghanaian finished with composure. That didn't spell the end of events in the first half, though, as Brek Shea was given a straight red card in injury time.
LAFC had six shots for the match compared Inter's seven, despite 53 per cent possession and an extra man. However, an Ismael Tajouri free-kick crept inside Inters back post in the 82nd minute to secure the win.
Steve Cherundolo's side are equal top in the Western Conference with Real Salt Lake, who defeated New England Revolution 3-2. Austin FC couldn't keep pace in the final Saturday game, however, going down 1-0 away to Portland Timbers through a Bill Tuiloma goal.
Columbus Crew share the lead in the Eastern Conference, following their 2-1 win over Toronto FC. They are joined by Philadelphia Union, who defeated San Jose Earthquakes 2-0.
A Darwin Quintero brace handed Houston Dynamo a 2-0 win against Vancouver Whitecaps, while Brandon Vazquez scored a double of his own in FC Cincinnati's 2-1 win at Orlando City.
FC Dallas, Chicago Fire and Colorado Rapids respectively secured 2-0 victories over Nashville, DC United and Sporting Kansas City in Saturday's other games.
Mitrita led the way for New York after opening the scoring just 30 seconds into the match at Red Bull Arena on Saturday.
It was the fastest goal in New York's history and quickest in MLS since Allan Cruz's 28-second effort for Cincinnati in 2019, per Opta.
After Cincinnati went close to equalising, Anton Tinnerholm doubled New York's lead from an acute angle in the 25th minute.
Mitrita made it a brace two minutes before half-time and Jesus Medina completed the scoring with two minutes remaining as New York moved up to fifth in the Eastern Conference, five points behind fourth-placed Toronto.
Elsewhere, Maynor Figueroa's 89th-minute equaliser rescued a 1-1 draw for Houston against Nashville.
Daniel Rios' 49th-minute goal had Nashville on track for maximum points until Figueroa scored from a set-piece situation.
Houston are ninth in the Western Conference, while Nashville sit ninth in the east.
Tesho Akindele's header after 12 minutes to give Orlando City a 1-0 victory against Toronto FC, giving the Florida side three wins and three draws through six matches.
The Revolution saw off 10-man New York Red Bulls 3-1 behind first-half goals from Gustavo Bou and Tajon Buchanan and an Adam Buksa tally late to seal it.
Two late strikes from Lucas Zelarayan helped the Columbus Crew stun New York City FC 2-1 after the home side led into the 82nd minute.
Felipe Mora's second-half brace and a penalty from Diego Valeri lifted Portland to a 3-0 triumph over 10-man LA Galaxy.
Diego Rossi scored twice before the break as Los Angeles FC held on to defeat Colorado Rapids 2-1.
Houston's Memo Rodriguez and Maximiliano Urruti provided the winning margin for Houston as they won 2-1 over Vancouver.
Sporting Kansas City continued their strong start, shaking off an early San Jose Earthquakes goal from Javier Lopez en route to a 3-1 win as Jaylin Lindsey, Alan Pulido and Daniel Salloi found the back of the net.
Luka Stojanovic lifted Chicago Fire past Inter Miami 1-0 for their first win of the season, and FC Cincinnati also emerged victorious for the first time this term with a 2-1 win at Montreal.
Real Salt Lake escaped with a 2-2 draw at FC Dallas thanks to Damir Kreilach's goal after 86 minutes.
Alexandre Pato's 94th-minute free-kick cannoned into the crossbar, with Andres Perea forcing home the rebound, ushering in scenes of celebrations as it would have sealed a post-season berth for Orlando.
That jubilation turned into frustration when the goal was later disallowed after referee Allen Chapman consulted the video, deeming Daryl Dike committed a foul on Alistair Johnston amid the goal-line scramble.
"It's a very sad day for the league," Orlando head coach Oscar Pareja said. "There is no explanation on a play that we saw evident. And it destroyed the joy of our people."
United States international Dike had earlier opened the scoring in the 18th minute, before Hany Mukhtar levelled it up for Nashville eight minutes into the second half.
Orlando – fifth in the Eastern Conference – can still reach the play-offs if they beat Montreal on the final day of the season on Sunday, while Nashville are third.
Philadelphia Union moved above Nashville into second in the east with their routine 2-0 home victory over struggling FC Cincinnati.
The Union are ahead of Nashville on goal difference only, with strikes from Daniel Gazdag and Paxten Aaronson securing the win.
Cincinnati are eight points adrift at the foot of the table and have lost 11 games in a row and 14 of their past 15, while they have only one win in their past 24 games.
