Pep Guardiola saw Manchester City squander a glorious chance to all but make sure of the Premier League title, and their quest could go to the final day.
City rallied from two goals down to draw 2-2 at West Ham, but Riyad Mahrez's late penalty miss might yet be a telling moment in the race for silverware.
Tottenham piled pressure on Arsenal in the battle for fourth after a narrow win over a Burnley side who would have been devastated by Leeds United's late leveller against Brighton and Hove Albion, shaking up the relegation battle.
Everton might have seen the visit of Brentford as a chance to banish their own worries about dropping into the second tier, but a home defeat keeps the Toffees on unsteady ground, as Opta data tells the story of the day.
West Ham 2-2 Manchester City: Bowen's bullseye strikes and Mahrez's miss keep title race alive
Jarrod Bowen's double carried West Ham into a 2-0 interval lead, but Jack Grealish and Vladimir Coufal's own goal hauled City level.
This match almost produced a Premier League first for City; however, Mahrez's spot-kick was saved by Lukasz Fabianski in the closing stages to mean they could not complete the turnaround.
This was only the second time City had avoided defeat from two or more down at half-time (D2 L51), but that probably felt like scant consolation, given Liverpool are back in the hunt, providing the FA Cup winners collect three points at Southampton on Tuesday.
Mahrez has missed two penalties in all competitions for City – his first was against Liverpool in October 2018. Between that and the miss at the London Stadium, the Algerian had converted nine consecutive penalties.
Bowen has scored 12 times and provided 10 assists in the Premier League this season, with his 22 goal involvements the third most in a single campaign in the competition by a West Ham player, after Paolo Di Canio (29 in 1999-00) and John Hartson (23 in 1997-98).
Fabianski, the toast of east London and large parts of Liverpool, saved a penalty for the 10th time in the Premier League. Only David James (13) and Thomas Sorensen (12) have saved more in the competition.
Leeds United 1-1 Brighton and Hove Albion: Late Struijk lifts Marsch men
Pascal Struijk headed a last-gasp leveller to negate the impact of Danny Welbeck's opener as Leeds gave themselves a relegation lifeline, climbing above Burnley to reach 17th place.
This felt significant, with Leeds avoiding defeat in a Premier League home game after conceding the opening goal for the first time since October (1-1 v Wolves), having lost each of their last seven such games.
Former Manchester United man Welbeck was looking like delivering three points for Brighton, and his first-half goal means the ex-England international has scored in both of his two Premier League appearances against Leeds. Indeed, they are the only opponent he has scored in his first two Premier League games against.
The Leeds late show has become a habit. Only Manchester City (9) have scored more goals in the 90th minute or stoppage time than Leeds (7) in the Premier League this season, with all seven of their goals in this period being scored by different players (Luke Ayling, Patrick Bamford, Joe Gelhardt, Daniel James, Raphinha, Rodrigo and Struijk).
Tottenham 1-0 Burnley: Cool-eye Kane keeps Spurs in hunt for fourth
When Harry Kane stepped up for a penalty that would have ramifications at each end of the table, the outcome was entirely predictable. Of course Kane scored, just as he now has with each of the last 21 penalties he has taken in all competitions for Tottenham, excluding shoot-outs, and each of his last 15 in the Premier League.
That match-winning spot-kick for Tottenham, after 52 minutes and 36 seconds of play, was the second-latest first-half goal scored in a Premier League game since Opta has exact times available (from 2006-07), behind only Trincao’s strike for Wolves against Leeds in March this year (55mins 11secs).
Kane has scored more Premier League goals against Burnley than any other player, with his ninth strike against the Clarets seeing him overtake Mahrez and Pierre-Emerick Aubameyang (both eight). Burnley are the fourth side that Kane is the outright top Premier League goalscorer against, along with Arsenal (13 goals), Leicester (17) and West Brom (nine).
Burnley, who have games against Aston Villa and Newcastle United to come, need to find at least one point to stand hope of survival. Points at Tottenham have been hard to come by for Burnley, so this defeat came as little surprise. They have lost nine of their last 10 away league games at Spurs (D1).
Everton 2-3 Brentford: Red, red, whine
Everton had Jarrad Branthwaite and Salomon Rondon sent off in this one, with boss Frank Lampard complaining afterwards: "The reality is we're on the bad end of a lot of decisions this season."
Nineteen-year-old Branthwaite became the first teenager to receive a red card in a Premier League game for Everton since a 17-year-old Wayne Rooney in December 2002 against Birmingham City. Indeed, Everton have been shown more red cards than any other side in Premier League history (104).
There are more unwanted statistics starting to emerge in Everton's dismal season. They have conceded 59 goals now, their joint-most in a 38-game Premier League campaign alongside 2000-01.
Seamus Coleman, who put the ball into his own net for a first-half Brentford equaliser, has scored more Premier League own goals (5) than any other Everton player, while the Toffees have put through their own net the most often in Premier League history (58).
Brentford, who twice trailed after Dominic Calvert-Lewin and Richarlison scored either side of Coleman's own goal, have gained the most points from losing positions in the Premier League this term (15).
This was just the fourth match in Premier League history to see a first-half red card (Branthwaite), own goal (Coleman) and penalty (Richarlison), after Coventry v Wimbledon (November 1995), Charlton v Aston Villa (April 2001) and Tottenham v Fulham (February 2003).