Friday did not go according to plan for Uruguay. La Celeste were beaten 1-0 by Lionel Messi's Argentina in their Copa America opener.

It was another match and another blank for Uruguay, who have not scored this calendar year amid a four-game winless streak.

Not since 2013 have Uruguay got the better of their old rivals, while Argentina are undefeated in five games against Uruguay at the Copa America.

Despite Uruguay's current problems and attacking woes, even with Luis Suarez and Edinson Cavani in the line-up, Oscar Tabarez's legend continues to grow.

Tabarez is battling an ailment but is still serving the football-mad nation, dating back to 2006.

His story is not only legendary, but inspirational.

Tabarez has Guillain-Barre syndrome – a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system.

But that has not stopped the 74-year-old in his second stint in charge of Uruguay, having also coached La Celeste from 1988 to 1990.

Responsible for resurrecting Uruguay, Tabarez still celebrates goals even as an elderly man with a stick, struggling to walk.

"I am not living with any pain. This neuropathy sometimes causes me problems, especially to walk. But since this is a chronic illness, sometimes I am a little better," Tabarez previously said, having been expected to resign in 2016 following the diagnosis.

Tabarez, remarkably, is overseeing his seventh Copa America campaign. He guided Uruguay to their 15th CONMEBOL crown in 2011 and first since 1995.

Only three other coaches have managed more Copa America matches than Tabarez – a primary school teacher before embarking on a coaching career that has taken him to the likes of Boca Juniors and Milan.

On his watch, Uruguay have reached the quarter-finals on three occasions, finishing fourth in 2007. Tabarez's team also rode a wave en route to the 2010 World Cup semi-finals. A last-16 berth and quarter-final appearance followed in 2014 and 2018.

"What the Teacher achieved in this time is very big because he started totally from scratch," Uruguay goalkeeper Fernando Muslera said previously. "He has created everything we achieved and what is yet to come. If Uruguay is this respected worldwide it is because he made it."

Fast forward to 2021. His 31st meeting with La Albiceleste was a fruitless one for Tabarez and Uruguay, who have not conquered Argentina in Copa competition since 1989.

Uruguay have their work cut out this year but Tabarez has built a team that can never be underestimated.

More importantly, while silverware is at the forefront of El Maestro's mind, this is a story about human endeavour and a hero with an unwavering belief and refusal to quit.

Lionel Messi set up the winner as Argentina edged rivals Uruguay 1-0 to claim their first victory of the 2021 Copa America in Brasilia on Friday.

Argentina, who have not lifted the Copa America since 1993, had drawn 1-1 with Chile in their opening game but secured three points thanks to Guido Rodriguez's first international goal in the 13th minute.

Messi pulled the strings for 14-time Copa runners-up La Albiceleste – beaten finalists in 2015 and 2016 – with his cross from the left flank finding Real Betis midfielder Rodriguez for his winner, which snapped Argentina's run of three consecutive draws while extending their unbeaten streak to 15 matches.

Uruguay, playing their first game of this year's CONMEBOL tournament, were left frustrated by a resolute Argentina, while they were left to bemoan a first-half penalty shout which was turned down.

Argentina started brightly as Messi stung the palms of Uruguay keeper Fernando Muslera with a curling seventh-minute effort, before Nicolas Otamendi had a header saved.

Messi then created space down the left for a cross which found Rodriguez, who nodded in off the inside of the post for his maiden Argentina goal.

In the 27th minute, Uruguay had a penalty shout turned down when Rodriguez appeared to make slight contact with Edinson Cavani inside the box.

Argentina raced down the other end with Messi laying off for Nahuel Molina, who tested Muslera at the near post.

Opportunities were few and far between in the second half, with Uruguay star Cavani almost glancing in a half-chance in the 69th minute while a subdued Luis Suarez flashed a volley over as Uruguay built some momentum.

Argentina struggled to create anything of note after the break, relying in attack on Messi, who was regularly crowded out by Uruguay's defence.