Elsewhere, Minnesota United stayed firmly in the play-off hunt thanks to a 2-1 home win over Western Conference leaders Sporting Kansas City.
Dominique Badji's 58th-minute goal was enough for Colorado Rapids to edge Houston Dynamo 1-0, meaning they tied their club record for points in a season with 58.
The Galaxy, who were without Javier Hernandez due to injury and Jonathan dos Santos, Efrain Alvarez and Sebastian Lletget to Gold Cup call-ups, were brushed aside by Dallas who were last in the Western Conference prior to the game.
Pepi, who turned 18 in January, becomes the youngest player in MLS history to net a hat-trick.
The teenager netted twice in the first half before completed his treble with a low shot from the edge of the box in the 50th minute.
Substitute Jader Obrian added another in the 88th minute as Dallas moved up to 10th in the west, while the Galaxy are third but are winless in their past three.
Carlos Vela got on the scoresheet as LAFC came from two goals down to rescue a 2-2 home draw with struggling Vancouver Whitecaps.
Colombian pair Deiber Caicedo and Cristian Dajome had put the Whitecaps two-up inside the first 38 minutes, before Vela pulled one back in the 40th minute.
Diego Palacios provided the pass for fellow Ecuadorian Jose Cifuentes to level in the 75th minute.
Charles Sapong scored twice as Nashville SC moved up into second spot in the Eastern Conference with a 3-0 victory over Cincinnati.
Toronto maintained their good recent run with a 2-1 win at Chicago Fire, while Minnesota United scored twice in the final 20 minutes to win 2-1 over Portland Timbers.
San Jose Earthquakes drew 1-1 with Houston Dynamo and Real Salt Lake won 3-0 over Colorado Rapids.
A 2-1 victory over the Chicago Fire saw Philadelphia push three points clear of Toronto in the Eastern Conference, and for the Supporters' Shield, which they are bidding to win for the first time.
Kacper Przybylko opened the scoring from the penalty spot approaching the half-hour mark, following a handball in the area.
Chicago's chances of a comeback were dealt a blow nine minutes before half-time, Francisco Calvo sent off after a tackle on Alejandro Bedoya.
However, they managed to find an equaliser prior to the break as Robert Beric headed in from close range.
But Philadelphia scored what proved to be the winner in the 65th minute, when Cory Burke headed in a cross from Olivier Mbaizo.
According to Opta, Union became the first team to win their first eight home matches of an MLS season since San Jose in 2002, when the Earthquakes claimed their first 10.
The Timbers clinched a spot in the play-offs thanks to a 5-2 thrashing of the struggling LA Galaxy.
Jaroslaw Niezgoda scored a brace for Portland, who were 3-0 up after 30 minutes following Diego Valeri's penalty.
Eryk Williamson and Andy Polo also netted as the Timbers thrashed the Galaxy, who are bottom of the Western Conference.
Portland became the first team with multiple five-goal games against an opponent in a single MLS season since the Fire against the New York Red Bulls in 2008, having thrashed the Galaxy 6-3 earlier this month.
Chris Wondolowski scored a brace as the Earthquakes enjoyed a 2-0 win over Real Salt Lake.
It was his 24th multi-goal game in MLS. Only Landon Donovan (32) has more.
The New York Red Bulls left it late to edge the New England Revolution 1-0 and reach the play-offs, Sporting Kansas City overcame Cincinnati 1-0 and Orlando City thrashed Atlanta United 4-1.
New York City upset Toronto 1-0, Minnesota United beat the Colorado Rapids 2-1, DC United were too good for Columbus Crew 1-0, Dallas claimed a 2-1 win over Inter Miami and Los Angeles FC were 2-1 victors over the Houston Dynamo to clinch their play-off place.
Union scored first-half goals from Alejandro Bedoya and Daniel Gazdag, while Sergio Santos had a goal disallowed on the stroke of half-time, as Philadelphia got some revenge after last season's Eastern Conference final defeat to City.
Bedoya put Philadelphia ahead in the 12th minute, but City thought they had an avenue back into the game when referee Ted Unkel awarded them a penalty and sent off Jack Elliott for a 28th-minute last-man push on Santiago Rodriguez.
However, VAR intervened and determined that Rodriguez had illegally used his hand in the lead-up, meaning the penalty and red card were overturned.
The win was Philadephia's first at Yankee Stadium and came despite City bossing the possession count with 74 percent.
Former Liverpool and Bayern Munich attacker Xherdan Shaqiri netted his first MLS goal as Chicago Fire won 3-1 over Sporting KC.
