Second seed Stefanos Tsitsipas was bundled out of the Miami Open in straight sets during Tuesday's fourth round by 2022 US Open semi-finalist Karen Khachanov.

The Russian 14th seed prevailed 7-6 (7-4) 6-4 over Tsitsipas in one hour and 34 minutes, powering 25 winners and making only nine unforced errors, compared to the Greek's 14.

Khachanov's triumph ended a winless 0-6 head-to-head record against Tsitsipas, while it also snapped his own 23-match losing streak against top-10 opponents.

The Russian, who also made this year's Australian Open semi-finals, has qualified for four of his six tour-level events this year.

Khachanov will take on 25th seed Francisco Cerundolo in the quarter-finals, with the Argentinian fighting back to get past Lorenzo Sonego 3-6 6-3 6-2 in just over two hours.

Defending champion and top seed Carlos Alcaraz had less trouble against Tommy Paul, cruising into the quarter-finals with a 6-4 6-4 victory.

Alcaraz won the winners' count 24-9, setting up a quarter-final clash with ninth seed Taylor Fritz, as the Spanish 19-year-old chases a rare Sunshine Double, having won last week's Indian Wells Open.

Fritz progressed after getting past seventh seed Holger Rune 6-3 6-4 in 86 minutes, sending down eight aces and 22 winners for the match.

Fourth seed Daniil Medvedev played late into the evening after a lengthy rain delay in Miami, but made light work of Quinten Halys 6-4 6-2, triumphing just past 1:30am local time.

Medvedev, who is into his third straight Miami quarter-final, will face American qualifier Christopher Eubanks in the last eight after he got past Frenchman Adrian Mannarino 7-6 (7-2) 7-6 (7-5) in another rain-delayed contest.

Italian 10th seed Jannik Sinner knocked off sixth seed Andrey Rublev 6-2 6-4, advancing to face Emil Ruusuvuori after he beat Botic van de Zandschulp 4-6 6-4 7-5.

Top seed and reigning champion Carlos Alcaraz dished out a bagel as he continued his outstanding form with a straight-sets victory over Dusan Lajovic to ease into the Miami Open fourth round on Sunday.

Alcaraz, who triumphed at last week's Indian Wells Open, beat the 76th-ranked Serbian 6-0 7-6 (7-5) in one hour and 32 minutes.

The 19-year-old Spaniard hit 26 winners compared to Lajovic's eight, while Alcaraz also sent down three aces on a 75 per cent first serve percentage.

Alcaraz won the first frame to love in 32 minutes, registering his fourth career bagel at ATP Masters 1000 level, equaling the most by a teenager alongside Rafael Nadal.

The world number one will face 2023 Australian Open semi-finalist Tommy Paul in the fourth round after the American got past 20th seed Alejandro Davidovich Fokina 6-3 7-5.

Third seed and 2022 Miami Open finalist Casper Ruud blew a first-set lead to lose 3-6 6-4 6-4 to Botic Van De Zandschulp.

The Dutchman improved his head-to-head record against Ruud to 3-1 with his first-ever top five win, with the Norwegian left to lament converting only two of 15 break points.

Ninth seed Taylor Fritz progressed into the fourth round with a 6-4 6-4 win over Denis Shapovalov, improving his head-to-head record against the Canadian to 4-5. Fritz committed only eight unforced errors and did not face one break point.

Jannik Sinner maintained his excellent hard-court form with his 18th win this season on the surface, as he defeated Grigor Dimitrov 6-3 6-4 in one hour and 28 minutes. The Italian 10th seed will be Andrey Rublev in the next round.

Sixth seed Rublev needed less than an hour to get past Miomir Kecmanovic 6-1 6-2, while compatriot Daniil Medvedev advanced via a walkover against Alex Molcan due to a right hip injury.

Seventh seed Holger Rune cruised past Diego Schwartzman 6-4 6-2, while Finland's Emil Ruusuvuori got past Taro Daniel 6-3 7-6 (7-3).

World number one Carlos Alcaraz wasted no time in advancing to the Miami Open third round with a straight-sets win over Facundo Bagnis in just 64 minutes, while 13th seed Alexander Zverev suffered an early exit on Friday.