Lionel Messi issued something of a rallying cry as Argentina attempt to kick-start their Copa America campaign against Uruguay on Friday.

Messi scored Argentina's only goal – a gorgeous free-kick – last time out, but it was not enough to seal a victory against Chile.

Eduardo Vargas levelled for La Roja after Arturo Vidal failed to convert an initial penalty, and despite Argentina creating a plethora of chances, they could not find a way past Claudio Bravo again.

Nicolas Gonzalez, who is reportedly close to joining Brighton and Hove Albion, was particularly culpable, spurning several good opportunities. He had six shots with a total xG (expected goals) value of 1.2, but he failed to find the net with any of them – Neymar is the only player with a higher xG (1.5) who failed to score so far.

As it turns out, Lionel Scaloni is reportedly considering resting Gonzalez due to him coming into the tournament with an injury, though Cristian Romero is potentially in line for a return at the back after a thigh issue.

Whoever plays, Messi is looking to ensure they are suitably motivated ahead of what will undoubtedly be another bruising encounter, given the historic rivalry between Argentina and Uruguay, who have not lost any of their last five Copa America games (after 90 minutes).

On his official Instagram account, the six-time Ballon d'Or winner wrote: "We are prepared to compete and we will continue fighting to win every game. Vamos Argentina!"

PLAYERS TO WATCH

Argentina – Nicolas Otamendi

While Argentina certainly are not shy of talent going forward, they are less convincing at the back. Otamendi has come in for criticism in recent times lately, and even posted a message on social media this week addressing the situation, saying: "Don't allow the noise of other people's opinions to silence your inner voice. Always be positive." But in fairness to him, his four tackles was twice as many as any of his team-mates last time out, while his six clearances was five more than anyone else.

Uruguay – Lucas Torreira

Sure, Luis Suarez and Edinson Cavani carry a lot of responsibility going forward for Uruguay, but they need to do their best to keep Messi quiet as well. A fool's errand that may be, but – if he starts – Torreira is likely to have some say in whether or not La Celeste can keep the Barcelona man quiet. A feisty competitor and tough tackler, his potential duel with Messi could be crucial.

KEY OPTA FACTS

-Argentina and Uruguay will meet in a Copa America campaign after going two tournaments without doing so (2016 and 2019). La Albiceleste are unbeaten in their last four meetings against La Celeste (W3 D1). The last Uruguay win was in 1989.

-Argentina have lost just one of their last nine meetings with Uruguay in all competitions (W5 D3). Their last defeat against Uruguay was in October 2013.

-Uruguay come into this game on an unbeaten run of five games (90 minutes only). Their last defeat in 90 minutes in this competition was in June 2016 (0-1 vs Venezuela).

-Argentina scored with only six per cent of their shots – the lowest conversion ratio of any team in the opening round of games.

-Oscar Tabarez will be managing his seventh Copa America. He will face Argentina for the 31st time and is the manager with the fourth-most games overseen in this tournament.

There are aspects to the Edinson Cavani and Luis Suarez of 2021 that make them wonderfully reflective of the Uruguay national team.

Impassioned? Yes. Belligerent? Certainly. A footballing pedigree to rival the best in the world? Absolutely.

What about quality? After all those years, are they still match-winners, entertainers, undimmed by the passing of time? Of course they are. Just ask Paris Saint-Germain and Barcelona.

Last August, Suarez was informed by new Barca coach Ronald Koeman that he would not be in his plans at Camp Nou. Too old to be relied upon, too expensive to bench seemed to be the feeling. Regardless, the Catalans reportedly had a list of teams to whom they would not sell Suarez for fear of the deal coming back to haunt them, a list that, apparently, inexplicably, did not include Atletico Madrid. He duly went to the capital on a two-year deal.

Likewise, Cavani seemed to be offloaded all too readily by PSG, who had just lost the Champions League final to Bayern Munich and appeared eager to freshen things up without their record goalscorer. Manchester United were, eventually, the team to gamble on the striker, who joined on a one-year deal with an option for another in October, by which time the Red Devils had failed to sign top target Jadon Sancho and been linked with several other alternatives.