Shaqiri scored from the spot in the 50th minute to make it 2-0 as Chicago extended its unbeaten start to the new season with Kacper Przybylko hitting a double.
Jesus Ferreira scored a first-half hat-trick as Dallas defeated Portland Timbers 4-1 in a sign of intent for the forward ahead of USA's upcoming World Cup qualifiers.
All three of Ferreira's goals came in a 10-minute span, marking his first-ever MLS hat-trick.
Gonzalo Higuain scored, but Inter Miami remain winless this term after a 3-1 loss away to last season's strugglers Cincinnati.
The result leaves Phil Neville's side with an MLS-worst record of one point from four games, having conceded 10 goals and only scored two.
Karol Swiderski netted a double as Charlotte upset New England Revolution 3-1, while Luis Amarilla's 32nd-minute strike lifted Western Conference leaders Minnesota United past San Jose Earthquakes 1-0.
Tyler Pasher's 90th minute goal salvaged a 1-1 home draw for Houston Dynamo against Colorado Rapids, while 10-man Atlanta United scored twice in the final five minutes to rescue a 3-3 draw with Montreal.
Facundo Torres' early goal got Orlando City past LA Galaxy 1-0, Bob Bradley's Toronto knocked off DC United 2-1 and Real Salt Lake edge 10-man Nashville 2-1.
Javier 'Chicharito' Hernandez scored twice for the Galaxy in a 3-3 draw with Minnesota United on Decision Day, but RSL's last-gasp 1-0 win over Sporting Kansas City changed the landscape of the Western Conference.
RSL pipped the Galaxy – without post-season football for the second straight campaign – to the seventh and final play-off spot on victories for the season via a 95th-minute winner, having finished level on 48 points at the end of 34 rounds.
Minnesota finished fifth to clinch a post-season berth in the west, along with sixth-placed Vancouver Whitecaps, who drew 1-1 against Seattle Sounders.
Seattle's stalemate and Sporting KC's late loss allowed Colorado Rapids to secure top seed in the Western Conference following a 5-2 rout of Los Angeles FC, who were eliminated as a result.
In the Eastern Conference, Orlando City beat Montreal 2-0 for a spot in the play-offs, along with Atlanta United (2-1 over FC Cincinnati) and New York Red Bulls – the latter using a 1-1 draw against Nashville to extend their post-season streak to 12 years.
Supporters' Shield winners New England Revolution lost 1-0 to already eliminated Inter Miami, Portland Timbers eased past lowly Austin 3-0, DC United defeated Toronto 3-1, 10-man New York City drew 1-1 with Philadelphia Union and reigning champions Columbus Crew – who will not defend their title – beat Chicago Fire 2-0.
Chris Wondolowski scored in the San Jose Earthquakes' 1-1 draw against Dallas before the league's all-time leading scorer announced his retirement.
A win for either side would have sealed their play-off fate, but the Red Bulls and Atlanta must wait until Sunday's Decision Day following the midweek stalemate.
Red Bulls forward Patryk Klimala came closest for either side, with his 48th-minute effort hitting the crossbar from Caden Clark's cross.
Four minutes later, Atlanta goalkeeper Brad Guzan denied Klimala from a one-on-one opportunity, while Clark had a goal disallowed for offside nine minutes into the second half.
In the Eastern Conference, the seventh-placed Red Bulls go to third-placed Nashville on Sunday, while Atlanta – fifth in the standings – visit bottom club FC Cincinnati.
Portland Timbers, fourth in the Western Conference, booked their play-off spot with a 3-1 win away to Real Salt Lake, sparked by Sebastian Blanco's brace.
RSL remain two points behind LA Galaxy in the final Western Conference play-off position and face Sporting Kansas City on Sunday.
Montreal stayed in the hunt courtesy of a 2-0 home win over Houston Dynamo, moving them up to eighth in the east, within one point of the Red Bulls.
Struggling Austin dented Sporting Kansas City's hopes of claiming top spot in the west with a 3-1 triumph
Sporting KC are second, a point behind Seattle Sounders heading into the final round of the regular season.
Fabio scored the 79th-minute winner, his second goal of the season, after Coronel had saved Mauricio Pereyra's penalty on the stroke of half-time.
Venezuelan midfielder Cristian Casseres fired in an excellent left-foot strike to open the scoring in the sixth minute but Orlando had a chance to level moments before half-time.
Uruguayan midfielder Pereyra shot low to Coronel's left but the Brazilian dived well and palmed away the spot-kick.