Reigning US Open champion Alcaraz eased past Bagnis 6-0 6-2, firing 12 winners and three aces for the match, committing only 11 unforced errors.

The Spaniard won the first set in 24 minutes, marking the first time he has won an opening frame 6-0 at an ATP Masters 100 event. It was also the first bagel he has dished out since beating Bagnis in Umag last year.

"I knew that I needed to be focused for my first match," Alcaraz said after his win, having triumphed in Indian Wells last week. "To start a new tournament is never easy, different conditions.

"I have to be ready to get used to these new conditions, but I was really focused on the match from the beginning, and I'm happy with the way that I played. I try to improve every day."

Alcaraz will face Dusan Lajovic after he beat 30th seed Maxime Cressy 6-4 7-6 (7-2), having knocked off Andy Murray in the first round.

Zverev was the highest seed to bow out on Friday, going down 6-0 6-4 to Japan's Taro Daniel, who beat world number four Casper Ruud last month in Acapulco.

Daniel triumphed in 73 minutes against the German, hitting 17 winners and committing only two unforced errors for the match, while Zverev gave up 18.

The Japanese wild card will meet Emil Ruusuvuori in the third round after the Finn beat 22nd seed Roberto Bautista Agut 6-4 7-6 (7-5) to open up that section of the draw.

Third seed Ruud also had few problems getting past Ilya Ivashka 6-2 6-3 to set up a clash with Botic van de Zandschulp after his three-set win over Alexei Popyrin.

Sixth seed Andrey Rublev overcame J.J. Wolf 7-6 (7-3) 6-4, having been broken in the opening game of what was a tight contest.

Jannik Sinner beat Laslo Djere 6-4 6-2, marking his 16th win out of 20 appearances at the Sunshine Double (Indian Wells and Miami), with only three other players – Novak Djokovic, Alcaraz and Hubert Hurkacz – having as many wins within their first 20 matches.

Ninth seed Taylor Fritz defeated fellow American Emilio Nava 6-4 6-1, and will face Denis Shapovalov in round three after he beat Guido Pella 6-3 3-6 6-3.

American 16th seed Tommy Paul came from a set down to beat Marc-Andrea Huesler 5-7 6-3 6-4, while seventh seed Holger Rune beat Martin Fucsovics 6-3 7-5.

Tennis will never see a "big three" with the quality of Rafael Nadal, Novak Djokovic and Roger Federer again, believes Juan Martin del Potro.

The trio, who have combined for a total of 64 men's singles grand slam titles across a near-two-decade-long period of dominance, have come to define the sport's modern era.

Federer retired last year and while Nadal and Djokovic continue, both are well into the twilight of their careers, despite astonished continued success.

Del Potro, the 2009 US Open winner, also retired in 2022, and he thinks the trio's dominance is unlikely to be replicated going forward, even though he sees Carlos Alcaraz, Jannik Sinner and Holger Rune as three players who could possibly go on to enjoy great success.

"The only thing I lacked was being number one [in the ATP Rankings]," he said. "It was always a dream, and I always worked for it. I never made it because there was either Federer, or Nadal, or Djokovic.

"When I look at the rankings and the years of my career and who was fighting to be number one I see that it was beautiful that these were the ones who didn't let me make it, this dream."

"One day, the big three will end. We have Carlos Alcaraz, Jannik Sinner [and] Holger Rune, other young people who will mark the circuit.

"But for me, [for] many years, [it was] the big three. There will not be anything similar."

Del Potro reached a career high-mark of third in the ATP Rankings in 2018, with Andy Murray the only man other than Nadal, Federer or Djokovic to top the charts between 2005 and 2021.

Top seed Carlos Alcaraz and reigning champion Taylor Fritz both overcame challenges to progress into the third round of the Indian Wells Open on Saturday.

Alcaraz won 6-3 6-3 over Thanasi Kokkinakis in one hour and 18 minutes in his opening match of the event, which also marked his return from a fortnight out with a hamstring injury.

The Spaniard, who reached the semi-finals at Indian Wells last year, could return to the number one ranking with victory at this year's event in the absence of Novak Djokovic.

Alcaraz hit 21 winners against the 94th-ranked Australian, dropping only one point on serve in the opening frame.