Both players, then, had a point to prove. Boy, did they prove it.

Suarez scored twice and set up another on his LaLiga debut for Atleti in a 6-1 win over Granada in September. He then scored three times for Uruguay in the October international break, and again in the 3-0 win at Colombia in November.

From December 19 to February 8, Suarez scored 11 goals in nine league games, including three braces in a run of four matches. He would end the season with winners against Osasuna and Real Valladolid, his 21 goals overall securing 21 points for Atleti throughout the campaign, the most of any player in the competition. And, of course, he won the title, for the fifth time in seven seasons.

Not that such a contribution should really have been in doubt. While he may no longer be quite the all-round dynamo of his Liverpool and early Barca days, his ruthlessness in the opposition box has scarcely diminished; since 2011-12, only Lionel Messi (492) and Cristiano Ronaldo (411) have been directly involved in more goals in Europe's top five leagues than Suarez (325).

Unlike his international team-mate, Cavani ended the club season empty-handed, despite scoring United's goal in the Europa League final with Villarreal, which they lost on penalties. Still, few could argue Ole Gunnar Solskjaer's decision to sign him was a mistake.

Cavani did not play a full league game until December 29, and he served a three-game domestic ban for a social media post deemed racist by the Football Association, a decision decried as culturally insensitive in Uruguay. He still ended 2020-21 with 17 goals and five assists at a rate of one goal every 128 minutes, the best return of any United player. He also became the third Red Devil to score 10 or more Premier League goals in a single season in which he was 33 or older at the start (also Teddy Sheringham in 2000-01 and Zlatan Ibrahimovic in 2016-17), and he equalled the record of five substitute goals over a whole campaign held by Javier Hernandez (2010-11) and Solskjaer (1998-99).

In the Europa League last-four tie against Roma, Cavani became the first player to score at least twice in each leg of a major European semi-final since 1986, when Klaus Allofs did so for Cologne against KSV Waregem. He was also the oldest player to score twice and assist twice in a Champions League or Europa League match, at 34 years and 74 days old. No wonder Solskjaer was so desperate to see him accept the one-year extension to his contract, and was presumably so relieved when he did.

Cavani and Suarez finished 2020-21 on 22 and 24 direct goal involvements, respectively. Among South America players, only Messi (50), Luis Muriel (36), Duvan Zapata  (31), Lautaro Martinez (26) and Neymar (25) had more.

So they come, then, to the Copa America, as two of the remaining members of that squad that lifted the trophy in 2011. They have the form, and undoubtedly the pedigree; they are Uruguay's all-time leading goalscorers, Suarez on 63 and Cavani 51.

And yet Uruguay are often consigned to the also-rans when it comes to tournament predictions. While they have waited a decade to lift the trophy, they are the most successful team in the competition's history, with the most appearances (45) and titles (15), yet few will look beyond emergency hosts Brazil and Argentina as favourites or Chile and Colombia as outside bets.

Perhaps the problem lies in a perception of bluntness around Uruguay's play, far removed from the ideals of jogo bonito. Despite holding the most Copa America titles, Uruguay boast a worse goal-per-game average (2.02) at the tournament than Argentina or Brazil; somewhat fittingly, their last triumph a decade ago came in the worst finals for goalscoring (54 in 26, or 2.08 per match) since 1922 (22 in 11, or 2.00 per match). Oscar Tabarez's men have also gone three games without a goal since a 3-0 win over Colombia last November.

If only they had a couple of star strikers who have spent the past year defying the doubters...

Before every major tournament, eyes are trained on the next generation of stars set to take the football world by storm.

This year's rescheduled Copa America is no different with the likes of Ecuador midfielder Moises Caicedo, Brazil right-back Emerson Royal and Colombia forward Jaminton Campaz on the scene.

