Shohei Ohtani struck two home runs and hit eight RBI's for the Angels in a stellar individual performance but his side suffered a 12-11 defeat to the Royals in extra innings.

The Angels rallied from deficits of 5-0, 6-1 and 10-7 to send the game to the 11th inning, with Ohtani's career-high of eight runs in a performance that also saw him set a single-game record for a Japanese-born player in the MLB.

A 423-foot homer in the sixth was followed by a game-tying, 438-foot homer in the ninth, with his record-setting RBI coming in the 11th with a sacrifice that pulled the score back to 12-11.

However, it wouldn't be enough after Whit Merrifield and Kyle Isbel drove in runs off Jose Quijada earlier in the final innings.

For Ohtani, it was a 10th multi-HR game in MLB and his fourth of the season, and earned him praise from his opponents after the game.

Royals catcher Salvador Perez said: "Ohtani is unbelievable. He’s the best there is right now. It’s impressive what he’s doing. Thank god I have the opportunity to watch him."

Other records came close to tumbling for Ohtani, who's eight RBIs were the most by an Angels player since Garret Anderson had a franchise-record 10 RBIs against the Yankees in August 2007.

He will be starting pitcher for the final game of the series against the Royals, with the Angels looking to avoid a whitewash after back-to-back defeats.

The New York Yankees survived a disappointing starting performance by ace pitcher Gerrit Cole to come back and defeat the Minnesota Twins 10-7 on Thursday.

Cole, who entered the contest with an ERA of 2.78, got beat up in the very first inning, giving up three consecutive home runs to the top of the Twins' order. Homers by Luis Arraez, Byron Buxton and Carlos Correa all travelled at least 396 feet, and would have been home runs in all 30 major league stadiums.

The pain did not end there for Cole, as Buxton launched his second long-ball with a three-run shot in the second inning, before giving up his fifth home run of the game courtesy of a 441-foot bomb from Trevor Larnach an inning later.

Larnach's blast spelled the end of Cole's night, finishing with seven earned runs in two-and-a-third innings, and five conceded home runs from seven hits.

But the Yankees made sure their ace would not have to take a loss on his record, with two home runs from Joey Gallo in the first five innings, the second cutting the Twins' lead to 7-4.

D.J. Lemahieu then hit his own solo home run in the fifth inning, before Aaron Hicks tied things at 7-7 with another two-run homer in the sixth.

RBI base hits to Anthony Rizzo and Hicks in the seventh inning gave the Yankees some breathing room, before Rizzo came home on a wild pitch in the eighth to ice the game.

The win moves the Yankees' to 41-16 as the best record in baseball, four games clear of the field.

Harper's heater continues

Philadelphia Phillies star Bryce Harper hit his fifth home run in six games as his side defeated the Milwaukee Brewers 8-3 on the road.

Harper, who is trying to win his second consecutive NL MVP, was one of three Phillies to go deep off the Brewers' Cy Young candidate Corbin Burnes.

After Milwaukee's Hunter Renfroe hit a solo shot to cut the Phillies' lead to 3-2, Harper's solo homer restored the margin. Then, a 432-foot, two-run shot by Kyle Schwarber in the eighth inning, and another two-run shot by pinch-hitter Odubel Herrera in the ninth secured the win.

Ohtani carries Angels to first win in 15 games

The Los Angeles Angels' franchise-record of 14 consecutive losses finally came to an end as Shohei Ohtani delivered with both bat and ball in a 5-2 home win against the Boston Red Sox.

Ohtani started on the mound and pitched seven strong innings, conceding one earned run from four hits and two walks, striking out six. 

He also provided his own run-support, scoring the Angels' first runs of the night with a two-run homer in the fifth inning, giving his side a 2-1 lead they never relinquished.

Andrew Velasquez finally allowed the home fans to breathe in the sixth inning, with his three-run blast opening up the margin to 5-1, letting the bullpen coast to the win without issue.

Shohei Ohtani had a bad time in the Bronx on Thursday, as the New York Yankees took the first of two games in a double-header against the Los Angeles Angels.

Matt Carpenter continued his solid form since signing as a free agent, seeing his way through an 11-pitch at-bat to score a lead-off home run off Ohtani in the 6-1 win.

Carpenter now has three home runs from 16 at-bats for the Yankees, while the reigning American League MVP gave up eight hits and four runs on the way to being pulled after three innings.

