Copious injuries, late positive COVID-19 tests and a suspension; a highly anticipated clash between Serie A leaders Milan and defending champions Juventus at San Siro on Wednesday threatened to seriously underwhelm.

There was no Alvaro Morata for the Juve, while full-backs Alex Sandro and Juan Cuadrado were forced to sit out after returning positive coronavirus results.

Milan were without star striker Zlatan Ibrahimovic and their midfield was decimated by the absences of Sandro Tonali (suspension), Ismael Bennacer (injury) and Rade Krunic (coronavirus). The dire situation forced Stefano Pioli to start right-back Davide Calabria alongside Franck Kessie in the central pivot.

Yet despite the difficulties faced by both teams, a thriller was served up in Milan, and Federico Chiesa took centre stage as Milan's unbeaten streak in Serie A was ended at 27 by a 3-1 loss to Juve.

ACT ONE

The last time Milan held a superior position to Juve heading into a meeting of the sides was in November 2015, and on that occasion the Bianconeri emerged triumphant thanks to a goal from Paulo Dybala.

While the Argentina international, who has been struggling for consistency and dealing with a fever, was not the man to open the scoring on this occasion, he still played a pivotal role.

After drifting across the pitch to offer support to Chiesa, he held up a pass from the winger before returning it by dragging the ball back behind his standing leg and flicking it around Alessio Romagnoli.

It was weighted perfectly for Chiesa's dart into the box, which was not tracked adequately by Theo Hernandez, and he drilled a shot across Gianluigi Donnarumma into the bottom-left corner.

ACT TWO

A thoroughly entertaining first half saw Juve control possession but Milan get more shots away. There were 21 in total during the opening 45 minutes, 12 for the Rossoneri and nine for Juve, a number only two Serie A games this season have exceeded (Sassuolo v Cagliari – 22, Cagliari v Napoli – 23).

Wojciech Szczesny kept out Samu Castillejo, Rafael Leao and Hakan Calhanoglu, as well as stopping Aaron Ramsey from scoring what would have been an incredible own goal, before he was finally beaten by the unlikely source of Calabria.

Juve did not appear happy the goal was allowed to stand, with Calhanoglu putting in a contentious challenge on Adrien Rabiot to launch the counter-attack from which Leao fed Calabria to guide a fine finish into the top-right corner.

It ensured Milan found the back of the net for a 36th consecutive Serie A game – a run only bettered by Juve (43 in 2014 and 44 in 2017) – with Leao involved in an eighth goal in 12 league appearances this season, one more than he managed across the entirety of the previous campaign.

ACT THREE

Unsurprisingly the game was far less open after the interval, but Chiesa was able to separate the teams once more.

Again it was Dybala leading the supporting cast, spotting his team-mate in space on the right and drilling a pass across for him to attack Hernandez once more.

Just as in the first half, Chiesa's feet proved too quick as he shifted the ball to his left and threaded a curling shot between Hernandez and Romagnoli and into the bottom-left corner. It was his sixth goal involvement (three scored, three assisted) against Milan in Serie A, which is more than he has managed against any other side.

The 23-year-old is proving himself to be a man for the big occasion. Since the start of last season, he has been thoroughly impressive against the best teams in the league. In that time, he has had a hand in three goals against Milan (two scored, one assisted) and Atalanta (two scored, one assisted) and also scored in meetings with Inter, Napoli and Lazio.

THE UNDERSTUDIES

While Cristiano Ronaldo was arguably the quietest of Juve's forward-thinking players, Chiesa made way for Dejan Kulusevski a minute after his goal, as Weston McKennie entered for Dybala.

The pair combined to put the game to bed in the 76th minute, McKennie sweeping in after a fine run down the right from Kulusevski.

The sole consolation for the Rossoneri was that they remained top of the league due to Inter's defeat to Sampdoria earlier on Tuesday, but Chiesa's blockbuster display proved Juve will not be content with solely being extras in the title race this season.

Lionel Messi scored twice as Barcelona ruined Marcelino's first match in charge of Athletic Bilbao with a hard-fought 3-2 triumph at San Mames.

