The Minnesota Vikings earned an important divisional win at home in Week 1, defeating the Green Bay Packers 23-7 after a massive game from star receiver Justin Jefferson on Sunday.

Jefferson was named second-team All-Pro last year in his second season in the league, and he showed against the Packers why many feel he could be the top wide receiver in the entire league.

He had three catches for 47 yards and a touchdown on the first drive alone, before going on to finish with gaudy figures of nine catches for 184 yards and two scores.

While Jefferson was the offensive star, the Vikings' defense was the reason they won the game, holding the Packers scoreless in the first half to head into the long break leading 17-0.

With Aaron Rodgers' former top target Davante Adams traded to the Las Vegas Raiders in the offseason, he struggled to move the ball downfield. While Adams racked up 10 catches and 141 yards from 17 targets in his Raiders debut, no Green Bay receiver finished with more than Romeo Doubs' four catches for 37 yards from five targets, although running back A.J. Dillon did reach 46 receiving yards after some garbage-time action.

Coming off back-to-back league MVP awards, Rodgers finished a disappointing 22-of-34 for 195 yards, throwing one interception and no touchdowns. He was also sacked four times by the impressive Vikings pass rush, including one by former Packers edge rusher Za'Darius Smith.

Vikings quarterback Kirk Cousins enjoyed a clean start to the season, going 23-of-32 for 277 yards and two touchdowns, with no interceptions, while top running back Dalvin Cook was strong with 20 carries for 90 yards.

Barkley announces return to form in Giants win

New York Giants running back Saquon Barkley had not scored a touchdown since Week 4 of last season, but he found form again in style as he carried his side to a 21-20 win on the road against the Tennessee Titans.

Barkley, the second overall pick in the 2018 NFL Draft, had been questioned about if he would ever return to his best, but he looked like the old Barkley against the Titans as he piled up 164 yards and a touchdown from 18 carries, while adding six catches for 30 yards through the air.

As well as dominating through the middle stages of the contest, he also delivered in a big spot to decide the game, converting a two-point conversion after Daniel Jones threw what ended up being the game-winning touchdown with one minute to play.

The Titans got the ball back and worked their way into field goal range, but with a chance to hit a walk-off game winner, Randy Bullock pulled the 47-yard kick left to gift the win to the Giants.

T.J. Watt is being assessed by the Pittsburgh Steelers as reports suggest the reigning NFL Defensive Player of the Year has suffered a torn pectoral.

Watt left the game in the fourth quarter of the Steelers' wild 23-20 overtime win over the Cincinnati Bengals in Week 1.

The Pittsburgh pass-rusher had played a key role in stifling Bengals quarterback Joe Burrow, who finished with five turnovers – four interceptions and a lost fumble.

Watt dominated the game with six tackles, three tackles-for-loss, an interception and a sack, but the Steelers now fear he faces an extended period on the sideline.

"I'm appreciative of the effort – it wasn't without cost," said coach Mike Tomlin afterwards, revealing Watt was "being evaluated with an upper body injury".

Running back Najee Harris was also being evaluated having exited the game with a foot injury.

The worst game of Joe Burrow's NFL career almost turned into a memorable Week 1 win for the Cincinnati Bengals, who instead blew their chance for an overtime victory over the Pittsburgh Steelers.

The Bengals went down 23-20 to the Steelers after missing kicks at the end of regulation and in the additional period that would have secured a winning start.

Instead, Chris Boswell kicked the game-winning field goal for the Steelers in the final seconds of overtime.

Burrow had put the Bengals in position to succeed despite his dismal start, looking nothing like the 2021 Comeback Player of the Year who led Cincinnati to the Super Bowl.

The quarterback had four turnovers before half-time – a career high for an entire game – including a pick-six for Minkah Fitzpatrick from his very first pass.

Burrow finished with four interceptions, a lost fumble and seven sacks, but he also threw two touchdown passes, including one for Ja'Marr Chase that appeared to set up a stunning Bengals win.

However, Fitzpatrick blocked Evan McPherson's PAT, and McPherson missed his target again in overtime.

Boswell similarly squandered a chance to win the game, hitting the left post, but he made amends just as it looked as though the NFL would see two ties in the same week for the first time since Week 2 in 1973, with the Houston Texans and Indianapolis Colts also tied 20-20.

Browns deny Baker's Panthers

The Bengals were the only team not to win in the AFC North – a division that had it all on Sunday. While Lamar Jackson guided the Baltimore Ravens to victory over the New York Jets, the Cleveland Browns celebrated their first Week 1 win since 2004 as former QB Baker Mayfield saw his Carolina Panthers beaten 24-23 by a late field goal.

