Lorenzo Musetti headlined a day of shocks at the Monte Carlo Masters as Felix Auger-Aliassime fell to a first-round defeat.

Auger-Aliassime already has one singles title to his name this year, having prevailed in Rotterdam, and also reached the final of the Open 13 in Marseille and helped Canada to victory in the ATP Cup at the start of 2022.

However, the sixth seed entered this contest with just one win from his last four matches and came unstuck once again at the hands of Musetti. 

Musetti, who won two sets in the fourth round of the French Open against Novak Djokovic last year, is very much at home on the clay in Monaco.

He demonstrated that in 6-2 7-6 (7-2) success, setting up a last-16 meeting with Diego Schwartzman.

“I live here and practice here,” Musetti said in his on-court interview. "It is nice to be here and play here in front of such a crowd. I am really happy.

"My backhand down the line was a key to many of my great shots. After a really good first set, he came back with such powerful serving, but I was calm and patient and that was the most beautiful thing about today."

Auger-Aliassime's exit came a day after top seed Djokovic was knocked out in the second round by Alejandro Davidovich Fokina, but there were no such problems for second seed Alexander Zverev as he saw off Federico Delbonis in straight sets.

Fifth seed Andrey Rublev came from a set down to defeat Alex de Minaur and fourth seed Casper Ruud, coming off his defeat in the final in Miami, edged qualifier Holger Rune in two tight sets.

The man who vanquished Ruud in Florida will go no further on the Cote d'Azur, however, Carlos Alcaraz losing in just over three hours to Sebastian Korda on his Monte Carlo debut.

Korda lost to Alcaraz in the final of last year's Next Gen ATP Finals, but avenged that defeat with a 7-6 (7-2) 6-7 (5-7) 6-3 victory.

World number 10 Cameron Norrie lost to Albert-Ramos Vinolas and his British compatriot Dan Evans fell to David Goffin, while 16th seed Lorenzo Sonego was beaten by the in-form Laslo Djere.

Elsewhere in the draw, there were wins for Jannik Sinner, Taylor Fritz, Hubert Hurkacz and Pablo Carreno Busta.

World number one Novak Djokovic explained that he could just not get up to the level of sharpness required in his shock defeat at the Monte Carlo Masters.

Djokovic slumped out in the second round on Tuesday when he lost 6-3 6-7 (5-7) 6-1 to world number 46 Alejandro Davidovich Fokina.

The Serbian's status as an unvaccinated player has limited his ability to compete on the ATP Tour this year and he has played in just one tournament so far, getting to the quarter-finals in Dubai. 

Yet his preparations for the French Open, which starts at the end of next month, hardly got off to a good start as he made 51 unforced errors in what was still, despite his rustiness, a surprise defeat.

"I didn't like the way I felt physically in the third. I just ran out of the gas completely," Djokovic told the media. 

"Just couldn't really stay in the rally with him. I mean, if you can't stay in the rally, not feeling your legs on the clay, it's mission impossible.

"I'm going to look with my team into reasons why that was the case and go back to the drawing board. Hopefully next week will be better in Belgrade."

Though Djokovic has won twice in Monte Carlo, it has not been a happy hunting ground for him in recent years. He has not advanced past the quarter-final stage since 2015.

He added: "It's going to take some time for me to really feel my best on the clay.

"That's historically always been the case. [I have] never played very well in the opening tournaments of the clay season.

"But it's okay. Obviously it is what it is. I have to accept the defeat and keep working."

While unhappy with his own performance, Djokovic had nothing but praise for his opponent. 

"I would like to congratulate Alejandro. He was the better player," Djokovic said. "He managed to find a better rhythm I think in the first two sets. I was hanging on the ropes the entire match. I was really chasing the result constantly.

"I always believed that I could come back and win the match, and I stayed there even though a lot of things were against me in terms of how I felt on the court. Game-wise, physically I was just far from my best.

"I expected this match to be [a] really tough match, [a] physical battle, and that's what it was. Unfortunately I'm on the shorter end of the stick, and my week ends here."

Djokovic's defeat also means a mouthwatering contest with teenager sensation Carlos Alcaraz, who he might have met in the quarter-finals, will not be taking place.

Novak Djokovic suffered a stunning defeat in his first ATP Tour match since February, the world number one losing in the second round of the Monte Carlo Masters to Alejandro Davidovich Fokina.

