Fabregas, who played at club level for Arsenal, Barcelona, Chelsea, Monaco and Como, has stepped up from his role as the Italian outfit’s under-19 coach.
The 36-year-old finished his playing career with Como last season and will now take his first senior role in management.
Mirwan Suwarso, representative of the Como ownership group, said on the club’s Twitter account: “We thank Moreno Longo for all his hard work and dedication, especially after coming in following a difficult period last season.
“However, we would like to embark on a new path that hopefully will provide more excitement and entertainment for the fans in Como and beyond.
“We hope to make a new appointment for the head coach position in the near future. We thank the fans for understanding and their unwavering loyalty and support. As always, Forza Como.”
Como, who are sixth in the table, are not in action again until Saturday, November 25 when they face bottom-placed Feralpisalo.
The former Arsenal, Chelsea and Barcelona star confirmed the news via his Twitter account on Wednesday.
"She has overcome the virus at 95 years old. Yesterday, the test came out negative!" the tweet said.
"My great-grandmother is a super-heroine, but none of this would be possible without the help of all the nurses and doctors who are giving their lives at every moment so that all of us can be better and live a little better in such difficult times."
Fabregas went on to pay tribute to the staff at his great-grandmother's care home in Barcelona, adding: "All our respect. Nothing is impossible."
The 32-year-old has reportedly offered to defer his Monaco salary until July to help the club cope with the economic impact of the coronavirus pandemic.
On Tuesday, it was confirmed the 2019-20 Ligue 1 season will not restart as all major sport in France remains suspended until September.
Paris Saint-Germain were declared champions and Amiens and Toulouse were relegated after the season was called off last month, with most teams still having 10 games remaining.
As the Bundesliga prepares to restart on May 16 and the Premier League, Serie A and LaLiga try to resume, Fabregas believes the Ligue de Football Professionnel (LFP) could have waited before ending the season.
"It was a big decision that was made and I can understand why they took it," Spanish midfielder Fabregas told beIN SPORTS.
"But maybe it was taken a little too soon, considering a lot of the big league are still all trying to resume.
"Although I completely understand the meaning behind it and it's better to be safe in all accounts, because the most important is the families and the health security of everyone and support this 100 per cent.
"But maybe we could've considered individual training, where you have basically no risk. You're not touching anyone, you're not close to anyone. See if everyone was getting closer to football behind played all over the world.
"Obviously, it's very difficult and I understand someone needs to make decisions. We just have to do what they're telling us. Difficult moment in our professional lives and personal lives, but we just have to hold on and everything will be fine in the future for sure."
Monaco were ninth and nine points outside of the European qualification places when the season was called off.
The 35-year-old left Monaco at the end of his deal with the Ligue 1 outfit, having played just two league games last season due to injury, but insisted he was not about to retire.
The former Arsenal, Barcelona and Chelsea midfielder was presented to the media as a Como player on Monday and said he was looking forward to getting started in a league he believes to be a strong one.
"The quality of the championship is high, as is that of the relegated teams [from Serie A]," Fabregas said. "I can't wait to start, do well, play and win a lot. And then I would like to do some magic here in Como."
Como finished 13th in Serie B last season, but chief executive and Dennis Wise – another former Chelsea player – eventually hopes to get the club into the top flight, and he revealed Fabregas has also become a shareholder.
"Cesc will become a shareholder of the company, that's another reason why he came here," Wise said. "He will be here longer than expected.
"He wanted to join the club for our ambitions, to fix the stadium, open a new sports centre and get to Serie A."
Fabregas explained the conversations he held with Wise as well as club owners' representative Mirwan Suwarso and general and sporting manager Carlalberto Ludi that led him to accept a move to Italy.
"I have been extremely fortunate that my career has allowed me to play at the most wonderful clubs. Como is no exception," he said.
"After lengthy talks with Mirwan, Dennis and Charlie, they explained in detail one of the most exciting and ambitious projects in football.
"This is why I am looking to build a long-term future here, not just on the pitch but also off it, too. I believed in the vision from the first moment, and I have decided to invest personally to be part of the bigger picture.
"I cannot wait to get out on the pitch and play in front of the fans in such a beautiful setting. The tradition, infrastructure and desire that the owners have to take this club to the next level is inspiring. I cannot wait to start."
Fabregas, now 33 and playing for Monaco, has been one of European football's most recognisable midfielders since breaking into the Arsenal first-team as a 16-year-old in 2003.
His emergence as one of the world's best saw him switch back to Barcelona – whom he had represented as a child – in 2011 and he played under club icon Guardiola, winning six trophies across three seasons.
It was around this time that the Clasico divide with Real Madrid was arguably at its most vociferous in a generation, stoked by off-pitch – and occasional mid-match – barbs thrown by either Guardiola or his Los Blancos counterpart Mourinho.
But despite the fierce backdrop of the Clasicos of this era, which were said to have led to issues within the Spanish national team, Fabregas was ultimately lured away from Barca in 2014 by Mourinho and Chelsea.
"Mourinho was the one who inspired me the most to leave Barca," Fabregas explained to Tot Costa.
"He told me that we had them on the pitch when he was at Chelsea and I at Arsenal, and then when he was training for Real Madrid and I was at Barcelona, but for him it all ended there.
"He told me about his project. I prioritised the professional side, and today I continue to write with him and consider him a friend, he helped me a lot at the time and maybe with him I played one of my best seasons."
It is easy to see why Fabregas feels such a way – in his year and a half under Mourinho, who was sacked in December 2015, the Spaniard was highly influential and won the 2014-15 Premier League title.
He attempted more passes (3,832) than anyone else in the Premier League during this time, while his 3,238 completed passes was not matched by anyone.
On top of that, he also recorded a league-high 20 assists and 4,698 ball touches in this period, highlighting his importance.
Similarly, his 120 chances created was bettered by only three players.
But Fabregas' time working with Guardiola did not inspire the same kind of friendship despite previously idolising the former midfielder.
"With Guardiola, I have not spoken again," he said. "There are things that happened that I do not have to talk about.
"He was my idol in my childhood, perhaps he is the person from whom I have learned the most as a player, as an idol and later as a coach, but that's it."
France and Gunners legend Henry was confirmed as a shareholder of the ambitious club, owned by the Djarum Group, on Monday.
Ex-Spain midfielder Fabregas recently signed a two-year deal with the Italian side, while also becoming a shareholder in the club.
Henry said: "It is with great pleasure that I announce that I will join Como as a shareholder. I had been waiting for a long time to be involved in a project like that of Como.
"An ambitious club, but above all a club that lives my same values: not just a football team but a reality that helps the local community "
Como chief executive Dennis Wise, a former Chelsea midfielder, said: "It is a great pleasure for us to introduce Thierry Henry, our new shareholder, who doesn't really need many introductions in the world of football.
"After explaining to him our vision as a club within the community and our ambition to reach Serie A, Thierry has decided to join our journey and we are very happy to have him in Como."