The Miami Dolphins' 20-7 win over AFC East rivals the Patriots was far more straightforward, with Tua Tagovailoa becoming the first QB to remain unbeaten against Bill Belichick in the regular season having started at least four games against New England.

49ers flounder at sodden Soldier Field

Miserable conditions in Chicago hampered the San Francisco 49ers as they suffered a shock 19-10 loss to the Bears, with Trey Lance's miserable 13-of-28 passing including an awful fourth-quarter interception for a quarterback rating of just 50.3.

Elsewhere in the NFC, Jalen Hurts also did not throw a single touchdown pass in the Philadelphia Eagles' 38-35 victory over the Detroit Lions – he contributed one of four rushing scores – but the QB connected with A.J. Brown for 155 yards on 10 catches. Marquee offseason trade signing Brown had 128 receiving yards before half-time, the most in the first half of a team debut by any non-rookie since at least 1991.

It is widely expected Tom Brady will play the first game of his final NFL season on Sunday, but the legendary quarterback explained in a social media video why he has returned for another year.

Brady briefly retired in the offseason and then missed part of the Tampa Bay Buccaneers' training camp ahead of his 23rd NFL season.

However, the 45-year-old is set to line up under center against the Dallas Cowboys in Week 1 as he continues his remarkable career.

Sunday brought a report from NFL Network's Ian Rapoport that suggested "the end is coming" for Brady, and "this is the final year".

Brady did not dispute that as he posted on Twitter ahead of the Cowboys game, but he clearly still feels he has plenty to offer in 2022.

The seven-time Super Bowl champion said: "It's been a unique offseason, and lately I've been seeing the same question on social media: 'Why d'you come back?'

"I can give you a long speech, but the answer is actually pretty simple. We've got a hell of a team, I'm still feeling pretty good, and an arm is a terrible thing to waste.

"I've been reminded for almost a decade now: 'You're headed for extinction.' And maybe so, but not today. I'll see you in Dallas."

The Bucs are not expecting to get another year out of Rob Gronkowski, however, according to ESPN.

Brady's long-term team-mate with both the New England Patriots and the Bucs retired in June. The tight end has already retired once previously and will reportedly not return a second time.

Lamar Jackson turned down a new contract worth around $250million due to a lack of fully guaranteed money, according to reports.

The Baltimore Ravens and quarterback Jackson ended negotiations for a long-term contract extension prior to Sunday's kick off of the new NFL season.  

Jackson will play for just over $23m on the fifth-year option of his rookie contract, having previously said he would not continue to negotiate during the season.

"Despite best effort on both sides, we were unable to reach a contract extension with Lamar Jackson," Ravens general manager Eric DeCosta said in a statement on Friday.

While talks will resume next offseason, NFL.com's Ian Rapoport reported on Sunday that while the offer to Jackson "eclipsed" the $242.5m one handed to Russell Wilson by the Denver Broncos earlier this year, "fully guaranteed money is believed to be at the heart of the issue".

Rapoport's sources also indicated the offer "fell short of the $230m, fully guaranteed deal that Browns quarterback Deshaun Watson received after Cleveland traded for Watson in March", and it is understood Watson's deal was the barometer used by Jackson in negotiations.

ESPN's Adam Schefter also reported on the deal, stating his sources believe Jackson turned down an offer worth around $250m.

The 2019 NFL MVP negotiated for himself with help from his mother and the NFL Players' Association, and the Ravens are expected to apply their franchise tag to prevent Jackson from hitting free agency if the sides are unable to reach a deal at the end of the season.

Even if no other quarterbacks sign lucrative deals in the meantime, exclusively tagging Jackson would cost the Ravens $45.4m in 2023 and $54.4m in 2024.

According to NFL reporter Chris Mortensen, Jackson rejected the offer of a six-year deal, with $133m fully guaranteed, more than Wilson's $124m and Kyler Murray's $103.3m with the Arizona Cardinals, though short by some way of Watson's $230m.

The Ravens kick off their season at the New York Jets on Sunday.

Matt LaFleur can join a select NFL club if the Green Bay Packers prevail in what should be an enthralling NFC North clash with the Minnesota Vikings in Week 1.

LaFleur has enjoyed a stunning start to his head coaching career in Green Bay, guiding the Packers to two NFC Championship Game appearances in the past three seasons.

He has compiled a 39-10 regular-season record, and no head coach has won more games in his first three seasons, with LaFleur surpassing George Seifert, who won 38 after taking over from the great Bill Walsh with the San Francisco 49ers.