But there is still no changing of the guard as Lionel Messi, Luis Suarez and Edinson Cavani, among others, continue to dominate on the international stage.

Stats Perform looks at six players above the age of 30 and their eye-catching numbers heading into the 47th edition of the Copa America.

Lionel Messi, 33, Argentina

Messi enters the showpiece South American tournament on the back of another impressive club campaign. With 30 league goals in 2020-21, Barcelona superstar Messi has now recorded 25-plus goals in each his past 12 league seasons. Craving senior international silverware with La Albiceleste following runners-up appearances at the Copa America in 2007, 2015 and 2016 and the World Cup in 2014, Messi scored 11 LaLiga goals direct following a ball carry last season – the most of any player in Europe's top five leagues. Following a third-placed finish in 2019, Messi – the country's all-time leading scorer with 72 goals, while only Javier Mascherano (147) has earned more caps than the six-time Ballon d'Or winner (144) – will be hoping this year's tournament delivers that much-coveted international prize. Argentina are in Group A alongside matchday one opponents Chile, Uruguay, Paraguay and Bolivia.

Luis Suarez, 34, Uruguay

Suarez upstaged close friend Messi in 2020-21 after swapping Barca for Atletico Madrid. Having been forced out of Camp Nou amid concerns his best years were behind him, veteran forward Suarez found vindication and the ultimate revenge by leading to Atletico Madrid to LaLiga glory. His 21 goals were worth 21 points last season – the most of any player in the competition. Since 2011-12, only Messi (492) and Cristiano Ronaldo (411) have been directly involved in more goals in Europe's top-five leagues than Suarez (325 – 233 goals and 92 assists). Uruguay's all-time leading goalscorer (63), Suarez is far from a spent force as Oscar Tabarez's side – who are scheduled to open their campaign against Argentina – fight to win a first Copa America crown since 2011. Suarez has been directly involved in nine goals in 10 games at the Copa America (six goals and three assists).

Edinson Cavani, 34, Uruguay

Cavani and Suarez are the face of a generation that delivered the 2011 title, finished fourth at the 2010 World Cup and reached the quarter-finals at Russia 2018. Cavani joined Manchester United on a free transfer from Paris Saint-Germain at the beginning of 2020-21 and made an immediate impact at Old Trafford, finishing the season with 10 Premier League goals and 17 across all competitions – his minutes per goal ratio both in the Premier League and in all competitions the best among his team-mates (137 and 128). In the Europa League final loss to Villarreal, Cavani became just the third player aged 34 or above to score in a major European decider for an English club, after Gary McAllister (36) for Liverpool in the UEFA Cup final against Deportivo Alaves in 2000-01 and Didier Drogba (34) for Chelsea in the Champions League final versus Bayern Munich in 2011-12. Only Suarez has scored more goals for Uruguay than Cavani (51 in 118 appearances), who earned a new deal in Manchester.

Alexis Sanchez, 32, Chile

Sanchez's club career had been on a steep decline since he left Arsenal for Premier League rivals United in 2018. But the Chile star has enjoyed success at Inter. Although a squad player under former Nerazzurri coach Antonio Conte, Sanchez – who joined Inter permanently last year – scored seven goals and supplied five assists in just 12 starts last term. An option in place of regular starting duo Romelu Lukaku and Lautaro Martinez, Sanchez ranked better in shooting accuracy excluding blocks (69.6 per cent), passing accuracy (80.0), passing accuracy ending in the final third (73.5) and dribbled success rate (60.0) than both men. His big chance conversion rate (50.0) was only second to Lukaku, likewise his shot conversion rate (24.1). At international level, there is no disputing his role for Chile after leading La Roja to Copa America success in 2015 and 2016. Chile's most capped player (138) and leading goalscorer (46), Sanchez will once again carry the weight of his country this month.

