The Champions League returns on Wednesday as the first legs of the round of 16 come to an end.
Manchester United travel to the Wanda Metropolitano to face Atletico Madrid, with the visitors aiming to become just the fourth team to 500 goals in the European Cup and Champions League combined.
Erik ten Hag's Ajax thrilled in the group stages with their high-scoring and free-flowing football, and they make the trip to the Estadio da Luz to face Benfica in the other first-leg meeting.
Here, Stats Perform unpacks the pick of the Opta data behind the pair of knockout fixtures in Europe's premier club competition.
Atletico Madrid v Manchester United
United and Atletico have somehow only faced each other in the same European campaign once previously, when the Spanish side were 4-1 victors on aggregate in the last 16 of the 1991-92 Cup Winners' Cup.
The Red Devils, on their only previous visit to Atletico, lost the first leg of that tie 3-0 at the old Vicente Calderon stadium against Luis Aragones' team.
Ralf Rangnick's away side will be hoping for happier returns on their next visit to Spain, where they have won just one of their last seven trips in the knockout stages of the Champions League (D4 L2).
But Diego Simeone's team have also tasted defeat in each of their last four matches against English teams in the competition, double the number of losses they suffered across their first 12 such matches (W4 D6 L2).
Atletico have won just four of their last 14 in the Champions League. Additionally, they have lost more times in their last four home games (three) than they did in across their previous 37 (two) in the competition.
The LaLiga outfit will have to contend with an old foe Cristiano Ronaldo, who has scored 25 goals in 35 matches against them, only managing more versus Sevilla during his entire career.
Indeed, four of the forward's club hat-tricks have come against the Spanish side, two of which have been netted in this competition – no other player has recorded more against a single opponent in Europe's top club tournament.
Benfica v Ajax
Benfica may have won the first European meeting with Ajax, a 3-1 win in the first leg of the 1968-69 European Cup quarter-finals, but they are winless in their six games against them since.
Ajax are unbeaten in their previous three away games at Benfica in the European Cup and Champions League (W1 D2), with the most recent of these coming under Ten Hag’s stewardship, a 1-1 draw in November 2018.
The reigning Eredivisie champions are unbeaten in their four meetings with Portuguese sides in the competition (W3 D1), while Benfica have won just two of their last 11 clashes with Dutch opponents across the European Cup and Champions League (D4 L5).
To reach this stage, Ten Hag's men recorded six wins from six, which is the longest winning streak by a Dutch team in the European Cup and Champions League.
Should they manage victory in Portugal, Ajax's seven-game winning run would be the longest in the history of the two competitions by a team outside of the current big five European leagues (England, France, Germany, Italy, Spain).
Sebastian Haller fired his side into the knockout stages with 10 goals in six European outings, the most by any player in his opening six matches in the competition.
Playmaker Dusan Tadic has also created more chances from open play than any other player in the competition (77) since his debut in September 2018, but Benfica will not just roll over given they have recorded clean sheets in five of their last seven Champions League games.