Should he guide the Packers to triumph in Minnesota, LaFleur will become the third head coach in NFL history with 40 wins through 50 career games, joining Paul Brown (41) and Chuck Knox (40).

The Packers lost a 34-31 thriller on the road against the Vikings last year and, while the outcome is far from guaranteed, there is a strong chance this game will also be high scoring.

Indeed, in their 22 road games against the Vikings this century, Green Bay have scored 30 or more points in 10 of them. That is tied for the most 30-point games by an NFL team at a single opponent in that time with the New England Patriots at the Buffalo Bills. 

The Packers will not have Davante Adams after his blockbuster offseason trade to the Las Vegas Raiders.

Yet history says Aaron Rodgers will have no problem putting up points despite the departure of his former favourite target.

Since becoming Green Bay’s starter in 2008, Rodgers has thrown 169 touchdowns against division opponents compared to 25 interceptions.

By comparison, the Vikings have 121 passing touchdowns and 73 interceptions against the NFC North in that span.

A trip to Minnesota represents an early test of the Packers' Super Bowl credentials, but the numbers point to them passing it and LaFleur bringing up win 40.

The New York Jets placed starting left tackle Duane Brown on injured reserve on Saturday, keeping him out of the team's first four games of the season at the very least. 

Brown, 37, suffered a shoulder injury in practice on Monday and was held out of team activities for the rest of the week. 

The 15th-year veteran was ruled out for Sunday's season opener against the Baltimore Ravens on Friday, but his injured reserve status opens a roster spot for the Jets. 

Brown's is just the latest injury for a New York team trying to escape the AFC East cellar. 

Brown was signed to a two-year, $22million contract last month after tackle Mekhi Becton was shut down for the season with a fractured right kneecap. 

Jets starting quarterback Zach Wilson will miss at least three games as he recovers from surgery to repair a non-contact knee injury suffered in a preseason game. Joe Flacco will start under center in the meantime. 

Brown was a First-Team All-Pro choice in 2012 and has been selected to five Pro Bowls while playing for the Houston Texans and Seattle Seahawks. 

The Trey Lance discussion has been an impossible one to escape during the NFL's long offseason.

That is largely because the circumstances in which he takes his first steps as a starter are unprecedented.

Lance was selected by the 49ers with the third overall pick in last year's draft after they traded three first-round selections for the right to move into that slot.

After a rookie year largely spent watching on the sideline, he now steps in to start at the most important position for a team who were minutes away from reaching a second Super Bowl in three years last season, which ended in heart-breaking defeat to the Los Angeles Rams in the NFC Championship Game.

Young quarterbacks have taken over Super Bowl-calibre teams in years gone by. Aaron Rodgers took over from Brett Favre in 2008 after the Green Bay Packers had agonisingly lost the NFC Championship Game to the New York Giants in overtime.

But Rodgers had spent three years as Favre's backup in an era where spending an apprenticeship on the bench was de rigueur for highly drafted quarterbacks, and he had previously produced two seasons of stellar play for a Power 5 school during his college career with the Cal Bears.

Lance, by contrast, played just one full season of college ball at North Dakota State in the FCS – college football's second tier – back in 2019, losing the chance to add to his experience as the coronavirus pandemic wiped out his 2020 campaign with the Bison, save for one exhibition that essentially served as a pre-draft audition for the dual-threat signal-caller.

A quarterback of such little experience being given the keys to one of the best teams in the NFL is an objectively fascinating situation, one made even more intriguing by the Niners' decision to hang on to Jimmy Garoppolo, his predecessor, after failing to find a partner for a potential trade.

Rodgers did not have Favre looming as the backup in Green Bay. Favre retired, then came back, but was traded to the New York Jets, leaving Rodgers to plot his path to becoming one of the all-time greats.

Lance will be tasked with keeping a win-now team firmly in contention for a Super Bowl title while dealing with the possibility of the man who twice helped the 49ers to the cusp of the Lombardi Trophy stepping in should he struggle.

The flashes Lance produced in his two starts in relief of an injured Garoppolo last season were promising, but with the 49ers set to kick off their new era against the Chicago Bears on Sunday, can he immediately rise to the challenge of leading the NFL's most interesting team on a deep playoff run they hope will end with a sixth league championship? 

An ideal offensive ecosystem

In order to answer that question, it is important to look at just how strong Lance's supporting cast is.

Head coach Kyle Shanahan and general manager John Lynch have put together one of the most complete rosters in the NFL having taken over a team in need of a colossal rebuild in 2017.