Fritz went a set down against 2023 Australian Open quarter-finalist Ben Shelton but eventually prevailed 4-6 6-4 6-3 in one hour and 53 minutes.

Both players were excellent on serve throughout the contest, with Fritz earning a break in the 10th game of the second set to tie up the match, before swooping again in the sixth game of the decisive frame.

Veteran Andy Murray moved into the third round with a 6-4 6-3 win over Radu Albot, with the Briton to take on countryman Jack Draper next. Draper won 6-4 6-2 over 24th seed Daniel Evans.

Murray had been set to face 15th seed Pablo Carreno Busta in the second round, but he withdrew due to a muscle injury, allowing Albot into the draw as a lucky loser. Murray's win was his first in straight sets since October.

Seventh seed Holger Rune won 7-5 6-3 over American Mackenzie McDonald, progressing to face Stanislas Wawrinka after he toppled 26th seed Miomir Kecmanovic 7-6 (10-8) 6-4.

Ninth seed Hubert Hurkacz got past Australian Alexei Popyrin 6-3 6-3, setting up a third-round clash with 17th seed Tommy Paul who won 6-3 6-3 over Jan-Lennard Struff.

Eighth seed Felix Auger-Aliassime won 7-6 (7-5) 6-4 over Pedro Martinez, while 11th seed Jannik Sinner got past veteran Richard Gasquet 6-3 7-6 (7-2).

Last week's Mexican Open champion and 16th seed Alex de Minaur was the highest seed to be knocked out on Saturday after a 6-4 6-2 loss to Martin Fucsovics.

Seventh seed Tommy Paul claimed a spot in the Mexican Open final after proving too good for countryman Taylor Fritz in the longest match in Acapulco history on Friday.

Paul edged the third seed 6-3 6-7 (2-7) 7-6 (7-2) in three hours and 29 minutes in their semi-final clash in Acapulco.

World number 23 Paul actually generated a match point late in the second set but spurned his initial chance, then waiting another two hours before winning in the third-set tie-break.

Paul let match point slip at 5-4 in the second set and had to rally back from 3-1 down in the third, but triumphed on his fourth match point.

"I couldn't be happier," Paul said. "The goal for this year was to get the ranking up and get more trophies. I only have one trophy on Tour between singles and doubles.

"You don't get trophies unless your in the final, and hopefully I can play another good match tomorrow and get the winner's trophy."

The 2023 Australian Open semi-finalist will take on Alex de Minaur in Saturday's decider, after he defeated Holger Rune 3-6 7-5 6-2 in two hours and 50 minutes.

In the Chile Open, local Nicolas Jarry progressed into the semi-finals with a 3-6 6-3 6-4 win over German qualifier Yannick Hanfmann. Jarry will face Spaniard Jaume Munar after he won 6-3 3-6 6-2 over Thiago Monteiro.

Third seed Sebastian Baez got past Laslo Djere 7-6 (7-4) 6-4, setting up a semi-final date with Tomas Martin Etcheverry after he won 6-1 6-2 over Dusan Lajovic.

Second seed Casper Ruud suffered a shock three-sets second-round defeat to Japan's Taro Daniel at the Mexican Open in Acapulco on Wednesday.

The 2022 US Open and French Open runner-up had struggled past Guido Andreozzi in the first round and followed up that up with a 7-5 2-6 7-6 (7-5) loss to Daniel.

The Japanese qualifier, ranked 125th in the world, won in just under three hours, winning the final three points of the deciding tie-break after Ruud led 5-4.

Ruud had more winners (38-32) but committed 30 unforced errors compared to Daniel's 12.

Taylor Fritz cruised into the last eight with a 6-4 6-4 win over Canada's Denis Shapovalov, setting up a quarter-final with sixth seed Francis Tiafoe, who eased past Feliciano Lopez 6-2 7-6 (8-6).

Fourth seed Holger Rune was too strong for Nuno Borges 6-0 6-2 inside an hour, while eighth seed Alex De Minaur crushed Jacopo Berrettini in just over an hour 6-1 6-0.

Top seed Lorenzo Musetti was a surprise second-round loser at the Chile Open with Jaume Munar triumphing 6-4 6-4 in one hour and 31 minutes.