Inaki Williams made an instant impression on Athletic's new boss - appointed following the dismissal of Gaizka Garitano - by scoring inside three minutes for the home team on Wednesday.

Capitalising on a ridiculously high defensive line, the forward ran clear from inside his own half and, after cutting back inside a half-hearted challenge from Clement Lenglet, fired low past Marc-Andre ter Stegen to break the deadlock. 

However, with Messi leading the way, Barca recovered from the setback to turn the game around by the interval, albeit with some help from the hosts.

Unai Simon was tempted out to deal with Messi's seemingly over-hit cross for the equaliser, the alert Frenkie de Jong stretching out to volley the ball back into the middle for Pedri to nod into an unguarded net. 

The Athletic goalkeeper was caught again when his side conceded seven minutes before the break, Pedri the provider as his clever back-heeled assist set up the supporting Messi to pass the ball in, Simon - who had initially rushed out expecting the teenager to shoot - stranded out of position.

Athletic briefly threatened a recovery of their own early in the second half, yet it was always their opponents who carried the far greater threat in attack.

Having seen a goal ruled out for offside and a long-range shot denied by a post, Messi finally scored again when sweeping Antoine Griezmann's square pass home via the underside of the crossbar.

There was late drama when a turnover in possession allowed Alex Berenguer to tee up Iker Muniain for a first-time finish that cut the gap in the 90th minute, but Barca held firm to claim all three points.

Federico Chiesa scored a brilliant brace as Juventus ended Milan's unbeaten start to the season and clinched a crucial 3-1 victory that moves the Serie A champions up to fourth in the table.

Andrea Pirlo's men produced a scintillating attacking display to become the first team to beat leaders Milan in the league in 28 matches and did so without leading scorer Alvaro Morata.

Ably assisted by Paulo Dybala on both occasions, Chiesa scored with confident finishes in either half and Milan's waves of attacking pressure found Juventus goalkeeper Wojciech Szczesny in fine form before Davide Calabria found the net.

The Bianconeri, who added a third through substitute Weston McKennie, will hope this was a turning point in a tumultuous season, having played with the guile and poise they have lacked for so much of it, while Milan will reflect on a missed opportunity to extend their lead at the top to four points after Inter lost to Sampdoria.

Juventus' high press overwhelmed Milan early on and Paulo Dybala tested Gianluigi Donnarumma from six yards before Chiesa crashed a thunderous shot onto the post.

With 18 minutes played the Old Lady's superb start paid dividends, Dybala's smart back-heel sending Chiesa into the area and the Fiorentina loanee sent a low shot bouncing into the far corner of Donnarumma's net from 12 yards.

Juve had Szczesny to thank for keeping them ahead with a string of saves but he was powerless to stop Calabria's shot from finding the top corner after the lively Rafael Leao teed him up – although Juventus claimed Adrien Rabiot was fouled in the build-up.

Szczesny got down well to save Diogo Dalot's powerful 20-yard shot as Milan came out firing after the interval but Juve weathered the storm before Aaron Ramsey missed a golden chance to give them the lead, shooting wide from close range with just Donnarumma to beat.

Just after the hour mark, Chiesa struck again, Dybala picking him out on the edge of the box where he bent a superb left-footed shot into the far corner.

Chiesa then left the field with an injury and was replaced by McKennie, who swept home Juventus' third in the 76th minute after a jinking run through Milan's defence by fellow substitute Dejan Kulusevski.

What does it mean? The fightback is on

Juventus have now won three of their last four Serie A matches and are playing with real verve.

Having had such a short pre-season with his side, Pirlo has been playing catch-up but his expansive, fast-attacking style of play seems to be finally bearing fruit as his players cut out defensive errors.

Dybala at his best

Dybala's two assists were as incisive and spectacular as Chiesa's finishes and the Argentina international also won six duels to help Juventus stay on top.

Leao rues missed chances

Milan could have been ahead at half-time had Leao made more of the clear-cut chances that fell to him and, despite his assist for Calabria's goal, he will remember this game for his three unsuccessful shots at goal.