Marcelo Martins, 33, Bolivia

The heart and soul of a nation? Look no further than Martins. The iconic forward stands alone as Bolivia's record holder for goals (25 in 83 appearances). Of those, 18 have come in CONMEBOL World Cup qualifying, also making Martins Bolivia's top scorer in that competition. Currently playing his football for Cruzeiro in Brazil, Martins scored three goals in the two qualifiers immediately prior to the Copa America, helping his side to earn four points. With their talisman leading the line, Bolivia – who won their only Copa America title on home soil in 1963 and lost the final when they hosted again in 1997 – are seeking to advance from the group stage for the first time since 2015. They start against Paraguay.

Paolo Guerrero, 37, Peru

Like Martins in Bolivia, Guerrero epitomises Peruvian football. The success of Peru has long been linked to the striker, who is in the history books for the most goals (38) for La Blanquirroja. Having debuted in 2004, this will be the captain's sixth Copa America appearance, having guided two-time winners Peru to third place in the 2011 and 2015 editions before securing a runners-up medal in 2019 – finishing as top scorer in all three of those tournaments. Guerrero is now the leading Copa America scorer in among active players (14) and only three shy of the all-time record (Norberto Mendez and Zizinho, both 17). While in the twilight of his career, Ricardo Gareca and Peru – who will come up against Brazil, Colombia, Ecuador and Venezuela – will be leaning on his experience across the border in Brazil.

Thiago Silva, 36, Brazil

There were some doubts about Silva's suitability to the Premier League when he saw out his PSG contract and opted to test himself with Chelsea. But the star centre-back did not look out of place in England, despite his advancing years, ending the campaign as a Champions League winner for the first time in his career. In all competitions in 2020-21, Silva led Chelsea in passing accuracy (93.0 per cent). He became Chelsea's oldest player (36 years and 249 days) to appear in a major European final, overtaking Claude Makelele against United in the 2008 Champions League decider (35 years and 93 days) as the Blues trumped Manchester City in Porto. The Selecao captain now turns his attention to Brazil's bid to claim back-to-back Copa America trophies. They have won five of the past nine.

At long last, after a 12-month delay and then so much uncertainty over the past few weeks, Copa America will start this weekend.

While the fact it is going ahead remains a bone of contention, with even Brazil players suggesting they are reluctantly playing it, Copa America is a tournament that rarely disappoints in terms of entertainment.

A bevvy of world-renowned stars such as Neymar, Luis Suarez and Lionel Messi will be hoping to make the difference.

There will also be some less-familiar faces hoping to either establish themselves or introduce their names to a wider audience.

Stats Perform has identified seven players worth keeping an eye on over the next month.

Rodrigo de Paul, 27, central midfielder - Argentina

Perhaps the odd one out here given his age, but De Paul is certainly one to keep tabs on. Having just enjoyed a wonderful individual campaign with Udinese, the creative midfielder is eager on a move and will surely be keen to impress.

He had a hand in 18 Serie A goals this term (nine goals, nine assists), while his xA value (expected assists) of 10.3 was the best in the division, the 1.3 differential suggesting De Paul was occasionally let down by poor finishing.

Further to that, he also attempted (191) and completed (122) more dribbles than anyone else, so Argentina will look to him to drive them forward from midfield.

Moises Caicedo, 19, central midfielder - Ecuador

Caicedo joined Brighton and Hove Albion in January to much fanfare from South American experts, who assured Seagulls fans they were getting a future superstar.

He's yet to make a senior appearance in England, with Graham Potter patient regarding his adaptation, but the Copa America could give fans a chance to see him in action.

A well-rounded, all-action midfielder, Caicedo was the teenager with the most goals (four), shots attempted (24), chances created (19), successful passes (748) and dribbles completed (23) in Ecuador's top flight in 2020, while his passing accuracy of 90.1 per cent was the highest among players to attempt 500 or more.

Emerson Royal, 22, right-back - Brazil

An impressive two-year spell at Real Betis has persuaded Barcelona to bring Emerson back to Camp Nou after a complicated three-way transfer in 2019.

