After winning 95 caps for Armenia, who have never qualified for a World Cup or European Championship, the former Manchester United and Arsenal midfielder will end his career in club football.
Mkhitaryan was captain of his country and a record goalscorer for the national team after netting 32 times.
He announced his retirement from the team on social media, writing a message that he titled, "Farewell my beloved national team".
The 33-year-old wrote: "I wanted to win every step of my career, no matter how difficult that would be. It was an honour to play for my nation for the past 15 years and even more so of an honour to captain it for the last six years.
"After 95 international caps, hard work, passion and unprecedented ups and downs along the journey representing my country on the field, I have taken the decision to retire from my international career with the Armenian national team.
"I came to this decision after my last game against Germany in November. I think it is the right time. I've given everything I can possibly give to my national team. For the coming years, I will therefore be fully focused on my club career.
"My soccer nest was woven in Armenia, my homeland, and I will forever be grateful to every single person who supported me, who coached me, who I played with and who contributed to my growth as a footballer and as a person."
Mkhitaryan is approaching the end of a one-year extension to his Roma contract and has performed well for head coach Mourinho.
He has started 24 Serie A games this season, with just two Roma players (Rui Patricio and Tammy Abraham) making Mourinho's starting XI more often. He has contributed five assists and three goals, with only Jordan Veretout and Lorenzo Pellegrini creating more than the 37 chances Mkhitaryan has teed up.
Italian newspaper Corriere dello Sport reported on Thursday that a deal to keep Mkhitaryan at the capital club is increasingly likely to be agreed at the end of the season.
It said there had been interest from Russian clubs Krasnodar and Spartak Moscow but that the possibility of either move has diminished amid the conflict involving Russia and Ukraine, with Mkhitaryan said to be happy about the prospect of an extended Serie A stay.
The LaLiga club appear set for a busy close season amid links to numerous players.
While Arsenal forward Pierre-Emerick Aubameyang is said to be a target, it seems Madrid have other priorities.
TOP STORY – HAALAND, MANE TOP TARGETS FOR REAL MADRID
Borussia Dortmund forward Haaland and Liverpool star Mane are Real Madrid's top targets, according to the Daily Express.
The report says Aubameyang is also wanted at the Santiago Bernabeu, but is behind Haaland and Mane.
Real Madrid were two points behind LaLiga leaders Barcelona when the season was suspended due to the coronavirus pandemic.
ROUND-UP
- Staying at Real Madrid and the LaLiga giants are tracking Sao Paulo midfielder Igor Gomes, according to AS. A Brazil youth international, Gomes, 21, has been compared to former AC Milan star Kaka.
- Ousmane Dembele is seemingly unwanted at Barcelona and could be set for a move. Sport reports Liverpool and Jurgen Klopp want Dembele, who has struggled with injuries since joining the LaLiga club.
- Barcelona are continuing their bid to land Lautaro Martinez. Sport claims left-back Junior Firpocould be part of a deal to bring the Inter star to Camp Nou. It says Inter, and Roma, are interested in the left-back and Barca would want the €18million they paid Real Betis for Junior last year.
- Manchester United could be set to make a big move this close season. The Daily Star reports the Premier League club are confident of landing Atletico Madrid midfielder Saul Niguez for a club-record £135m (€150.8m).
- Perhaps Manchester United had another target. However, Sport says Real Madrid have told United that midfielder Federico Valverde is worth his incredible release clause – £448m (€500m).
- Henrikh Mkhitaryan is loving life in Rome. The Daily Mail reports the midfielder, who is on loan at Roma from Arsenal, wants to stay at the club and hopes they can agree to a €11.2m (£10m) deal.
Werner, 24, was heavily linked with a move to Liverpool from RB Leipzig, but the coronavirus pandemic may have changed that.
Meanwhile, Dybala's future is set to be clear shortly.
TOP STORY – LIVERPOOL PUT WERNER PLANS ON HOLD
Liverpoolhave put their plans to sign Werner on hold and also stopped contract talks due to coronavirus, according to The Daily Mail.
There is uncertainty over the financial statuses of sporting clubs around the world due to coronavirus and Liverpool are waiting until there is greater clarity.
Star midfielder Georginio Wijnaldum and defender Dejan Lovren are among the Liverpool players out of contract in 2021.
One club seemingly not prepared to wait are Juventus, with CalcioMercato reporting Dybala is getting closer to a contract extension with the Serie A giants.
ROUND-UP
- Luka Modric is going nowhere. AS claims the midfielder will see out his contract, which runs until 2021, at Real Madrid. Just what Madrid's midfield looks like next season remains to be seen. Sport says Madrid will let James Rodriguez leave and bring Martin Odegaard back from his loan spell at Real Sociedad. It also reports Takefusa Kubo will be used as part of a deal to bring back Odegaard.
- Talk about a deal that would see Neymar return to Barcelona and Antoine Griezmann join Paris Saint-Germain remains alive. According to Sport, PSG would welcome Griezmann while they attempt to re-sign Kylian Mbappe to unite the France team-mates at club level.
- One player unlikely to be at PSG is Edinson Cavani. Tuttosport reports Napoliare thinking about bringing the forward, who is out of contract at the end of the season, back to the Stadio San Paolo.
- Marc-Andre ter Stegen's future remains unclear. Sport claims Barcelona and the goalkeeper are no closer to renewing a contract that will expire in 2022.
- Henrikh Mkhitaryan is seemingly happy on loan at Roma, but whether he stays remains to be seen. The Daily Express says Arsenal have rejected two bids – the last one around €11.4million (£10m) – from the Serie A club, who may instead turn to Chelsea's Pedro.
- As they plan a move for Borussia Dortmund star Jadon Sancho, Chelsea have told Willian he has no chance of getting a three-year deal, according to the Mirror. Willian is out of contract at the end of the season.