Key Opta Facts

- Juventus have won 14 of their last 16 Serie A games against AC Milan (L2).
- AC Milan are enjoying the third-longest streak of Serie A consecutive matches with a goal: 36. In the history of the competition, the only two longer streaks have both been by Juventus: 43 in 2014 and 44 in 2017.
- Federico Chiesa has been involved in six Serie A goals against AC Milan (3 goals, 3 assists).
- Prior to Wednesday, the last time a player twice assisted the same Juve team-mate was in February 2018 against Sassuolo (Federico Bernardeschi to Gonzalo Higuain).

What's next?

Milan are at home against struggling Torino on Saturday, and Juventus entertain in-form Sassuolo a day later.

Paris Saint-Germain failed to get off to a winning start under Mauricio Pochettino as they were held to a 1-1 draw by Saint-Etienne in Ligue 1.

Thomas Tuchel oversaw a 4-0 defeat of Strasbourg in PSG's final game of 2020, although it was not enough for the German to keep his job as the defending champions sat third.

And Pochettino was unable to mastermind a victory to kickstart his reign as a rather lethargic PSG struggled to build on Moise Kean's 22nd-minute equaliser.

That goal cancelled out Romain Hamouma's opener, but PSG were ultimately fortunate Saint-Etienne did not snatch a first win over the capital club since 2012, their point enough to move second but three points behind Lyon.

Both goalkeepers were called into action inside the opening 10 minutes as Keylor Navas denied Harold Moukoudi at one end before Moise Kean tested Jessy Moulin at the other.

Yet Pochettino's tenure had its first setback 19 minutes in when PSG played themselves into trouble, Idrissa Gueye's slip pounced on by Denis Bouanga, with Hamouma supplying a neat finish over Navas.

PSG hit back inside three minutes, however, as Marco Verratti played in Kean to slam in the first goal of the Pochettino era on the turn.

Mathieu Debuchy's low strike forced Navas into a smart stop before half-time, and PSG's goalkeeper came to their rescue again in the second period, blocking Bouanga's path to goal.

Navas was beaten with 20 minutes remaining, but the crossbar kept out Bouanga's header.

Kean snatched at a good chance as PSG sparked back into life, yet Angel Di Maria's low strike – well saved by Moulin – was the only shot on target the visitors managed in the second half as Pochettino was forced to settle for a point.

John Stones ended his long goal drought as holders Manchester City secured a 2-0 derby win over Manchester United to set up an EFL Cup final showdown with Tottenham.

Stones has been outstanding at the heart of the City defence since forcing his way back into the side this season and he scored his first City goal in 1,162 days at Old Trafford on Wednesday.

The in-form centre-back had earlier put the ball in his own net early on but Marcus Rashford was offside, summing up how his fortunes have changed.

United were unable to respond following Stones' goal early in the second half and Fernandinho doubled City's lead seven minutes from time with an excellent finish.

Pep Guardiola's side were worthy winners, dumping their neighbours out at the same stage they did 12 months ago as they aim to win the competition for a fourth consecutive season.

Diego Simeone hinted at the idea he could leave Atletico Madrid at the end of the season after their awful Copa del Rey defeat to third-tier Cornella.

Simeone's LaLiga leaders exited the Copa on Wednesday, losing 1-0 to a goal from former Atletico B defender Adrian Jimenez.

Ricard Sanchez was sent off as Atleti slumped to a shock reverse swiftly described by the Spanish media as a "disaster" among the very worst of Simeone's 502 games in charge of the club.

The long-time coach named a strong side, including record signing Joao Felix, but saw his team remarkably unable to register a single shot on target.

Copa failings are a familiar story by now, though, with the Rojiblancos losing to Cultural Leonesa last season. Meanwhile, they have not beaten a fellow LaLiga outfit in the competition since seeing off Elche in January 2017.

Simeone recognised Atleti are struggling in one-off knockout matches - also losing in last season's Champions League to RB Leipzig - but added the surprising qualifier that it would be an issue to consider only if he was still at the helm next year.

"[Cornella] played better," he said. "In the whole game, what they wanted was always done better than what we wanted.

