Kaoru Mitoma and Tariq Lamptey were both on target in the second half as Arsenal were knocked out of the EFL Cup in the third round after a 3-1 home defeat to Brighton and Hove Albion.
The Gunners faltered for just a second time in their last 20 appearances in the third round of the competition, despite dominating for large periods at Emirates Stadium on Wednesday.
Danny Welbeck's first-half penalty had cancelled out Eddie Nketiah's opener, before Mitoma and Lamptey struck in the space of 13 second-half minutes to end Arsenal's nine-match home winning run.
Julio Enciso headed just off target before Jeremy Sarmiento fired narrowly wide but Arsenal struck in the 20th minute when Reiss Nelson found Nketiah, who curled a smart first-time finish past Jason Steele.
Debutant Karl Hein's slip offered Brighton their equaliser, though, as the goalkeeper brought down Welbeck, who coolly converted his spot-kick into the bottom-right corner.
A fizzing Nketiah right-footed drive cannoned against the left post after the interval, before Steele kept out Nelson's header with a stretching stop.
Brighton hit the front as Sarmiento danced through the middle before laying off for Mitoma to whip a right-footed effort into the bottom-right corner from inside the area.
Former Chelsea defender Lamptey sealed victory soon after as he drilled under Hein after being teed up by Billy Gilmour.
What does it mean? Gunners blunted by Seagulls
Brighton had lost all five of their all-Premier League clashes in the EFL Cup since reaching the top flight in 2017-18, but produced a resolute showing to earn another victory at Arsenal.
The Seagulls have now won three of their last four trips to Arsenal, having lost all eight of their previous visits to the Gunners between November 1979 and May 2019.
Arteta's side will be frustrated to drop out of the EFL Cup so early on but have much bigger tasks to focus on as they compete for Premier League and Europa League glory.
Welbeck scores on return again
Welbeck showed all of his experience to draw Hein into the foul for the first-half penalty he calmly dispatched by sending the goalkeeper the wrong way.
The striker became the first player to score at Emirates Stadium with four different clubs (Manchester United, Arsenal, Watford and Brighton) as he came back to haunt his former side.
Hein mistake proves costly
Hein was made to wait for his first chance at Arsenal since leaving his native Estonia to join from FC Nomme United in 2018.
But the 20-year-old goalkeeper failed to impress when called upon, with his erroneous decision to rush out before slipping to bring down Welbeck allowing Brighton a way back into the game after going a goal down.
What's next?
Arsenal play their final Premier League game before the World Cup break at Wolves on Saturday, while Brighton host Aston Villa the day after.
'Cristiano is perfect' - Martinez plays down early Ronaldo substitution
Roberto Martinez took Cristiano Ronaldo off just after the hour mark against Poland but assured he was only managing the 39-year-old's minutes.
Ronaldo was on target for Portugal in their 3-1 win over Poland, doubling their tally after Bernardo Silva's opener.
Piotr Zielinski provided the Selecao with a late scare, but Jan Bednarek's own goal ensured Portugal kept their 100% record, and they are the only team to win all three games so far in League A.
The Portugal captain was replaced by Diogo Jota, who had a hand in their third goal, in the 63rd minute, having had three shots and accumulating 1.43 expected goals (xG).
And Martinez insisted Ronaldo would have a part to play against Scotland as he praised the team's resilience to get the win over the line.
"It's part of managing players when you have two games in 72 hours. Diogo Jota came on very well. Cristiano is perfect," Martinez said.
"The first half was very good. We controlled the game, created opportunities, had very good synchronisation as a team, defended Poland's strengths very well and scored great goals.
"I'm happy with the new players who came in, it seems they have several international caps.
"Conceding a goal was a difficult moment, and it was great to see the reaction and score another goal. Overall, a very good performance.
"The challenge is two away games. 72 hours, recovering well. The players showed all their commitment during training and work at the Football City."
Martinez was also impressed by debutant Renato Veiga, who started alongside Ruben Dias at centre-back.
The Chelsea defender made seven clearances, the most of any player on the team, and helped limit Robert Lewandowski to just two shots, neither of which were on target.
"He has a very special profile. In his first training session, he showed that he gained maturity during the September training camp," Martinez added.
"He is an aggressive player, with great communication skills, who can defend large spaces, play in the air, against a Poland side that is very strong in set pieces.
"It was a fantastic debut. With a striker like Lewandowski, I think it is a debut that shows Renato's potential and how he is working at the moment."
Carsley did not apply for full-time England job, wants 'no regrets'
Lee Carsley revealed he did not formally apply to become the next England manager and wants "no regrets" over his time as interim boss.
Gareth Southgate left his position as England manager following their Euro 2024 final defeat in July, with the Football Association (FA) turning to Carsley for the Nations League fixtures.
He has won two of his three games so far, following up back-to-back wins over the Republic of Ireland and Finland with a disappointing 2-1 defeat to Greece at Wembley on Thursday.
With the return trip against Finland in Helsinki next up for the Three Lions, Carsley admitted prior to the game that he did not apply for the job during the application process earlier this year.
"No, I didn't apply for it," he told talkSPORT. "Because hopefully… I have been doing the U21s, and I am really happy with my job.
"I am an employee of the FA, and I was asked to take the senior team, which is a privilege. It was the proudest moment of my career.
"I am in a really fortunate position in that I am on the inside and I can see how much potential this team's got. It is one of the best jobs in world football.
"There aren’t many jobs where you’ve got a chance of winning. I believe the coach that comes in has got a really good chance of winning, and we deserve the best one that's out there."
Carsley was aiming to become the first England manager to win his first three competitive matches in charge since Fabio Capello in 2008, before Greece claimed their first-ever win over the Three Lions.
The 50-year-old selected an experimental line-up against Greece, fielding five attacking players, but no recognised striker, leaving the side unbalanced,
Harry Kane missed that game with a knock but is expected to return for the trip to Helsinki, having scored twice when they met them in September.
There was widespread criticism of the team after the full-time whistle, but Carsley says he did not want to play it safe during his time as interim boss.
"I think the reaction [to the loss against Greece] is fair enough. You have to respect people's opinions. We didn't perform as well as we can on the night, and I would expect a reaction [against Finland]," Carsley said in his press conference.
"I think it's something that I'll look back on in maybe two or three months and, you know, be better for it.
"I wanted to give this job my best shot for the three camps that we spoke about. I didn't want to have any regrets.
"It's important we do try something different at times. I think I'll be a better coach for that."
Salah, Van Dijk released early in boost for Liverpool ahead of Chelsea clash
Mohamed Salah will return to Liverpool earlier than expected, along with Virgil van Dijk, after he was released from international duty by Egypt on Saturday.
The 32-year-old was on the scoresheet as Egypt defeated Mauritania 2-0 in an Africa Cup of Nations qualifier on Friday, and was also expected to feature in the return fixture on Tuesday.
However, in a boost for the Reds, who face fourth-placed Chelsea in the Premier League on October 20, Salah will head back to Merseyside having played just once for his country.
"The technical staff of Egypt's senior football team led by manager Hossam Hassan held a meeting with Mohamed Salah, the captain of the Pharaohs," the Egyptian FA said in a statement.
"It was agreed during the meeting to rest the player from the upcoming match."
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