Djokovic's status as an unvaccinated player has limited his ability to compete on the tour this year. He missed the Australian Open in January after a saga surrounding his visa eventually resulted in his deportation on public health grounds, while laws around vaccination against COVID-19 in the United States prevented him from playing at Indian Wells and Miami.

Despite his inactivity, the Serbian - whose sole appearance on tour this year came during a run to the quarter-finals in Dubai - was expected to prevail on the clay against his Spanish opponent after receiving a bye in the first round.

But there were evident signs of rust in a mistake-riddled display against the world number 46, who remarkably emerged victorious to set up a meeting with either Dan Evans or David Goffin.

The tide looked to have turned in the second set tie-break, when an exquisite whipped forehand from Djokovic sent the match to a decider.

However, Djokovic, who committed 51 unforced errors, immediately surrendered the momentum by dropping serve in the first game of the third and he was broken twice more as Davidovich Fokina powered to a 6-3 6-7 (5-7) 6-1 victory in just under three hours.

"I knew that Nole hasn't had that confidence because he didn't play a lot," Davidovich Fokina said.

"This win is so special for me. I look at him every tournament. Here in Monte Carlo, full people [capacity], against the number one, I enjoy every moment."

Earlier, Evans saw off Benjamin Bonzi while Goffin, fresh off his triumph in Marrakech, came through against Jiri Lehecka to set up their second-round meeting.

Tenth seed Taylor Fritz defeated Monegasque wild card Lucas Catarina in three sets and 16th seed Lorenzo Sonego saw off Ilya Ivashka in straight sets. Laslo Djere, a semi-finalist in Marrakech, also progressed to the second round.

Kim Clijsters has called time on her latest tennis comeback, announcing her retirement from playing in official tournaments.

The Belgian surprisingly stepped away from the sport in 2007, before returning in 2009 to win back-to-back US Open titles in 2009 and 2010 before being crowned the 2011 Australian Open champion.

Clijsters retired again after the 2012 US Open, where she was beaten in the second round, before returning in February 2020 at the age of 36.

The former world number one's first match in over seven years came at the Dubai Duty Free Tennis Championships, losing in straight sets to Garbine Muguruza, while her last official match was in October, when she was defeated by Katerina Siniakova in the first round at Indian Wells.

Clijsters took to Instagram on Tuesday to announce her decision, posting: "I want to share with you that I have decided to no longer play official tournaments. I can't wait to see what new adventures will cross my path. Thank you to everyone who has supported me over the past two years!"

Mother of three Clijsters revealed stepping away from tennis again had "been on my mind for a while."

"I still love to hit the ball," she told the WTA website. "With my schedule, three, four days was enough to keep my rhythm under control but definitely not good enough if I decided to play another tournament. Say, if I picked Australia, it's three, four weeks. That's just not possible at this stage in our family life.

"Life just sort of takes over, right?"

Clijsters won three US Open singles titles in all, as well as her Australian Open crown, and in 2003 won both the French Open and Wimbledon doubles titles with Ai Sugiyama.

She became world number one on four separate occasions, winning 41 overall titles and boasting a career match record of 523-131 (80.0 per cent).

Carlos Alcaraz is hopeful of meeting Novak Djokovic in the Monte-Carlo Masters, but his first focus is on a second-round tie with Sebastian Korda. 

Alcaraz is one of the brightest prospects on the ATP Tour, with the 18-year-old Spaniard having won his first Masters title at the Miami Open and become the youngest men's champion of that tournament. 

That was Alcaraz's second title of 2022 and third overall. He is now up to 11th in the ATP world rankings. 

Seeded eighth, Alcaraz has been handed a bye to the second round but is in the same quarter of the draw as world number one Djokovic, who has triumphed twice in Monte Carlo. 

Alcaraz, though, is making sure not to get ahead of himself and think too much about a maiden meeting with Djokovic, with American Korda – who defeated Botic van de Zandschulp in his first-round match – first up. 

"I don't want to be in a rush, I just focus on the first [match]," Alcaraz told reporters ahead of what is a rematch of the Next Gen ATP Finals championship match which he won in straight sets. 

"Obviously, it would be a great match against Novak. 

"Playing against the number one player in the world [would be] amazing for me, but I hope to play well in the first [matches] and hope to meet him in the quarter-finals." 

Alcaraz seems set to have a future at the very top of the game but is insisting everything must be taken step by step. 

"Sometimes it is difficult, but I am trying to make it easy," he said. 

"Doing everything for the first time, I am trying my best, trying to manage the nerves of the first time well." 