"They took advantage of the set-piece situations and immediately found the goal.

"The boys tried to compete in the best way. In the first half, we had more chances, and in the second, it was rockier. It got difficult after the red card.

"This competition has not given us satisfaction in recent years but solutions will have to be found if we are here next year."

Saul Niguez, captain on the night, identified the same problem as he added: "We apologise to the fans. We never throw away competitions, but in these single-game editions we are not doing well."

Given Atleti's struggles, the decision to replace Joao Felix with 18-year-old debutant Mario Soriano 15 minutes from time prompted some discussion.

But the Portugal international mustered only one shot, which was blocked, prior to his withdrawal and failed to create a single chance - unlike his replacement.

Joao Felix epitomised the visitors' display as he completed just 13 of his 21 attempted passes and lost possession 13 times, winning none of his three aerial duels.

The change still appeared a big call, yet Simeone explained his star forward was struggling with an ankle injury.

"He was hurt," Simeone said. "We looked for a fresher guy. He had a bruised ankle and we wanted to find a guy in good condition."

Sampdoria coach Claudio Ranieri insists Fabio Quagliarella did not feature against Inter for tactical reasons, despite reports linking the striker with a stunning return to Juventus. 

Quagliarella previously spent four years with Juve, initially joining on loan before making his switch permanent, and won the Serie A title for three successive seasons under Antonio Conte. 

The 37-year-old is rumoured to be a potential target for the reigning champions as they look to strengthen their forward options for the second half of the 2020-21 campaign. 

Ranieri kept the veteran frontman on the bench for the entirety of Wednesday's 2-1 home win over Inter, yet insisted afterwards it had nothing to do with speculation over the player's future at the club.

"The fact that he did not enter has nothing to do with the transfer market, it was a technical choice," Ranieri explained to Sky Sport Italia. 

The evergreen Quagliarella has scored seven goals in 14 Serie A appearances this season for Samp, boasting a conversion rate of 25 per cent.  

Cristiano Ronaldo is the competition's top scorer but Juve want to provide support for the Portuguese.

They have also been linked with another experienced forward in Olivier Giroud, who could be on the move in the January window due to a lack of playing time at Chelsea. 

"We could use him," Juve head coach Andrea Pirlo told DAZN after a 4-1 win over Udinese at the weekend. "But these are things that [Juventus sporting director Fabio] Paratici knows better than me.  

"We talked about it but let's see if we will do something in the next few days." 

Atletico Madrid were the victims of a Copa del Rey giant-killing for a second successive season as Diego Simeone's side went down 1-0 to Cornella.

LaLiga leaders Atleti lost 2-1 to Cultural Leonesa in the round of 32 last season, and slumped out to Segunda B opposition on Wednesday.

The 10-time Copa winners fell behind to Adrian Jimenez's sensational flick seven minutes into the second-round tie in Catalonia.

Saul Niguez hit the woodwork and Lucas Torreira went close with a free-kick, but Ricard Sanchez's second booking compounded Atleti's issues as minnows Cornella claimed a famous triumph.

Sanchez was fortunate not to concede a penalty for handball in the opening minutes, before Jose Gimenez, making his 200th Atleti appearance, scythed down Raul Prieto.

With Gimenez, who was booked for his troubles, off the pitch receiving treatment, Cornella added insult to injury, with Agus Medina's cross flicked home expertly by Jimenez.

Atleti seemed set to restore parity shortly after the 20-minute mark, yet Angel Correa saw two efforts blocked either side of Saul hitting the crossbar.

Though Atleti were seeing over 60 per cent possession, they would have been 2-0 down heading into the break if not for Miguel San Roman's save from Pablo Fernandez.

Vitolo got in behind Cornella's backline early in the second half, only for an errant offside flag to deny him a chance to equalise.

Torreira's curling free-kick was inches away from levelling proceedings, though Atleti were then fortunate that Eloy Gila flicked over from close range at the other end.

Sanchez's frustrating night was made worse when he was deemed to have kicked out at Cornella goalkeeper Ramon Juan – the full-back seeing red just 11 minutes after receiving his first booking as Atleti's comeback efforts proved futile. 