Fourth seed Diego Schwartzman also bowed out, going down 6-4 4-6 7-6 (7-2) to local Nicolas Jarry.

Jarry will face Yannick Hanfmann in the quarter-finals, while Munar will take on Thiago Monteiro.

Taylor Fritz was forced to come from behind to claim a three-set victory over John Isner in the opening round of the Mexican Open in Acapulco on Monday.

Fritz was among the seeds to progress, alongside Casper Ruud, Holger Rune, Francis Tiafoe and Tommy Paul.

The third seed lost the opening set in 29 minutes but rallied back to win 3-6 6-3 6-4 in one hour and 49 minutes over the big-serving world number 38 Isner.

Fritz claimed his first break of the match in the 17th game before levelling things up at one set each, before breaking Isner at 4-4 in the third and serving out for victory.

The win means Fritz will take on Canada's Denis Shapovalov in the second round after he beat Miomir Kecmanovic in three sets, with the American looking to go one better after being runner-up in Acapulco in 2020.

Second seed Ruud found himself in an almighty battle with Argentina's Guido Andreozzi and eventually prevailed 6-4 4-6 7-6 (7-2).

World number four Ruud, ranked 338 places above his opponent, was broken in the first game of each set but dug deep to get the job done in a little under three hours. 

Fourth seed Rune got past 2023 Australian Open quarter-finalist Ben Shelton 6-7 (7-9) 6-4 6-2.

Sixth seed Tiafoe overcame Japan's Yoshihito Nishioka 7-6 (8-6) 6-4 while 2023 Australian Open semi-finalist Paul beat Emilio Gomez 6-1 7-6 (7-4).

Defending champion Pedro Martinez was bundled out of the Chile Open in the first round after losing 6-2 6-0 to German qualifier Yannick Hanfmann.

Jaume Munar progressed to set up a second-round clash with top seed Lorenzo Musetti after winning 6-0 6-7 (4-7) 7-6 (7-5) against Alejandro Tabilo.

Defending champion Felix Auger-Aliassime must overcome a dismal record against Daniil Medvedev to go any further at the Rotterdam Open after both won on Thursday to set up a heavyweight quarter-final, while Stefanos Tsitsipas crashed out.

Third seed Auger-Aliassime beat French qualifier Gregoire Barrere 6-4 6-3, while Medvedev earned a 6-2 6-2 victory against Dutchman Botic van de Zandschulp.

Despite being the higher-ranked of the two at present, Canadian Auger-Aliassime has a 0-4 career record against Russian Medvedev.

Those losses include a painful defeat from two sets up in the 2022 Australian Open quarter-finals, and a US Open semi-final knockout blow in the previous season.

It is a record that is all the more surprising considering Auger-Aliassime has wins over Novak Djokovic, Rafael Nadal, Roger Federer, Andy Murray and Carlos Alcaraz to his name.

Auger-Aliassime sits eighth on the ATP ranking list, three places clear of former number one Medvedev, who is relishing their clash on Friday.

Medvedev said on Amazon Prime: "Felix is a top player. He won here last year and played amazing at the end of last season. I'm looking forward to a tough match, and hopefully I can be at my best.

"He's going to take his opportunities. He's going to go for it when he has the chance. So I will need to be at my best and everything has to be better."

Top seed and Australian Open runner-up Tsitsipas was beaten 6-4 6-3 by Jannik Sinner, with last week's Open Sud de France champion winning in an hour and 21 minutes to set up a quarter-final against Stan Wawrinka.

It was Sinner's first career win over a top-three opponent. The Italian held a 0-8 record against such opponents coming into this match.

Fourth seed Holger Rune is also out after retiring hurt while 6-4 4-0 down to Dutch wildcard Gijs Brouwer, who advances to play compatriot Tallon Griekspoor.

Australian Alex de Minaur advanced to the final eight with a 7-5 3-6 6-3 win over American Maxime Cressy, earning a shot at Grigor Dimitrov next.

Andrey Rublev suffered a first-round defeat to Alex de Minaur on a bad day for the big names at the Rotterdam Open.

Second seed Rublev won this event two years ago but there will be no such run this time around after his 6-4 6-4 loss on Wednesday.