Taylor Fritz, who won a Masters title at Indian Wells earlier this year, could also be standing in the way of Alcaraz and the quarter-finals, should the American defeat wildcard Lucas Catarina and Marin Cilic. 

Djokovic, on the other hand, faces Alejandro Davidovich Fokina in his first match. 

Stan Wawrinka's ATP Tour return at the Monte-Carlo Masters ended in defeat, while Jannik Sinner came through a tense encounter with Borna Coric. 

The former world number three made his comeback after more than a year out with a left foot injury that required two surgeries but fell to a 3-6 7-5 6-2 defeat to Alexander Bublik in the first round. 

Wawrinka, who entered the tournament as a wildcard having slipped to 236 in the world rankings, came from a break down to take the opening set but fatigue eventually set in and he was eliminated after two hours and seven minutes. 

"I think the body's getting much better," said Wawrinka, who lost in straight sets to Elias Ymer at a Challenger tournament in Marbella two weeks ago. 

"I'm still far away from where I want to be, but I think I'm [going in] the right direction. I think today was a positive match. It was a tough loss, of course, but I'm happy with the way I was playing today. 

"I was playing better, feeling better on the court physically. I spent a lot of mental energy to focus, to stay there as it was tough at the end. But I'm happy with what I have done."

Ninth seed Sinner was taken the distance by Coric before completing a 6-3 2-6 6-3 victory to advance to the second round. 

Sinner took a medical timeout in the second set while he dealt with some apparent abdominal pain, but he was able to battle back and take the win. 

Diego Schwartzman needed over three hours to come from behind and defeat Karen Khachanov 6-7 (5-7) 6-3 6-3, while his fellow Argentine Federico Delbonis set up a clash with second seed Alexander Zverev by besting Jaume Munar 6-4 3-6 6-4. 

Reigning champion Stefanos Tsitsipas faces a meeting with Fabio Fognini in the second round after the Italian overcame Arthur Rinderknech 7-5 4-6 6-3.  

There were also wins for Hubert Hurkacz, Pablo Carreno Busta, Marin Cilic, Alex de Minaur, Albert Ramos-Vinolas and Sebastian Korda. 

American Reilly Opelka defeated compatriot John Isner 6-3 7-6 (9-7) to win a history-making final of the US Men's Clay Court Championships in Houston.

In a clash between two of the tour's elite servers, and two of the tallest men to ever play professional tennis, break points were hard to come by, and even harder to convert, as Opelka saved all eight opportunities he faced, while Isner saved four out of five.

That one break decided the first set, as 6ft 10in Isner fought back from 40-0 down to force deuce, but the fourth break point of the game was converted by 6ft 11in rival Opelka.

The ATP said their respective heights made it the tallest tour final in the Open Era.

In a match that was always likely to be decided by whoever served best, Opelka had five aces to Isner's two in the first set, while Isner also had the only double fault.

Isner was much stronger in the second set, creating seven break-point opportunities, but he just could not win the important points as Opelka's serve repeatedly got him out of trouble.

Isner then had three opportunities at set point in the tie-break to force a decider, but it was Opelka's day, as he saved all three and converted his first chance at match point.

After dropping a set in his first-round match against Mitchell Krueger, Opelka was perfect the rest of the tournament, beating Gijs Brouwer and Nick Kyrgios in straight sets on his way to the final.

Belinda Bencic continued her strong run of form in the United States as she defeated world number 10 Ons Jabeur 6-1 5-7 6-4 to win the Charleston Open.

Sunday's success made it 10 victories from her past 11 matches for Bencic, with the lone defeat coming in a semi-final against Naomi Osaka at the Miami Open.

The Swiss Olympic gold medallist flew out of the gates in the opening set, winning 80 per cent of her points on serve (16 of 20) and breaking Jabeur twice.

It was a far more competitive second set as Jabeur's return game improved, the Tunisian also saving six of eight break points to force a decider.

Bencic prevailed in a rollercoaster of a third set, where Jabeur converted two breaks of serve, but the eventual champion managed three, finding a response every time she was challenged.

Jabeur becomes the second top-10 scalp claimed by Bencic this tournament after also defeating world number three Paula Badosa in three sets in the quarter-finals.

Germany's Tatjana Maria sank the hopes of Brazil's Laura Pigossi by carrying off the Copa Colsanitas title in Bogota, landing a 6-3 4-6 6-2 victory in Sunday's final.

Maria, who won her only previous WTA singles title in Mallorca in 2018, had the serving advantage in a contest between two qualifiers, hitting six aces to Pigossi's zero.