Antonio Conte felt Inter were hard done by as their Scudetto ambitions suffered a blow with a 2-1 defeat at Sampdoria. 

Alexis Sanchez missed a first-half penalty before Antonio Candreva converted from the spot for the hosts at the Stadio Luigi Ferraris. 

Keita Balde doubled Sampdoria's advantage in the 38th minute and, although Stefan de Vrij reduced the deficit and Romelu Lukaku - short of match fitness - came off the bench, Inter were unable to pull level. 

Milan host champions Juventus in a mouth-watering San Siro clash later on Wednesday, where victory would increase the Rossoneri's advantage over Inter at the summit to four points. 

The result halted an 11-match unbeaten run for Conte's men and he refused to be too harsh on his players after they failed to overcome a chastening first half. 

"We found ourselves going from the missed penalty to having a penalty against us. There was this one-two from Sampdoria that clearly created some difficulties for us," he told reporters. 

"At the same time, the team was doing well, in the first few minutes they created a lot of scoring situations. Sometimes you lose games you deserve to lose, other times there are situations where you can score and you don't." 

Despite those missed chances and struggles in attack for Lautaro Martinez, Conte refused to blame Lukaku's recuperation from a thigh strain for Inter falling short.

"It wasn't the first time we played without Romelu, we know that he is a player with certain qualities, but he wasn't 100 per cent and you saw it when he came on," he said. 

"Sorry because I think we deserved something more." 

Christian Eriksen was also introduced from the bench, despite being told he can leave Inter this month. 

"I always try to exploit the players according to the situations that arise and I am at the club's complete disposal on every decision," Conte explained. 

"I get to work, as I have always done since I have been at Inter, but every decision will always be shared." 

Inter return to action with a crunch clash against third-placed Roma on Sunday.

Pele has denied changing his Instagram bio after Cristiano Ronaldo overtook his haul of 757 goals in official competitions.

Five-time Ballon d'Or winner Ronaldo moved on to 758 career goals with a double in Juventus' 4-1 victory over Udinese on Saturday.

It came just two weeks after Brazil great Pele, a three-time World Cup winner, saw his record for the most goals with a single club - 643 at Santos - surpassed by Barcelona captain Lionel Messi.

Following Ronaldo's goals against Udinese, Pele was accused of updating his Instagram bio to include "Leading Goal Scorer of All Time (1,283)", a total that remains the subject of much debate.

However, the 80-year-old has refuted the allegation, insisting he is not trying to detract from the achievements of Ronaldo and Messi.

"I was accused by the press of having changed my Instagram bio to overshadow these big stars that are breaking my records," Pele posted on Twitter.

"The bio text has always been the same since I joined the platform. None of this should distract us from their incredible achievements."

Only Czech striker Josef Bican, who is credited with scoring 805 goals, lies ahead of Ronaldo in the all-time goalscoring list.

After Messi scored his 644th goal for Barcelona, Santos published an article on their official website – attributed to club historian Fernando Ribeiro – with the headline, 'King Pele – 1,091 goals for Santos FC'.

Ribeiro claimed that Pele's official haul for Santos was 1,091 when friendlies against some of the world's best teams, including Barca and Inter, were included.

The PFA has urged its members to remember the "vital importance" of following coronavirus and club protocols as the United Kingdom enters a third period of national lockdown.

On Monday, the UK government confirmed England would be placed under strict restrictions as COVID-19 infection rates and deaths continue to rise.

Though vaccines are starting to be rolled out to vulnerable groups, the UK recorded 62,322 new cases and 1,041 deaths on Wednesday.

On Tuesday, the Premier League confirmed that 40 players and staff members – a new high – had tested positive for the virus over the most recent two rounds of testing, up from 18 the previous week.

Three matches in England's top flight were postponed over the festive period, while a number of EFL games have also been unable to take place.

With elite sport allowed to continue despite the new lockdown regulations, the Premier League has insisted it has full faith in its protocols, while the EFL announced on Wednesday it would introduce a twice-weekly testing regime, starting from January 11.