De Minaur broke the world number five early in each set and sealed the win at the first time of asking, moving to a 3-0 head-to-head record against Rublev on hard courts.

The Australian will face Maxime Cressy in the next round, who bounced back from his Open Sud de France final defeat by beating Tim van Rijthoven.

Jannik Sinner saw off Cressy in that Montpellier showdown and the Italian carried that form into this tournament, though he needed three sets to overcome Benjamin Bonzi.

Frenchman Bonzi forced a decider but Sinner regained his composure in the final set to prevail 6-2 3-6 6-1 and set up a heavyweight clash with top seed Stefanos Tsitsipas.

There was no such progress for Alexander Zverev, who joined Rublev in suffering an early exit.

The German came unstuck 4-6 6-3 6-4 to home favourite Tallon Griekspoor, whose four wins over top-20 opponents have all come in Rotterdam.

Stan Wawrinka, the champion in 2015 and runner-up four years later, will face the winner of that tie, after he beat Richard Gasquet 6-3 6-3 to reach the quarter-finals.

Holger Rune reached the semi-finals in Montpellier, and like Sinner the fourth seed progressed into round two, claiming a routine straight-sets victory over qualifier Constant Lestienne.

"It was tricky. It's a lot about finding the rhythm here in the beginning of the tournament and first match you have to really be on your toes, especially I played a qualifier today who already has two matches in his bag," Rune said.

"It made it more difficult, but I'm happy how I handled every situation today."

Hubert Hurkacz was another seed to fall out, with the world number 10 going down 7-6 (7-4) 7-6 (7-5) to Grigor Dimitrov.

Maxime Cressy sprang a shock by beating top seed Holger Rune to reach the Open Sud de France final, where Jannik Sinner awaits him.

Paris-born American Cressy won 7-5 6-7 (3-7) 7-6 (7-4) in a little over two and a half hours, countering 10 double faults with 15 aces on his way to victory.

Rune, the Danish 19-year-old who sits ninth in the world rankings, had won his three previous matches against Cressy, including a second-round clash at the Australian Open last month, but he could not extend that dominance at the indoor event in Montpellier.

It means Cressy faces second seed Sinner, a player he lost to at a low-level tournament in Lexington in 2019, their only past meeting.

Sinner beat 18-year-old French wildcard Arthur Fils in Saturday's first semi-final, ending the teenager's eye-catching run with a 7-5 6-2 victory.

Fils had beaten Richard Gasquet and Roberto Bautista Agut on his way to the last four but found world number 17 Sinner was more than his match.

Last year saw Sinner reach just one ATP final, taking a title on clay in Umag, after making it through to five title matches in the 2021 season.

He had his best year at the grand slams, however, reaching quarter-finals at three of the four majors.

Cressy recognises the threat posed by the Italian, saying in an on-court interview: "Jannik Sinner is an incredible player, just like Holger Rune and everyone else in the tournament. I believe you've just got to bring your 'A' game every time and I'm really looking forward to it."

Competing well in France has been pleasing for Cressy, who is set to climb from 51st in the rankings and into the top 40 on Monday.

"I lived and grew up here, and I'm extremely happy," Cressy said.

Open Sud de France top seed Holger Rune stayed on course to make the final in Montpellier after a straight-sets defeat of Gregoire Barrere.

Last year's Paris Masters champion Rune, who is in the hunt for his first title of the season, beat the Frenchman 7-6 (7-2) 7-6 (7-5) and is yet to drop a set in the tournament.

The 19-year-old looks sharp, but so too does Jannik Sinner. Two years Rune's senior, the Italian made light work of his good friend and compatriot Lorenzo Sonego on Friday.

Sinner took just over 90 minutes to triumph 6-4 6-2 and tee up a semi-final with history-making 18-year-old Arthur Fils.

Fils, the world number 163, beat Quentin Halys to become the youngest Frenchman to reach a tour-level semi-final since Richard Gasquet in 2004.

"I have seen him [Fils] play here at this tournament," Sinner said of Fils, as quoted by the ATP Tour's official website.

"He is very strong physically already. He understands the game very well. He started off the year very well, so it is going to be an interesting match for sure."