In the two sets that she won, Maria won 80 per cent of her successful first serves (28 of 35), not allowing Pigossi a look at a break point in the opener and saving two opportunities in the third.

Maria won seven matches in nine days while at the event in Colombia, with the 34-year-old dropping only two sets in the process.

The win will see a significant jump in Maria's world ranking, which is currently number 237 after taking time off to have a child.

David Goffin secured his sixth ATP Tour title by coming from behind to beat Alex Molcan in the Grand Prix Hassan II final on Sunday.

Slovakian Molcan, in search of a first triumph at main tour level, came flying out of the blocks, but ultimately Belgian Goffin's experience showed as he recorded a 3-6 6-3 6-3 victory.

World number 65 Molcan, who defeated Goffin in the first week of the season in Melbourne, was in early control of this meeting in Marrakesh, a set to the good and serving at 2-1 up in the second.

However, former world number seven Goffin responded from that point onwards and did not look back as he won in one hour and 58 minutes.

Goffin feels he can take confidence from this success into the rest of the clay-court segment of the 2022 season.

"I'm very happy, proud of my week. It was not easy, a lot of tough matches," Goffin said. "But at the end, I have my sixth title, here in Marrakesh. It gives me a lot of happiness and confidence for the season on the clay.

"It was the case twice before that match that I lost the first set and I always stayed calm the whole week to turn it around. It was the case again today, because he was playing well.

"He was better than me in the first set, and then I managed to play better and better, serving better, being more aggressive in the middle of the second. I was the better player [after that]."

Quoted on the ATP website, Goffin said: "I was playing even better in the third set, so I'm really happy the way I finished with another break [and] a good match point. I didn't want to serve for the match, I preferred to finish with a break."

Molcan reflected on a positive week in Morocco that saw him most notably beat top seed Felix Auger-Aliassime.

"It was an amazing week for me," he said. "I won a lot of matches and enjoyed it very much."

Reilly Opelka and John Isner will meet in the US Men's Clay Court Championship final in Houston, after they claimed semi-final wins on Saturday.

Opelka kept up his strong early-season form with an imposing 6-3 7-5 victory over Nick Kyrgios in the first semi-final, getting the job done in just one hour and nine minutes.

Opelka slung down 18 aces to 11 from Kyrgios and faced only one break point across the contest.

The 24-year-old Opelka won a title in Dallas in February and followed up with a run to the Delray Beach final, with a third trophy match of the season now awaiting him.

The American world number 18 said he admired the "intangibles" from Kyrgios that "you can't teach."

"He's got one of the best serves in the world and when he turns it on he can come up with some shots that not many guys outside the top 10 can," Opelka said in his on-court interview.

Opelka enjoyed the high-tempo match with Kyrgios, who typically wastes no time between points.

"I prefer to play at that speed rather than, for example, Rafa [Nadal] where it's 50-55 seconds between points," Opelka said.

"It's a totally different speed here and I thought I did a good job managing the whole tempo of the match. I put a lot of returns into play and I came up big with my second serve."

He will face 2013 Houston champion Isner, who came from a set down to defeat defending champion Cristian Garin 4-6 6-3 6-4.

The 36-year-old's serve improved as the match went on and ultimately propelled him to victory, facing four break points in the opening set, one in the second and none in the decider.

Isner also served 17 aces on his way to the final, and won 80 per cent of points on his first serve.

"It's never easy when you have to come back from one set down," he said. "My serve certainly helped me out a lot. I didn't have to hit too many balls there in the end, and I didn't want to.

"I'm so happy to be in the final again here. At my age you never really know when you can get back to a final of a tournament like this."

Belinda Bencic wondered if she would ever be able to compete for titles on clay but will do exactly that on Sunday.

The Swiss reached her first ever WTA Tour final on the red dirt of the Charleston Open, beating semi-final opponent Ekaterina Alexandrova 6-4 6-3.

Although she has four WTA titles to her name, this was only Bencic's third last-four appearance on clay – losing the prior two, including a 2014 Charleston challenge as a 17-year-old.

But she finally has glory in her sights, and the omens are good for the final, facing Ons Jabeur having won their only prior meeting in 2021 at the Madrid Open, another clay-court event.

"I'm happy this moment came," Bencic said. "I didn't think it would, but I'm super happy with how I played today. I thought it was a great match in tough conditions."

Bencic needed only 78 minutes to complete the job, but Jabeur found life tougher, forced to rally from a set down to Amanda Anisimova.

