Wyatt hit 75 and Nat Sciver-Brunt made 77, with the pair sharing a match-winning stand in an imposing total of 197 for six.
Sophie Ecclestone ensured their work did not go to waste, rounding out the result with figures of three for 15 on her comeback appearance after four months out with a shoulder injury.
Opener Wyatt began the match by becoming the first English cricketer to reach the cap landmark but soon found herself in a scrap at the Wankhede Stadium, losing two batting partners in the first over of the day and before she had even got off the mark.
Renuka Singh was responsible for her side’s fine start, bowling Sophia Dunkley via a deflection off the bat and then knocking over Alice Capsey for a golden duck as she took out off stump with a beauty.
Wyatt and Sciver-Brunt were unfazed by the double setback and proceeded to put on 138 off the next 87 balls.
Wyatt helped herself to eight fours and two sixes, the first a slog sweep off Deepti Sharma and the second a big swing over long-off charging debutant Shreyanka Patil.
Sciver-Brunt added 13 boundaries of her own as the scoreboard raced along but Wyatt’s 47-ball attack ended with five overs left as she was stumped off newcomer Saika Ishaque.
Captain Heather Knight fell cheaply and Sciver-Brunt was caught behind in the 19th but Amy Jones ensured an action-packed finish by scoring 23 off nine balls at the death.
Sciver-Brunt was back in the thick of things early in the chase, coming on for the third over and forcing an error from the dangerous Smriti Mandhana, who was bowled middle stump.
Shafali Verma collected a handful of fours as she kept India in touch with the required rate but when Freya Kemp had Jemima Rodrigues caught behind in the final powerplay over it was another big boost to the tourists’ cause.
India were relying on a big stand between Verma and Harmanpreet Kaur, the latter briefly looking in rude health before Ecclestone’s arrival spelled the end. The left-arm spinner had not played since dislocating her shoulder in August but needed just one sighter before bowling Kaur via an inside edge.
With five overs left India still needed 74, leaving England to mop up a clinical win as Ecclestone added the battling Verma (52) and Kanika Ahuja to her haul.
Propelled by Matthews’ 47-ball knock including nine fours and a six, Mumbai posted 161-6 from their 20 overs after being put in to bat by the Warriorz.
The Bajan received good support from Yastika Bhatia with 26 and Amelia Kerr with 23.
The Warriorz then needed only 16.3 overs to reach 163-3 and get their first win of the season.
Openers Alyssa Healy and Kiran Navgire all but killed any chance of a Mumbai victory with a rapid opening partnership of 94 in just 9.1 overs.
Navgire led the charge with a top score of 57 off 31 balls including six fours and four sixes. Healy was more measured in her approach, making a 29-ball 33 including five fours.
The finishing touches were put on by Grace Harris and Deepti Sharma who made 38* and 27*, respectively.
Harris’ innings came off just 17 deliveries and included six fours and a six while Sharma’s knock came off 20 balls and included four fours.
Pacer Issy Wong took 2-30 off three overs for the Indians.
The West Indies were restricted to 118-6 from their 20 overs, a total India overhauled getting to 119-4 from 18.1 overs.
Winning the toss and opting to bat, the West Indies, despite the early loss of Captain Hayley Matthews for two, laid a solid foundation for a competitive score in the Powerplay.
After losing Matthews to the bowling of Pooja Vastrakar with only four runs on the board, Stafanie Taylor and Shemaine Campbell shared in a second wicket partnership of 73 before disaster struck in the 14th over bowled by Deepti Sharma.
With her third ball, Sharma caught and short third-man for 30. Three balls later and one run later, Sharma struck again trapping Taylor lbw for 42.
The West Indies were in further trouble when Chinelle Henry was run out for two in the 15th.
From there the West Indies Women struggled to accelerate the scoring despite the efforts of Chedean Nation who scored an unbeaten 21 from 18 balls and Shabika Gajnabi’s 15 from 13.
Player of the Match Sharma would later bowl Afy Fletcher for a duck to finish the impressive figures of 3-15.
Rashada Williams was not out on two at the other end as the West Indies innings closed on 118-6.
Karishma Ramharck and Matthews tried to make a fight of it claiming the first three Indian wickets with 43 runs on the board in the eighth over.
Ramharack took the wickets of openers Shafali Verma for a 23-ball 28 with the score at 32 and Matthews got Jerimah Rodriquez caught and bowled for one to make it 35-2.
Ramharack then Smriti Mandhana stumped for 10 in the eighth over and India were 43-3.
However, by the 10th over India were scoring at better than six runs an over as Captain Harmanpreet Kaur and Richa Ghosh, helped by some wayward bowling, filled their boots with an stand of 72 that took India within four runs of victory.
Ghosh, unbeaten on 44, struck Shamilia Connell for the winning runs first ball of the 19 over for match to send the West Indies Women to their 15th consecutive defeat in T20 internationals and their eighth straight against India.
Ramharack was the best of the bowlers with 2-14 with Matthews taking 1-12 and Henry 1-21.
The Warriorz won the toss and elected to field first at the Dr DY Patil Sports Academy in Mumbai.
West Indies captain Hayley Matthews led the way with 35 while Issy Wong scored 32 and Mumbai Indians skipper Harmanpreet Kaur 25 as the Indians were bowled out for 127 in their 20 overs.
Sophie Ecclestone led the way with the ball for the Warriorz, taking 3-15 from her four overs while Rajeshwari Gayakwad and Deepti Sharma took 2-16 and 2-35 from their respective four over spells.
The successful chase was then led by Grace Harris’ 28-ball 39 while Talia McGrath got 38 as the Warriorz reached 129-5 in 19.3 overs to secure their third win out of six games to move to third in the table behind Mumbai, who lead the table only having one loss in six games, and Delhi who have two losses in their six outings.
Amelia Kerr was the best Mumbai bowler on the day with 2-22 from her four overs while Hayley Matthews, Nat Sciver-Brunt and Issy Wong all took a wicket each.
Scores: Mumbai Indians 127 off 20 overs (Hayley Matthews 35, Issy Wong 32, Harmanpreet Kaur 25, Sophie Ecclestone 3-15, Rajeshwari Gayakwad 2-16, Deepti Sharma 2-35)
UP Warriorz 129-5 off 19.3 overs (Grace Harris 39, Talia McGrath 38, Sophie Ecclestone 16*, Deepti Sharma 13*, Amelia Kerr 2-22).