Pereyra partly made up for his miss, laying off the pass for Chris Mueller to equalize high into the back of the net in the 59th minute.
But Fabio held off a defender to fire home to secure the Red Bulls' first road win of the season, moving them up to seventh in the Eastern Conference.
DC United had seven different scorers as they trounced Toronto 7-1, keeping them ahead of the Red Bulls in sixth in the East.
Andy Najar, who did not score one of United's goals, set up two and was named Player of the Match.
Eastern Conference leaders New England Revolution blew a two-goal lead to draw 2-2 away to Columbus Crew.
Goals from Tajon Buchanan and Gustavo Bou had New England on the path to victory but Columbus fought back with Andrew Farrell's comical own goal levelling it up.
LAFC grabbed their maiden road win of the campaign, edging Real Salt Lake 1-0 after Jose Cifuentes' 69th-minute strike from Eddie Segura's pass.
Segura was the hero moments later with a diving goal-line clearance to deny Rubio Mendez's on-target lob.
Houston Dynamo and Cincinnati traded goals inside the opening five minutes in a 1-1 draw. Houston have drawn four games in a row.
Argentine forward Ignacio Aliseda scored twice as Chicago Fire claimed their second win of the season, triumphing 3-0 over Atlanta United.
Inter Miami's struggles continued with a 1-0 defeat away to Montreal. Miami have only managed eight points from 11 games, losing their past five.
Benjamin Kikanovic scored late to earn a 2-2 draw for struggling San Jose Earthquakes at Minnesota United. The Earthquakes are winless in eight.
Charles Sapong's second-minute goal was enough for Nashville to secure a 1-0 home win over fellow Eastern Conference contenders Philadelphia Union.
Clark – aged 17 years, four months and 18 days – became the youngest player to score in his first two MLS appearances on Wednesday, per Opta.
Hours after joining the Red Bulls, Clark capped his debut with a goal in Saturday's 1-0 win over Atlanta United.
Clark became the youngest player to score his maiden goal for the Red Bulls since Jozy Altidore in 2006.
He continued where he left off against Toronto, netting the equaliser with 13 minutes remaining midweek.
Following Alejandro Pozuelo's 23rd-minute penalty, Clark earned the visiting Red Bulls a point by firing a shot into the top corner of the net from outside the box.
The Red Bulls are seventh in the Eastern Conference, while Toronto – already play-off bound – remain top through 18 games.
Elsewhere, reigning Supporters' Shield holders Los Angeles FC and struggling LA Galaxy were beaten.
Lucas Cavallini's brace lifted Vancouver Whitecaps to a 2-1 victory against fourth-placed LAFC.
Canada international Cavallini has now scored in back-to-back games after finding the net just twice in his first 11 MLS matches for the Whitecaps, who climbed up to eighth in the standings and in the play-off positions.
As for the Western Conference's bottom side – the Galaxy – they were swept aside 4-0 by San Jose Earthquakes in the Cali Clasico.
Former Manchester United and Real Madrid striker Javier Hernandez was substituted early in the second half, with the Galaxy only managing four goals in the 652 minutes 'Chicharito' has been on the pitch this season.
It was a sixth consecutive defeat for the slumping Galaxy as the Earthquakes moved within a point of LAFC in the west.
Wednesday's scheduled Minnesota United-Chicago Fire fixture was postponed due to a suspected coronavirus case among Minnesota's team delegation.
In other results, New England Revolution edged Montreal Impact 3-2, FC Cincinnati were 2-1 winners over Columbus Crew, Orlando City and New York City drew 1-1, Atlanta saved a 1-1 draw at Inter Miami, Sporting Kansas City fell 1-0 to Dallas, DC United and Philadelphia Union shared the points in a four-goal clash, Real Salt Lake trumped Portland Timbers 2-1 and Nashville accounted for Houston Dynamo 3-1.
Thomas McNamara's goal in the 88th minute gave New England a 3-2 victory over New York City FC, just three minutes after Ismael Tajouri-Shradi had equalised for the home side.
Gustavo Bou and Jon Bell also found the net for the Revolution, who are five points clear of Orlando City in the Eastern Conference.
Out west, goals four minutes on either side of half-time from Yeimar Gomez and Raul Ruidiaz lifted unbeaten Seattle to a 2-1 win at LA Galaxy.
Orlando City got early goals from Tesho Akindele and Nani before Junior Urso netted in the 84th minute to defeat Toronto FC 3-2.