Jameson Taillon took a perfect game into the eighth inning as the Pinstripes won Thursday's second game 2-1, moving their record for the season to 36-15.

Further misfortune was dealt to Ohtani in the second game, with Wandy Peralta striking him out to confirm the save.

Rookie Ashcraft leads Reds in Nationals win

Rookie starting pitcher Graham Ashcraft continued his impressive start in the major leagues, as the Cincinnati Reds defeated the Washington Nationals 8-1.

The 24-year-old secured his first win last Friday, throwing six scoreless innings against the San Francisco Giants, and did not have to wait long for his second in another dominant performance.

The right-hander struck out five and gave up four hits over 92 pitches in seven innings, setting up what was only the Reds' 18th win of the season.

Alcantara assumes control against Giants

Sandy Alcantara allowed only three hits in an assured display, leading the Miami Marlins to a 3-0 win over the San Francisco Giants.

The 26-year-old walked two and struck out eight, while extending his run of at least seven innings pitched to five starts, and lowering his ERA to 1.81.

The Marlins scored early via a Jacob Stallings single, and that was all the run-support Alcantara needed, moving them to 21-28 for the season.

Los Angeles Angels superstar Shohei Ohtani hit a home run in each of his first two at-bats on Sunday, but it was not enough to stop the Toronto Blue Jays from winning the high-scoring battle 11-10.

Ohtani scored the game's opening run with a solo home run in the first inning, but by the time he stepped to the plate for a second time, his side trailed 6-2.

After sending his first blast 413 feet to center field, his second shot was a 425-foot, two-run homer, trimming the score back to 6-4.

Los Angeles catcher Max Stassi tied the game with a two-run single later in the third inning, before Travis Ward's two-run home run in the fourth frame made it 8-6 Angels.

Ward drove in another run with an RBI double in the sixth inning, but the Blue Jays tied things up at 9-9 in the seventh when three runs came home from a pair of bases-loaded walks, and an RBI single to Raimel Tapia.

Stassi made sure that tie was short-lived with a solo home run in the bottom of the seventh, before Bo Bichette again pulled the Blue Jays level with his own solo homer in the eighth.

After Blue Jays star Vladimir Guerrero Jr was intentionally walked, Lourdes Gurriel made the Angels pay, driving in what would be the game-winning run with a double to make it 11-10, setting the table for David Phelps to come in and secure the save.

Overall the two teams combined for 25 hits, and while nine players finished with multiple knocks, Stassi was the top performer with the bat, going four-for-five with three singles and a home run.

McClanahan bests the Yankees

New York Yankees MVP candidate Aaron Judge hit his league-leading 18th home run, but his side was no match for Tampa Bay Rays Cy Young candidate Shane McClanahan, going down 4-2 on the road.

McClanahan pitched six complete innings, striking out seven, while conceding just one run from seven hits and no walks.

As he kept the Yankees quiet, the Rays were able to build a lead thanks in large part to solo home runs from Choi Ji-man and Taylor Walls, leading 4-1 before Judge blasted a 420-foot consolation shot in the eighth inning.

Red Sox hold their own Home Run Derby

The Boston Red Sox hit a season-high five home runs in their 12-2 home win against the Baltimore Orioles – and they were the first five scoring hits of the game.

Bobby Dalbec got things started with a two-run homer in the second inning, with Franchy Cordero adding a solo shot later in the inning – his 448-foot bomb would be the biggest of the day.

Rafael Devers sent his moonshot 431 feet over the right-field wall in the third frame, and just an inning later both Christian Arroyo and Enrique Hernandez chipped in with their own solo home runs to make it 6-0.

Nick Pivetta was terrific on the mound in front of the Fenway Park faithful, pitching six innings for one earned run and five strikeouts.

Shohei Ohtani starred with a home run in his second consecutive game as the Los Angeles Angels defeated the Oakland Athletics 4-1 on Sunday.

After becoming the third Japanese-born player to hit 100 home runs in the major leagues, the 27-year-old went deep over right-field in the first inning off Frankie Montas. Mike Trout also scored after his single ahead of Ohtani.

It was the reigning American League MVP's eighth home run of the season, trailing Trout by one among the Halos, while the team leads baseball in that category with 49 for the season so far.