Shanahan himself is a key reason for confidence the transition to Lance will work. No play-caller in the NFL does a better job of consistently putting his receivers in space and his quarterback in favourable situations, while his diverse running torments opposing defenses year in, year out.

The league's pre-eminent play-caller also has experience of building an offense around a dual-threat quarterback, having done so while working as offensive coordinator for the Washington Commanders under his father Mike as Robert Griffin III produced an Offensive Rookie of the Year campaign.

Shanahan's play-calling acumen is a critical factor in the 49ers' ceaseless efficiency on offense. The 49ers' offense finished last season ranked first in Stats Perform's Efficiency Versus Expected (EVE) metric. EVE looks at down, distance, yards from goal, quarter, time remaining and score difference. Using those six factors, Stats Perform trained a model to predict yardage output for any game situation. From there, the projected yards are compared to the actual yards gained or prevented in those situations.

But San Francisco's superiority in that metric would not be possible without a star-studded cast of offensive skill-position players, which Stats Perform AI ranks as the sixth-best in the NFL coming into the year.

Between Deebo Samuel, whose ability to excel as a dual wide receiver-running back inspired the Niners' turnaround from a 3-5 team to one who came within a whisker of an eighth Super Bowl appearance, fellow wideout Brandon Aiyuk and All-Pro tight end George Kittle, Lance is not short of targets who will make his life much easier.

A run game that ranked eighth in explosive runs of 10 yards or more in 2021 with 58 – a tally Lance's presence will surely embellish – will also provide him with plenty of assistance, as will a defense that has a compelling case for being considered the league's gold standard.

Stellar defensive support

The 49ers' Divisional Round win over the Green Bay Packers last season perhaps provided the clearest evidence yet as to the value of their outstanding defense.

San Francisco shackled back-to-back MVP Rodgers, limiting Green Bay to one touchdown and field goal in an improbable 13-10 road win against the number one seed in the snow at Lambeau Field.

Defensive coordinator DeMeco Ryans called a masterful game as the 49ers' defensive front sacked Rodgers five times, and it is the seemingly endless supply of depth on the defensive line that makes Ryans' group arguably the league's most fearsome.

The 49ers led the league in pass rush win rate and did so while blitzing at the fifth-lowest rate in the NFL (20.4 per cent). That D-line now heads into 2022 arguably in an even stronger position. Nick Bosa, coming off a 15.5-sack season, leads an edge rusher rotation that is six players deep and includes a rookie, in second-round pick Drake Jackson, whose pressure rate of 24.2 per cent was fifth among draft prospects at his position last year. 

On the interior, the 49ers are hoping former first-round pick Javon Kinlaw, with his hulking 6ft 5in, 319-pound frame, can put it all together in his third season following knee surgery and form an imposing tandem with Arik Armstead, whose 2021 stunt-adjusted pass rush win rate of 44.34 per cent was fifth among defensive tackles (min. 100 matchups).

Behind the D-line, the coverage versatility of a linebacker core headlined by the game's best in Fred Warner opens a wealth of options for Ryans, yet it may be the additions in the secondary that solidify his defense as the league's elite this season.

The 49ers are starting a fifth-round rookie at nickel corner. That is a frightening sentence on the surface, but Samuel Womack III allowed a burn rate – which measures how often a receiver wins his matchup with a defender on a play where he is targeted – of just 33.3 per cent in his final year with Toledo. That was tied for the best among draftable corners. He backed up those numbers with a preseason that saw him record two interceptions.

While the 49ers are hoping Womack's leap to the highest level is seamless, it is the performance of free-agent signing Charvarius 'Mooney' Ward that could determine the ceiling of this defense. Ward's burn rate of 39.8 per cent was the fourth-best among corners with at least 50 targets last year, with the former Kansas City Chief fifth in burn yards per target (7.96).

The acquisitions of Ward and Womack have significantly strengthened the cornerback room. Though there is justified concern about a lack of depth at safety, Ward's arrival may facilitate the 49ers leaning more on the man coverage in which he specialises, enabling San Francisco to blitz up front more often and perhaps even improve their pressure numbers from a year ago.

Regardless of whether the pressure statistics do get even better, it is clear Lance is entering an outstanding ecosystem for a young quarterback. The 49ers have the talent to survive the ups and downs he may experience. The unknown is whether Lance can take advantage of his environment to help this team realise their glaringly obvious potential by enhancing an already excellent offense.

Becoming the 'because of' QB

Lance is a substantial departure from what the 49ers are used to at quarterback, and there are upsides and downsides to that change in direction.