He has proven himself to be both a dependable defender and a capable attacking outlet, his 10 assists over the past two seasons bettered by only one LaLiga defender (Jesus Navas, 13), while his 853 duels over the past two years is nearly 200 more than any other defender.

This paints a picture of an all-action defender who will work tirelessly up and down the right flank, and on the evidence of the past couple of years, it shouldn't take him too long to usurp Danilo as Brazil's primary option.

Yangel Herrera, 23, central midfielder - Venezuela

A long-term future for Herrera and parent club Manchester City looks unlikely, but he enjoyed a promising season with Granada in LaLiga – that coupled with a breakout tournament in Brazil could lead to promising suitors making their feelings known.

Herrera's a hard-working midfielder who made more tackle attempts (59) than any other Granada player this term, while it was a similar story with regards to duels (509) and duels won (261). Don't expect him to create much, but he's not shy about getting stuck in.

Jaminton Campaz, 21, left-winger - Colombia

Arguably the next big hope of the Colombian national team, Campaz only received his first call-up this month for the recent World Cup qualifiers. Although he did not get on the pitch, his inclusion in the squad was well-received among fans.

Colombia great Carlos Valderrama was among them as he urged the 21-year-old to grasp the opportunity in a post on his official Twitter account.

A livewire on the left flank, Colombia may look to his explosiveness and trickery should games remain tight in the latter stages.

Julio Enciso, 17, attacking midfielder - Paraguay

The youngest player at the 2021 Copa America, Enciso has already played 24 top-flight matches back home for Libertad and was briefly the youngest player to score in the Copa Libertadores this century with his goal against Jorge Wilstermann last year when still 16.

A good dribbler and not shy to take a shot, Enciso has been used almost everywhere across the front for Libertad and could be an interesting wildcard option for Paraguay.

Carlos Palacios, 20, right-winger - Chile

Earlier this year, Palacios made the jump to Brazil when he joined Internacional on loan from Union Espanola, where he had developed into one of Chile's most-promising young players as a lively winger.

While he's yet to score for his new club, he proved in Chile that he has a penchant for a spectacular goal one or two, while his regular appearances for Internacional have exposed him to a far greater standard of football.

Luis Suarez was determined to prove his doubters wrong after getting the chance to continue playing at the highest level with Atletico Madrid.

Suarez left Barcelona after a 2019-20 season that saw the Spanish giants finish without a trophy. Having lost out to Real Madrid in a tight title race, hopes of Champions League glory were emphatically ended at the quarter-final stage by Bayern Munich.

The Uruguay striker had scored 21 goals in all competitions yet was deemed surplus to requirements at Camp Nou, allowed to leave on the cheap as he remained within LaLiga at Atleti.

Barca have watched on as their former player has scored 19 league goals to help Diego Simeone's squad push to be crowned Spanish champions - they top the table by two points with two games remaining, the first of which is at home to Osasuna on Sunday.

For Suarez, the desire to succeed following his switch to the capital was fuelled by those who had declared him to be in a state of decline.

"You like a challenge. And coming here was a very big challenge for me for many things," he said in an interview for Club del Deportista magazine.

"Last year I received criticism and they said that I was not here to compete for important things, or that at Barcelona I could not compete at a high level.

"That will generate a challenge to an individual, you want to continue to demonstrate that you can do something at the elite level of football, something I've been demonstrating as the kind of player I am for many years.

"I experienced it as a great challenge and with great enthusiasm. I'm not sorry at all, on the contrary, excited and eager to continue demonstrating."

Suarez also revealed his future plans at international level as he intends to finish his Uruguay career after next year's World Cup in Qatar.

The 34-year-old is his country's all-time leading scorer and helped them win the 2011 Copa America, a year after a fourth-place finish at the World Cup in South Africa.

"My wish is to be able to play the World Cup in Qatar and afterwards one must realise that the time has come," the former Ajax and Liverpool forward said.

"First by age and then by the young people who come after, so that they have the possibility. When the time comes I will make the appropriate decision, although assuming that costs a player a lot, but I have been working on it for a long time."