Patrick Sandoval pitched into the seventh inning for Los Angeles, striking out four and giving up four hits over 101 pitches.

The Halos moved to 24-13 for the season with the win, five games behind the AL West-leading Houston Astros, while the A's remain bottom of the division on 15-22.

Pujols pitches ninth as Cardinals run riot

Albert Pujols pitched for the first time in his major league career, with the St. Louis Cardinals routing the San Francisco Giants 15-6.

Brendan Donovan and Corey Dickerson were the only Cardinals not to claim hits in the lineup, while Yadier Molina got two hits and four RBIs from three at-bats, as their team went 15-2 up heading into the final frame.

It meant Pujols, the Cardinals' designated hitter, went to pitch for the first time in his 22-year career. The 42-year-old gave up a three-run homer to Luis Gonzalez and a solo shot to Joey Bart, but managed to get the final three outs for the win.

Lux lights up late as Dodgers defeat Phillies

Gavin Lux earned late redemption for the Los Angeles Dodgers in their come-from-behind 5-4 win over the Philadelphia Phillies

The second baseman's fielding error allowed the Phillies to gain a 4-0 lead in the second inning, but Lux scored in the eighth inning to move the Dodgers to 4-3 after the eighth.

He then drove the winning two runs home with a walk-off shot deep into the right-field corner to deny the Phillies a four-game sweep at Dodger Stadium.

Milwaukee Brewers outfielder Christian Yelich made history on Wednesday with his third career cycle, but it came in a high-scoring 14-11 loss to the Cincinnati Reds.

Yelich's cycle began with an automatic double in the first inning, before he blasted a three-run home run his next time up in the third frame.

A single in the fifth inning meant he just needed a triple to accomplish the rare feat, and after a fly-out in the seventh, Yelich connected on a first-pitch changeup in the last inning, hooking it into the right-field corner and hustling around to third base to complete his cycle.

He is now one of six players to ever hit for the cycle on three occasions and, incredibly, all three have come against the Reds. He is the only player to have three cycles against one team.

The action from the game did not stop with Yelich as there were 29 combined hits between the two sides, including six home runs.

For the Brewers, as well as Yelich, Hunter Renfroe hit two home runs, while Jace Peterson and Mike Brosseau hit one each.

Colin Moran was the only Reds player to go deep as the team with the worst record in baseball (7-24) found another way to win, manufacturing runs with consecutive singles and walks.

In the most eye-catching stat-line of the game – other than the cycle – Reds relief pitcher Dauri Moreta conceded five runs from five hits, including two home runs, while failing to get a single out before being pulled.

Torres stays hot for the Yankees

After hitting a walk-off home run against the Texas Rangers earlier in the week, New York Yankees second-baseman Gleyber Torres was the hero again in his side's 5-3 win against the Toronto Blue Jays.

Torres drove in all five Yankees runs, with a three-run home run in the fourth inning, and a base hit in the sixth inning when runners were on second and third base.

Yankees starting pitcher Jameson Taillon was credited with the win, with two earned runs from six hits and one walk in five-and-a-third innings, striking out four.

Angels waste quality Ohtani start

Reigning AL MVP and Los Angeles Angels superstar Shohei Ohtani pitched a gem against the Tampa Bay Rays, but it was not enough as the visiting Rays won 4-2 in extra innings.

Ohtani pitched six full innings, allowing just one run from two hits and two walks, but a lack of run support meant his side was trailing 1-0 when he was withdrawn.

Shane McClanahan was also nearly flawless on the mound for the Rays to win the pitching duel, finishing with seven shutout frames, striking out 11 batters and allowing two hits with one walk.

Rookie pitcher Reid Detmers pitched the second no-hitter of the MLB season on Tuesday, as the Los Angeles Angels shut the Tampa Bay Rays out 12-0.

The 22-year-old struck out two on the way to 108 pitches over the full nine innings, recording the Angels' 12th no-hitter in franchise history.

There was no let up from an offensive standpoint for the Halos, either, with Shohei Ohtani, Mike Trout, Jared Walsh and Brandon Marsh all claiming multiple hits at the top of the order.

Trout and Anthony Rendon scored three RBIs respectively, as the Angels moved to 21-11 for the season.

They hold a one-game lead over the Houston Astros at the top of the American League (AL) West, making up two of the three best records in the AL.