There is no question Lance will significantly increase the 49ers' threat on deep passes. Last season, Garoppolo completed just nine passes of 21 air yards or more across the entire 2021 season. Lance completed four in his 10 full quarters of play as a rookie.

On top of that, Lance's air yards per attempt average of 10.1 was the second-highest in the NFL among quarterbacks with at least 50 pass attempts.

While the downfield passing game figures to be more explosive, Lance will need to improve in one area where Garoppolo has traditionally excelled.

Garoppolo has consistently done an impressive job of leading his receivers to the ball on throws over the middle, setting up regular opportunities for yardage after the catch.

Over the last three seasons, Garoppolo has averaged 6.7 yards after the catch (YAC) on his completed passes, almost a full yard more than his nearest challenger Patrick Mahomes (6.0).

The same sort of accuracy on throws where the receivers can relieve the burden on the quarterback with YAC was lacking from Lance during the preseason, and curbing a tendency to put those passes behind his intended target will be critical for him to realise his potential in Shanahan's vaunted offensive scheme.

But Shanahan is making a calculated trade-off in switching to Lance. The 'gimme' plays Garoppolo can hit with ease may not come as easy with Lance, but the 49ers will benefit from the 'second reaction' plays the new quarterback can make when the pocket breaks down.

Though Garoppolo can make throws on the move, the improvisation factor is significantly higher with Lance, who last season averaged a gaudy 13.06 air yards throwing on the run. 

On top of his threat as a downfield passer in such situations, Lance also put 8.45 yards per carry on scrambles in 2021. Only Jameis Winston (8.67) had more among quarterbacks with at least 10 scrambles.

Lance adds new dimensions to the 49er offense, but he also has shown substantial promise in a staple feature of the Shanahan attack.

Though it was on a small sample size, Lance displayed encouraging accuracy in the play-action game as a rookie. Ten of his 12 play-action throws were well-thrown, with Lance averaging 14.67 air yards on those attempts.

It is far too early to definitively say Lance will continue to be as accurate on play-action over the course of a full season. However, given the effectiveness of the 49er run game, the play-action should still continue to be extremely effective, with Lance's prowess on the ground giving defenders more to think about when he fakes the hand-off.

Former Los Angeles Rams, Buffalo Bills and Seattle Seahawks head coach Chuck Knox once said: "There are two kinds of quarterbacks. There is what I call the 'because of' quarterback and the 'with' quarterback. You win 'because of' Joe Montana or John Elway. You win 'with' Phil Simms or Doug Williams."

Garoppolo has produced game-winning performances for San Francisco, but while he has operated the offense extremely efficiently, he is firmly in the 'win with' category. In the biggest games where the team has asked him to put them over the top, he has not delivered.

The 49ers moved up for Lance due to their belief he can be a 'because of' quarterback. He may not perform with the same efficiency as Garoppolo, but he has already delivered showings to suggest he can be the decisive factor for a team who have come agonisingly close to glory. Lance's ability to reproduce those flashes over the course of an entire season will determine whether the 49ers were right in their assessment.

The Las Vegas Raiders and tight end Darren Waller have agreed to a three-year, $51million contract extension, ESPN’s Adam Schefter reported on Saturday.  

Waller, who turns 30 next week, was already under contract for the next two seasons, so his new deal keeps him tied to the Raiders through 2026.  

The 2020 Pro Bowl selection had no guaranteed money left on his previous deal, with this extension giving Waller some insurance on the eve of the Raiders’ 2022 campaign.  

Drafted in the sixth round by the Baltimore Ravens in 2015, Waller was a practice squad player to begin his career and had just 18 career catches through the 2018 season.  

Since 2019, Waller has made 252 catches for 3,006 yards – both second in the NFL by tight ends over that span – and caught 14 touchdowns.  

Waller broke the Raiders single-season franchise record by making 107 receptions in 2020, eclipsing Tim Brown's mark of 104 catches that stood for 23 years.  

The Raiders’ passing offense is poised to be productive and stable for years to come, with Waller, quarterback Derek Carr and receivers Davante Adams and Hunter Renfrow all under contract through at least the 2025 season.  

The Baltimore Ravens and quarterback Lamar Jackson have ended negotiations for a long-term contract extension with their season poised to kick off on Sunday.  

Jackson will play for just over $23million on the fifth-year option of his rookie contract. Earlier this week he said he would not continue to negotiate during the season.  

"Despite best effort on both sides, we were unable to reach a contract extension with Lamar Jackson," Ravens general manager Eric DeCosta said in a statement.

