The Champions League returns on Wednesday as the first legs of the round of 16 come to an end.
Manchester United travel to the Wanda Metropolitano to face Atletico Madrid, with the visitors aiming to become just the fourth team to 500 goals in the European Cup and Champions League combined.
Erik ten Hag's Ajax thrilled in the group stages with their high-scoring and free-flowing football, and they make the trip to the Estadio da Luz to face Benfica in the other first-leg meeting.
Here, Stats Perform unpacks the pick of the Opta data behind the pair of knockout fixtures in Europe's premier club competition.
Atletico Madrid v Manchester United
United and Atletico have somehow only faced each other in the same European campaign once previously, when the Spanish side were 4-1 victors on aggregate in the last 16 of the 1991-92 Cup Winners' Cup.
The Red Devils, on their only previous visit to Atletico, lost the first leg of that tie 3-0 at the old Vicente Calderon stadium against Luis Aragones' team.
Ralf Rangnick's away side will be hoping for happier returns on their next visit to Spain, where they have won just one of their last seven trips in the knockout stages of the Champions League (D4 L2).
But Diego Simeone's team have also tasted defeat in each of their last four matches against English teams in the competition, double the number of losses they suffered across their first 12 such matches (W4 D6 L2).
Atletico have won just four of their last 14 in the Champions League. Additionally, they have lost more times in their last four home games (three) than they did in across their previous 37 (two) in the competition.
The LaLiga outfit will have to contend with an old foe Cristiano Ronaldo, who has scored 25 goals in 35 matches against them, only managing more versus Sevilla during his entire career.
Indeed, four of the forward's club hat-tricks have come against the Spanish side, two of which have been netted in this competition – no other player has recorded more against a single opponent in Europe's top club tournament.
Benfica v Ajax
Benfica may have won the first European meeting with Ajax, a 3-1 win in the first leg of the 1968-69 European Cup quarter-finals, but they are winless in their six games against them since.
Ajax are unbeaten in their previous three away games at Benfica in the European Cup and Champions League (W1 D2), with the most recent of these coming under Ten Hag’s stewardship, a 1-1 draw in November 2018.
The reigning Eredivisie champions are unbeaten in their four meetings with Portuguese sides in the competition (W3 D1), while Benfica have won just two of their last 11 clashes with Dutch opponents across the European Cup and Champions League (D4 L5).
To reach this stage, Ten Hag's men recorded six wins from six, which is the longest winning streak by a Dutch team in the European Cup and Champions League.
Should they manage victory in Portugal, Ajax's seven-game winning run would be the longest in the history of the two competitions by a team outside of the current big five European leagues (England, France, Germany, Italy, Spain).
Sebastian Haller fired his side into the knockout stages with 10 goals in six European outings, the most by any player in his opening six matches in the competition.
Playmaker Dusan Tadic has also created more chances from open play than any other player in the competition (77) since his debut in September 2018, but Benfica will not just roll over given they have recorded clean sheets in five of their last seven Champions League games.
Bayer Leverkusen 2-3 Leipzig: Visitors fightback halts unbeaten streak for Alonso's side
Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.
Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.
It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.
However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.
Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months.
Data Debrief: Leverkusen's long streak comes to a shuddering halt
Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.
The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.
They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.
As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.
Sancho given fresh start with Chelsea loan move
Jadon Sancho has secured a move away from Manchester United, having joined Chelsea on Deadline Day on a season-long loan.
The deal includes an obligation to buy for between £20-£25 million at the end of the loan, according to widespread reports, meaning that the 24-year-old will not be returning to Old Trafford next summer.
Work to complete the transfer came late on Deadline Day, with a deal sheet being submitted to ensure the signing could go through after the 11pm deadline.
Chelsea were able to get the deal over the line, confirming the move was complete on Saturday evening.
"I’m really excited to be here," Sancho said. "London is where I grew up and I’m happy to be back.
"The manager spoke to me about the project and, for a young player, it's exciting. Hopefully I can bring goals and assists to the Bridge."
It brings an end to a three-year spell at Old Trafford for Sancho. The winger originally joined United on a five-year contract in 2021 but, following a public falling out with manager Erik ten Hag, found his first-team opportunities limited.
Sancho made 83 appearances in all competitions for United, but his last start for the club came against Manchester City in the 2023 FA Cup final. He made three substitute appearances in August 2023 before moving back to Dortmund on loan in January, where he scored three goals in 21 appearances.
His final outing in a United shirt came off the bench in their Community Shield defeat to Manchester City, but he was not included in the squad for the first two league games.
Sancho joins a club with plenty of competition for attacking places, with Cole Palmer, Christopher Nkunku, Nicolas Jackson, Pedro Neto, Joao Felix and Noni Madueke among their roster.
Chelsea did also manage to move some players on during Deadline Day. Raheem Sterling secured a loan move to Arsenal on Deadline Day, while Trevoh Chalobah joined Crystal Palace, Armando Broja moved to Everton and Djordje Petrovic was loaned by Strasbourg.
'We really let ourselves down' - Coleman slams Everton after late Bournemouth collapse
Seamus Coleman acknowledged Everton "really let ourselves down" and must "look at ourselves in the mirror" following their spectacular late collapse against Bournemouth.
Sean Dyche's side, who were seeking their first points of the season, led 2-0 in the 87th minute at Goodison Park through goals from Michael Keane and Dominic Calvert-Lewin.
However, the hosts were undone by three crosses in the latter stages, with Antoine Semenyo pulling a goal back and Lewis Cook levelling, before Luis Sinisterra completed a sensational turnaround in the sixth minute of stoppage time.
Boos rung around Goodison Park as the Toffees remained pointless and rooted to the foot of the Premier League table, and Coleman echoed the supporters' frustrations.
"We really let ourselves down in front of our fans," the skipper said. "We cannot take our foot off the gas at this level. Unfortunately, we did that.
"We cannot be conceding the goals that we did. We have to look at ourselves in the mirror."
Meanwhile, Dyche bemoaned the lack of responsibility amongst his players, as they became the first side in Premier League history to lose a game after leading by two or more goals in the 87th minute.
"We did so much right until they scored their first goal," the Everton head coach said. "The game should have been out of sight. We conceded one and then threw it away. I can't put my finger on it right now.
"They kept raining it forward and got their reward in the end. They were playing it forward and crossing it into the box, and we didn't deal with it. Simple stuff, but we threw it away. It is the third game we have thrown away this season.
"Everyone was looking at someone else to deal with things and that is when there is trouble. You could see the body language change. You have to see games through, and we have enough experience to do that, but today we didn't."
Bournemouth boss Andoni Iraola added: "It was the worst game we played this season. Everton deserved to win today, but the players kept pushing.
"I always have hope because this team has spirit. We have done it before and had some good comebacks. The spark of the first goal made us believe we could do it again."
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