Judge rules out Blue Jays stand against Yankees

The New York Yankees maintained the best record in the AL, meanwhile, defeating the divisional-rival Toronto Blue Jays 6-5.

Aaron Judge scored the first walk-off home run of his career with a three-run home run off Jordan Romano to secure a big comeback win.

This came after Giancarlo Stanton's own three-run shot in the sixth inning, as the Yankees moved four games clear of the Rays atop the AL East with the victory.

Wood wins it for Giants

Alex Wood pitched into the sixth inning for the San Francisco Giants, who defeated the Colorado Rockies 9-2.

Wood allowed seven hits and struck out four in five-and-a-third innings for the Giants, who kept within touching distance of the Los Angeles Dodgers in the National League West.

Curt Casali contributed three hits and two RBIs, with the Giants claiming a fourth consecutive win to bounce back from a five-game losing stretch.

The Cleveland Guardians pulled off a spectacular comeback to beat the Chicago White Sox 12-9 on the road in extra innings, as Josh Naylor finished with a remarkable eight RBIs.

After an action-packed first inning, highlighted by Gavin Sheets' three-run home run for Chicago, the White Sox led 4-1.

There would be no more runs over the next five innings as Cleveland's Zach Plesac and Chicago's Michael Kopeck found a nice rhythm, with both starters withdrawn at the beginning of the seventh inning.

This also happened to be when the action picked back up, with the White Sox adding another run via a Tim Anderson double to make it 5-1 going into the eighth.

Naylor collected his own RBI double in the eighth to peg back one run, but the game appeared to be done when the White Sox's AJ Pollock blasted a three-run homer to make it 8-2 with one inning to play.

The Guardians had other ideas, as Andres Gimenez led off the inning with a solo home run, and a pair of errors first allowed Amed Rosario to advance from first base to third, and then brought him home, making it 8-4 with no outs.

After the next two batters were retired, a walk and a single loaded the bases for Naylor to be the hero. Naylor blasted the first pitch he saw over the right-centre wall for a grand slam, tying the game and sending it to extra innings.

Gimenez added a run in the top of the 10th inning, which was matched by Reese McGuire's RBI in the bottom of the frame, forcing an 11th innings.

With two outs, capping off an outrageous day at the plate, Naylor hit a three-run home run, giving him eight RBIs with three hits and a walk from six at-bats.

Stars shine in Los Angeles

The Los Angeles Angels' two MVP hopefuls put on a show in their 11-3 win against the Tampa Bay Rays.

After a fourth-inning solo home run for Tampa Bay's Randy Arozarena, Angels stars Shohei Ohtani and Mike Trout collected back-to-back hits later in the inning, setting the table for Jared Walsh to blast a three-run homer.

There was more back-to-back magic in the sixth inning, as Trout stepped up and blasted a two-run home run, before Ohtani came out next and sent a 407-foot shot over the wall at left-centre.

Trout would drive in another run an inning later with his bases-loaded walk, before Ohtani once again followed him in style, bombing a 413-foot grand slam.

Yankees no-hitter broken up late

New York Yankees starting pitcher Nestor Cortes took his no-hit bid into the eighth inning as his side beat the Texas Rangers 1-0.

Through seven complete innings, the score was tied at 0-0, with the Rangers' four base-runners for the game all reaching via walk.

After the first batter of the eighth inning was struck out, Texas' Eli White finally broke up the no-hitter with a base hit to centre-field, before New York's Anthony Rizzo drove in the one and only run for the contest later in the same frame. Cortes finished with 11 strikeouts from his seven-and-a-third innings.

Minnesota Twins pitcher Josh Winder etched his name into the history books on Friday night as he guided his team to a 2-1 win against the Oakland Athletics.

Winder, 25, in his second career start, pitched six shutout innings, giving up three hits and no walks with eight strikeouts. It comes after allowing just two hits and one walk from six scoreless innings in his first start against the Tampa Bay Rays.

He is the first pitcher since ERA became an official stat in 1913 to have 15 strikeouts, no more than one walk and allow no earned runs over his first two career starts.

It was almost not enough for the Twins, who scored their two runs from two solo homers, courtesy of Byron Buxton and Jorge Polanco. 

The Athletics cut the margin back to one when a fielding error allowed Cristian Pache to third base, where he would get brought home by a sacrifice fly, before Twins closer Emilio Pagan allowed a base hit and two walks to load the bases in the bottom of the ninth inning.