"We greatly appreciate how he has handled this process and we are excited about our team with Lamar leading the way.  

"We will continue to work toward a long-term contract after the season, but for now we are looking forward to a successful 2022 campaign."

While talks will resume next offseason, NFL Network's Tom Pelissero reported that Jackson is likely to receive the franchise tag in 2023. 

Dak Prescott played the 2020 season for the Dallas Cowboys under the franchise tag before the sides agreed to a four-year, $160m deal before last season.  

The quarterback market has been booming this offseason, with Deshaun Watson, Kyler Murray and Russell Wilson each signing contracts with an average annual value of at least $46m and with total guarantees over $165m.  

Watson's $230m contract with the Browns is fully guaranteed, and Jackson could be looking for something similar.  

Watson's contract could further complicate the Ravens' situation, with his scheduled $55m cap hit for next season inflating the value of the franchise tag, which is the average of the top five salaries at the position.  

Even if no other quarterbacks sign lucrative deals in the meantime, tagging Jackson would cost the Ravens $45.4m in 2023 and $54.4m in 2024.

The first week of the 2022 NFL season is here, with all the possibilities a new campaign brings.

Things kicked off on Thursday with the Buffalo Bills beating the Los Angeles Rams 31-10 thanks to a starring role from quarterback Josh Allen, who threw three touchdowns against the defending champions.

There are even more enticing games to look forward to over the weekend, with last season's Super Bowl runners up the Cincinnati Bengals hosting the Pittsburgh Steelers, Patrick Mahomes and the much-fancied Kansas City Chiefs facing Kyler Murray and the Arizona Cardinals, and it will be Aaron Rodgers v Kirk Cousins as the Green Bay Packers go to the Minnesota Vikings.

Stats Perform dives head first into Opta data to preview those games and more of the opening weekend of NFL action.

Pittsburgh Steelers @ Cincinnati Bengals

The Bengals have won their last three games against the Steelers (27-17 in December 2020, 24-10 and 41-10 last season). It is the Bengals' longest winning streak versus the Steelers since they won six consecutive games from 1988 through 1990.

Mitch Trubisky will be the first quarterback other than Ben Roethlisberger to start a season opener for the Steelers since Dennis Dixon in 2010 (Roethlisberger was suspended). Trubisky is 1-2 in season openers, losing to the Packers twice and beating the Detroit Lions (all when he was with the Chicago Bears).

The Bengals played a league-high seven games decided by exactly three points during the 2021 regular season (won three, lost four), the highest single-season total by an NFL team since the 2012 Steelers (seven). Three of Cincinnati's four postseason games were also decided by exactly three points, including the 23-20 Super Bowl loss to the Rams.

Bengals quarterback Joe Burrow completed 67 of 85 passes for 971 yards, eight touchdowns and no interceptions over his final two games in the 2021 regular season (Week 16 against the Ravens, Week 17 against the Chiefs). Burrow's passing yardage is the second-highest two-game total by one player in NFL history, trailing only Dak Prescott's 974 passing yards over a two-game span in 2020.

Kansas City Chiefs @ Arizona Cardinals

The Chiefs have won their division in six consecutive seasons, which is three more than the next longest active streak (Green Bay). Only two teams in NFL history have had longer streaks (New England - 11, 2009-2019 and LA Rams - seven, 1973-1979).

Patrick Mahomes has won 50 of his 63 career starts as Kansas City's quarterback. The only QB in the Super Bowl era to reach 50 wins in fewer career starts than Mahomes was Kenny Stabler, who earned his 50th win in his 62nd start.

Arizona scored 30 or more points in nine different games in 2022, tied for the most in a single season in team history. Since a 56-14 win over the Vikings in Week 4 of 1963, the Cardinals have gone 903 games without scoring 50 points, which is the longest streak in NFL history (Broncos, 761 straight games from 1963-2013).

Cardinals QB Kyler Murray will not want to be upstaged by Mahomes, and is the only player in NFL history to have at least 70 passing touchdowns and 20 rushing touchdowns in the first three seasons of his NFL career.

Green Bay Packers @ Minnesota Vikings

In their 22 road games against the Vikings this century, Green Bay has scored 30 or more points in 10 of them. That is tied for most 30-point games by an NFL team at a single opponent in that time with the Patriots at the Bills.

No NFL head coach has won more games over his first three NFL seasons than Matt LaFleur (39; George Seifert had 38). A win Sunday would make LaFleur the third coach in NFL history with 40 wins through 50 career games as head coach, joining Paul Brown (41) and Chuck Knox (40).