However, amid the rise in cases and deaths, there have been high-profile examples of players breaking coronavirus rules over recent weeks.

Manchester City, who have been hit by an outbreak within their squad, launched an investigation into reports of Benjamin Mendy hosting a party on New Year's Eve that included guests from outside his household.

Meanwhile, Tottenham head coach Jose Mourinho was disappointed to learn of a Christmas gathering which saw Sergio Reguilon, Erik Lamela and Giovani Lo Celso breach regulations, with West Ham's Manuel Lanzini also in attendance.

The PFA has released a statement, which read: "Following the announcement of a third national lockdown, the PFA would like to reinforce the message that players must follow the current COVID-19 rules and club protocols as a matter of vital importance.

"In a close-knit football environment, the ramifications of any rule breaches are potentially hugely damaging for fellow players, clubs and the game as a whole.

"It is a testament to the hard work of everyone involved that the vast majority of matches have gone ahead as scheduled and the risks to players, staff and their families have been well managed and kept to a minimum.

"Although prospects are brighter due to the vaccine's imminent rollout, players must continue to take the lead and act responsibly and professionally.

"Between now and the end of the season, we ask that you continue to take personal responsibility and follow the lockdown rules, without exception.

"Throughout the pandemic, we have seen that players have a unique position to inspire and influence society positively.

"Your compliance with the national restrictions sets the right example to millions of fans and young people. Following the rules is also the best way to protect your loved ones, your colleagues and their families from harm."

Lionel Messi is the only player who can ensure Barcelona's value, according to presidential candidate Lluis Fernandez.

Messi wanted to leave Barca last year, due to frustration with the club's board and then-president Josep Maria Bartomeu.

The six-time Ballon d'Or winner ultimately elected to stay and see out his contract, which runs out at the end of the season, before Bartomeu and the entire Barca board resigned in October.

There has been talk that Messi may choose to remain at the club he has been at since 2001, having helped them to 10 LaLiga titles and four Champions Leagues.

However, Messi, who marked his 500th LaLiga appearance by teeing up Frenkie de Jong's winner against Huesca last time out, will not make a decision until towards the end of the season – something Barca coach Ronald Koeman insists is not a problem.

With the presidential elections coming up on January 24, each candidate is outlining their vision for the future of the club, and Fernandez has vowed to do all he can to keep Messi at Camp Nou, outlining the financial benefits of retaining the 33-year-old.

"We can't forget that Barcelona have a greater income because of Messi," he told Radio Marca. "Barcelona would have less value without Messi.

"He is the only player in the squad who, by his mere presence, ensures Barcelona have more value and more income.

"We need income, but we also need to manage the club's structure. There's a need to negotiate the debt.

"But, there's no danger of Barcelona being forced to become a limited company. The members can rest assured about that."

Fernandez also wants the club to return to its roots and promote more players from its famed La Masia academy.

Ansu Fati is the most recent prodigy off Barca's production line and, should he win the election, Fernandez will speak to Koeman about the importance of giving youth a chance.

"We agree that Ronald Koeman should be given a chance," Fernandez added. "We need to speak with him because there's a need to give opportunities to the players from the academy.

"No starter has come out of La Masia since 2011, when Sergi Roberto did so. So, there's a need to speak to Koeman about this and about giving opportunities.

"From next year, we need to promote young players, as we won't be able to sign as much and we'll need to reduce the wage bill."

Antonio Candreva and Keita Balde were on target against their former club as Inter's eight-match winning run in Serie A ground to a halt in a 2-1 defeat at Sampdoria.

The Nerazzurri were aiming to go top, at least temporarily, and Alexis Sanchez saw an early penalty saved at the Luigi Ferraris.

Another VAR check led to Candreva opening the scoring from the spot and Keita – on loan at Sampdoria from Monaco – doubled the hosts' lead in an enthralling first half.

Stefan de Vrij finally headed wasteful Inter onto the scoreboard after 65 minutes, but Antonio Conte's side failed to find and a leveller and remain second, one point adrift of Milan.