After a ground ball allowed the Twins to stop the third-base runner from getting to home plate, Pagan finished the job with a strikeout, sealing the victory and collecting the hard-earned save.

Trout delivers for Angels

AL MVP hopeful Shohei Ohtani's biggest competition for back-to-back trophies may be on his own team, as Mike Trout lifted the Los Angeles Angels to a 3-0 win against the Washington Nationals.

Reigning MVP Ohtani finished zero-for-three with a walk and an RBI, while three-time MVP Trout batted in two runs with a clutch double in the fifth inning.

It was a terrific performance by the Angels pitching staff, as starter Jhonathan Diaz gave up three hits and four walks through five scoreless frames, before the bullpen allowed just one hit and no walks the rest of the way.

Acuna bombs in Brewers win

Atlanta Braves star Ronald Acuna Jr gave the home fans something to cheer for, despite going down 6-3 to the Milwaukee Brewers.

In his second game back in Atlanta after a long-term injury, Acuna blasted a 450-foot home run to center-field for his first since July, but a four-run sixth inning for the Brewers put the visitors in front, where they would stay.

Los Angeles Angels manager Joe Maddon is worried baseball fans might start to take Shohei Ohtani's "otherworldly" two-way talents for granted.

In his third start of the year against the Boston Red Sox on Friday, Ohtani struck out 11 in seven shutout innings, allowing only six hits and no walks in throwing 81 of his 99 pitches for strikes.

In the pitch-count era (since 1988, minimum 50 pitches), his 81.8 per cent strike rate is the highest by a visiting pitcher at Fenway Park. Only one Red Sox pitcher – Nathan Eovaldi (82.0 per cent) last season – has topped that mark.

For good measure, Ohtani added two hits – falling just short of a home run with a single in the fourth, before cannoning another single off the Green Monster in the eighth, knocking his number 17 out of the manual scoreboard and driving in a run. He soon scored himself, too.

That late flurry contributed to an 8-0 Angels win that maintained a game-and-a-half lead in the AL West, but the focus after the game was on Ohtani and Ohtani alone.

"I hope you don't start taking that for granted, like it's old hat," Maddon said. "It's just so unusual. It's otherworldly on this level of this game."

Ohtani's start had been delayed by two days due to groin tightness, with the reigning AL MVP revealing he was "pretty fatigued", yet it was worth the wait.

Coming at Fenway Park – "one of my favorite ballparks," Ohtani said – there were inevitable comparisons to 1910s Red Sox legend Babe Ruth, arguably the greatest player of all time.

And Red Sox starter Rich Hill acknowledged it may now take another 100 years for anyone to match Ohtani's feats.

"He's the best player in the league," Hill said. "I think that's one thing everybody can pretty much unanimously agree upon.

"It's pretty special to see somebody like that come along. I think everybody should be really appreciating what we're seeing, because it’s something we haven't seen in 100 years and we may never see it again for another 100 years."

The New York Mets produced a remarkable ninth-inning comeback to stun the Philadelphia Phillies 8-7.

It was all Philadelphia early in front of their home fans, piling on four runs in the first inning, with Bryce Harper's RBI double to deep left-field the highlight.

Nick Castellanos also batted in one of the four early runs, and then added another in the second inning to make it 5-0 through two innings in a rough start for Mets pitcher Taijuan Walker. 

Walker's work came to an end at the end of the fourth inning after Harper and Castellanos both hit solo home runs, with Harper's 427-foot shot the biggest hit of the game, opening up a 7-0 lead.

Starling Marte finally got the Mets on the scoreboard with a solo home run in the sixth inning, but that would be all Phillies ace Aaron Nola would give up, pitching seven full innings for one earned run from three hits and one walk, striking out seven.

Leading 7-1 in the bottom of the eighth inning, ESPN gave the Phillies a win probability of 99.9 per cent – but the ninth inning would be one to remember for Mets fans.

Marte led off the inning with an infield single, with Francisco Lindor driving him home with a two-run homer for two of the eight Mets hits in the final frame.

Pete Alonso doubled as the next man to the plate, and after an out, Jeff McNeil singled to put runners on first and third.

Mark Canha's infield single brought Alonso home, but a strikeout for the next batter still left the Mets trailing 7-4 with two outs.