The 20-year-old American had herself recovered to eliminate top seed Aryna Sabalenka earlier in the tournament but was now on the wrong side of such a comeback.

Jabeur, who lost in the final of the WTA 250 Charleston Open II last year, prevailed 2-6 6-1 6-4.

Meanwhile, at the Copa Colsanitas, there will be no repeat win for Camila Osorio after the defending champion and top seed lost to Laura Pigossi in straight sets in the semis.

Tatjana Maria is now Pigossi's opponent in the title match.

David Goffin is wary he will face "a great fighter" when he tackles Alex Molcan in Sunday's final of the Grand Prix Hassan II in Marrakesh.

Experienced Belgian Goffin is a five-time tournament winner on the ATP Tour, and his Slovakian opponent is chasing his first title at this level.

However, their one past meeting went Molcan's way when they met in the Melbourne ATP 250 tournament in January, and although that match was on hardcourts and this final is on clay, Goffin respects his left-handed opponent's game.

Goffin made sure of his place in the title match with a 6-3 6-3 win over Argentinian Federico Coria, while Molcan, who beat Felix Auger-Aliassime earlier in the week, was a 6-1 7-5 victor against Serbian Laslo Djere.

Speaking of the threat posed by Molcan, Goffin said: "He's a great fighter, he's moving so well. He's lefty, so he's using his lefty game really well on clay, especially two days ago against Felix, he played well. So it's a tough opponent."

Goffin, quoted on the ATP Tour website, said he was pleased to get his clay season under way in fine style, even if he felt jittery at times against Coria.

"I managed to deal with my emotions at the end to finish the match, so I'm happy to play another final, especially here, the first tournament on clay," Goffin said. "I will give everything tomorrow."

World number 18 Reilly Opelka is through to the semi-final of the US Men's Clay Court Championships in Houston after defeating qualifier Gijs Brouwer 6-3 7-5.

The giant American, who measures in at six-foot-11, was terrific in the opening set, winning 84 per cent of his successful first serves (16-19) and allowing no break point opportunities.

The second set was much more competitive, as Brouwer broke first to go up 3-1, but Opelka answered instantly and then grabbed the match-winning break when 6-5 up to avoid a tie-breaker.

Opelka will face a fresh Nick Kyrgios in the semi-final after the Australian was gifted a walkover win against Michael Mmoh due to injury.

In a clash between two top-five seeds, world number 29 Christian Garin got the better of world number 13 Taylor Fritz 6-2 6-7 (5-7) 6-3.

What made Garin successful in the first and third sets was his return game, winning more than half of his return points in those sets combined (26-51).

Fritz had chances to get back into the game, but Garin saved 11 of 14 break point opportunities, including six of seven in the deciding third set.

Garin will play American John Isner in the semi-final after Isner triumphed in a three-set battle against Frances Tiafoe 6-4 2-6 6-3.

Isner's trademark serve was inconsistent, and abandoned him in a grim second-set performance, winning just 11 of 21 service points on his way to getting broken twice to allow Tiafoe to force the match into a third frame.

In Isner's two successful sets, he won more than 80 per cent of his first serves (35-41), and allowed no break point opportunities in the third.

Belinda Bencic has beaten world number three Paula Badosa 2-6 7-6 (7-2) 6-4 to move on to the semi-finals of the Charleston Open.

Bencic, the 10th seed, appeared overmatched early on as she won less than half (12-25) of her service points in the opening set, getting her serve broken twice.

But as Bencic found her rhythm with her serve – winning 77 per cent of her first-serve points in the second set (24-31) – she wrestled the momentum away from Badosa, dominating the tie-break before breaking in the opening game of the third frame.

Bencic will face Ekaterina Alexandrova in the semi-final after the Russian dominated Magda Linette 6-0 6-2.

For the match, Alexandrova won 62 per cent of her points on serve (28-45) and 62 per cent of her points on return (26-42).

Fourth seed Ons Jabeur needed just 64 minutes to get the job done 6-3 6-2 against Anhelina Kalinina, winning 81 per cent of her successful first serves (29-36).

Jabeur will play 15th seed Amanda Anisimova in the semi-final after the American cruised past compatriot Coco Vandeweghe 6-1 6-2.

It was not a perfect performance from Anisimova, but she saved all five break points that she faced to never allow her opponent to get close.

Meanwhile, in Bogota at the Copa Colsanitas, top seed Camila Osorio is through to the semi-final after defeating Elina Avanesyan 6-1 6-4, where she will meet Laura Pigossi.

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