Kirk Cousins has thrown for at least 3500 yards and 25 TDs in seven consecutive seasons, the longest active streak in the NFL. He is the fifth QB in NFL history to have more than five straight, joining Peyton Manning, Drew Brees, Philip Rivers and Tom Brady.

Since becoming Green Bay's starter in 2008, Aaron Rodgers has thrown 169 TDs against division opponents, compared to 25 interceptions. The Vikings have a total of 121 passing touchdowns and 73 interceptions against the NFC North in that span.

Elsewhere...

When Carolina host Cleveland, with Baker Mayfield starting for the Panthers and Myles Garrett starting for the Browns, they will become the second pair of number one overall draft picks for the same team to go on to play against one another. The others were Jeff George and Steve Emtman in 1995.

The Eagles head to the Lions, with no team targeting their receivers less frequently than Philadelphia last season (239 targets), which led to the acquisition of A.J. Brown. The fourth-year WR has scored a TD on 13.0 percent of his career catches, third-highest rate among active players (min. 150 receptions).

The New Orleans Saints will need to beware of Foye Oluokun, who led the NFL last season with 192 total tackles, becoming the first Atlanta Falcon to lead the league in that category since Jessie Tuggle in 1995 (152). Oluokun's 192 total tackles were the most in a season by an NFL player since Chris Spielman had 195 in 1994 for the Lions.

Tom Brady is back for Tampa Bay Buccaneers after a very brief retirement as they travel to the Dallas Cowboys. The 45-year-old's last two seasons mark the first time in NFL history a QB has had 40 or more TD passes and a passer rating of 100.0 or better in back-to-back seasons.

Los Angeles Rams coach Sean McVay admitted it was a "humbling experience" to lose 31-10 to the Buffalo Bills in the opening game of the new NFL season.

The Bills looked strong throughout at SoFi Stadium, with quarterback Josh Allen putting in a sensational performance as he threw three touchdowns, rushed for one of his own, and completed 26 of 31 passes for a total of 297 yards.

After unveiling their Super Bowl LVI banner, the Rams struggled in front of their own fans as all 10 of their points came in the second quarter, with Buffalo shutting them out in the second half.

"When you look at a lot of the ways that this game unfolded, [I] feel a huge sense of responsibility to this team," McVay said after the loss.

"We weren't ready to go. I take a lot of pride in that, and that's on me. I've got to do better. There were a lot of decisions that I made that I felt didn't put our players in good enough spots.

"So it was a humbling experience, but we're going to stay connected. We're going to all look inward. We're going to do a better job moving forward."

Allen became the first QB in NFL history to record 250+ passing yards, 50+ rushing yards, three or more passing TDs, a rushing TD, 80 per cent completions and a win in the same game.

Speaking to NBC after the victory, Allen said: "We knew if we came out and tried to execute the way we know we can execute, we were going to move the ball the ball and score. Our defense played a hell of a game.

"Defense's job is to get the ball back, but the offense can help and let them go and pin their ears back by getting up and putting them in legit passing situations and letting them go. 

"We got a bunch of dawgs up front. [Former Ram Von Miller] is the leader of that D-line and they played outstanding."

The Bills play the Tennessee Titans at Highmark Stadium in Week 2, while the Rams will look to put their opening defeat behind them as they host the Atlanta Falcons.

The Buffalo Bills were too strong for the reigning Super Bowl champions in the NFL's season kickoff on Thursday night, shutting the Los Angeles Rams down in the second half to run away 31-10 winners on the road.

It was a stylish start for the Bills as they received the opening kick and marched down the field in nine plays, culminating in a 26-yard touchdown pass from Josh Allen to Gabriel Davis for the first score of the season.

That set the table for what looked like it may be a shootout, but the rust was still clearly not shaken off as the next five combined possessions resulted in three turnovers and two punts.

A beautiful throw from Matthew Stafford found Cooper Kupp in the back corner of the endzone late in the second quarter, and after Allen's second interception of the game, a 57-yard field goal as time expired from Matt Gay had things tied at 10-10 going into halftime.

There were warning signs for the Rams as they needed three Bills turnovers to remain competitive, and when the visitors cleaned things up in the second half, the hosts had no answer.

The first three Bills drives of the second half all resulted in touchdowns, with Allen rushing for one score, finding Isaiah McKenzie for a short-range touchdown, and heaving long for a 53-yarder to Stefon Diggs to complete the rout.

Stafford could only find success throwing to star receiver Cooper Kupp, who finished with 13 catches for 128 yards and a touchdown from his 15 targets, while the five other players to catch a pass combined for 16 catches for 112 yards on 25 targets. He also had three interceptions after one more in garbage time.