Columbus Crew got a brace from Gyasi Zardes to beat Chicago Fire 2-0, while Colorado Rapids won by the same scoreline at FC Cincinnati as Diego Rubio and Jonathan Lewis found the scoresheet.
Ola Kamara's 72nd-minute penalty was the difference for D.C. United in a 1-0 win over Inter Miami, who saw Gregore and Ryan Shawcross shown red cards.
Portland Timbers defeated Sporting Kansas City 2-1 on first-half goals from Dairon Asprilla and Marvin Loria.
Ricardo Pepi's 68th-minute equaliser gave FC Dallas a 1-1 draw with Minnesota United after Franco Fragapane had given the visitors a first-half lead, while Austin FC and San Jose Earthquakes finished in a 0-0 draw.
Houston Dynamo earned a point on the road in a 1-1 draw against Los Angeles FC as Maximiliano Urruti matched Jose Cifuentes' second-half goal.
Reynoso scored twice inside the opening 20 minutes to set up the triumph which lifts United up to sixth spot after they had suffered back-to-back defeats.
The Argentine fired in a low left-foot shot to open the scoring in the fourth minute before jinking inside and netting from similar range in the 20th minute to double the lead.
United goalkeeper Tyler Miller saved well to deny Dejan Joveljic prior to half-time, before Ethan Finlay got in behind the Galaxy defence from Franco Frangapane's pass to add a third in the 66th minute.
The result sees Minnesota move up to sixth in the Western Conference with 34 points, while Galaxy stay fourth but are winless from their past six games.
Runaway league leaders New England were held to a 1-1 home draw with Columbus Crew.
Polish attacker Adam Buksa netted a 62nd minute equalizer after US international Gyasi Zardes had put Crew ahead in the 58th minute.
Zardes had missed a gilt-edged header in the 22nd minute but he took his opportunity early in the second half from Harrison Afful's cross.
Buksa levelled, swooping on a poor Jonathan Mensah pass in defence, handing the Pole a sniff on goal which he converted with a left-foot shot.
An injured Eloy Room made two crucial late saves to deny Buksa a winner as the Crew held on.
Struggling Austin slumped to a fifth straight defeat after blowing a 3-1 second-half lead to lose 4-3 to San Jose Earthquakes.
The Earthquakes scored three goals in 14 second-half minutes to complete the comeback headlined by Javier Lopez's double.
New York City firmed up their grip on a playoffs spot after a 2-1 win away to Cincinnati who were reduced to nine men after red cards to Alvaro Barreal and Isaac Atanga.
Damir Kreilach's early second-half goal was enough to get Real Salt Lake past Seattle Sounders 1-0, while Houston Dynamo won 3-2 over Dallas in the Texas derby.
Lowly Toronto ended their six-game losing run with a shock 2-1 home win over Nashville, while Atlanta United secured their third straight triumph with a 3-2 victory over DC United.
Alan Pulido, Luis Martins and Daniel Salloi all scored within 16 minutes as KC raced to a 3-0 lead. Salloi's classy volley took his tally to nine goals this MLS season.
Israeli midfielder Gadi Kinda added a fourth in the 58th minute with Graham Zusi getting his second assist, before LAFC got a consolation from Danny Musovski.
The win lifted Sporting KC past Seattle Sounders who conceded in the 90th minute to draw 1-1 at home with Dallas.
Fredy Montero had put the Sounders ahead in the 72nd minute with a set-piece header but Dallas equalised from Franco Jara's 90th-minute close-range strike.
Sporting KC are ahead of Seattle on goal difference, with both sides having 33 points, although the leaders have a game in hand.
LA Galaxy are third following a 1-0 victory over Real Salt Lake, secured by Efrain Alvarez's cool 53rd-minute winner.
Eastern Conference leaders New England extended their unbeaten run to five games with a 0-0 draw against Nashville, who slip to fourth despite the result.
The draw also extends Nashville's undefeated streak to nine games.
Former England international Kieran Gibbs netted a 66th-minute equaliser to earn Inter Miami a 1-1 draw away to fellow Florida outfit Orlando City. The goal was Gibbs' first in the MLS.
Philadelphia Union ended their three-game winless run with a 3-0 victory over Toronto after three first-half strikes.
Ola Kamara and Yordy Reyna both netted doubles as DC United won 4-2 over Columbus Crew.
Tomas Pochettino scored a first-half brace as struggling Austin won 3-2 over Houston Dynamo.
Chicago Fire and 10-man New York City played out a goalless draw, while New York Red Bulls and Cincinnati also ended 0-0 and Portland Timbers drew 1-1 with San Jose Earthquakes.
