The San Francisco 49ers survived a fourth-quarter comeback from the Dallas Cowboys to claim a dramatic 23-17 upset win in the Wild Card round.

Despite losing Nick Bosa to a concussion and linebacker Fred Warner to an ankle injury, the 49ers' defense held a Cowboys offense that led the NFL in yards per game with 407 to just 17 points, and it was the resistance of that group that ultimately proved decisive.

Yet such a summation does a disservice to a wild finish in which the Niners looked to have won the game several times, only to give the Cowboys hope as this historic rivalry delivered another classic in the first playoff meeting between the two teams since the 1994 season.

Dallas got the ball back with 32 seconds left and needing a touchdown to win and moved to San Francisco's 41-yard line in three plays, but an inexplicable decision to run the ball with quarterback Dak Prescott saw time expire on the game and the Cowboys' season as the 49ers progressed to a Divisional Round meeting with the Green Bay Packers at Lambeau Field.

The 49ers set their stall out with a dominant seven-play, 75-yard drive to start the game that ended with a four-yard touchdown scamper by rookie running back Elijah Mitchell.

San Francisco tacked on two field goals to make it 13-0 before Prescott hit back with a superb 20-yard touchdown pass to Amari Cooper.

Another three-pointer gave San Francisco a 16-7 half-time lead and their defense continued to hold Prescott in check after the break even with star edge rusher Bosa ruled out. 

Prescott was sacked five times and when he was intercepted by K'Waun Williams and versatile wide receiver Deebo Samuel pounced on that turnover with a 26-yard rushing touchdown a blowout appeared on the cards.

Dallas, though, pulled back within 13 points with a Greg Zuerlein field goal and an overthrown interception by Jimmy Garoppolo teed up Prescott to fray the nerves with a five-yard rushing score.

San Francisco's job looked to be done when a deep fourth-down throw from Prescott fell incomplete and the Niners should have been celebrating victory when Garoppolo executed a quarterback sneak on fourth and inches, only for that play to be called back for a false start.

However, the Cowboys could not capitalise on that reprieve despite their initial progress down the field, Prescott and center Tyler Biadasz forgetting that an official needed to spot the ball after his run in the final seconds, with a collision between a referee and Biadasz before he spotted the ball meaning the clock hit triple zeros before the quarterback could spike it to set up a Hail Mary attempt.

After the Patriots saw their playoff campaign emphatically come to an end on Saturday, the man who left New England to further his legacy begins his quest for an eighth ring on Sunday.

Tom Brady and the Tampa Bay Buccaneers will be expected to win in routine fashion in their Wild Card round matchup with the Philadelphia Eagles, while the team they beat in last season's Super Bowl, the Kansas City Chiefs, are anticipated to end Ben Roethlisberger's career with a routine victory over the Pittsburgh Steelers.

Sandwiched between those two potential blowouts is the game of the weekend as two storied rivals, the San Francisco 49ers and Dallas Cowboys, contest a long overdue renewal of acquaintances in the postseason.

As Stats Perform's look at Sunday's action explains, both the Niners and the Cowboys possess the offense firepower to ensure the matchup lives up to its lofty expectations.

Philadelphia Eagles @ Tampa Bay Buccaneers

The defending champion Bucs are unsurprisingly the heavy favourites against an Eagles team that claimed nine wins in the regular season, none of which came against an opponent that made the postseason.

Not much stock will be put in the history of this encounter, even if it does make pleasant reading for any Eagles fans looking for reason for hope.

The Eagles and Buccaneers have split their 20 all-time meetings, with each team winning eight regular-season games and two in postseason play. Their only postseason matchup in Tampa was a 24-17 win by the Bucs in 1979, their first-ever playoff win.

All eyes at Raymond James Stadium will be on Bucs quarterback Tom Brady, who is set for another piece of history in his seemingly endless career.

Brady will be playing in his 19th postseason and in his 46th career playoff start, the most by any player in NFL history. At age 44, Brady will break his own record for the oldest quarterback to start a playoff game. Brady has more playoff wins since turning 36 years old (17) than any other QB has in his entire career.

Dak Prescott deflected praise after setting new milestones with the most touchdowns in a single season in Dallas Cowboys history and a career-high five touchdowns in Saturday's 51-26 win over the Philadelphia Eagles.

The 28-year-old Cowboys quarterback completed 21 of 27 passes for 295 yards and five touchdowns against the under-strength Eagles.

Prescott, who missed the bulk of last season with an ankle injury, went past Tony Romo (36) for the most touchdown passes in a single season.

"It's special," Prescott told ESPN after the game. "A record like that that's this team, that's this offense.

"All the different guys that caught passes or the guys that protected, everybody played a part in it. I'm just the beneficiary of it.

"But to know where I was 12 months ago and to be where we are now, headed to the playoffs, I'm very excited."

The Cowboys win means they must wait on Sunday's results to learn their playoffs fate but they can be as high as the second seed in the NFC after finishing with a 12-5 record.