Allen finished 26-of-31 for 297 yards with three touchdowns and two picks, adding 10 rushes for 56 yards and a score on the ground. Diggs was his top receiver with eight catches for 122 yards and a touchdown from nine targets.

The NFL is set to hold a moment of silence ahead of Thursday's season-opening kick-off encounter between the Buffalo Bills and the Los Angeles Rams following the death of HRH Queen Elizabeth II.

The reigning Super Bowl champions will make the trip to New York state to start their defence in the 2022 campaign curtain raiser.

Before a ball is kicked however, both teams will pay tribute to the late monarch, Britain's longest-reigning sovereign at the time of her passing at the age of 96.

"Everyone at NFL UK is deeply saddened to hear of the passing of Her Majesty The Queen, Elizabeth II," read an official message posted to social media by the league.

"Our thoughts and deepest sympathies are with The Royal Family. We join all those mourning the loss of Her Majesty."

The NFL is due to hold three games in London this year as part of their International Series, with the first to come in week four between the Minnesota Vikings and the New Orleans Saints at Tottenham Hotspur Stadium.

Over seven decades on the throne, the Queen oversaw a number of major events – not least in the sporting world.

Sport was a significant feature of Her Majesty's 70-year reign, from attending events to handing over trophies, most famously in 1966 when England lifted the World Cup at Wembley.

Following the announcement of her passing on Thursday, Stats Perform looks at the major sporting events that coincided with prominent milestones throughout the Queen's reign.

The Queen's Coronation, 1953

Princess Elizabeth was officially crowned Queen on June 2, 1953, a year after the death of her father George VI. Aged just 25, her ascension to the throne took place amid a glittering ceremony at Westminster Abbey. In the sporting world, Alberto Ascari won the Formula One championship for a second successive year shortly after the historic moment. He remains one of only two Ferrari drivers to have won multiple titles, along with the great Michael Schumacher, while no Italian has triumphed since. This was also the year Ken Rosewall, one of the greatest tennis players of all time, won the first of his eight grand slam titles with victory at the Australian Open, aged just 18. Incredibly, the last of those major triumphs arrived 21 years after his maiden success at Wimbledon in 1974.

The Silver Jubilee, 1977

The Queen's Silver Jubilee marked the 25th anniversary of her accession and was celebrated by millions throughout the United Kingdom and the Commonwealth. Known for her love of horse racing, Her Majesty would no doubt have had a watching eye on that year's Grand National, won that year for an unprecedented third time by Red Rum – a record that stands to this day. A week on from that event, Tom Watson edged out Jack Nicklaus in a thrilling conclusion to the Masters, and he did likewise later in the year when coming out on top at The Open.

The Golden Jubilee, 2002

The Queen's 50-year anniversary on the throne coincided with a bumper year of sport, the highlight being the 2002 World Cup in South Korea and Japan – the first time the football showpiece had been held outside of the Americas or Europe – which was won by Brazil for a fifth time. While the World Cup, Winter Olympics and Commonwealth Games garnered plenty of attention, that year's must-see one-off event was Lennox Lewis' heavyweight bout with Mike Tyson in Tennessee, with the Briton winning by knockout in the eighth round.

The Diamond Jubilee, 2012

The London Olympics was the biggest sporting event on home soil during the Queen's lifetime – bigger even than England's famous World Cup triumph of 1966 – and coincided with her Diamond Jubilee. The Games were a massive success, particularly for Great Britain, and proved one of many highlights in a remarkable sporting year. Europe produced one of the Ryder Cup's greatest ever comebacks in what is now known as 'The Miracle at Medinah', while Spain thrashed Italy 4-0 to win Euro 2012. Perhaps bigger than all that, though, was the news that Lance Armstrong had been banned from cycling for life and stripped of his seven Tour de France titles after being found to have used performance-enhancing drugs over the course of his career.

The Sapphire Jubilee, 2017

Sixty-five years is a long time, with this Jubilee making the Queen the first British monarch to hit the Sapphire milestone. Sergio Garcia's wait for a first major would have felt just as long, the Spaniard claiming victory in a sudden-death play-off with Justin Rose at the Masters in what was his 74th major. The conclusion to that tournament provided drama aplenty, yet it was nothing compared to that year's Super Bowl as the New England Patriots recovered from a 28-3 deficit to beat the Atlanta Falcons 34-28 in the largest comeback in the showpiece's history. It also remains the only Super Bowl to be decided in overtime.