Andy Murray stormed to a straight-sets win over Sam Querrey at the Hall of Fame Open in Rhode Island, while 2020 US Open champion Dominic Thiem earned his first victory in over a year in Sweden.
Murray needed less than an hour to record a 6-2 6-0 triumph over the big-serving American, setting up a last-16 meeting with Australia's Max Purcell.
Three-time grand slam champion Murray hobbled out of his last meeting with Querrey at the Wimbledon quarter-finals in 2017, a defeat which marked the start of his injury woes.
But he produced a polished display on the grass to wrap up his eighth career win over the American on Tuesday.
Elsewhere in Rhode Island, eighth seed James Duckworth battled to a 6-2 4-6 6-2 win over Liam Broady, and seventh seed Jiri Vesely raced to a 6-4 6-2 triumph against Spain's Feliciano Lopez.
Meanwhile, Thiem ended a 426-day wait for a Tour-level win by overcoming Finland's Emil Ruusuvuori 3-6 6-1 7-6 (7-5) at the Swedish Open.
The Austrian, who has won 17 career titles, halted a run of 10 consecutive losses on the ATP Tour with his first triumph since he beat Marton Fucsovics at the last-32 stage of the Internazionali d'Italia in May 2021.
The 28-year-old expressed his delight at ending his drought in the aftermath, saying: "It's a long time. My last victory was in Rome in 2021, it feels like a different world somehow.
"Many, many things happened. It was tough, but it was also a very good experience I think, for life in general. I'm so happy that I got this first victory here today."
Thiem will face fourth seed Roberto Bautista Agut in the last 16, while Sebastien Baez will take on Alejandro Davidovich Fokina after the former beat Fabio Fognini in straight sets.
The round of 32 did see two shock exits, however, with seventh seed Holger Rune succumbing to a 6-3 6-3 defeat against Switzerland's Marc-Andrea Huesler, and Nikoloz Basilashvili being forced to retire at one set down against Hugo Gaston.
Also, Francisco Cerundolo beat Pedro Sousa to set up an enticing clash with top seed Casper Ruud.