J.D. Davis kept the game alive with a clutch double, bringing one more run home to leave runners on second and third, needing a base hit from Brandon Nimmo to tie the game.

Nimmo delivered, bringing home the two runners to tie the game at 7-7.

Not done there, Marte came back to the plate and collected his second hit of the inning, with his long double hitting the wall on the full to bring Nimmo home from first base and take the 8-7 lead, before the next batter grounded out.

Mets closer Edwin Diaz made no mistakes, retiring the last three batters in order for an unlikely victory.

Ohtani gives MVP performance

Shohei Ohtani showed why he could be in line to go back-to-back as the American League MVP, as he dominated the Boston Red Sox to give the Los Angeles Angels a 8-0 win.

Ohtani pitched seven shutout innings for the Halos in his pitching debut at Fenway Park, striking out 11 while only allowing six hits and no walks over 99 pitches.

He also went two-for-four with the bat, driving in a run with a base hit in the eighth inning.

Astros walk-off against Tigers

The Detroit Tigers gave the Houston Astros a scare in the ninth inning, but the Astros sent their fans home happy with a 3-2 walk-off win.

In a strong pitching showing from both teams, the only two runs through eight innings were solo home runs to Jose Altuve and rookie Jeremy Pena to give the Astros a 2-0 lead.

Jeimer Candalario tied the game in the top of the last inning with a two-run homer, but any hope of a win was short-lived as Kyle Tucker hit a walk-off base hit in the bottom of the ninth.

Five New York Mets pitchers combined on Friday to throw the franchise's second ever no-hitter, beating the Philadelphia Phillies 3-0.

Tyler Megill got things started for the Mets, pitching five innings for three walks and five strikeouts before being withdrawn after 88 pitches.

Megill was replaced by Drew Smith, who struck out four of the five batters he faced, issuing one walk before he was then replaced by Joely Rodriguez for the seventh frame.

Seth Lugo came in to finish off the eighth inning, setting the table for closer Edwin Diaz to finish the job. The Mets' second no-hitter comes nearly 10 years after their first, when Johan Santana did it by himself in June 2012.

Diaz struck out all three batters in the ninth inning, becoming the first player to ever strike out every batter he faced to close out a no-hitter. It was also the first time since 1990 that the first no-hitter of the season was a combined effort.

It was a scoreless game on both sides until the fifth inning when Jeff McNeil's base hit brought home Eduardo Escobar and Mark Canha, with Pete Alonso's solo home run an inning later giving the Mets their winning margin.

Aaron Nola was no slouch on the mound for the Phillies, with nine strikeouts through six complete innings to go with three earned runs from seven hits and no walks.

The win moves the Mets' record to 15-6 – the best in the MLB.

Showtime for Shohei in Chicago

Just one game back in the standings from the Mets, the Los Angeles Angels claimed another stylish win as they defeated the Chicago White Sox 5-1.

It was a terrific pitching performance from the Angels staff as starter Jimmy Herget was pulled after just three innings, with six relievers combining to hold the White Sox scoreless the rest of the way.

With the bat, Shohei Ohtani made sure fans did not have to wait long to get their money's worth, sending a high fastball on a 3-1 count back over the pitcher's head and over the center-field wall. It was the Angels' second homer of the opening frame after Taylor Ward hit a lead-off bomb to start the game.

Guardians win back-and-forth thriller

In a game with five lead changes, the Cleveland Guardians prevailed 9-8 against the Oakland Athletics.

A Jose Ramirez solo home run gave the Guardians a 1-0 lead in the first inning, but it was short-lived as the Athletics responded with four runs in the bottom of the frame, with three coming home on a 407-foot Sean Murphy home run.

The momentum shifted again in the third inning as an Andres Gimenez grand slam pushed the Guardians back ahead 5-4, but once again the Athletics answered straight back, scoring the next four runs to lead 8-5.

Cleveland had the last laugh in the seventh inning, as a Ramirez double brought two runs home to trim the deficit to one, before a two-run Josh Naylor homer made it 9-8, allowing Emmanuel Clase to close things out with the save.

An imposing Shohei Ohtani claimed his first win of the MLB season as the Los Angeles Angels defeated the Houston Astros 6-0 on Wednesday.

Ohtani threw 81 pitches on a night where an 85-pitch limit seemed likely, as well as getting two at-bats in a six-run first inning.

