Eddie Jones says Joe Marler's decision to withdraw from England's Six Nations squad does not mean his Test career is over.

Marler on Monday revealed he has opted against playing in the upcoming tournament so he can remain with his family during the coronavirus pandemic.

He tweeted: "Always grateful for the opportunity so not an easy decision, but want to do right by my family in these crazy times and won't be meeting up with the squad for this tournament. Look forward to watching the team rip in. Go well."

Marler announced his international retirement in 2018 in order to spend more time with his family but has gone on to take his tally of caps to 72 after reversing that decision.

England head coach Jones said the 30-year-old Harlequins prop, who also made himself unavailable for the tour of Australia in 2016 as he needed a rest, will be considered when he is ready to play for his country again.

"Joe has made a decision that we 100 per cent support," Jones said at the 2021 virtual Six Nations launch.

"When he decides to make himself available again we will have another look at selection. And that's how we look at it - 100 per cent. No ifs or buts, it's as clear as day.

"There will be some time in the future when he's ready to come back and will get selected. We'll take that when it comes.

"Joe has been an outstanding player during my time with England and I'm sure he was outstanding before that.

"He is tough, abrasive, a good defender, a great guy off the field. He's a bit nutty, but we like that, it's good to have characters like that in the squad."

England have also lost Sam Underhill (hip) and Joe Launchbury (fibula stress fracture) for the defence of their title, which they start against Scotland at Twickenham a week on Saturday.

Sam Underhill is the latest player to withdraw from England's Six Nations squad due to a hip injury.

Jack Willis has been called up as a replacement for back-row Underhill, who is another big loss for the defending champions.

Underhill played a big part in England's Six Nations and Autumn Nations Cup triumphs last year but sustained an injury blow before he was due to link up with the squad at St. George's Park on Wednesday.

Willis made his Test debut against Georgia last November and will be hoping to make his Six Nations bow in the coming weeks.

Underhill's withdrawal comes a day after Joe Launchbury and Joe Marler were ruled out due to a fibula stress fracture and personal reasons respectively.

England head coach Eddie Jones' preparations had already been disrupted last week when he was forced to go into self-isolation after his assistant Matt Proudfoot tested positive for coronavirus.

The Red Rose start the defence of their title against Scotland at Twickenham a week on Saturday.

Dan Lydiate has been recalled to the Wales squad for the Six Nations but there is no place for Rhys Webb.

Back-row Lydiate last played for his country against Australia in 2018, but the 33-year-old is among the 36 players selected by head coach Wayne Pivac.

Scrum-half Webb has been overlooked, with Gareth Davies, Tomos Williams and Kieran Hardy getting the nod.

Scarlets back-row Josh Macleod is the only uncapped player in the squad for a tournament Wales will start with an encounter against Ireland at the Principality Stadium on February 7.

Pivac revealed he was unable to pick Rhys Priestland, despite the fly-half being set to return to his homeland with Cardiff Blues next season, due to the 60-cap rule.

Captain Alun Wyn Jones is hopeful of being fit to face Ireland in Dublin as he continues his recovery from a knee injury.

Ross Moriarty, Gareth Anscombe, Rhys Patchell and Scott Williams are among the players ruled out due to injury.

Pivac said: "We are hugely looking forward to meeting up as a squad on Monday and to the forthcoming campaign. The Guinness Six Nations is an important tournament and we have selected a squad accordingly.

"As we consistently spoke about, the autumn for us was about opportunity and development, looking ahead to RWC 2023 and it served that purpose for us.

"This campaign is different, it is tournament rugby and we are excited to get going and to play our part. We have picked a squad for this tournament based on form and we are excited to meet up on Monday and to get our preparation underway."

Wales squad:

Forwards: Rhys Carre, Wyn Jones, Rhodri Jones, Elliot Dee, Ryan Elias, Ken Owens, Leon Brown, Tomas Francis, Dillon Lewis, Jake Ball, Adam Beard, Alun Wyn Jones (captain), Will Rowlands, Cory Hill, Dan Lydiate, Josh Navidi, Aaron Wainwright, Taulupe Faletau, Josh MacLeod, Justin Tipuric.

Backs: Gareth Davies, Tomos Williams, Kieran Hardy, Dan Biggar, Callum Sheedy, Jarrod Evans, Johnny Williams, Jonathan Davies, Nick Tompkins, Owen Watkin, George North, Josh Adams, Hallam Amos, Louis Rees-Zammit, Leigh Halfpenny, Liam Williams.

Rassie Erasmus says South Africa will "explore any option" to ensure they do not miss out on facing the British and Irish Lions.

The Lions are scheduled to lock horns with the world champions in July and August, but the tour is in doubt due to the coronavirus pandemic.

Playing the series in the United Kingdom has been mooted as a potential alternative to the Lions flying out to South Africa.

Delaying the tour until next year could be another alternative and a decision is expected to be made next month, with talks among the Lions board ongoing.

South Africa's director of rugby Rassie Erasmus, who who coached the Springboks to Rugby World Cup glory in 2019, says the Webb Ellis Cup holders are willing to be flexible over where and when they take on the Lions.

"We desperately want to play the Lions, and we will do anything to play them," he said in a press conference.

"This series only comes around every 12 years. I have heard the different calls and opinions about the tour, and although we didn't play in the Rugby Championship because of player welfare, it was also because we knew there was this big series in 2021.

"If option one of playing in South Africa doesn't work out, we will go to option Z to make it happen.

"We don't want to lose out on the Lions series, we feel we deserve to play against them. I want to, Jacques Nienaber [Springboks head coach] wants to, the players want to. So from our side, we'll do anything.

"But yes, we will explore any option to play the Lions, we will play next year, we will play over there. This is the view from a player and management perspective."

French Rugby Federation (FFR) president Bernard Laporte says there is "no question" that the Six Nations will be staged this year.

The Telegraph this weekend reported that the tournament was in doubt after the French sports ministry imposed a ban on playing cross-border elite sports with clubs from the United Kingdom due to a new strain of coronavirus.

With the European Champions Cup and Challenge Cup reportedly set to be suspended, the French government and Six Nations officials are expected to hold talks on Monday.

Yet Laporte does not believe there is any doubt that the competition, which starts in just four weeks' time, can be staged. 

He told RMC on Sunday: "It's a puzzle, but I think we should not be alarmed for the Six Nations tournament.

"The tournament will be played, with a health protocol dictated by the government, and linked to this mutant virus. Everything went well in the autumn [when the Autumn Nations Cup was staged], so will the upcoming Six Nations tournament, I'm no more worried than that."

The former Les Bleus coach added: "We have a meeting at the beginning of the week with the ministry of sports, a meeting also with the Six Nations Council.

"But we already talked to each other every day, and today there is no question of considering anything, except that we will play the tournament."

France are due to face Italy in the first game of the Six Nations at Stadio Olimpico on February 6.