In a breathless opening, Emil Audero foiled Ashley Young's whipped shot and Milan Skriniar skewed wide from the same corner that saw Morten Thorsby pinged for handball after VAR's intervention.

Audero kept out Sanchez's penalty and Young smashed the rebound against the post, while Lorenzo Tonelli's looping header for Sampdoria hit the crossbar soon after.

Candreva succeeded where Sanchez failed after 23 minutes, firing into the left of the goal after VAR spotted Nicolo Barella had handled a Tonelli header.

Things worsened for Inter when Keita swept home Mikkel Damsgaard's low right-wing centre seven minutes before the break.

Sanchez was denied by Audero again and Lautaro Martinez wastefully headed wide, before the former followed suit in similar style after the break.

Inter finally responded when De Vrij headed home Marcelo Brozovic's corner with 25 minutes left and substitute Romelu Lukaku saw a powerful downward header brilliantly stopped by Audero.

Ivan Perisic was twice off target with headers either side of Martinez testing Audero at his near post but Inter were frustrated in their endeavours.

Milan pair Ante Rebic and Rade Krunic have tested positive for coronavirus ahead of Wednesday's Serie A meeting with Juventus.

Both players are asymptomatic and have begun a period of self-isolation at home, Milan confirmed on their official website.

The news comes on the back of Juve announcing that full-backs Alex Sandro and Juan Cuadrado had contracted COVID-19, also ruling them out of the crunch clash at San Siro.

Rebic has featured 14 times for Milan in all competitions this season, while Krunic has been used on 20 occasions.

The pair have appeared together in eight Serie A matches this season, Milan winning each of those games. On the seven occasions they have not featured, meanwhile, the Rossoneri's win rate drops from 100 per cent to 43.

Serie A leaders Milan are already without injured quartet Zlatan Ibrahimovic, Alexis Saelemaekers, Ismael Bennacer and Matteo Gabbia, while Sandro Tonali is suspended.

The club said in a statement: "AC Milan announces that Ante Rebic and Rade Krunic tested positive for a molecular swab carried out yesterday in anticipation of the match against Juventus.

"The players, asymptomatic, remained in isolation at home where a second control swab was taken today. The health authorities were promptly informed.

"All members of the team group underwent a further test today with negative results."

Speaking on Tuesday, doctor Roberto Testi, the director of the Department of Prevention at the Turin ASL, warned the high-profile contest may be called off if Juve report further positive tests on the day of the game.

"If there should be more positive tests and the evidence of an uncontrolled breakout within the squad, that would become a problem of safety for the other players," he told Corriere della Sera.

"Clearly, at that point, the ASL would be forced to intervene, isolating everyone and blocking Juve's departure towards Milan."

Milan enter the game 10 points better off than reigning champions Juventus having played a game more.

Stefano Pioli's men won the most recent encounter between the sides 4-2 last July and are seeking successive league wins in this fixture for the first time since 2010.

It will mark the first time Milan have faced Juve sitting ahead of their rivals in the table since November 2015, when losing 1-0 through a Paulo Dybala goal. 

Barcelona midfielder Carles Alena has joined Getafe on loan for the remainder of the campaign.

The Barca academy product spent the second half of 2019-20 on loan with Real Betis and has struggled to establish himself under Ronald Koeman since returning ahead of this season.

Alena has made five appearances in LaLiga and the Champions League this term, just one of those coming from the start.

Koeman confirmed on Tuesday that Alena was close to departing Camp Nou on a temporary basis after Getafe president Angel Torres had revealed his side's interest.

Barca announced on their official website on Wednesday that the deal had gone through, with Getafe to pick up the player's wages in full until he returns to Catalonia.

Alena has played 43 times for Barcelona in total since making his first-team debut in the 2016-17 campaign.

Including his spell on loan with Betis last season, the 23-year-old has three goals and zero assists across 43 LaLiga outings, the first of those coming against Granada on April 2, 2017.

He may only have created one big chance for team-mates in that time, but the Spain Under-21s international ranks highly in terms of passes in the opposition half, averaging 47.45 per 90 minutes.

That places him behind only eight players who have featured at least 16 times across that period.