The reigning American League MVP pitched perfect into the sixth inning, with a career-best 12 strikeouts, while also getting two hits and two RBIs in the shutout.

With the Astros traditionally providing him trouble, the 27-year-old did not allow a baserunner until Jason Castro hit a single with one out in the sixth.

The Angels moved to 8-5 with the win, leading the Seattle Mariners by a game atop the AL West.

Tapia leads Blue Jays to win over Red Sox

Raimel Tapia hit his maiden home run since joining from the Colorado Rockies, with a two-run slam in a five-run second inning as the Toronto Blue Jays beat the Boston Red Sox 6-1.

Jose Berrios claimed his first win in three starts this season, giving up just one run and eight hits in six innings, with six strikeouts and a solitary walk.

Meanwhile, Nick Pivetta gave up five runs, seven hits and four walks on the way to being pulled before the fifth inning – a second time in as many starts for the Canadian.

Giants ride Rodon to victory

Carlos Rodon broke a franchise record for the San Francisco Giants in their 5-2 win over the New York Mets.

After signing from the Chicago White Sox, Rodon struck out eight over five scoreless innings and moved to 27 over his first three starts, breaking the previous record of 26 set by Cliff Melton in 1937.

While Joc Pederson, Brandon Crawford and Wilmer Flores helped build an early 3-0 lead, Rodon was the star of the show, limiting the National League East-leading Mets to three hits and two walks on 95 pitches.

After seven consecutive road games to start their season, the New York Mets put on a show for their home crowd at Citi Field in a 10-3 win against the Arizona Diamondbacks.

Making his second start of the season, Chris Bassitt was lights out again for the Mets, pitching six full innings for six strikeouts while only giving up one run and four total baserunners.

After Pete Alonso drove in the first two runs through two sacrifice-fly balls, Robinson Cano delivered the first big shot of the day with a solo home run in the third inning, before Francisco Lindor bombed a two-run jack in the fifth frame.

Starling Marte would get in on the action in the eighth inning, connecting on a 391-foot three-run homer, before Lindor added his second long ball of the day in the very next at-bat.

Orioles walk-off with a walk

The New York Yankees went down 2-1 in extra innings against the Baltimore Orioles as the winning run was gifted home plate with a walk.

Giancarlo Stanton was the lone bright spot for the Yankees on the offensive side of the ball, getting three hits from five at-bats and driving in New York's only run.

The two starting pitchers – Jordan Montgomery for the Yankees and Jordan Lyles for the Orioles – combined for 10 innings of work for only one earned run.

The Milwaukee Brewers rode a quality start from Brandon Woodruff to a 5-1 home win against the St Louis Cardinals.

After a horrible first showing where he conceded seven runs in less than four innings, Woodruff was terrific in a bounce-back performance on Thursday, pitching five scoreless frames and allowing only four baserunners.

Milwaukee was always in control of the contest, leading 4-0 after three innings thanks to a big home run from Omar Narvaez and RBI hits to Andrew McCutchen and Hunter Renfroe.

However, the best hit of the game belonged to the Cardinals, as Tommy Edman blasted a big 423-foot consolation home run in the eighth inning for the visiting side's only score.

After going one-for-four with a double, Brewers star Christian Yelich now has hits in five of his past six games as he looks to return to form following two down seasons by his standards.

Ohtani gets grand-slammed

Reigning AL MVP Shohei Ohtani was on the receiving end of a Jonah Heim grand slam as the Los Angeles Angels lost to the Texas Rangers 10-5.

Ohtani, who was the Angels' starting pitcher and lead-off hitter, was disappointing on the mound on Thursday, giving up six runs in less than four innings, and finished the game one-for-four in the batter's box after a ninth-inning double.

It was a frustrating game for the Angels after it started so well, as Mike Trout hit one of the biggest home runs of his career in the first inning, travelling 472 feet.

Yankees get out of a jam

Leading 3-0 heading into the ninth inning, the New York Yankees found themselves in a sticky situation when closer Aroldis Chapman walked three consecutive Toronto Blue Jays batters to load the bases with no outs.

Chapman was pulled from the game and replaced with Michael King, who struck out George Springer. 

King then got Bo Bichette to line out to second base for a game-ending double play as Matt Chapman got caught too far away from first base when the catch was made.