A new era will start for both South Africa and West Indies when Aiden Markram and Rovman Powell lead the sides in the opening Twenty20 International match of the series on Saturday.
Markram this month replaced Temba Bavuma as captain, with the Test and one-day international skipper axed from the T20I squad.
The opener at SuperSport Park will also be the first T20I since Rob Walter took over as white-ball head coach and comes on the back of a 1-1 ODI series draw with the Windies.
Markram was given the honour of captaining his country in only his third ODI back in 2018, when Faf du Plessis was absent along with other senior players.
The batter felt that opportunity came too soon and believes the experience he has gained since then should stand him in good stead.
He said: "I was quite fresh back then. I was very hard on myself, and always wanted to do well and we know this sport, it doesn't always work out that way."
Markram added: "Being with the legendary team the Proteas had at the time, I paid attention to how Faf managed to marshal his troops.
"That is something I looked up to and strived for probably without him knowing, it was just through me observing from the side."
It will also be a special weekend for Powell in Centurion, where there will be a double-header before the series ends with a contest at JB Marks Oval Potchefstroom on Tuesday.
Powell was selected as the man to replace Nicholas Pooran, who stepped down after the T20 World Cup in Australia last November.
South Africa will be looking to take the momentum from a record-breaking series-levelling ODI win over the Windies in which Heinrich Klaasen was the star of the show.
Klaasen struck 119 off 61 balls as the Proteas chased down their victory target of 261 in just 29.3 overs in Potchefstroom, becoming the first team to score 250 or more to win in under 30 overs.
De Kock set to move level with De Villiers
Wicketkeeper-batter Quinton de Kock is set to go joint-third on the list of the highest appearance-makers for the Proteas in T20Is, as he is currently one behind AB de Villiers' tally of 78.
De Kock has enjoyed facing West Indies in the shortest format, scoring half-centuries in each of his past three knocks.
Windies away form must be addressed
West Indies have won only one of their past 15 T20Is on tour, that coming against Zimbabwe last October.
Facing South Africa could present a good opportunity to address that poor record, as the Proteas have lost four multi-game bilateral T20I series at home – that is their longest losing run in this format.