Sinner will be the favourite despite Fils' hot streak, while Rune will go up against Maxime Cressy in a rematch of their Australian Open second-round match.

Cressy went down 7-5 6-4 6-4 in that meeting in Melbourne last month, though has the chance for revenge after seeing off Borna Coric 7-6 (7-2) 6-4.

Holger Rune made a winning start at Open Sud de France after defeating Marc-Andrea Huesler 7-6 (7-5) 6-2 to reach the quarter-finals in Montpellier.

Appearing as the top seed at an ATP event for the first time, Rune had lost both his previous meetings with Huesler, including last season's Sofia Open.

However, the world number nine made it third time lucky to set up a last-eight clash with Gregoire Barrere, who beat Nikoloz Basilashvili in straight sets.

Meanwhile, third seed Borna Coric is now just one win away from securing a return to the top 20 in the ATP rankings. The world number 23 – and reigning Cincinnati champion –saw off Arthur Rinderknech 6-3 7-5.

Although, there was no joy for Alejandro Davidovich Fokina. The fifth seed was ousted 6-3 6-3 by world number 70 Quentin Halys, who claimed only his second top-50 career win in 20 attempts.

Seventh seed Emil Ruusuvuori was also eliminated in straight sets by Maxime Cressy, but Lorenzo Sonego overcame Filip Krajinovic to book a quarter-final date with Jannik Sinner.

Marc-Andrea Huesler will face top seed Holger Rune in the second round of the Open Sud de France after coming through a battle with teenager Luca Van Assche.

Huesler arrived in Montpellier on a high from victories over German duo Alexander Zverev and Oscar Otte for Switzerland in Davis Cup qualifiers last weekend.

The left-hander saw off 18-year-old Frenchman Van Assche 6-3 3-6 6-3 and will get a chance to improve his perfect record against Rune to 3-0.

Italian Lorenzo Sonego sent eighth seed Benjamin Bonzi packing with a 6-4 6-3 win, while French-born American Maxime Cressy progressed with a 6-3 6-2 defeat of Antoine Bellier.

Arthur Rinderknech and Quentin Halys also advanced on home soil, along with Marton Fucsovics and Filip Krajinovic.

Andrey Rublev suggested he had given up hope at 5-0 down in the deciding tie-break against Holger Rune.

Rublev prevailed 6-3 3-6 6-3 4-6 7-6 (11-9) in a three-and-a-half-hour thriller against the Dane on Monday to progress to the quarter-finals of the Australian Open.

The Russian salvaged two match points to force a tie-break at the end of the fifth set, but found himself staring down the barrel of an exit from the season's first major as Rune cruised into a commanding lead.

Yet Rublev won nine of the next 11 points and, at the third attempt, sealed a remarkable victory when a shot that hit the net cord trickled just over.

"Yes, I was lucky," Rublev said in his post-match press conference.

"I started to think it's over, for sure. Somehow... I was able to start to play with much more focus."

Asked how he maintained his self-belief, Rublev quipped: "I was not believing."

"Beginning of the fifth set, I was completely frozen. Inside I was thinking that I cannot [win]. I cannot move. I cannot hit.

"I was thinking it's over. He's playing much better than me. He deserves to win. He's going for the shots. He's doing something that normally I am supposed to do if I want to win the match.

"I let it go. Somehow the stress that I had, I was able to relieve it. At the end of the match I played much better than during the rest of the match."

During his on-court interview, Rublev said: "I was never able to win matches like this, this is the first time I've won something like this.

"At a very special tournament, to be in a quarter-final, it's something I'll remember all my life. I'm shaking!"

Rublev has qualified for his second Australian Open quarter-final, and his seventh at a grand slam. However, he has lost all of those matches.

The world number six, seeded fifth in Melbourne, has won three successive matches that have gone the distance, a career-first. Now, he will meet nine-time champion Novak Djokovic, who defeated Alex de Minaur in straight sets.

"I don't know," Rublev replied when asked if Djokovic was unbeatable. 

"Novak is very tough player to beat, especially in the slams.

"He has the best experience to win these matches. He's one of the best in history. The only chance I have is if I play my best tennis, just fight for every ball, and that's it. That's the only chance."