Among Dallas' potential playoffs match-ups is the 11-5 Arizona Cardinals who defeated the Cowboys last weekend 25-22.

"It doesn’t matter," Prescott said when asked if he wanted to face the Cardinals again to get revenge.

"Line them up. To get to where we wanna go, you've got to beat the best. Whoever it is, wherever it is, we're ready for this run."

The Cowboys piled on seven touchdowns against the Eagles, with five different scorers meaning they set a new NFL record for most players (22) to score TDs in a single season.

"We got some momentum going," Prescott said. "We were able to score some touchdowns on offense. We had some success running the ball and throwing the ball.

"More importantly the momentum, the rhythm and fun. The camaraderie we have, we just played together and wanted to finish the season off the right way. I think we did that in all facets of the game."

Dak Prescott threw a career-high five touchdown passes and broke a franchise-record single-season record as the Dallas Cowboys defeated the Philadelphia Eagles 51-26 on Saturday.

Prescott completed 21 of 27 passes for 295 yards, claiming the Cowboys' record for most single-season touchdown passes, going past Tony Romo's mark of 36.

The win improves means the Cowboys finish the regular season with a 12-5 record but will need to wait on Sunday's result to learn their NFC seeding which could be as high as second and as low as fourth.

Dallas head into the playoffs with a 5-1 run across their past six games after a two-game mid-season losing streak and go 6-0 in the NFC East.

Cedric Wilson (119 yards for five receptions) and Dalton Schultz both scored two TDs, while Corey Clement, Ito Smith and JaQuan Hardy also got on the scoresheet.

Upon Hardy's 22-yard rushing touchdown, the Cowboys broke the record for most players (22) to score a TD in a single season.

The Eagles, who rested numerous key players, are playoffs bound despite a 9-8 record. Eagles QB Gardner Minshew, who stepped in for Jalen Hurts due to an ankle injury, threw 19 of 33 passes for 186 yards and two TDs with one interception.

The Dallas Cowboys are fearing the worst with wide receiver Michael Gallup sustaining a suspected torn ACL in his left knee in Sunday's 25-22 loss to the Arizona Cardinals.

Gallup landed awkwardly when he caught a touchdown in the second quarter of the defeat, before limping off the field and leaving for the locker room on crutches.

Cowboys owner and general manager Jerry Jones confirmed Gallup will undergo an MRI on Monday to confirm the severity of the injury but teammate Dak Prescott and head coach Mike McCarthy feared the worst.

"It was tough, very tough," Prescott said at the post-game news conference. "Coming in at half-time and going to see him, just unfortunate. A guy that I love. Can't get a better teammate than MG. Sick about it."

McCarthy added: "Feel terrible for Michael. Obviously made a huge play, but you could see just the way he came down."

Gallup has had 35 receptions for 445 yards and two touchdowns this season for the playoff-bound Cowboys.

The Arizona Cardinals continued their excellent road form as they edged the Dallas Cowboys 25-22 in a potential-playoff preview with Kyler Murray leading the way on Sunday.

The Cardinals improved their season record to 11-5 and their road record to 8-1, snapping a three-game skid, with Texas-born Murray throwing two touchdowns as he completed 26 of 38 attempts for 263 yards.

The Cowboys had trailed 22-7 at the final charge but stormed back into contention as Dak Prescott threw three TD passes for the game but Murray expertly managed the clock late.

Murray found Antoine Wesley for two TDs including a spectacular catch in the third quarter, while Jonathan Ward made a remarkable helmet catch on a fake punt.

The Cowboys lost Michael Gallup to injury upon his second-quarter receiving touchdown and did not return, not helping their cause.

Prescott, who completed 24 of 38 passes for 226 yards along with 20 rushing yards, found Cedrick Wilson and Amari Cooper for final-quarter TDs to tighten the game but he also had a costly fumble at 22-14.

Chargers snap skid as Williams scores 101-yard return

The Los Angeles Chargers snapped a two-game skid with a 34-13 victory over the Denver Broncos to boost their Wild Card hopes as they improve to a 9-7 record.

Chargers quarterback Justin Herbert threw 22 of 31 passes for 237 yards with two touchdowns, breaking the franchise record for single-season touchdown passes at 35.

Andre Williams scored a 101-yard kickoff return touchdown in the fourth quarter, while Austin Ekeler returned to LA's line-up and was important, with 17 carries for 58 yards and a touchdown, along with three receptions for 54 yards.

Lance leads 49ers to key win in Wild Card race

Trey Lance stepped in for the injured Jimmy Garoppolo and provided two touchdown passes as the San Francisco 49ers won 23-7 over the Houston Texans.

Lance completed 16 of 23 passes for 249 yards with the two TDs and an interception to help the 49ers improve to 9-7 in the NFC Wild Card pursuit.

Deebo Samuel and Elijah Mitchell scored the touchdowns as the 49ers scored 20 second-half points to secure the win.