Rashford begs for rematch after exiting England's FIFA tournament to Sancho
Sancho prevailed 2-1 despite initially trailing to a goal created by the in-game version of the Borussia Dortmund winger, his cross finding Rashford, controlled by Rashford.
"Oh, Jadon Sancho to Marcus Rashford! Sanch is under pressure right now," Rashford laughed on camera. "Oh my lord, I know you're sweating."
However, Sancho equalised through Rashford himself and then netted a winner with Raheem Sterling.
"I threw the game away, man," Rashford moaned, before adding: "You know what? I'm going to play you again. I'm going to go back to the drawing board and play you later."
Sixteen players across England's senior men's and women's teams and the Under-21s are involved in a tournament designed to raise awareness for staying at home during the coronavirus pandemic.
In the competition - which also highlighted the National Emergencies Trust, a collection of community foundations that distributes money to charities - Tammy Abraham, James Maddison, Todd Cantwell and Lucy Bronze were among the others to also advance to the quarter-finals.
Abraham was helped by a hat-trick from Rashford as he defeated Chelsea colleague Callum Hudson-Odoi 5-2.
Meanwhile, Maddison scored as himself in a come-from-behind 3-2 victory over Callum Wilson that was sealed with a winner from Harry Kane.
"Look who it is! The dangerman," Maddison cried after finding the net with his computerised self.
Cantwell won the battle of the midfielders against Mason Mount, with substitute Rashford scoring a hat-trick in a 5-0 win after the Norwich City man brought him off the bench.
Mount had threatened to quit if Cantwell scored with the virtual version of the Chelsea midfielder, though he vowed to retire from the game after the drubbing.
"Go and win this and I won't feel bad," he told Cantwell.
Cantwell's club team-mate Max Aarons had his own hat-trick hero as Maddison grabbed all the goals in the 3-1 victory over Trent Alexander-Arnold's England.
Elsewhere, Ryan Sessegnon won 3-1 against Reiss Nelson, who was in disbelief that it was only a one-game series, while a golden goal earned Bronze a victory over Ellie Roebuck.
Bronze is the only female representative in the last eight after Eddie Nketiah saw off fellow Arsenal star Jordan Nobbs, setting up a meeting with Sancho.