Clark, the first overall pick in this year's draft, has already set a number of benchmarks in her rookie WNBA season.
And that continued on Saturday even as the Fever lost 90-80 to the Minnesota Lynx.
Clark finished with 23 points and eight assists, and in doing so improved her seasonal tally to 520 points and 240 assists.
She is now the youngest player in WNBA history to pass 500 points and 200 assists.
Clark had already set a new record for assists in a rookie WNBA season, with her performances keeping the Fever on course for the playoffs.
The 22-year-old is stepping up to the professional league as the most successful college player in history, which has made her the new star of the sport.
She joins last year’s first pick Aliyah Boston – a former team-mate of hers in the United States Under-19s – at the Fever as the club try to revive their fortunes after again failing to reach the play-offs in 2023.
Clark said on the WNBA website: “I dreamed of this moment since I was in second grade, and it’s taken a lot of hard work, a lot of ups and downs, but more than anything, just trying to soak it in.
“Obviously going to an organisation that has, in my eyes, one of the best post players (Boston) in the entire world.
“My point guard eyes just light up at that. And obviously, Aliyah has been one of my team-mates before. I’m excited. I can’t wait.”
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Fever head coach Christie Sides said on the club’s website: “Caitlin is one of the most naturally gifted basketball players I have ever seen enter the WNBA from the college level.
“Her shooting and passing abilities captivated an entire audience of basketball fans, and her ability to make those around her better was even more evident during her collegiate career.
“We can’t wait to bring her to Indiana and incorporate her into our locker room with a group ready to get back to the postseason.”
Clark’s Fever career kicks-off in the WNBA opener against the Connecticut Sun on May 14.
